MBC - MEDICINAL AND BIOLOGICAL CHEMISTRY

Department of Medicinal & Biological Chemistry (PHM)


MBC - 3310 MEDICINAL CHEMISTRY I: DRUG ACTION AND DESIGN
[3 hours] An introductory course presenting the basic chemical principles governing the behavior of drugs and the design of new therapeutics. Prerequisite: CHEM 2420 Corequisite: MBC 3550


MBC - 3320 MEDICINAL CHEMISTRY II: DRUG TARGETING TO RECEPTORS
[3 hours] A course presenting basic chemical principles governing the design and behavior of therapeutics targeted to receptors in physiologic systems which are key to the integrated control of human metabolism. Prerequisite: MBC 3310 and MBC 3550 Corequisite: MBC 3560


MBC - 3550 PHYSIOLOGICAL CHEMISTRY I: STRUCTURE AND FUNCTION OF BIOLOGICAL MACROMOLECULES
[3 hours] An examination of the levels of structure of proteins, nucleic acids, other biomolecules and biomolecular assemblies. Prerequisite: CHEM 2420 or completion of one year of Organic Chemistry


MBC - 3560 PHYSIOLOGICAL CHEMISTRY II: CHEMICAL REGULATION OF CELLS AND ORGANISMS
[3 hours] An examination of the chemistry and regulation of metabolic processes in cells, interacting cells, and tissues. Prerequisite: MBC 3550 or equivalent


MBC - 3600 MICROBIOLOGY AND IMMUNOLOGY
[4 hours] A lecture and laboratory course with an emphasis on how the immune system protects the body against bacterial, viral, and parasitic invaders. Medically important human infectious diseases are described, along with chemotherapeutic intervention. Prerequisite: MBC 3550 Corequisite: MBC 3560 and admission to the professional pharmacy program


MBC - 4300 MEDICINAL CHEMISTRY III: CHEMOTHERAPY AND IMMUNOTHERAPY
[3 hours] The chemical bases for actions of drugs that counter infectious disease and cancer, including use and modulation of the immune system and its products to target infectious disease and cancer. Prerequisite: MBC 3600 or BIOL 4030 & BIOL 4050


MBC - 4340 CONTEMPORARY NATURAL REMEDIES
[2 hours] An introduction to natural remedies, their history, source, chemical constituents, documented therapeutic utility, and toxicity. Prerequisite: MBC 3320 or permission of instructor


MBC - 4380 MEDICINAL PLANTS
[2 hours] A lecture/field course emphasizing medicinal and poisonous plants of this locale. Prerequisite: Admission to professional division BS program in pharmacy


MBC - 4390 GENES AND PROTEINS IN THERAPY
[2 hours] Consideration of the symptoms, molecular nature, current treatment, and amelioration by gene therapy of diseases caused by gene and protein defects. Prerequisite: MBC 3550


MBC - 4410 NUTRITION IN HEALTH AND DISEASE
[2 hours] A comprehensive examination of the role of carbohydrates, lipids, proteins, vitamins, and minerals in maintaining good health, as well as our current understanding of the interplay between nutrition and disease. Prerequisite: MBC 3560


MBC - 4420 NEUROSCIENCE
[2 hours] An examination of the basic anatomy, chemistry, and physiology of neural systems. The organization of the brain and its role in behavior and in disease states are presented in an interdisciplinary way. Prerequisite: MBC 3560


MBC - 4430 BIOCHEMISTRY OF DISEASE
[2 hours] Mechanisms of pathogenesis and pathophysiological consequences in diseases already well-understood at a biochemical level. Emphasis is placed on the logic behind existing and future drug therapies in disease. Prerequisite: MBC 3560


MBC - 4450 NEW DRUG DEVELOPMENT
[2 hours] An examination of all phases of drug discovery and development from conception to marketing: case histories from pharmaceutical research and development. Prerequisite: MBC 3560 or permission of instructor


MBC - 4470 ADVANCED IMMUNO-THERAPEUTICS
[2 hours] This course emphasizes the development of methods for immunotherapeutic intervention in cancer and autoimmune and infectious disease. The course has a seminar/discussion/student presentation format. Prerequisite: MBC 4300


MBC - 4480 CHEMICAL DEFENSE MECHANISMS IN PLANTS
[2 hours] A study of the effects on plant predators of secondary metabolites in plants as a basis for the novel development of therapeutics. Prerequisite: MBC 3560


MBC - 4710 TARGETED DRUG DESIGN
[3 hours] A survey of novel macromolecular targeting approaches to drug design in important human disorders. The course has a seminar/discussion/student presentation format. Prerequisite: MBC 3320


MBC - 4720 ADVANCES IN DRUG DESIGN
[3 hours] A survey of novel approaches to drug design and development. The course has a seminar/discussion/student presentation format. Prerequisite: MBC 3320


MBC - 4760 BIOCHEMICAL TOXICOLOGY
[2 hours] The biochemical principles underlying toxicological phenomena, including biotransformation, host and environmental modulation, and target organs. Prerequisite: MBC 3550 Corequisite: MBC 3560


MBC - 4770 MOLECULAR MODELING IN DRUG DESIGN
[3 hours] Theoretical and graphical approaches to the geometry of drug interactions with their receptors. Methods of determining and predicting conformation at drug receptor sites are examined. Prerequisite: MBC 3320


MBC - 4800 QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS
[2 hours] Linear free energy relationships and substituent effects in pharmacologically related agents are considered in the quantitative description of structure vs. drug activity. Prerequisite: MBC 3320


MBC - 4900 HONORS SEMINAR IN MEDICINAL AND BIOLOGICAL CHEMISTRY
[3 hours] An examination of a specific question in the context of the primary literature in medicinal or biological chemistry. Prerequisite: Permission of College of Pharmacy Honors Program Adviser


MBC - 4910 PROBLEMS IN BIOMEDICINAL CHEMISTRY
[1 - 3 hours] Selected study of topics in biomedicinal chemistry. New chemical and biochemical strategies in drug design are examined in detail. Prerequisite: 4th year status (professional division BS Pharm Prog)


MBC - 4950 RESEARCH IN MEDICINAL CHEMISTRY
[6 - 8 hours] Selected research and study in medicinal chemistry. Prerequisite: Permission of instructor


MBC - 4960 HONORS THESIS IN MEDICINAL AND BIOLOGICAL CHEMISTRY
[2 - 5 hours] An examination of a specific research question in medicinal or biological chemistry that can be answered through experimental work. Prerequisite: Permission of College of Pharmacy Honors Program Adviser


MBC - 4980 SPECIAL TOPICS IN DRUG DESIGN
[1 - 4 hours] A detailed examination of new chemical and biochemical strategies in drug design. Prerequisite: MBC 3320, 3560


MBC - 5100/7100 RESEARCH PRACTICES IN MEDICINAL CHEMISTRY
[1 hour] Consideration of the scientific, ethical, and legal obligations of the graduate student researcher. Prerequisite: Admission to the graduate program in medicinal chemistry, chemistry, biology, pharmaceutical sciences, or permission of instructor.


MBC - 5620/7620 BIOCHEMICAL TECHNIQUES
[2 hours] A detailed study of biochemical laboratory techniques necessary for the development of novel therapeutics, including bioassays and data analysis. Prerequisite: Admission to the graduate program in medicinal chemistry, chemistry, biology, pharmaceutical sciences or permission of instructor.


MBC - 5900/7900 MEDICINAL CHEMISTRY SEMINAR
[1 hour] Presentation and discussion of advanced research topics in medicinal chemistry, with an emphasis on evaluating and criticizing emerging data as a way of testing to test hypotheses. Prerequisite: Admission to graduate program in medicinal chemistry, chemistry, biology, or pharmaceutical sciences or permission of instructor


MBC - 6100/8100 ADVANCED IMMUNOLOGY
[2 hours] Readings in and critical analysis of the recent literature in immunology and basic immunologic responses, especially as considered in immunotherapy. Prerequisite: Admission to Ph.D. program in chemistry, medicinal chemistry, or biology, and permission of the instructor.


MBC - 6190/8190 ADVANCED MEDICINAL CHEMISTRY
[4 hours] Discussion of the qualitative and quantitative aspects of the design of new therapeutic agents. Approaches to the design of drugs and new therapeutic modalities directed at enzymes, receptors, membrane transport proteins and nucleic acids are examined. Prerequisite: Admission to the graduate program in medicinal chemistry, biology, or pharmaceutical sciences, or permission of instructor.


MBC - 6200/8200 BIOMEDICINAL CHEMISTRY
[4 hours] Examination of the primary literature on approaches to the design of new therapeutic agents. Recent novel directions in the design of drugs will be examined and compared. Prerequisite: MBC 6190/8190 or permission of instructor


MBC - 6300/8300 BIOMEDICINAL CHEMISTRY LABORATORY I
[4 hours] Experimental research problems in biomedicinal chemistry. Prerequisite: MBC 6190, 6550/8550


MBC - 6310/8310 BIOMEDICINAL CHEMISTRY LABORATORY II
[4 hours] Additional experimental research problems in biomedicinal chemistry (see MBC 6300/8300). Prerequisite: MBC 6190 and 6550/8550 or permission of course director


MBC - 6420/8420 PROTEIN CHEMISTRY
[4 hours] A detailed analysis of the structure and function of proteins: current methodology for the analysis of structure, the basis for molecular associations, and relationships between structure and biological function Prerequisite: MBC 6550/8550 or equivalent


MBC - 6430/8430 NUCLEIC ACID CHEMISTRY
[4 hours] The chemical basis for storage and transmission of genetic information. Prerequisite: MBC 6550/8550 or equivalent


MBC - 6440/8440 ENZYMOLOGY
[4 hours] The principles of chemical catalysis applied to molecular enzymology. Prerequisite: MBC 6550 or equivalent


MBC - 6550/8550 BIOCHEMISTRY
[4 hours] A consideration of the structure and function of biological macromolecules as well as the basic and regulated metabolism of cells. Prerequisite: Admission to Graduate Program in medicinal chemistry, chemistry, biology, or pharmaceutical sciences, or permission of instructor; Undergraduate course in Organic Chemistry


MBC - 6750/8750 BIOORGANIC CHEMISTRY: CHEMICAL APPROACHES TO ENZYMES
[2 hours] An advanced course in the application of organic chemistry, stereochemistry, synthesis, and kinetics to the study of enzymes, enzyme inhibition, and enzyme mechanisms. Prerequisite: MBC 6550/8550; and a graduate course in Organic Chemistry, or permission of instructor


MBC - 6800/8800 METHODS IN BIOTECHNOLOGY
[3 hours] Experimental investigations of current techniques in biochemistry and molecular biology that involve DNA or protein amplification, modification, and interactions relevant to drug research. Prerequisite: MBC 6550/8550


MBC - 6960 M.S. THESIS RESEARCH IN MEDICINAL CHEMISTRY
[1 - 15 hours] Development and pursuit of research leading to an M.S. thesis in medicinal chemistry. Prerequisite: Admission to M.S. program in medicinal chemistry


MBC - 6980/8980 SPECIAL TOPICS IN BIOMEDICINAL CHEMISTRY
[1 - 5 hours] Selected study of topics in medicinal chemistry. New chemical and biochemical strategies in drug design are examined in detail. Prerequisite: Admission to graduate program in medicinal chemistry, chemistry, biology, or pharmaceutical sciences, or permission of instructor.


MBC - 8960 PH.D. DISSERTATION RESEARCH IN MEDICINAL CHEMISTRY
[1-15 hours] Development and pursuit of research leading to a Ph.D. dissertation in medicinal chemistry. Prerequisite: Admission to Ph.D. program in medicinal chemistry


MBC - 8980 SPECIAL TOPICS IN BIOMEDICINAL CHEMISTRY
[1 - 5 hours] Selected study of topics in medicinal chemistry. New chemical and biochemical strategies in drug design are examined in detail. Prerequisite: Admission to Ph.D. program in medicinal chemistry, chemistry, or biology, or permission of instructor.

Last Updated: 1/3/12