Medical Microbiology and Immunology

Nancy H. Collins, Ph.D.

 

	Dr. Nancy Collins Hematopoietic Stem Cell Transplantation    Phone: (419) 383-3971 E-mail Address: Nancy.Collinsl@uToledo.edu

Research Interests

Dr. Collins' research interest is in the translation of cellular therapies from the research laboratory into clinical application primarily in the setting of hematopoietic stem cell transplantation.  Working with bone marrow, peripheral blood stem cells, and cord blood cells, her laboratory at Memorial Sloan-Kettering Cancer Center developed various methods to improve the safety and efficacy of hematopoietic cell transplantion and treatment of post-transplant complications.  Dr. Collins founded professional organizations in cellular therapy, helped establish professional standards, and helped develop programs to accredit cellular therapy programs.  She is currently chair of the Standards Committee for the Foundation for Cellular Therapy, and is working with the Alliance for Paired Donation, an organization that is applying a new model for living kidney donor transplantation.  Dr. Collins also organized the UTHSC Women's Programs Initiative that is charged with encouraging and developing programs to serve the needs of women at UT Health Science Campus.

Education

Dr. Collins received her Ph.D. (microbiology/immunology) in 1977 from the University of Rochester, Rochester, New York. She received her postdoctoral training: United States Public Health Service Postdoctoral Fellow Award; 1977-1979, Research in immunology: "Maternal modulation of the paternal histocompatibility antigens," University of Pennsylvania, Department of Pathology.  Dr. Collins joins us after extensive research positions and appointments from the Memorial Sloan-Kettering Cancer Center (MSKCC); Adjunct Professor, Department of Health Professions, Long Island University.  
New York State Department of Health Certificate of Qualification (2001-2007):

      Cellular Immunology, Lymphoid Function, Lymphoid Immunophenotyping, Non-lymphoid Analysis

Representative Publications (out of 47)

Collins NH, Gee AP, Durett AG, Kan F, Zhang MJ, Champlin RE, Confer D, Eapen M, Howard A, King R, Laughlin MJ, Plante RJ, Setterholm M, Spellman S, Keever-TaylorC, Wagner JE, Weisdorf DJ.  The Effect of the Composition of Unrelated Donor Bone Marrow and Peripheral Blood Progenitor Cell Grafts on Transplantation Outcomes.  Biol Blood Marrow Transplant. 2010 Feb; 16(2):253-262. Epub 2009 Oct 12.

Perales, M-A, Jenq R, Goldberg JD, Wilton A, Lee SSE, Castro-Malaspina HR, Hsu K, Papadopoulos EB, van den Brink MrM, Boulad F, Kernan NA, Small TN, Wolden S, Collins, NH,  Chiu M, Heller G, O'Reilly RJ, Kewalramani T, Young JW, Jakubowski AA.  Second-Line Age-Adjusted International Prognostic Index Predicts Overall  Survival in Patients with Advanced Non-Hodgkin Lymphoma after T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplant.  Bone Marrow Transplant. 2010 Jan 11. [Epub ahead of print]

Collins NH. Product Review, Release, and Administration.  In, Cell Therapy cGMP Facilities and Manufacturing. AP Gee Ed. Springer New York, 2009, pp 215-228.

Camacho, R, Wnek, R, Shah, K, Zaller, DM, O'Reilly, R, Collins, N, Fitzgerald-Bocarsly P and Koo, G.C. 2004 Intra Thymic/splenic engraftment of human T cells in HLA-DR-1 Transgenic NOD/scid mice, Cellular Immuno. 232:86-95.

Cheung IY, Lo Piccolo MS, Collins N, Kushner BH, Cheung NK.  2002 Quantitation of GD2 synthetase mRNA by real-time reverse transcription-polymerase chain reaction: Utility in bone marrow purging of neuroblastoma by anti-GD2 antibody 3F8, Cancer 94:3042-3048.

Boulad F, Gillio A, Small TN, George D, Prasad V, Torok-Castanza J, Regan AD, Collins N, Auerbach A, Kernan NA, O'Reilly RJ. 2002 Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts, British Journal of Haematology 111:1153-1157.

Small TN, Papadopoulos E, Boulad F, Black P, Castro-Malaspina H, Childs B, Collins N, George D, Gillio A, Heller G, Jakubowski A, Kernan NA, Mackinnon S, Szabolcs P, Young J, O'Reilly RJ. 1999 Comparison of immune reconstitution following unrelated and related T-cell depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions.  Blood  93(2):467-480.

McGuirk J, Yan Y, Childs B, Fernandez J, Barnett L, Jagiello C, Collins N, O'Reilly RJ.  1998 Differential growth patterns in SCID mice of patient-derived chronic myelogenous leukemias.  Bone Marrow Transplantation 22:367-374.