BRIM Center News
New and Continuing Biomarker Related Awards
| Contact Principal Investigator | Project Title | Administering IC | Project Start Date |
| HENSLEY, KENNETH | NANOTECHNOLOGY FOR AMYOTROPHIC LATERAL SCLEROSIS | NINDS | 1-May-09 |
| JOE, BINA | INNOVATIVE MODELS FOR MECHANISTIC STUDIES OF NOVEL HYPERTENSION GENES | NHLBI | 1 Dec-11 |
| NAJJAR, SONIA MICHAEL | INSULIN RESISTANCE IN THE PATHOGENESIS OF NASH | NIDDK | 30-Sep-09 |
| TAKASHIMA, AKIRA | THE ROLE OF COMPLEMENT PROTEINS IN CARDIOVASCULAR DISEASE | NHLBI | 30-Sep-09 |
| WILLEY, JAMES C | IMPLEMENTATION OF INNOVATIVE RNA SAMPLE QUALITY CONTROL METHODS | NCI | 11-Mar-10 |
| WILLEY, JAMES C | IMPLEMENTATION OF INNOVATIVE RNA SAMPLE QUALITY CONTROL METHODS | NCI | 11-Mar-10 |
| WILLEY, JAMES C | VALIDATION OF A MULTI-GENE TEST FOR LUNG CANCER RISK | NCI | 30-Sep-09 |
Biomarker Publications
Tietjen GE, Khubchandani J, Herial NA, Shah K. Adverse childhood experiences are associated with migraine and vascular biomarkers. Headache. Jun;52(6):920-9, 2012; pubmed/22533684.
Riaz AH, Tasma BE, Woodman ME, Wooten RM, Worth RG. Human platelets efficiently kill IgG-opsonized E. coli. FEMS Immunol Med Microbiol. 2012 Jun;65(1):78-83, PMID:22340259
Kumarasamy S, Gopalakrishnan K, Kim DH, Abraham NG, Johnson WD, Joe B, Gupta AK. Dysglycemia induces abnormal circadian blood pressure variability. Cardiovasc Diabetol. 2011 Nov 22;10:104; PMID:22108527.
Vanella L, Kim DH, Sodhi K, Barbagallo I, Burgess AP, Falck JR, Schwartzman ML, Abraham NG. Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):54-62. Epub 2011 Jul 27. PubMed PMID:21821145
AbouAlaiwi, WA, Rodriguez, I , Nauli, SM. Spectral karyotyping to study chromosome abnormalities in humans and mice with polycystic kidney disease. J Vis Exp (60), e3887, 2012.
Rasche SS, Phillips M, McInerney MF, Sercarz EE, Quinn A. IL-13Rα1 expression on β-cell-specific T cells in NOD mice. Diabetes. 2011 Jun;60(6):1716-25. PubMed PMID: 21617187; PubMed Central PMCID: PMC3114389.
Cao J, Sodhi K, Inoue K, Quilley J, Rezzani R, Rodella L, Vanella L, Germinario L, Stec DE, Abraham NG, Kappas A. Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension. Hum Gene Ther. 2011 Mar;22(3):271-82. Epub 2011 Jan 27. PubMed PMID: 20836698; PubMed Central PMCID: PMC3057195.
Antczak AJ, Vieth JA, Singh N, Worth RG. Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets. Clin Vaccine Immunol. 2011 Feb;18(2):210-6. Epub 2010 Dec 22. PubMed PMID: 21177916; PubMed Central PMCID: PMC3067351
Vestal DJ, Jeyaratnam JA. The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. J Interferon Cytokine Res. 2011 Jan;31(1):89-97. Epub 2010 Dec 13. PubMed PMID: 21142871
Saladi SV, Keenen B, Marathe HG, Qi H, Chin KV, de la Serna IL. Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness. Mol Cancer. 2010 Oct 22;9:280. PubMed PMID: 20969766.
Wang G, Khattar M, Guo Z, Miyahara Y, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation. Immunol Lett. 2010 Aug 16;132(1-2):61-8. Epub 2010 Jun 8. PubMed PMID: 20570629; PubMed Central PMCID: PMC2922908.
Saunders RA, Fujii K, Alabanza L, Ravatn R, Kita T, Kudoh K, Oka M, Chin KV. Altered phospholipid transfer protein gene expression and serum lipid profile by topotecan. Biochem Pharmacol. 2010 Aug 1;80(3):362-9. Epub 2010 Apr 21. PubMed PMID: 20416282; PubMed Central PMCID: PMC2883626.
Vieth JA, Kim MK, Pan XQ, Schreiber AD, Worth RG. Differential requirement of lipid
rafts for FcγRIIA mediated effector activities. Cell Immunol.
2010;265(2):111-9. Epub 2010 Aug 1. PubMed PMID: 20728077; PubMed Central PMCID: PMC2975250.
Messmer-Blust AF, Balasubramanian S, Gorbacheva VY, Jeyaratnam JA, Vestal DJ. The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase. Mol Biol Cell. 2010 Jul 15;21(14):2514-28. Epub 2010 May 26. PubMed PMID: 20505078; PubMed Central PMCID: PMC2903678.
Kanjwal K, Cooper CJ, Virmani R, Haller S, Shapiro JI, Burket MW, Steffes M, Brewster P, Zhang H, Colyer WR Jr. Predictors of embolization during protected renal artery angioplasty and stenting: Role of antiplatelet therapy. Catheter Cardiovasc Interv. 2010 Jul 1;76(1):16-23. PubMed PMID: 20209644.
Warrier M, Hinds TD Jr, Ledford KJ, Cash HA, Patel PR, Bowman TA, Stechschulte LA, Yong W, Shou W, Najjar SM, Sanchez ER. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology. 2010 Jul;151(7):3225-36. Epub 2010 Apr 28. PubMed PMID: 20427484; PubMed Central PMCID: PMC2903936.
Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski SM, Chen W. "Default" generation of neonatal regulatory T cells. J Immunol. 2010 Jul 1;185(1):71-8. Epub 2010 May 24. PubMed PMID: 20498359.
Smedlund K, Tano JY, Vazquez G. The constitutive function of native TRPC3 channels modulates vascular cell adhesion molecule-1 expression in coronary endothelial cells through nuclear factor kappaB signaling. Circ Res. 2010 May 14;106(9):1479-88. Epub 2010 Apr 1. PubMed PMID: 20360250.
Huang S, Kaw M, Harris MT, Ebraheim N, McInerney MF, Najjar SM, Lecka-Czernik B. Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation to CEACAM1. Bone. 2010 Apr; 46(4): 1138-45. Epub 2010 Jan 4. PubMed PMID: 20044046; PubMed Central PMCID: PMC2862391.
Hu S, Mrak RE, Goldblatt PJ. Tripartite components of a hepatocellular carcinoma with distinct immunohistochemical and metastatic features. Conn Med. 2010 Feb;74(2):79-83. PubMed PMID: 20218042.
Vieth JA, Kim MK, Pan XQ, Schreiber AD, Worth RG. Differential requirement of lipid rafts for FcγRIIA mediated effector activities. Cell Immunol. 2010;265(2):111-9. Epub 2010 Aug 1. PubMed PMID: 20728077; PubMed Central PMCID: PMC2975250.
Antczak AJ, Singh N, Gay SR, Worth RG. IgG-complex stimulated platelets: a source of sCD40L and RANTES in initiation of inflammatory cascade. Cell Immunol. 2010;263(1):129-33. Epub 2010 Mar 20. PubMed PMID: 20378102.
News
Breast Cancer DNA Study Yields New Targets for Therapy
A new study from the Cancer Genome Atlas Network published in Nature analyzed primary breast tumors from 825 patients, provides confirmation of four characteristic tumor types. Read more.
Mayo Clinic plans to sequence patients' genomes to personalise care
Project will give doctors the genetic information they need to choose drugs that work
best and minimise side effects. Doctors have drawn up plans to sequence the full genetic code of thousands of people
in a landmark project to personalise their medical care. Read more.
Clinical Sequencing News
GenomeWeb is pleased to announce the Academic Access Program for Clinical Sequencing News, a newsletter dedicated to covering the tools and technologies relevant to bringing genome sequencing into a clinical setting.
To give you a sense of what it's about, here are the latest headlines from Clinical Sequencing News:
- FDA Mulls Options for Regulating Next-Gen Sequencing Platforms in Clinical Diagnostics
- UK Government Funding Development of Sequencing-Based Cancer Tests
- Q&A: Pfizer's Dominic Spinella on the Challenges of Using NGS in Clinical Trials
- Whole-Genome Sequencing Delivers New Treatment Options for Twins with Rare Genetic Movement Disorder
Thanks to Knome's exclusive sponsorship of the Clinical Sequencing News Academic Access Program, this newsletter is freely available to all researchers in academia, government, and nonprofit research institutions. Click here to access the online archive of prior issues of Clinical Sequencing
Interpretome: new online tools for analysing personal genome data. Written by Daniel MacArthur
Konrad Karczewski and colleagues from Stanford have put together a very handy set
of online tools for analysing personal genomic data. The tools work within your browser
(Chrome and FireFox only, so the ~18% of you who continue to use Internet Explorer
now have yet another incentive to change), meaning your genetic data never actually
leaves your computer. Read more...
Study Finds MicroRNA Signatures for Blood-Based Lung Cancer Test
In a study published earlier this spring in The Proceedings of the National Academy
of Sciences, Carlo Croce, who will be a speaker at this year's Personalized Health Care National Conference at Ohio State, and colleagues investigated miRNA expression profiles in tissue and plasma samples
from a completed spiral-computed tomography screening trial, identifying a set of
signatures in blood that could predict cancer much earlier than CT alone and distinguish
more aggressive forms of the disease. Read more