Medical Microbiology and Immunology

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Health Science Campus
Health Education Building
Medical Microbiology and Immunology
Room 229, MS1021
Office: 419-383-4323
Fax: 419-383-3002 Microbiology.Immunology@utoledo.edu

Mithun Khattar, M.Phil., M.S., Ph.D.

  Dr. Mithun Khattar, Ph.D.
 

Post-doctoral Fellow
Affiliation: Dr. Stanislaw Stepkowski’s laboratory
University of Toledo – College of Medicine
Department of Medical Microbiology & Immunology, HEB 263A
3000, Arlington Avenue
Toledo, OHIO 43614, United States

Tel: +1-419-383-6681
E-mail: Mithun.Khattar@utoledo.edu

PUBLICATIONS:

Publications as a first author: * Equal Contribution

Khattar, M., Schroder, P.M., Miyahara, Y., Chen, W., and Stepkowski, S.M. (2013). Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions. PLOS One. (submitted for review)

Khattar, M., Xie, A., Baum, C.E., Schroder, P.M., Chen, W., and Stepkowski, S.M., (2013). Blockade of IL-21 signaling reverses spontaneous onset of T1D in NOD mice by exhaustive differentiation of pancreatic infiltrating T cells. J. Immunol. (In preparation)

Khattar, M., Baum, C.E., Xie, A., Schroder, P.M., Chen, W., and Stepkowski, S.M., (2013). A novel and critical role of IL-21 signaling in regulating chronic immune responses to promote cardiac allograft rejection and vasculopathy. Am. J. Transpl. (In preparation)

Khattar,M.*, Schroder, P.*, Deng R., Xie A., Miyahara,Y., Chen, W. and Stepkowski,S.M. (2013). PD-1 dependent restoration of self-tolerance by anti-TCRb mAb therapy in NOD mice. Diabetes (In preparation)

Guo, Z.*, Khattar, M.*, Schroder, P.*, Miyahara, Y.*, Wang, G.*, He, X., Chen, W., and Stepkowski, S.M. (2013). A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. J. Immunol. Apr 1;190(7):3153-62.

Khattar, M.*, Deng R.*, Kahan B.D., Schroder P., Phan T., Rutzky L.P., and Stepkowski S.M. (2013). Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally-delivered regulatory T-cells induces permanent acceptance of pancreatic islet allografts. Transplantation. Apr 15;95(7):919-27.

Miyahara, Y.*, Khattar, M.*, Schroder, P., Mierzejewska, B., Chen W., and Stepkowski, S.M. (2012). An anti-TCRβ monoclonal antibody induces tolerogenic effects to promote allograft survival and prevent type 1 diabetes. Am J Transplant. Jun; 12(6):1409-18.

Wang,G.*, Khattar,M.*, Guo,Z.*, Miyahara,Y., Linkes,S.P., Chen,W., and Stepkowski,S.M. (2010). IL-2 deprivation and TGF-beta: two non-redundant suppressive mechanisms of Foxp3+ regulatory T cells jointly restrain CD4+CD25 cell activation. Immunol. Lett. 132(1-2):61-8.

Khattar,M., Chen,W., and Stepkowski,S.M. (2009). Expanding and converting regulatory T cells: a horizon for immunotherapy. Arch. Immunol. Ther. Exp. (Warsz.) 57, 199-204. (Invited Review)


Publications as a corresponding author:
               Corresponding author

Baum, C.E., Meirzejewska, B., Schroder, P.M., Khattar, M., and Stepkowski, S.M. (2013). Optimizing the use of regulatory T cells in allotransplantation: Recent Advances and Future Perspectives. Exp. Rev. Clin. Immunol. Nov; 9(12): 1303-14 (Invited Review)

Peer-reviewed manuscripts:

Deng, R., Xie, A., Schroder, P.M., Khattar, M., He, X., Chen, W., and Stepkowski, S.M. (2013). Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. J. Immunol. (submitted for review)

Schroder, P., Khattar, M., Deng, R., Xie, A., Chen, W., and Stepkowski, S.M. (2013). Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. PLOS One. Jul 24;8(7):e69397.

Wang,G., Miyahara,Y., Guo, Z., Khattar,M., Stepkowski,S.M. and Chen, W. (2010). “Default” generation of neonatal regulatory T cells. J. Immunol. 185(1):71-8.

Guo,Z., Wang,G., Miyahara,Y., Khattar,M., Linkes,S.P., Wang,C., Xia,J., Pan,Y., Chen,W., He,X., and Stepkowski,S.M. (2010). IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4(+) T cells. Immunol. Lett. 128(2):116-23.


Awards and Honors:

The Journal of Immunology Young Investigator Award (2013)

Pre-doctoral fellowship award to pursue Ph.D. at University of Toledo – College of Medicine (2007 – 2012)

“Outstanding PhD Student of the year 2012” awarded at the Annual College of Medicine & Life Sciences commencement ceremony, University of Toledo, 2012


2011 Robert R. Buell Memorial Achievement Award for comprehensive excellence in the physical, biological and social sciences 2011

Travel award to present and attend Immunology 2011: The 98th annual meeting of the American Association of Immunologists (AAI), San Francisco, California (2011)

Third place winner at 2011 Biomedical Science Graduate Research Forum, University of Toledo (2011)

 Travel award of 2000$ to attend and present at the International Congress in Immunology (ICI 2010) at Kobe, Japan (2010)

Second place winner at 2010 Biomedical Science Graduate Research Forum, University of Toledo (2010)

Second place winner at 2009 Biomedical Science Graduate Research Forum, University of Toledo (2009)

Pre-doctoral fellowship award to pursue Ph.D. at Institute of Genomics & Integrative Biology (IGIB), CSIR, New Delhi, India (2006)

Graduate fellowship from Department of Biotechnology (DBT), Government of India to pursue Advanced Diploma in Bioinformatics at Jawaharlal Nehru University, New Delhi, India (2005 - 2006)

Qualified Graduate Aptitude Test in Engineering (GATE) with ranking at top 96.33 percentile (2005)

Certificate of Merit for scoring an overall 1st place in M.S. Fermentation & Microbial Technology at Guru Nanak Dev University Amritsar, Punjab, India (2005)


Conference Presentations, Poster Presentations and Attendances
:

Khattar, M., Schroder, P.M., Baum, C.E., Deng, R., Chen, W., and Stepkowski, S.M. IL21 is a critical regulator of chronic/persistent but not acute/accelerated auto-immune and allo-immune responses. International Congress in Immunology (ICI 2013), Milan, Italy. (Invited talk as the winner of “Young Investigator Award”)

Khattar, M., Schroder, P.M., Miyahara, Y., Deng, R., Mierzejewska, B., Chen, W., and Stepkowski, S.M. (2012). An anti-TCRb monoclonal antibody prevents and reverses the onset of Type 1 Diabetes in NOD mice. IDS-2012: 12th Meeting of Immunology of Diabetes Society, Victoria, BC, Canada. (Poster)

Khattar, M., Schroder, P.M., Miyahara, Y., Deng, R., Mierzejewska, B., Chen, W., and Stepkowski, S.M. (2012). Reprogramming T Cells by an Anti-TCRb mAb to Permanently Accept Heart Allografts. American Transplant Congress (ATC 2012), Boston, MA (Oral Presentation at the concurrent sessions)

Khattar M., Miyahara Y., Schroder P., Mierzejewska B., Chen W., Stepkowski S. (2011) Transient TCR engagement with an anti-TCRβ monoclonal antibody induces tolerogenic effects to allografts as well as prevents the development and reverses the onset of type 1 diabetes. Immunology 2011: The 98th annual meeting of the American Association of Immunologists (AAI), San Francisco, California. (Poster)

Khattar M., Schroder P., Rees M., Chen W., Stepkowski S. (2011) Jak3/Stat5 Regulates the Survival Predominantly of Activated CD8 T-Cells While Stat3 in Both Activated CD4 and CD8 T-Cells. American Transplant Congress (ATC 2011), Philadelphia, PA (Poster)

Khattar M., Miyahara Y., Schroder P., Mierzejewska B., Rees M., Chen W., Stepkowski S. (2011) Simultaneous TCR Binding by Anti-TCR mAb with Antigen Induces Tolerance by Selective Deletion of Antigen-Reactive T-Cells While Enriching Regulatory T-Cells. American Transplant Congress (ATC 2011), Philadelphia, PA (Poster) - selected as Poster of Distinction.

Khattar M., Chen W., Stepkowski S.M. (2010) Characterizing the T-cell survival and differentiation during priming with downregulated gamma-c cytokine/Jak3 signals. International Congress in Immunology (ICI2010), Kobe, Japan. (Poster) The Abstract was awarded with a travel bursary of 2000$ cash.

Khattar,M., Chen, W. and Stepkowski,S.M. (2010) Impact of Downregulated gamma-chain cytokine signals on survival and differentiation of T-cells during priming. Immunology 2010: The 97th annual meeting of the American Association of Immunologists (AAI), Baltimore, Maryland. (Poster)

Khattar M., Wang G., Miyahara Y., Guo Z., Ye Q., Chen W, Stepkowski S. (2010) Jak3/Stat5 Regulates Survival of CD4 vs. CD8 Cells, Conversion of Treg vs. Th17 Cells, and Transplantation Tolerance. American Transplant Congress (ATC 2010), San Diego, CA. (Invited Talk)

Khattar,M., Chen, W. and Stepkowski,S.M. (2009) Distinct regulatory roles for Janus Tyrosine Kinase 3 (Jak3) in generation of T-helper 17 (TH17) and inducible regulatory T cells (Tregs). Immunology 2009: The 96th annual meeting of the American Association of Immunologists (AAI), Seattle, Washington. (Poster)

Khattar,M., Chen, W. and Stepkowski,S.M. (2009) Jak3/Stat5a/b Signaling Is Critical for Both Natural (nTreg) and Inducible (iTreg) CD4+CD25+Foxp3+ Regulatory T Cell Function. American Transplant Congress (ATC2009), Boston, Massachusetts (Invited talk). The abstract was selected in the top 10 “What’s hot, what’s new” category.

 



 

Last Updated: 6/26/15