BRIM6200/8200=
Biomarker
Discovery, Validation and Implementation; Spring 2012
Course time line: 14 Weeks - less two sessions for e=
xams
=3D13 weeks x 2 lectures/wk less 2
sessions for project presentation =3D 24 lectures as 2 groups of 12 =
Unit 1 Bio=
marker
discovery and validation
Course direct=
or:
Alexei Fedorov, PhD
Lecture 1 Definition and Clinical Need for biomarkers
(Her2/neu; PSA) (D. Gmerek, PhD, Assoc. Dean for Research/K. Crist, PhD, De=
pt.
of Surgery)
Lecture 2 Introduction to genomics and RNomics (A. Fed=
orov,
PhD, Dept. of Medicine, based on ABPG)
Lecture 3 Single Nucleotide Polymorphism p1 (J. Gray, =
PhD,
Dept. of Biological Sciences based on ABPG)
Lecture 4 Single Nucleotide Polymorphism p2 (J. Gray, =
PhD,
based on ABPG)
Lecture 5 Epigenomics (Ivana de la Serna, PhD, Dept. of
Biochemistry and Cancer Biology and A. Prakash, PhD, Post-doctoral Research
Asst.)
Lecture 6 Transcriptomic p1 (Introduction, A. Fedorov,=
PhD)
Lecture 7 Transcriptomic biomarkers p2 (Tools, ASE, A.
Fedorov, PhD)
Lecture 8 Proteomic biomarkers (N. Modyanov, PhD, Phys=
io
Pharm Meta Cardio)
Lectu=
re 9
Metabolomics biomarkers (D. Isailovic, PhD, Dept. of Chemistry and L. Fedor=
ova,
PhD, Dept. of Medicine)
Lectu=
re 10 a)
Challenges in Population Genetics (A. Fedorov, 45 min)
b) Ge=
nome
Wide Association Studies - requirements for validity (M. Ratnam, PhD, Dept.=
of
Biochemistry & Cancer Biology 45 min)
Lecture 11 Systems Biology (Tools, Statistics, Modelin=
g) (A.
Fedorov)
Lecture 12 Projects (30 years of Evolution of bacteria,
Richard Lensky papers)
Exam
Reserve materials: None
Unit 2. Individualized Medicine
Course Director: Beata Lecka-Czern=
ik,
PhD
Lecture 13 Clinical Need - where has it been important=
(D.
Gmerek, PhD, Assoc. Dean for Research and K. Crist, PhD, Dept. of Surgery) =
Lecture 14 Pharmacogenomics and personalized ADMET (W.
Messer, PhD, Dept. of Pharmacology)
Lecture 15 Biomarkers for individualized therapy for b=
reast
and prostate cancer (M. Ratnam, PhD, Dept. of Biochemistry and Cancer Biolo=
gy)
Lecture 16 Biomarkers of cancer cell motility (K. Eise=
nmann,
PhD, Dept. Biochemistry and Cancer Biology)
Lecture 17 Endothelial biomarkers of cardiovascular di=
sease
and stem cell therapy (N. Abraham, PhD, Dept. of Physiology and Pharmacolog=
y)
Lecture 18 Biomarkers of bone formation and stem cell
therapy (B. Lecka-Czernik, PhD, Dept. of Orthopaedic Surgery)
Lecture 19 Biomarkers for stroke (G. Tietjen, MD, Dept=
. of
Neurology)
Lecture 20 Biomarkers for Alzheimer disease (K. Hensle=
y,
PhD, Dept. of Pathology)
Lecture 21 Individualized immunotherapy (R. Worth, PhD,
Dept. of Microbiology and Immunology)
Lecture 22 Targeted transplant, donor-recipient matchi=
ng (S.
Stepkowski, PhD, Dept. of
Microbiology and Immunology)
Lecture 23 Validation - Design and conduct of trials -
Patient selection (J. Willey, MD, Dept. of Medicine)
Lecture 24 Statistical methods for Biomarkers - (S. Kh=
uder,
PhD, Dept. of Medicine)
Exam
END-OF-COURSE=
STUDENT
EVALUATION FORM: please click h=
ere
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