MBC - 3310 MEDICINAL CHEMISTRY I: DRUG ACTION AND DESIGN
[3 hours] An introductory course presenting the basic chemical principles
governing the behavior of drugs and the design of new therapeutics. Prerequisite: CHEM 2420 Corequisite: MBC 3550
MBC - 3320 MEDICINAL CHEMISTRY II: DRUG TARGETING TO RECEPTORS
[3 hours] A course presenting basic chemical principles governing the
design and behavior of therapeutics targeted to receptors in physiologic systems which are key to the integrated control of human metabolism.
Prerequisite: MBC 3310 and MBC 3550 Corequisite: MBC 3560
MBC - 3550 PHYSIOLOGICAL CHEMISTRY I: STRUCTURE AND FUNCTION OF BIOLOGICAL MACROMOLECULES
[3 hours] An examination of the levels of
structure of proteins, nucleic acids, other biomolecules and biomolecular assemblies. Prerequisite: CHEM 2420 or completion of one year of
Organic Chemistry
MBC - 3560 PHYSIOLOGICAL CHEMISTRY II: CHEMICAL REGULATION OF CELLS AND ORGANISMS
[3 hours] An examination of the chemistry and
regulation of metabolic processes in cells, interacting cells, and tissues. Prerequisite: MBC 3550 or equivalent
MBC - 3600 MICROBIOLOGY AND IMMUNOLOGY
[4 hours] A lecture and laboratory course with an emphasis on how the immune system protects the
body against bacterial, viral, and parasitic invaders. Medically important human infectious diseases are described, along with chemotherapeutic
intervention. Prerequisite: MBC 3550 Corequisite: MBC 3560 and admission to the professional pharmacy program
MBC - 4300 MEDICINAL CHEMISTRY III: CHEMOTHERAPY AND IMMUNOTHERAPY
[3 hours] The chemical bases for actions of drugs that counter
infectious disease and cancer, including use and modulation of the immune system and its products to target infectious disease and cancer.
Prerequisite: MBC 3600 or BIOL 4030 & BIOL 4050
MBC - 4340 CONTEMPORARY NATURAL REMEDIES
[2 hours] An introduction to natural remedies, their history, source, chemical constituents,
documented therapeutic utility, and toxicity. Prerequisite: MBC 3320 or permission of instructor
MBC - 4380 MEDICINAL PLANTS
[2 hours] A lecture/field course emphasizing medicinal and poisonous plants of this locale. Prerequisite:
Admission to professional division BS program in pharmacy
MBC - 4390 GENES AND PROTEINS IN THERAPY
[2 hours] Consideration of the symptoms, molecular nature, current treatment, and amelioration
by gene therapy of diseases caused by gene and protein defects. Prerequisite: MBC 3550
MBC - 4410 NUTRITION IN HEALTH AND DISEASE
[2 hours] A comprehensive examination of the role of carbohydrates, lipids, proteins,
vitamins, and minerals in maintaining good health, as well as our current understanding of the interplay between nutrition and disease.
Prerequisite: MBC 3560
MBC - 4420 NEUROSCIENCE
[2 hours] An examination of the basic anatomy, chemistry, and physiology of neural systems. The organization of
the brain and its role in behavior and in disease states are presented in an interdisciplinary way. Prerequisite: MBC 3560
MBC - 4430 BIOCHEMISTRY OF DISEASE
[2 hours] Mechanisms of pathogenesis and pathophysiological consequences in diseases already
well-understood at a biochemical level. Emphasis is placed on the logic behind existing and future drug therapies in disease. Prerequisite: MBC
3560
MBC - 4450 NEW DRUG DEVELOPMENT
[2 hours] An examination of all phases of drug discovery and development from conception to marketing:
case histories from pharmaceutical research and development. Prerequisite: MBC 3560 or permission of instructor
MBC - 4470 ADVANCED IMMUNO-THERAPEUTICS
[2 hours] This course emphasizes the development of methods for immunotherapeutic intervention
in cancer and autoimmune and infectious disease. The course has a seminar/discussion/student presentation format. Prerequisite: MBC 4300
MBC - 4480 CHEMICAL DEFENSE MECHANISMS IN PLANTS
[2 hours] A study of the effects on plant predators of secondary metabolites in plants
as a basis for the novel development of therapeutics. Prerequisite: MBC 3560
MBC - 4710 TARGETED DRUG DESIGN
[3 hours] A survey of novel macromolecular targeting approaches to drug design in important human
disorders. The course has a seminar/discussion/student presentation format. Prerequisite: MBC 3320
MBC - 4720 ADVANCES IN DRUG DESIGN
[3 hours] A survey of novel approaches to drug design and development. The course has a
seminar/discussion/student presentation format. Prerequisite: MBC 3320
MBC - 4760 BIOCHEMICAL TOXICOLOGY
[2 hours] The biochemical principles underlying toxicological phenomena, including biotransformation,
host and environmental modulation, and target organs. Prerequisite: MBC 3550 Corequisite: MBC 3560
MBC - 4770 MOLECULAR MODELING IN DRUG DESIGN
[3 hours] Theoretical and graphical approaches to the geometry of drug interactions with
their receptors. Methods of determining and predicting conformation at drug receptor sites are examined. Prerequisite: MBC 3320
MBC - 4800 QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS
[2 hours] Linear free energy relationships and substituent effects in
pharmacologically related agents are considered in the quantitative description of structure vs. drug activity. Prerequisite: MBC 3320
MBC - 4900 HONORS SEMINAR IN MEDICINAL AND BIOLOGICAL CHEMISTRY
[3 hours] An examination of a specific question in the context of the
primary literature in medicinal or biological chemistry. Prerequisite: Permission of College of Pharmacy Honors Program Adviser
MBC - 4910 PROBLEMS IN BIOMEDICINAL CHEMISTRY
[1 - 3 hours] Selected study of topics in biomedicinal chemistry. New chemical and
biochemical strategies in drug design are examined in detail. Prerequisite: 4th year status (professional division BS Pharm Prog)
MBC - 4950 RESEARCH IN MEDICINAL CHEMISTRY
[6 - 8 hours] Selected research and study in medicinal chemistry. Prerequisite: Permission
of instructor
MBC - 4960 HONORS THESIS IN MEDICINAL AND BIOLOGICAL CHEMISTRY
[2 - 5 hours] An examination of a specific research question in
medicinal or biological chemistry that can be answered through experimental work. Prerequisite: Permission of College of Pharmacy Honors Program
Adviser
MBC - 4980 SPECIAL TOPICS IN DRUG DESIGN
[1 - 4 hours] A detailed examination of new chemical and biochemical strategies in drug
design. Prerequisite: MBC 3320, 3560
MBC - 5100/7100 RESEARCH PRACTICES IN MEDICINAL CHEMISTRY
[1 hour] Consideration of the scientific, ethical, and legal obligations of
the graduate student researcher. Prerequisite: Admission to the graduate program in medicinal chemistry, chemistry, biology, pharmaceutical
sciences, or permission of instructor.
MBC - 5620/7620 BIOCHEMICAL TECHNIQUES
[2 hours] A detailed study of biochemical laboratory techniques necessary for the development of
novel therapeutics, including bioassays and data analysis. Prerequisite: Admission to the graduate program in medicinal chemistry, chemistry,
biology, pharmaceutical sciences or permission of instructor.
MBC - 5900/7900 MEDICINAL CHEMISTRY SEMINAR
[1 hour] Presentation and discussion of advanced research topics in medicinal chemistry,
with an emphasis on evaluating and criticizing emerging data as a way of testing to test hypotheses. Prerequisite: Admission to graduate program
in medicinal chemistry, chemistry, biology, or pharmaceutical sciences or permission of instructor
MBC - 6100/8100 ADVANCED IMMUNOLOGY
[2 hours] Readings in and critical analysis of the recent literature in immunology and basic
immunologic responses, especially as considered in immunotherapy. Prerequisite: Admission to Ph.D. program in chemistry, medicinal chemistry, or
biology, and permission of the instructor.
MBC - 6190/8190 ADVANCED MEDICINAL CHEMISTRY
[4 hours] Discussion of the qualitative and quantitative aspects of the design of new
therapeutic agents. Approaches to the design of drugs and new therapeutic modalities directed at enzymes, receptors, membrane transport proteins
and nucleic acids are examined. Prerequisite: Admission to the graduate program in medicinal chemistry, biology, or pharmaceutical sciences, or
permission of instructor.
MBC - 6200/8200 BIOMEDICINAL CHEMISTRY
[4 hours] Examination of the primary literature on approaches to the design of new therapeutic
agents. Recent novel directions in the design of drugs will be examined and compared. Prerequisite: MBC 6190/8190 or permission of instructor
MBC - 6300/8300 BIOMEDICINAL CHEMISTRY LABORATORY I
[4 hours] Experimental research problems in biomedicinal chemistry. Prerequisite:
MBC 6190, 6550/8550
MBC - 6310/8310 BIOMEDICINAL CHEMISTRY LABORATORY II
[4 hours] Additional experimental research problems in biomedicinal chemistry (see
MBC 6300/8300). Prerequisite: MBC 6190 and 6550/8550 or permission of course director
MBC - 6420/8420 PROTEIN CHEMISTRY
[4 hours] A detailed analysis of the structure and function of proteins: current methodology for the
analysis of structure, the basis for molecular associations, and relationships between structure and biological function Prerequisite: MBC
6550/8550 or equivalent
MBC - 6430/8430 NUCLEIC ACID CHEMISTRY
[4 hours] The chemical basis for storage and transmission of genetic information. Prerequisite:
MBC 6550/8550 or equivalent
MBC - 6440/8440 ENZYMOLOGY
[4 hours] The principles of chemical catalysis applied to molecular enzymology. Prerequisite: MBC 6550 or
equivalent
MBC - 6550/8550 BIOCHEMISTRY
[4 hours] A consideration of the structure and function of biological macromolecules as well as the basic
and regulated metabolism of cells. Prerequisite: Admission to Graduate Program in medicinal chemistry, chemistry, biology, or pharmaceutical
sciences, or permission of instructor; Undergraduate course in Organic Chemistry
MBC - 6750/8750 BIOORGANIC CHEMISTRY: CHEMICAL APPROACHES TO ENZYMES
[2 hours] An advanced course in the application of organic
chemistry, stereochemistry, synthesis, and kinetics to the study of enzymes, enzyme inhibition, and enzyme mechanisms. Prerequisite: MBC
6550/8550; and a graduate course in Organic Chemistry, or permission of instructor
MBC - 6800/8800 METHODS IN BIOTECHNOLOGY
[3 hours] Experimental investigations of current techniques in biochemistry and molecular
biology that involve DNA or protein amplification, modification, and interactions relevant to drug research. Prerequisite: MBC 6550/8550
MBC - 6960 M.S. THESIS RESEARCH IN MEDICINAL CHEMISTRY
[1 - 15 hours] Development and pursuit of research leading to an M.S. thesis in
medicinal chemistry. Prerequisite: Admission to M.S. program in medicinal chemistry
MBC - 6980/8980 SPECIAL TOPICS IN BIOMEDICINAL CHEMISTRY
[1 - 5 hours] Selected study of topics in medicinal chemistry. New chemical
and biochemical strategies in drug design are examined in detail. Prerequisite: Admission to graduate program in medicinal chemistry, chemistry,
biology, or pharmaceutical sciences, or permission of instructor.
MBC - 8960 PH.D. DISSERTATION RESEARCH IN MEDICINAL CHEMISTRY
[1-15 hours] Development and pursuit of research leading to a Ph.D.
dissertation in medicinal chemistry. Prerequisite: Admission to Ph.D. program in medicinal chemistry
MBC - 8980 SPECIAL TOPICS IN BIOMEDICINAL CHEMISTRY
[1 - 5 hours] Selected study of topics in medicinal chemistry. New chemical and
biochemical strategies in drug design are examined in detail. Prerequisite: Admission to Ph.D. program in medicinal chemistry, chemistry, or
biology, or permission of instructor.