CeDER PUBLICATIONS
All publications since inception of CeDER in 2006 or since joining CeDER
1. Bohan Chen, Pei Wang, Andrew Brem, Lance Dworkin, Zhangsuo Liu, Rujun Gong*.
Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunction.
EBioMedicine 2018 Dec 5. pii: S2352-3964(18)30558-9. doi: 10.1016/j.ebiom.2018.11.054.
2. Eman Shaban, George Bayliss, Deepak Malhotra, Douglas Shemin, Lijuan Wang, Reginald
Gohh, Lance Dworkin, Rujun Gong*.
Targeting Regulatory T Cells for Transplant Tolerance: New Insights and Future Perspectives.
Kidney Diseases (Basel) 4:205-213, 2018.
3. Minglei Lu, P. Wang, S. Zhou, Bryant Flickinger, Deepak Malhotra, Yan Ge, Marc
Tatar, Lance Dworkin, Z. Liu, Rujun Gong*.
Ecdysone elicits chronic renal impairment via mineralocorticoid-like pathogenic activities.
Cellular Physiology and Biochemistry 49:1633-1645, 2018.
4. Minglei Lu, Pei Wang, Yan Ge, Lance Dworkin, Andrew Brem, Zhangsuo Liu, Rujun Gong*.
Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic
ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3β
pathway signaling.
Scientific Reports 8(1):12225, 2018.
5. Pei Wang, Yan Zhang, Yu Wang, Andrew Brem, Zhangsuo Liu, Rujun Gong*.
Acquired resistance to ACTH therapy in nephrotic syndrome: role of de novo neutralizing
antibody.
Pediatrics 140(1): e20162169, July 2017.
6. Pei Wang, Sijie Zhou, Yan Ge, Minglei Lu, Zhangsuo Liu, Rujun Gong*.
Valproate hampers podocyte acquisition of immune phenotypes via intercepting the GSK3β
facilitated NFkB activation.
Oncotarget 8(51):88332-88344, 2017.
7. Sijie Zhou, Pei Wang, Yingjin Qiao, Yan Ge, Yingzi Wang, Songxia Quan, Ricky Yao,
Shougang Zhuang, Li Juan Wang, Yong Du, Zhangsuo Liu, Rujun Gong*.
Genetic and pharmacologic targeting of glycogen synthase kinase 3β reinforces the
Nrf2 antioxidant defense against podocytopathy.
Journal of the American Society of Nephrology 27(8):2289-308, 2016.
8. Chunming Jiang, Wei Zhu, Xiang Yan, Qiuyuan Shao, Biao Xu, Miao Zhang, Rujun Gong*.
Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic
kidney disease via targeting
GSK3β.
Scientific Reports 6: 36698; doi:10.1038/srep36698 (2016).
9. Rujun Gong, Pei Wang, Lance D. Dworkin.
What we need to know about the effect of lithium on the kidney.
American Journal of Physiology Renal Physiology 311(6):F1168-F1171, 2016.
10. Changbin Li, Yan Ge, Lance Dworkin, Ai Peng, Rujun Gong*.
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy.
Journal of Pathology 239(1):23-35, 2016.
11. Yingjin Qiao, Anna-lena Berg, Pei Wang, Yan Ge, Songxia Quan, Sijie Zhou, Hai
Wang, Zhangsuo Liu, Rujun Gong*.
MC1R is dispensible for the proteinuria reducing and glomerular protective effect
of melanocortin therapy.
Scientific Reports 6, 27589; doi: 10.1038/srep27589 (2016).
12. Hui Bao, Yan Ge, Ai Peng, Rujun Gong*.
Fine-tuning of NFkB by GSK3b directs the fate of glomerular podocytes upon injury.
Kidney International 87(6):1176-90, 2015
13. Zhangsuo Liu, Rujun Gong*.
Limb ischemic preconditioning for kidney protection: GSK3β-centric insights into the
mechanism of action.
American Journal of Kidney Disease 66(5):846-56, 2015.
14. Changbin Li, Yan Ge, Ai Peng, Rujun Gong*.
The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant
response in podocytes upon oxidative glomerular injury.
Oncotarget 6(37):39493-506, 2015.
15. Andrew S. Brem, Rujun Gong*.
Therapeutic targeting of aldosterone: a novel approach to the treatment of glomerular
disease.
Clinical Science 128(9):527-35, 2015.
16. Yongfang Jiang, Hui Bao, Yan Ge, Wei Tang, Du Cheng, Kaizhong Luo, Guozhong Gong, Rujun Gong*.
Therapeutic targeting of GSK3beta enhances the Nrf2 antioxidant response and confers
hepatic cytoprotection in hepatitis C.
Gut 64(1):168-79, 2015.
17. Weiwei Xu, Yan Ge, Zhihong Liu, Rujun Gong*.
Glycogen synthase kinase 3β orchestrates microtubule remodeling in compensatory glomerular
adaptation to podocyte depletion.
Journal of Biological Chemistry 290(3):1348-63 , 2015.
18. Zhen Wang, Yan Ge, Hui Bao, Shougang Zhuang, Ai Peng, Rujun Gong*.
Pharmacological targeting of GSK3beta confers protection against podocytopathy and
proteinuria via desensitizing mitochondrial permeability transition.
British Journal of Pharmacology 172(3):895-909, 2015.
19. Rujun Gong*.
Leveraging melanocortin pathways to treat glomerular diseases. [Invited Review]
Advances in Chronic Kidney Disease 21(2):134-151, 2014.
20. Weiwei Xu, Yan Ge, Zhihong Liu, Rujun Gong*.
Glycogen synthase kinase 3b dictates podocyte motility and focal adhesion turnover
by modulating paxillin activity:
implications in podocytopathy.
American Journal of Pathology 184(10):2742-56, 2014.
21. Hui Bao, Yan Ge, Zhen Wang, Shougang Zhuang, Lance Dworkin, Ai Peng, Rujun Gong*.
Delayed Administration of a Single Dose of Lithium Promotes Recovery from AKI.
Journal of the American Society of Nephrology 25(3):488-500, 2014.
JW, Eng Qiu, X., Dowling, A., Marino J., Faulkner L., Brüning, J., Elias, CF, Bryant B., Hill, JW. Delayed Puberty but Normal Fertility in Mice with Selective Deletion of Insulin Receptor from Kiss1 Cells, Endocrinology. Mar;154(3):1337-48, 2013 PMID: 23392256
Hill, JW, Alreja M., Elias CF. From precocious puberty to infertility: metabolic control of the reproductive function (invited review) Frontiers in Systems and Translational Endocrinology. March 2013 PMID: 23565110
Marino JS, Hinds TD Jr, Potter RA, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Sanchez ER, Hill JW. Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation. BMC Cell Biol. Sep 21;14:39, 2013 PMID: 24053798
Makani V, Sultana R, Sie KS, Orjiako D, Tatangelo M, Dowling A, Cai J, Pierce W, Butterfield DA, Hill J, Park J. Annexin A1 Complex Mediates Oxytocin Vesicle Transport. J Neuroendocrinol. Oct 3, 2013 PMID: 24118254
Dowling AR, Nedorezov LB, Qiu X, Marino JS, Hill JW. Genetic factors modulate the impact of pubertal androgen excess on insulin sensitivity and fertility. PLoS One. Nov 20;8(11):e79849, 2013 PMID: 24278193
Stechschulte LA, Wuescher L, Marino JS, Hill C, Hinds TD Jr. Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN. J Biol Chem. 289; 25; 17885-17894 June 20. 2014 PMID: 24817119
Faulkner LD, Dowling AR, Stuart RC, Nillni EA, Hill JW. Reduced melanocortin production causes sexual dysfunction in male mice with POMC neuronal insulin and leptin insensitivity. Endocrinology. Apr;156(4):1372-85, 2015 PMID: 25590244
Qiu X, Dao H, Heston A, Garcia KM, Sangal A, Wang M, Dowling, AR, Faulkner L, Molitor SC, Elias CF, Hill JW. Insulin and leptin signaling interact in the Kiss1 neuron during the peripubertal period. Plos One May 6;10(5):e0121974, 2015 PMID: 25946091
Wang M, Zhang Y, Lan D, Hill JW. The Efficacy of GnRHa Alone or in Combination with rhGH for the Treatment of Children with Central Precocious Puberty: A Systematic Review and Meta-Analysis. Scientific Reports 2016 Apr 13;6:24259. PMID: 27072597
Heinrich G, Russo L, Castaneda T, Pfeiffer V, Ghadieh H, Ghanem S, Wu J, Faulkner L, Ergun S, Hill J, and Najjar S. Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen Cell Adhesion Molecule 1. Journal of Biological Chemistry Volume: 291 Issue: 21 Pages: 11124-11132 MAY 20 2016
Hill JW and Faulkner LD. The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances. (Invited Review) Neuroendocrinology 104(4):330-346 2017
Jahromi MS, Tehrani FR, Hill JW, Noroozzadeh M, Zarkesh M, Ghasemi A; Zadeh-Vakili A. Alteration in follistatin gene expression detected in prenatally androgenized rats. Gynecological Endocrinology Feb 26:1-5 2017. PMID: 28277126
Semple E, Hill JW. Sim1 neurons are sufficient for MC4R-mediated sexual function in male mice. Endocrinology. 2017 Oct 19. PubMed PMID: 29059347.
Garcia-Galiano D, Borges BC, Donato J Jr, Allen SJ, Bellefontaine N, Wang M, Zhao JJ, Kozloff KM, Hill JW, Elias CF. PI3Kα inactivation in leptin receptor cells increases leptin sensitivity but disrupts growth and reproduction. JCI Insight. 2017 Dec 7;2(23). pii: 96728. PubMed PMID: 29212950.
Marino JS, Hinds TD, Hoover R, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Hill JW Suppression of Protein Kinase C Theta Contributes to Enhanced Myogenesis in vitro via IRS1 and ERK1/2 phosphorylation. BMC Cell Biology Accepted.
Hill, JW, Alreja M., Elias CF. From precocious puberty to infertility: metabolic control of the reproductive function (invited review) Frontiers in Systems and Translational Endocrinology. March 2013 PMID: 23565110
Qiu, X., Dowling, A., Marino J., Faulkner L., Brüning, J., Elias, CF, Bryant B., Hill, JW Delayed Puberty but Normal Fertility in Mice with Selective Deletion of Insulin Receptor from Kiss1 Cells, Endocrinology. 2013 Mar;154(3):1337-48 PMID: 23392256
Hill, JW. PVH Pathways Controlling Energy Homeostasis. (Invited Review) Indian Journal of Endocrinology and Metabolism. 2012 Dec;16(Suppl 3):S627-36. PMID: 23565499
Xu Y, Faulkner L., Hill, JW. Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons.
(Invited Review) Frontiers in Systems and Translational Endocrinology 2012 January
4.
Marino JS, Iler J, Dowling AR, Chua S, Bruning JC, Coppari R, Hill JW. Adipocyte Dysfunction in a Mouse Model of Polycystic Ovary Syndrome (PCOS): Evidence
of Adipocyte Hypertrophy and Tissue-Specific Inflammation. PLoS One. 2012;7(10):e48643. PMID: 23119079
Marino JS, Peterson SJ, Li M, Vanella L, Sodhi K, Hill JW, Abraham NG. ApoA-1 mimetic restores adiponectin expression and insulin sensitivity independent
of changes in body weight in female obese mice. Nature Nutrition and Diabetes. 2012 March 2; e33.
Patel PR, Ramakrishnan SK, Kaw MK, Raphael CK, Ghosh S, Marino JS, Heinrich G, Lee
SJ, Bourey RE, Hill JW, Jung DY, Morgan DA, Kim JK, Rahmouni SK, Najjar SM. Increased Metabolic Rate and Insulin Sensitivity in Male Mice Lacking the Carcinoembryonic
Antigen-Related Cell Adhesion Molecule 2. Diabetologia. 2011 Dec 11. PMID: 22159884
Joseph S. Marino, Yong Xu, Jennifer W. Hill. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endo and Met. 2011 Jul;22(7):275-85. Epub 2011 Apr 12. PMID: 21489811
Xu Y, Hill JW (joint first author), Fukuda M, Gautron L, Sohn J, Kim K, Lee CE, Choi MJ, Lauzon
D, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signalling in the ventromedial hypothalamus is required for normal energy homeostasis. Cell Metabolism. 2010 July 4;12(1), 88-95. PMID: 20620998
Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho Y, Chuang J, Xu Y,
Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE,
Lowell BB, Bruning JC, Elmquist JK. Direct Insulin and Leptin Action in Pro-opiomelanocortin Neurons is Required for Normal
Glucose Homeostasis and Fertility. Cell Metabolism. 2010 Apr 7;11(4):286-97. PMID: 20374961
Hill JW. Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons. The Open Neuroendocrinology Journal, 2010 January 3;21-27.
Hill JW, Yong X, Preitner F, Fukuda M, Cho Y, Luo J, Balthasar N, Coppari R, Cantley LC,
Kahn B, Zhao JJ, Elmquist JK. Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons
Contributes to the Regulation of Glucose Homeostasis. Endocrinology. 2009 Nov;150(11):4874-82. PMID: 19819947
Beata Lecka-Czernik, PhD
Lecka-Czernik B, Baroi S, Stechschulte LA, Chougule AS. Marrow Fat-a New Target to Treat Bone Diseases? Curr Osteoporos Rep. 2018 Apr;16(2):123-129. doi: 10.1007/s11914-018-0426-z. Review. PMID:29460176
Stechschulte LA, Lecka-Czernik B. Reciprocal regulation of PPARγ and RUNX2 activities in marrow mesenchymal stem cells: Fine balance between p38 MAPK and Protein Phosphatase 5. Curr Mol Biol Rep. 2017 Jun;3(2):107-113. doi: 10.1007/s40610-017-0056-8. Epub 2017 Apr 22. PMID:29276666
Gaihre B, Lecka-Czernik B, Jayasuriya AC. Injectable nanosilica-chitosan microparticles for bone regeneration applications. J Biomater Appl. 2018 Jan;32(6):813-825. doi: 10.1177/0885328217741523. Epub 2017 Nov 21. PMID:29160129
Lecka-Czernik B, Stechschulte LA, Czernik PJ, Sherman SB, Huang S, Krings A. Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency.Front Endocrinol (Lausanne). 2017 Aug 4;8:188. doi: 10.3389/fendo.2017.00188. eCollection 2017.PMID:28824548
Lecka-Czernik B.Diabetes, bone and glucose-lowering agents: basic biology. Diabetologia. 2017 Jul;60(7):1163-1169. doi: 10.1007/s00125-017-4269-4. Epub 2017 Apr 22. Review. PMID:28434032
Stechschulte LA, Ge C, Hinds TD Jr, Sanchez ER, Franceschi RT, Lecka-Czernik B. Protein Phosphatase PP5 Controls Bone Mass and the Negative Effects of Rosiglitazone on Bone through Reciprocal Regulation of PPARγ (Peroxisome Proliferator-activated Receptor γ) and RUNX2 (Runt-related Transcription Factor 2). J Biol Chem. 2016 Nov 18;291(47):24475-24486. Epub 2016 Sep 29. PMID:27687725
Stechschulte LA, Qiu B, Warrier M, Hinds TD Jr, Zhang M, Gu H, Xu Y, Khuder SS, Russo L, Najjar SM, Lecka-Czernik B, Yong W, Sanchez ER. FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone. Endocrinology. 2016 Oct;157(10):3888-3900. Epub 2016 Jul 21. PMID:27442117
Stechschulte LA, Czernik PJ, Rotter ZC, Tausif FN, Corzo CA, Marciano DP, Asteian A, Zheng J, Bruning JB, Kamenecka TM, Rosen CJ, Griffin PR, Lecka-Czernik B. PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption. EBioMedicine. 2016 Aug;10:174-84. doi: 10.1016/j.ebiom.2016.06.040. Epub 2016 Jun 29. PMID:27422345
Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV. Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes. Diabetes. 2016 Jul;65(7):1757-66. doi: 10.2337/db16-0063. Review. PMID:27329951
Nie Y, Kumarasamy S, Waghulde H, Cheng X, Mell B, Czernik PJ, Lecka-Czernik B, Joe B. High-resolution mapping of a novel rat blood pressure locus on chromosome 9 to a region containing the Spp2 gene and colocalization of a QTL for bone mass. Physiol Genomics. 2016 Jun;48(6):409-19. doi: 10.1152/physiolgenomics.00004.2016. Epub 2016 Apr 25. PMID:27113531
Hofbauer LC, Lecka-Czernik B, Seibel MJ. Sweet and brittle - Diabetes mellitus and the skeleton. Bone. 2016 Jan;82:1. doi: 10.1016/j.bone.2015.09.001. Epub 2015 Sep 9. PMID:26363338
Lecka-Czernik B, Rosen CJ. Skeletal integration of energy homeostasis: Translational implications. Bone. 2016 Jan;82:35-41. doi: 10.1016/j.bone.2015.07.026. Epub 2015 Jul 23. Review. PMID:26211994
Gehling DJ, Lecka-Czernik B, Ebraheim NA. Orthopedic complications in diabetes. Bone. 2016 Jan;82:79-92. doi: 10.1016/j.bone.2015.07.029. Epub 2015 Jul 23. Review. PMID:26211990
Lecka-Czernik B, Rosen CJ. Energy Excess, Glucose Utilization, and Skeletal Remodeling: New Insights. J Bone Miner Res. 2015 Aug;30(8):1356-61. doi: 10.1002/jbmr.2574. Epub 2015 Jul 14. Review. PMID:26094610
Meier C, Schwartz AV, Egger A, Lecka-Czernik B. Effects of diabetes drugs on the skeleton. Bone. 2016 Jan;82:93-100. doi: 10.1016/j.bone.2015.04.026. Epub 2015 Apr 23. Review. PMID:25913633
Lecka-Czernik B, Stechschulte LA, Czernik PJ, Dowling AR. High bone mass in adult mice with diet-induced obesity results from a combination of initial increase in bone mass followed by attenuation in bone formation; implications for high bone mass and decreased bone quality in obesity. Mol Cell Endocrinol. 2015 Jul 15;410:35-41. doi: 10.1016/j.mce.2015.01.001. Epub 2015 Jan 7. PMID:25576855
Cheng Y, Rodriguiz RM, Murthy SR, Senatorov V, Thouennon E, Cawley NX, Aryal DK, Ahn S, Lecka-Czernik B, Wetsel WC, Loh YP. Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. Mol Psychiatry. 2015 Jun;20(6):744-54. doi: 10.1038/mp.2014.136. Epub 2014 Oct 21. PMID:25330741
Lecka-Czernik B, Stechschulte LA. Bone and fat: a relationship of different shades. Arch Biochem Biophys. 2014 Nov 1;561:124-9. doi: 10.1016/j.abb.2014.06.010. Epub 2014 Jun 20. Review. PMID:24956594
Kolli V, Stechschulte LA, Dowling AR, Rahman S, Czernik PJ, Lecka-Czernik B. Partial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone mass. PLoS One. 2014 May 8;9(5):e96323. doi: 10.1371/journal.pone.0096323. eCollection 2014. PMID:24810249
Michael P Morran , Ali G Al-Dieri, Andrea L. Nestor-Kalinoski, Richard K Jordan, Nirdesh K. Gupta, Marcia F McInerney Insulin receptor lymphocyte trafficking in the progression of type 1 diabetes. Accepted for publication in Journal of Biological Methods October 29th, 2017 for publication in 2018.
Russo L, Ghadieh HE, Ghanem SS, Al-Share QY, Smiley ZN, Gatto-Weis C, Esakov EL, McInerney MF, Heinrich G, Tong X, Yin L, Najjar SM. Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis. J Lipid Res. 2016 Dec; 57(12):2163-2175. PMID: 27777319.
Heinrich G, Russo L, Castaneda TR, Pfeiffer V, Ghadieh HE, Ghanem SS, Wu J, Faulkner LD, Ergün S, McInerney MF, Hill JW, Najjar SM. Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1. J Biol Chem. 2016 May 20;291(21):11124-32. doi: 10.1074/jbc.M116.716431. Epub 2016 Mar 21. PMID: 27002145 PMCID: PMC4900262.
Tulsulkar J, Nada SE, Slotterbeck BD, McInerney MF, Shah ZA. Obesity and hyperglycemia lead to impaired post-ischemic recovery after permanent ischemia in mice. Obesity (Silver Spring). 2015 Dec 23. doi: 10.1002/oby.21388. [Epub ahead of print NIHMSID: NIHMS733570;PMID:26694743; PMCID: PMC4731242.
Lester SG, Russo L, Ghanem SS, Khuder SS, DeAngelis AM, Esakov EL, Bowman TA, Heinrich G, Al-Share QY, McInerney MF, Philbrick WM, Najjar SM.
Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue. Front Endocrinol (Lausanne). 2015 Aug 3;6:116. doi: 10.3389/fendo.2015.00116. eCollection 2015. PMID: 26284027 PMCID: PMC4522571.
Ebke LA, Nestor-Kalinoski AL, Slotterbeck BD, Al-Dieri AG, Ghosh-Lester S, Russo L, Najjar SM, von Grafenstein H, McInerney MF. Tight association between macrophages and adipocytes in obesity: Implications for adipocyte preparation. Obesity (Silver Spring). 2014 May; 22 (5):1246-55. doi: 10.1002/oby.20634. Epub 2013 Dec 4. NIHMSID: NIHMS527968; PMID: 24376179; PMCID: PMC3980195.
Angevine KR, Wuescher LM, Andrews K, Alexander LA, McInerney MF, Kieffer TJ,Mensah-Osman EJ. Menin and GIP are inversely regulated by food intake and diet via PI3/AKT signaling
in the proximal duodenum. Nutr Diabetes. 2012 Dec 3;2:e55. PMCID: PMC3542434
Rasche SS, Phillips M, McInerney MF, Sercarz, EE and Quinn A. IL-13Ra1 Expression on Beta Cell-specific T cells in NOD Mice. Diabetes 2011; June 60 (6): 1716-25
Dudley RW, Slotterbeck BD, McInerney MF, Peseckis SM. Fatty acylation enhances cellular localization of dansylated phenylalanines. Mol Cell Biochem. Molecular and Cellular Biochemistry: Volume 346, Issue 1 (2011),
Page 81.2010 Oct 8. PMID: 20931354
Ghosh S*, Kaw M*, Patel PR, Ledford KJ, Bowman TA, McInerney MF, Bourey RE, Erickson, SK and Najjar SM. Null mutation of Ceacam1 causes Non-alcoholic Steatohepatitis. Hepatic Medicine: Research
and Evidence. Hepatic Medicine: Research and Evidence. 2010; 2:69–78. PMID: 21949477
Huang S, Kaw M, Harris MT, Ebraheim N, McInerney MF. Najjar SM, Lecka-Czernik B. Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance
due to liver-specific inactivation of CEACAM1. Bone. 2010 Apr;46(4):1138-45. Epub 2010 Jan 4. PMCID:PMC2862391
Michael P, Morran, M. Alexander, LA, Slotterbeck, B. McInerney MF. Dysfunctional Innate Immune Responsiveness to P. gingivalis in Diabetes. Oral Microbiology and Immunology. 2009 Aug;24(4):331-9. PMID: 19572897
Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A
carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology. 2008 Dec;135(6):2084-95. Epub 2008 Aug 20. PMCID:PMC2784638
Morran, M, McInerney MF, M. Pietropaolo. Innate and Adaptive Autoimmunity in Type 1 Diabetes. Pediatr Diabetes. 2008 Apr;9(2):152-61. Epub 2008 Jan 25. PMID: 18221432
Quinn, A., McInerney, M.F. Huffman, D., McInerney, B.E., Mayo, S., Haskins, K., and Sercarz, E. T Cells to a Dominant Epitope of GAD65 Express a Public CDR3 Motif. Internat. Immunol. 2006 Jun;18(6):967-79. Epub 2006 Apr 26. PMID: 16641112
Mohammad, M., Morran, M. Slotterbeck, B., Leaman, D.W., Sun, Y. vonGrafenstein, H.,
Hong, S.C., and McInerney, MF. Dysregulated Toll-like Receptor Expression and Signaling in Bone Marrow-Derived Macrophages
at the onset of Diabetes in the Nonobese Diabetic Mouse. Internat. Immunol. 2006 Jul;18(7):1101-13. Epub 2006 May 25. PMID: 16728431
Marcia F. McInerney, Lindsey A. Alexander, Michael P. Morran, Massimo Pietropaolo. Innate Immunity, Toll-like Receptors, and Diabetes. Current Immunology Reviews 2009; 5(2): 111-121. (In Press)
Nikolai Modyanov, PhD
Pestov NB, Korneenko TV, Shakhparonov MI, Shull GE, Modyanov NN. Loss of acidification of anterior prostate fluids in Atp12a-null mutant mice indicates
that nongastric H-K-ATPase functions as proton pump in vivo. Am J Physiol Cell Physiol.
2006 Aug;291(2):C366-74. Epub 2006 Mar 8. PubMed PMID: 16525125.
Radkov R, Kharoubi-Hess S, Schaer D, Modyanov NN, Geering K, Horisberger JD. Role of homologous ASP334 and GLU319 in human non-gastric
H,K- and Na,K-ATPases in cardiac glycoside binding. Biochem Biophys Res Commun. 2007;356(1):142-6.
PMID: 17349614
Dmitriev RI, Korneenko TV, Bessonov AA, Shakhparonov MI, Modyanov NN, Pestov NB. Characterization of hampin/MSL1 as a node in the nuclear interactome.
Biochem Biophys Res Commun. 2007 Apr 20;355(4):1051-7. Epub 2007 Feb 23. PubMed PMID:17335777;
PubMed Central PMCID: PMC1855298
Pestov, N.B., Ahmad, N., Korneenko, T.V., Zhao, H., Radkov, R., Schaer,D., RoyS, BibertS,
Geering, K. and Modyanov, N.N. (2007). Evolution of Na,K-ATPase bm-subunit into a co-regulator of transcription in placental
mammals. Proc. Natl. Acad. Sci. USA 104:11215-11220.
Pestov, N.B., Zhao, H., Basrur, V., Modyanov N.N. (2011) Isolation and characterization of BetaM protein encoded by ATP1B4--a unique member
of the Na,K-ATPase ß-subunit gene family. Biochem. Biophys. Res. Commun. 412(4):543-548.
Pestov NB, Dmitriev RI, Kostina MB, Korneenko TV, Shakhparonov MI, Modyanov NN. (2012) Structural evolution and tissue-specific expression of tetrapod-specific second isoform
of secretory pathway Ca(2+)-ATPase. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1298-1303.
Pestov NB, Korneenko TV, Shakhparonov MI, Modyanov NN.Postnatal regulation of X,K-ATPases in rat skin and conserved lateroapical polarization
of Na,K-ATPase in vertebrate epidermis. Exp Dermatol. 2013:22(6):423-5. PMID 23651441
Salhi A, Lamouroux C, Pestov NB, Modyanov NN, Doucet A, Crambert G. A link between fertility and K(+) homeostasis: role of the renal H,K-ATPase type 2. Pflugers Arch. 2013 Feb 26. [Epub ahead of print] PMID: 23440459
Park,J.J., Cawley N.W., and Loh, Y.P. (2008). Carboxypeptidase E cytoplasmic tail anchors hormone
vesicles to microtubule motors for transport and activity – dependent secretion. Molecular
Endocrinology, 22(4): 989-1005.
Park,J.J., Cawley N.W., and Loh, Y.P. (2008). Carboxypeptidase E cytoplasmic tail anchors BDNF
vesicles to microtubule motors for transport and activity-dependent secretion. Molecular
and Cellular Neuroscience, 39(1): 63-73.
Park,J.J. and Loh, Y.P. (2008). How Peptide Hormone Vesicles are Transported to the Secretion
Site for Exocytosis. Molecular Endocrinology, 22(12): 2583-95.
Park, J.J., Koshimizu, H., and Loh, Y.P. (2009). Biogenesis and Transport of Secretory Granules
to Release Site In Neuroendocrine cells. Journal of Molecular Neuroscience, 37(2):
151-9.
Lou, H., Park, J.J., Sarcon, A., Adams, T., Cawley, N.X., and Loh, Y.P. (2010). Carboxypeptidase E Cytoplasmic
Tail Mediates Localization of Synaptic Vesicles to the Pre-Active Zone in Hypothalamic
Nerve Terminals. (as a co-author) Journal of Neurochemistry, 114(3): 886-96.
Hensley, K., Venkova, K., Christov, A., Gunning, W., and Park, J.J. (2011). Collapsin response mediator protein-2: An emerging pathologic feature and
therapeutic target for neurodisease indications. Molecular Neurobiology, 43(3): 180-91.
Park, J.J., Gondre-Lewis, M., Kim, T., and Loh, Y.P. (2011). A distinct trans Golgi network subcompartment
for sorting of synaptic and granule proteins in neuroendocrine cells. Journal of Cell
Science, 124 (5): 735-44.
Park,J.J. and Loh, Y.P. (2011). Visualization of Peptide Secretory Vesicles in Living Nerve
Cells. Methods in Molecular Biology, 789:137-45.
Cawley, N.X., Wetsel, W.C., Murthy, S.R.K., Park, J.J., Pacak, K., and Loh, Y.P. (2012). New Roles of Carboxypeptidase E in Endocrine and
Neural Function and Cancer. Endocrine Reviews 33:216-253
Park, J.J., Rubio, M.V., Zhang, Z., Um, T., Xie, Y., Knoepp, S.M., Snider, A.J., Gibbs, T.C.,
and Meier, K.E. (2012). Effects of lysophosphatidic acid on calpain-mediated proteolysis
of focal adhesion kinase in human prostate cancer cells. Prostate, 72:1595-610
Lou, H., Park, J.J., Phillips, A., and Loh, Y.P. (2012) Gamma-Adducin Promotes Process Outgrowth and Secretory
Protein Exit from the Golgi Apparatus. (as co-first author) Journal of Molecular Neuroscience, 49:1-10
Gondre-Lewis, M., Park, J.J., and Loh, Y.P. (2012) Cellular Mechanisms for the Biogenesis and Transport of Synaptic
and Dense-Core Vesicles. (as co-first author) International Review of Cell and Molecular Biology,
299:27-115
Makani, V., Hall, J, Qamar, K., Jain, P., Hensley, K., and Park, J.J. (2013) Tianeptine interferes with microtubule organization and hormone secretion
in pheochromocytoma cells. Molecular and Cellular Endocrinology, 381: 175-187
Makani, V., Sultana R., Dowling, A., Tatangelo, M., P., Butterfield, A., Hill, J.,
and Park, J.J. Annexin A1 complex mediates oxytocin vesicle transport. Accepted to ‘Journal of Neuroendocrinology'.
Edwin R. Sanchez, PhD
Yang, Z., Wolf, I. M., Chen, H., Periyasamy, S., Chen, Z., Yong, W., Shi, S., Zhao,
W., Xu, J., Srivastava, A., Sanchez, E. R. & Shou, W. FK506-binding protein 52 is essential to uterine reproductive physiology controlled
by the progesterone receptor a isoform. Mol Endocrinol. 2006;20:2682-2694. PMC2661205
Heitzer, M. D., Wolf, I. M., Sanchez, E. R., Witchel, S. F. & Defranco, D. B. Glucocorticoid receptor physiology. Rev Endocr Metab Disord. 2007; 8:321-330. PMID: 18049904
Yong, W., Yang, Z., Periyasamy, S., Chen, H., Yucel, S., Li, W., Lin, L. Y., Wolf,
I. M., Cohn, M. J., Baskin, L. S., Sanchez, E. R. & Shou, W. Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated
signaling and physiology. J Biol Chem. 2007;282:5026-5036. PMC2577319
Yong, W., Bao, S., Chen, H., Li, D., Sanchez, E. R. & Shou, W. Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated
(ATM)-mediated cell cycle arrest. J Biol Chem. 2007;282:14690-14694. PMC2577320
Periyasamy, S., Warrier, M., Tillekeratne, M. P., Shou, W. & Sanchez, E. R. The immunophilin ligands cyclosporin a and FK506 suppress prostate cancer cell growth
by androgen receptor-dependent and -independent mechanisms. Endocrinology. 2007;148:4716-4726. PMC2639775
Hinds, T. D., Jr. & Sanchez, E. R. Protein phosphatase 5. Int J Biochem Cell Biol. 2008; 40(11): 2358-2362. PMC2551559
Banerjee, A., Periyasamy, S., Wolf, I. M., Hinds, T. D. J., Yong, W., Shou, W. & Sanchez, E. R. Control of glucocorticoid and progesterone receptor subcellular localization by the
ligand-binding domain is mediated by distinct interactions with tetratricopeptide
repeat proteins. Biochemistry. 2008; 47:10471-10480. PMCID:PMC3045568
Wolf, I. M., Periyasamy, S., Hinds, T. D., Jr., Yong, W., Shou, W. & Sanchez, E. R. Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid
receptor transcriptional activity. J Steroid Biochem Mol Biol. 2009; 113:36-45. PMC2675912
Warrier, M., Hinds, T. D. J., Ledford, K. J., Cash, H. A., Patel, P. R., Bowman, T.
A., Stechschulte, L. A., Yong, W., Shou, W., Najjar, S. M.* & Sanchez, E. R *. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in
FK506-binding protein 52-deficient mice. Endocrinology. 2010; 151: 3225-3236. PMC2903936. * Equal contribution
Periyasamy, S., Hinds, T. J., Shemshedini, L., Shou, W. & Sanchez, E. R. FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell
growth and the targets of FK506 and cyclosporin A. Oncogene. 2010; 29:1691-1701. PMCID:PMC3040472
Hinds, T. D. J., Ramakrishnan, S., Cash, H. A., Stechschulte, L. A., Heinrich, G.,
Najjar, S. M. & Sanchez, E. R. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol. 2010; 24:1715-1727. PMC2940475
Chen, H., Yong, W., Hinds, T. D. J., Yang, Z., Zhou, Y., Sanchez, E. R. & Shou, W. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J Biol Chem. 2010; 285: 27776-27784. PMC2934645
Terry D. Hinds, Jr., Lance A. Stechschulte, Harrison Cash, Donald Whisler,Ananya Banerjee,
Weidong Yong,Khuder SS, Kaw MK, Weinian Shou, Najjar SM, and Edwin R. Sánchez. Protein Phosphatase 5 Mediates Lipid Metabolism Through Reciprocal Control of Glucocorticoid
Receptor and Peroxisome Proliferator-Activated Receptor (PPAR-g). Journal of Biological
Chemistry, 2011 Dec 16;286(50):42911-22. Epub 2011 Oct 12.
Lance A. Stechschulte, Edwin R. Sánchez. (2011) FKBP51-a selective modulator of glucocorticoid and androgen sensitivity.
Current Opinion in Pharmacology. 2011 May 10. [Epub ahead of print]
Marino, J. S., Hinds, T. D. J., Hoover, R. A., Ondrus, E., Onion, J. L., Dowling,
A. R., McLoughlin, T. J., Sanchez, E. R. & Hill, J. W. Suppression of Protein Kinase C Theta Contributes to Enhanced Myogenesis
in vitro via IRS1 and ERK1/2 phosphorylation. BMC Cell Biol In press, (2013).
Cynthia M. Smas, PhD
Ren G, Beech C, Smas CM. The immunoglobulin superfamily protein differentiation of embryonic stem cells 1 (dies1)
has a regulatory role in preadipocyte to adipocyte conversion., PLoS One. 2013 Jun 17;8(6):e65531. doi: 10.1371/journal.pone.0065531. Print 2013.
PMID23799023
Yang X, Heckmann BL, Zhang X, Smas CM, Liu J., Distinct mechanisms regulate ATGL-mediated adipocyte lipolysis by lipid droplet coat
proteins., Mol Endocrinol. 2013 Jan;27(1):116-26. doi: 10.1210/me.2012-1178. Epub 2012 Nov 30.
PMID: 23204327
Ren G, Kim JY, Smas CM., Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role
in lipid metabolism., Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E334-51. doi: 10.1152/ajpendo.00084.2012.
Epub 2012 May 8. PMID: 22569073
Wu Y, Zhou S, Smas CM. Downregulated expression of the secreted glycoprotein follistatin-like 1 (Fstl1) is
a robust hallmark of preadipocyte to adipocyte conversion. Mech Dev. 2010 Apr;127(3-4):183-202. Epub 2010 Jan 4. PMCID:PMC2849861
Wang, Y, Zhao, L., Smas, C.M. and Sul, H.S. Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Mol. Cell. Biol. 2010;30:3480-3492. PMCID:PMC2897553
Lee, J.H., Zhou, S. and Smas, C.M. Identification of RANBP16 and RANBP17 as Novel Interaction Partners for the bHLH Transcription
Factor E12. J. Cell. Biochem.2010;11:195-206. PMCID:PMC2930062
Charkrabarti, P., English, T., Shi, J., Smas, C.M. and Kandror, K. The mTOR complex 1 suppresses lipolysis, stimulated lipogenesis and promotes fat storage. Diabetes. 2010;59:775-781. PMCID:PMC2844824
Liu K, Zhou S, Kim JY, Tillison K, Majors D, Rearick D, Lee JH, Fernandez-Boyanapalli
RF, Barricklow K, Houston MS, Smas CM. Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent
apoptosis, and dimerization with CIDEA. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1395-413. Epub 2009 Oct 20. PMID:
19843876
Wu Y, Smas CM. Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E205-15. Epub 2008 May 20. PMCID:PMC2493586
Kim, J.Y., Lui, K., Zhou, S., Tillison, K., Wu, Y., and Smas, C.M. Assessment of fat specific protein 27 (FSP27) in the adipocyte lineage suggests a
dual role for FSP27 in adipocyte metabolism and cell death. Am. J. Physiol. Endocrinol. Metab. 2008;294:E654-E667. PMID: 18198355
Wu, Y., Kim, J.Y., Zhou, S. and Smas, C.M. Differential screening identifies transcripts with depot-dependent expression in white
adipose tissues. BMC Genomics. 2008;9:397. PMCID:PMC2547859
Wu Y, Smas CM. Expression and regulation of transcript for the novel transmembrane protein Tmem182
in the adipocyte and muscle lineage. BMC Res Notes. 2008 Sep 19;1:85. PMCID:PMC2564950
Kim, J.Y., Tillison, K.S., Zhou. S. Wu, Y. and Smas, C.M. The Major Facilitator Superfamily Member Slc37a2 is a Novel Macrophage-Specific Gene
Selectively Expressed in obese White Adipose Tissue. Am. J .Physiol. Endocrinol. Metab. 2007;293: E110—E120. PMID: 17356011
Kim, J.Y., Wu, Y., and Smas, C.M. Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue,
identifies genes for the molecular definition of preadipocytes. Physiol. Genomics. 2007;31:328-342. PMID: 17609412
Kim, J.Y., Tillison, K.S., Zhou, S. Lee, J.H., and Smas, C.M. Differentiation-dependent expression of Adhfe1 in adipogenesis. Arch. Biochem. Biophys. 2007; 464:100-111. PMCID:PMC2426734
Kim, J.Y., Tillison, K., Lee, J.H., Rearick, D.A., and Smas, C.M. The Adipose Tissue Triglyceride Lipase ATGL/PNPLA2 is Downregulated by Insulin and
TNFa in 3T3-L1 Adipocytes and is a Target for Transactivation by PPARg. American J. Phys. Endo. Metabol. 2006;291:E115-E127. PMID: 16705060
Stanislaw M. Stepkowski, PhD
Ross JA, Nagy ZS, Cheng H, Stepkowski SM, Kirken RA. Regulation of T cell homeostasis by Jaks and Stats. Arch Immunol Ther Exp. 2007;55:231-45. PMID:17659375
Chen W, Diao J, Stepkowski SM, Zhang L. Both Infiltrating Regulatory T Cells and Insufficient Antigen Presentation Are Involved
in Long-Term Cardiac Xenograft Survival. Journal of Immunology. 2007;179:1542-8. PMID: 17641020
Stepkowski SM, Chen W, Ross J, Nage Z, Kirken R. Stat3: The important regulator of multiple cell functions. Transplantation. 2008;85:1372. PMID:18497672
Wenderfer, SE, Stepkowski, SM, Braun, MC. Prolonged Survival and Reduced Renal Injury in the MRL/lpr Mouse after
Treatment with a Second Generation Sphingosine-1-Phosphate Receptor Agonist. Kidney
International. 2008;74:13190
Khattar M, Chen W, Stepkowski SM. Expanding and converting regulatory T cells. Arch. Immunol. Ther. Exp. 2009;57:199. PMID: 19479206
Fernandes I, Zhang Y, Qi Y, Wang ME, Podder H, Lisik W, Knight R, Kahan BD, Stepkowski SM. Impact of reduced nephron mass on cyclosporine- and/or sirolimus-induced nephrotoxicity. Transplantation. 2009; 88:1323. PMID:20029328
Wang G, Guo Z, Miyahara Y, Khattar M, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. IL-2-deprivation and TGF-b are two non-redundant suppressor mechanisms of CD4+CD25+Foxp3+ regulatory T cells which jointly restrain CD4+CD25– cell activation. Immunology Letters. 2010 Aug 16;132(1-2):61-8. PMCID:PMC2922908
Guo G, Wang G, Miyahara Y, Khattar M, Links S, Chen W, He X, Stepkowski SM. IL-7, but not thymic stromal lymphopoietin (TSLP), contributes to the programmatic
generation of memory CD4+ T cells. Immunology Letters. 2010;128:116. PMID: 20064560
Wang G, Guo Z, Miyahara Y, Khattar M, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. Default generation of neonatal regulatory T cells. J Immunol. 2010;185:71. PMID: 20498359
Wang G, Khattar M, Guo Z, Miyahara Y, Linkes SP, Sun Z, Stepkowski SM, Chen W. IL-2-deprivation and TGF-b are two non-redandant suppressor mechanisms of CD+CD25+
regulatory T cells which jointly restrain CD4+CD25- cell activation. Immunol Lett. 2010;132:61. PMCID:PMC2922908
Li J, Chen G, Ye P, Wang S, Zhang K, Chen W‡, Stepkowski SM, Junhua Li J, Zhong S, Xia J. CCR5 Blockade in Combination with Cyclosporine Increased Cardiac Graft Survival and
Generated Alternatively Activated Macrophages in Primates. J. Immunol. 186:3753-61,
2011.
Miyahara Y, Khattar M, Schroder P, Mierzejewska B, Deng R, Han R, Hancock WW, Chen
W, Stepkowski SM. An anti-TCRb monoclonal antibody induces long-term allograft survival by reducing
antigen-reactive T cells and sparing regulatory T cells. American J Transplantation
12:1409-18, 2012
Mierzejewska B, Baum C, Schroder PA, Durlik M, Lisik W, Rees M, Stepkowski SM. Diversity in kidney paired donation programs accommodates local requirements. Annals
of Transplantation 2013 in press
Khattar M, Deng R, Kahan BD, Schroder PM, Phan T, Rutzky LP, Stepkowski SM. Novel sphingosin-1-phosphate receptor modulator KRP203 combined with locally-delivered
regulatory T cells induces permanent acceptance of pancreatic islet allografts. Transplantation
2013 in press
Guo Z,Khattar M, Schroder PM, Miyahara Y, Wang G,He X, Chen W, Stepkowski SM. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive
regulatory T cells. Journal of Immunology 2013 in press
Brent D. Cameron, PhD.
Rui Zheng, Byung-Wook Park, Dong-Shik Kim, Brent D. Cameron. Development of a highly specific amine-terminated aptamer functionalized surface plasmon
resonance biosensor for blood protein detection. Optical Society of America: Biomedical Optics Express. 2011 Sep 1;2(9):2731-40.
Epub 2011 Aug 31. PMCID:PMC3184881
Raymond E. Bourey, MD. Since joining CeDER in 2007
Ghosh S, M. Kaw, P. R. Patel, K. J. Ledford, T. A. Bowman, M. F. McInerney, S. K.
Erickson, R. E. Bourey, S. M. Najjar. Mice with null mutation of Ceacam1 develop nonalchoholic steatohepatitis. Hepatic Medicine: Evidence and Research. 2010 May;2010(2):69-78. PMCID:PMC3177946
Bourey, R. E. Primary menopausal insomnia - definition, review, and practical approach. Endocrine practice. 2011 Jan-Feb;17(1):122-31. PMID: 20713350
Bourey, R. E., J. R. Bourey, N. Habbal, and A. Balaa. Early gain in body mass with continuous positive aiway pressure therapy for obstructive
sleep apnea. Somnologie. 2009 Nov;19(11):1472-6. Epub 2009 Aug 25. PMID: 19705206
Bowman, T. A., M. Kaw, S. J. Lee, P. R. Patel, R. E. Bourey, P. M. Haram, L. G. Koch,
S. L. Britton, U. Wisløff, A. D. Lee, S. M. Najjar. Caloric restriction reverses hepatic insulin resistance and steatosis in rats with
low aerobic capacity. Endocrinology. 2010 Nov;151(11):5157-64. Epub 2010 Sep 22. PMCID:PMC2954714
Pappada S.M., B. D. Cameron, R. E. Bourey, M. J. Borst, D. M. Shipp, J. D. Lather,
T. J. Sbrocchi. Neural Network Based Real-time Prediction of Glucose in Patients with Insulin Dependent
Diabetes. Diabetes Technology and Therapeutics. 2011 Feb;13(2):135-41. PMID: 21284480
Pappada SM, Borst MJ, Cameron BD, Bourey RE, Lather JD, Shipp D, Chiricolo A, Papadimos TJ. Development of a neural network model for predicting glucose levels in a surgical
critical care setting. Patient Saf Surg. 2010 Sep 9;4(1):15. PMID: 20828400
Bourey, R.E. and C. P. Lambert. Drug Treatment of Obesity. In: Angelopoulos, T. and
J. Rippe. Obesity: Prevention and treatment. CRC Press, Boca Raton. 2012 (In Press)
Khew_Voon Chin, PhD.
Saunders RA, Fujii K, Alabanza L, Ravatn R, Kita T, Kudoh K, et al. Altered phospholipid transfer protein gene expression and serum lipid profile by topotecan.
Biochem Pharmacol. 2010; 80(3):362-9. PMCID: PMC2883626.
Wu Q, Saunders RA, Szkudlarek-Mikho M, Serna ID, Chin KV. The obesity-associated Fto gene is a transcriptional coactivator. Biochem Biophys Res Commun. 2010 Oct 22;401(3):390-5. Epub 2010 Sep 19. PMCID:PMC2963669
Kablan A, Saunders RA, Szkudlaek M, Chin AJB, Bosio RM, Fujii K, Shapiro J, Chin KV. Prieurianin causes weight loss in diet-induced obese mice and inhibits adipogenesis
in cultured preadipocytes. J Diabet Metabol 2010 Sep 29;1(101). pii: 1000101. PMCID: PMC3093537
Shao, Q., and Chin, K.V. A survey of the American food trends and the growing obesity epidemic. Nutr Res Prac. 2011 Jun;5(3):253-9. Epub 2011 Jun 21. PMCID: PMC3133759
Liang L, Chen J, Vittal R, Selvanayagam ZE, McAteer JA, Deng L, et al. Expression profiling of crystalinduced injury in human kidney epithelial cells. Nephron Physiol. 2006;103(1):p53-62. Epub 2005 Dec 21. PMID: 16374038
Liao JG, Chin KV. Logistic regression for disease classification using microarray data: model selection
in a large p and small n case. Bioinformatics. 2007 Aug 1;23(15):1945-51. Epub 2007 May 31. PMID: 17540680
El-Okdi N, Smaili S, Raju V, Shidyak A, Gupta S, Fedorova L, et al. Effects of cardiotonic steroids on dermal collagen synthesis and wound healing. J Appl Physiol. 2008;105(1):30-6. PMCID: PMC2494826.
Szkudlarek M, Bosio RM, Wu Q, Chin KV. Inhibition of angiogenesis by extracellular protein kinase A. Cancer Lett. 2009;283(1):68-73. PMCID: PMC2713806.
Yang WL, Ravatn R, Kudoh K, Alabanza L, Chin KV. Interaction of the regulatory subunit of the cAMPdependent protein kinase with PATZ1
(ZNF278). Biochem Biophys Res Commun. 2010; 391(3):1318-23. PMCID: PMC2812659.
Saunders, R.A., Fuji, K., Alabanza, L., Ravatn, R., Kita, T., Kudoh, K., and Chin, K.V. “Altered phospholipid transfer protein gene expression and serum profile by topotecan”, Biochem. Pharmacol., 80:362-369, 2010.
Wu, Q., Saunders, R.A., de la Serna, I., and Chin, K.V. “The obesity-associated Fto gene is a transcriptional coactivator”, Biochem. Biophy. Res. Commun., 401:390-395, 2010.
Kablan, A., Saunders, R.A., Szkudlarek, M., Chin, A.J.B., Bosio, R.M., Fujii, K., Shapiro, J., Chin, K.V. “Prieurianin causes weight loss in diet-induced obese mice and inhibits adipogenesis in cultured preadipocytes”, J. Diabet. Metabol., 1:101, 2010.
Saladi, S.V., Keenen, B., Marathe, H.G., Qi, H., Chin, K.V., de la Serna, I.L. “Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness”, Mol. Cancer, 9:280, 2010.
Shao, Q., and Chin, K.V. “Survey of American food trends and the growing obesity epidemic”, Nutr. Res. Prac., 5:253-259, 2011.
Szkudlarek-Mikho, M., Saunders, R.A., Yap, S.F., Ngeow, Y.F., Chin, K.V. “Salinomycin, a polyether antibiotic, inhibits adipogenesis”, Biochem. Biophys. Res.
Commun. 428:487-493, 2012.
Joan R. Griffith, MD.
Ramirez, I, Griffith JR, Watkins M. “Bilateral Lower Extremity Edema in a 14 Year Old Female: A Case Report.”
Accept Consultant for Pediatricians May 2009.
King JT, Hall J, Griffith JR, Mullineaux DR, Clasey JL. “Comparison of body composition from the Bod Pod S/T”.
International Journal of Body Composition Research.2009;7:41-48.
Griffith JR, Assessing Childhood Obesity Program in Low-Socioeconomic and Diverse Communities. JNMA. 2009 May;101(5):421-9. PMID: 19476195
Griffith JR, Clasey JL, King JT, Gantz S, Kryscio RJ, Bada HS. Role of parents in determining children’s physical activity. World J Pediatr. 2007;3(4):265-270
Griffith JR, Gantz S, Lowry J, Dai H, Bada H. Insurance Reimbursement in a University-Based Pediatric Weight Management Clinic. JNMA. 2007 Sep;99(9):1037-41. PMID: 17913114
Griffith JR, Bada S. Chiari I Malformation: Patient report and a mini review. Clinical Pediatrics. 2006 Jul;45(6):570-3. PMID: 16893864
Guillermo Vazquez, PhD Since joining CeDER in 2008 -2015
Smedlund K, Vazquez G. Involvement of Native TRPC3 Proteins in ATP-dependent expression of VCAM-1 and Monocyte
Adherence in Coronary Artery Endothelial Cells. Arterioscler. Thromb. Vasc. Biol. 2008;28:2049-2055. PMID:18787184
Putney JW Jr., Smyth JT, Trebak M, Lemonnier L, Vazquez G, Bird G. Activation and Regulation of TRPC Cation Channels. Cell Membranes and Free
Radicals Research, 1, 51-55. 2008.
Vazquez, G. TRPC Channels: Emerging Roles in Cardiovascular Physiology and Disease. Frontiers
in Bioscience (Schol. Ed.), 15, 1022-1033. 2009.
Tano JY, Smedlund K, Vazquez G. Endothelial TRPC3/6/7 Proteins at the Edge of Cardiovascular Disease. Cardiovasc. Hematol. Agents Med. Chem. 2010;8:1-11. PMID: 20214601
Smedlund K, Tano JY, Vazquez G. The Constitutive Function of Native TRPC3 Channels Modulates VCAM-1 Expression in
Coronary Endothelial Cells through NFkappaB Signaling. Circ Res. 2010;106:1479-1488. PMID: 20360250
Vazquez G., Tano JY., Smedlund K. On the potential role of source and species of diacylglycerol in phospholipase-dependent
regulation of TRPC3 channels. Channels (Austin). 2010; 4:232-240. PMID:20458187
Tano JY, Vazquez G. Requirement for non-regulated, constitutive calcium influx in macrophage survival
signaling. Biochem. Biophys. Res. Commun. 2011;407: 432-437. PMID:21414290
Vazquez G, Smedlund K, Tano JY, Lee R. Molecular and cellular aspects of atherosclerosis: emerging roles of TRPC channels. In: Coronary Artery Diseases, Ed: Angelo Squeri, MD InTech Publisher. 2011. ISBN 978-953-307-712-3.
Smedlund K, Tano JY, Margiotta J, Vazquez G. Evidence for operation of nicotinic and muscarinic acetylcholine receptor-dependent
survival pathways in human coronary artery endothelial cells. Journal of Cell Biochemistry, 112, 1978-1984. 2011.
Vazquez G. TRPC Channels as Prospective Targets in Atherosclerosis: terra incognita. Frontiers in Bioscience, 2012 Jan 1;4:157-66. PMID:22202050
Tano JY, Smedlund K, Lee R, Abramowitz J, Birnbaumer L, Vazquez G. . Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. Biochem. Biophys. Res. Commun. 2011 Jul 8;410(3):643-7. PMID:21684255
Vazquez G, Smedlund K, Tano JY, Lee R. Molecular and cellular aspects of atherosclerosis: emerging
roles of TRPC channels. In: Coronary Artery Diseases, Ed: Angelo Squeri, MD InTech Publisher. ISBN 978-953-307-712-3.
2011
Tano JY, Lee RH, Vazquez G. Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced
survival of bone marrow derived macrophages. Biochemical and Biophysical Research Communications, 2012 Oct 12;427(1):178-84.PMID:22989752
Smedlund K, Bah M, Vazquez G. On the role of endothelial TRPC3 channels in endothelial dysfunction and cardiovascular
disease. Cardiovasc. Hematol. Agents Med. Chem. 2012 Sep;10(3):265-74. PMID:22827251
Tano JY, Lee RH, Vazquez G. Macrophage function in atherosclerosis: potential roles of TRP channels. Channels
(Austin), ”. Channels (Austin), 2012 May-Jun;6(3):141-8.PMID:22909953
Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT,
Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy
E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab. 2013 Aug;305(4):E519-29.PMID:23800882
Tano JY, Solanki S, Lee RH, Smedlund K, Birnbaumer L, Vazquez G. Bone Marrow Deficiency of
TRPC3 Channel reduces early lesion burden and necrotic core of advanced plaques in
a mouse model of atherosclerosis, Cardiovascular Research 2013 (in press)