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Grant Funded Research - Neurology

STROKE

Purpose of Stroke Research in the Department of Neurology:

• Speed the development of treatments and preventions
• Gain better understanding of the disease
• Improve quality of life for stroke patients

Stroke Prevention

1.  This clinical protocol is designed to assess and compare the outcome of a Patent Foramen Ovale (a PFO is a small hole or flap between the two sides of the heart) closure system versus best medical treatment of patients with stroke or Trancient Ischemic Attach (TIA) due to presumed paradoxical embolism. 

You may be eligible to participate if you are between the ages of 18 and 60, have had a positive contrast bubble study by Transesophageal Echocardiogram (TEE), demonstrating right to left shunting through a Patent Foramen Ovale (PFO), and have had a stroke or Transient Ischemic Attack (TIA) in the past six months.

2.  This clinical trial will examine a new therapeutic approach that is based on the detection and treatment of insulin resistance – the body’s reduced ability to process the sugars in food . In epidemiologic research (the study of factors affecting health and illness), insulin resistance has been associated with increased risk for stroke, and several vascular risk factors.  Based on these associations investigators have hypothesized that modification of insulin resistance may reduce the incidence of stroke and heart attack (Myocardial Infarction).

You may be eligible to participate if you are 45 or older and have had an ischemic stroke or TIA within the past six months.

 Acute stroke studies

This clinical trial beginning treatment within 6 hours of stroke onset should establish that an infusion of an experimental fibrinolytic vs placebo is a safe and effective treatment for subjects with acute ischemic stroke. 

You may be eligible to participate if you have a diagnosis of stroke based on a physical examination conducted by a neurologist.  Administration of the study medication is to begin within 6 hours of stroke symptoms

For more information on the UTMC stroke program contact:

Andrea Korsnack, RN, Certified Clinical Research Coordinator * 419-383-3801 * andrea.korsnack@utoledo.edu.