Medical Microbiology and Immunology



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Health Science Campus
Health Education Building
Medical Microbiology and Immunology
Room 229, MS1021
Office: 419-383-4323
Fax: 419-383-3002

Ren Guoping, Ph.D.

Dr. Ren Guoping

Postdoctoral Fellow
Affiliation:  Dr. Jason Huntley’s laboratory
University of Toledo – College of Medicine
Department of Medical Microbiology & Immunology, HEB 263A
3000, Arlington Avenue
Toledo, OHIO 43614, United States

E-mail address:


Ren, G, Lin, Z, Tsou, C and Wang, C (2003) Effects of macromolecular crowding on the Unfolding and the refolding of D-Glyceraldehyde-3-Phosophospate Dehydrogenase. J. Protein Chem. 22, 431–439

Huang, C, Ren, G, Zhou, H and Wang, C (2005) A new method for purification of recombinant human α-synuclein in Escherichia coli. Protein Expres. Purif. 42, 173-177

Ren, G*, Wang, X*, Hao, S, Hu, H and Wang, C (2007) Translocation of alpha-synuclein expressed in Escherichia coli J. Bacteriol. 189, 2777-2786

Hiniker, A, Ren, G, Heras, B, Zheng, Y, Laurinec, S, Jobson, RW, Stuckey, JA, Martin, JL, and Bardwell, J (2007) Laboratory evolution of one disulfide isomerase to resemble another. Proc Natl Acad Sci (USA) 104, 11670-11675

Ren, G, Stephan, D, Xu, Z, Zheng, Y, Tang, D, Harrison, SR, Kurz, M, Jarrott, R, Shouldice, S, Hiniker, A, Martin, J, Heras, B, and Bardwell, J (2009)

Li, H*, Ke, H*, Ren, G, Qiu, Q, Weng, Y, and Wang, C (2009) Thermal-Induced dissociation and unfolding of homodimeric DsbC revealed by Temperature-Jump Time-Resolved Infrared Spectra. Biophysical J. 97 2811-2819

Foit, L*, Mueller-schickert, A*, Mamathambika, B, Gleiter, S, Klaska, C, Ren, G, and Bardwell, J (2011) Genetic selection for enhanced folding in vivo targets the Cys14-Cys38 disulfide bond in bovine pancreatic trypsin inhibitor. Antioxid Redox Signal.14, 973-984

Ren, G, and Bardwell, J (2011) Engineered pathways for correct disulfide bond formation.Antioxid Redox Signal. 14, 2399-2412

Quan, S, Koldewey, P, Tapley, T, Kirsch, N, Ruane, K, Pfizenmaier, J, Shi, R, Hofmann, S, Foit, L, Ren, G, Jakob, U, Xu, Z, Cygler, M, Bardwell, J (2011) Genetic selection designed to stabilize proteins uncovers a chaperone called Spy. Nat Struct Mol Biol. 18, 262-269

This paper was the subject of a News and Views in Nature: Powers, E.T., & Balch, W.E. Protein folding: Protection from the outside. Nature 471:42-3 (2011)

Awards and Honors:

Scholarship for excellent student of Nanjing University. (1996 - 1999)

Entering the post-graduate program in the National Laboratory of Biomacromolecules, Chinese Academy of Sciences without admission examinations. (2000)

Scholarship for excellent graduate student of Chinese Academy of Sciences. (2001)

Di Ao Scholarship for excellent graduate student of Institute of Biophysics, Chinese Academy of Sciences. (2004)

Conference Poster Presentations and Attendances:

Ren, GThe 6th seminar on Enzymology. Beijing, China, May, 2002.

Ren, G Effects of macromolecular crowding on the unfolding and the refolding of D-Glyceraldehyde-3-Phosophospate Dehydrogenase. (Oral presentation)The 9th National Biophysics Meeting. Dalian, China , June, 2002.

Ren, G Translocation of α-synuclein in Escherichia coli. (Oral presentation) The 7th seminar on Enzymology. Kunming, China, June, 2004.

Ren, GThe 9th National Biochemistry Meeting. Xi’an, China, October, 2005.

Ren, GHoward Hughes Medical Institute, Science Meeting. Janelia Farm Research Campus, September, 2006.

Ren, G Engineered pathways for correct disulfide bond oxidation. (Poster) Molecular Chaperones and Stress Responses Cold Spring Harbor Laboratory, NY, May, 2010

Ren, G The 18th Midwest Microbial Pathogenesis Conference. Ann Arbor, MI, Sep. 2011

Ren, G The 7th international conference on Tularemia. Breckenridge, CO Sep. 2012

Ren, G Protein disulfide bond isomerase activity modulates Francisella tularensis virulence. (Poster) The 20th Midwest Microbial Pathogenesis Conference. Columbus, OH, Aug. 2013


Last Updated: 6/9/16