Sivarajan Kumarasamy, Ph.D.
Education and Training
- 2001-B.S., Biochemistry, University of Madras, TN, India.
- 2003- M.S., Medical Biochemistry, University of Madras, TN, India.
- 2009- Ph.D., Medical Biochemistry, University of Madras, TN, India.
- 2009-2014: Post-Doctoral Fellow, University of Toledo College of Medicine and Life sciences, OH.
2006-2007: Project Fellow, University Grants Commission, Department of Medical Biochemistry, University of Madras, India.
2007-2009: Senior Research Fellow- (SRF), Council of Scientific & Industrial Research (CSIR), Department of Medical Biochemistry, University of Madras, India.
2009-2013: Post-Doctoral Fellow, Center for Hypertension and Personalized Medicine, Program in Physiological Genomics, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Health Science Campus, Toledo, OH.
2014- Assistant Professor, Center for Hypertension and Personalized Medicine (CHPM), Department of Physiology & Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH.
The overall objective of my research program is to identify the novel genes/genetic components involved in onset and development of hypertension. Studies from humans and experimental animal models proven that hypertension is closely linked with diabetes, obesity and renal failure. Hypertension can quietly damage the vital organs in the body for years before symptoms develop. The onset and progression of high blood pressure is complex and multi-factorial. Understanding this complex physiology is important, because it may provide insight into developing novel therapeutic strategy to treat patients with high blood pressure and its associated diseases. Genetic linkage analysis in humans and rats we indentified two novel candidate genes for hypertension, chicken ovalbumin upstream promoter transcription factor II (CoupTFII) and Regulated endocrine specific protein 18 (Resp18). Currently, we are working to elucidate the molecular mechanisms and regulation of CoupTF II and Resp18 in salt induced increase in blood pressure, renal failure and de-regulation of metabolism. Understanding this novel gene functions in blood pressure regulation will further widen our knowledge towards better understanding of this complex trait and may help us to develop better therapeutic agents to treat patients with high BP. Fortunately, treatment with antihypertensive drug and lifestyle changes; we can control the development and progression of the disease to reduce the risk of life-threatening complications.
Honors and Awards
Trainee research recognition in Physiological Genomics (2012): American Physiological society, Physiological genomics group at Experimental biology Meeting, held during April 21-25 at San Diego, USA
Special Recognition Awards (2010-2011)- University of Toledo College of Medicine and Life Sciences, Toledo, OH.
Senior Research Fellowship (SRF) (2007-2009)-Awarded SRF in medical sciences discipline awarded by council of scientific and industrial research (CSIR), Govt. of. India.
SFRR- India Poster Award (2007)- International conference on Emerging Trends in Free Radical and Antioxidants Research Third Biennial meeting of the Society for Free Radical Research- Asia (SFRR-Asia) and sixth annual meeting of the Society for Free Radical Research- India (SFRR- India) held during January 8-11, 2007 at Lonavala, India.
SFRR- Poster Award (2007): International Conference on Society for Free Radical Research India Satellite Meet” held during 4-5th January 2007 at Cochin, India.
Mehta G, Kumarasamy S, Wu J, Walsh A, Liu L, Williams K, Joe B, de la Serna IL.. MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy. J Mol Cell Cardiol. 2015 Sep 24; 88:101-110.
Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B.. Mutation within the hinge region of the transcription factor Nr2f2attenuates salt-sensitive hypertension. Nat Commun. 2015 Feb17;6: 6252.
Gopalakrishnan K, Kumarasamy S, Mell B, Joe B. Genome-wide identification of long non coding rnas in rat models of cardiovascular and renal disease. Hypertension. 2015 Jan;65(1):200-10.
Kumarasamy S, Gopalakrishnan K, Abdul-Majeed S, Partow-Navid R, Farms P, Joe B. Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria. Am J Physiol Heart Circ Physiol, 2013,304(1):H22-32.
Gopalakrishnan K, Kumarasamy S, Abdul-Majeed S, Kalinoski AL, Morgan EE, Gohara AF, Nauli SM, Filipiak W E, Saunders TL, Joe B. Targeted disruption of adamts16 gene in a rat genetic model of hypertension. Proc Natl Acad Sci USA, 2012,109(50),20555-9.(This article was highlighted in Nat Rev Nephrol. 2013 Feb; 9(2):64. doi:10.1038/nrneph.2012.268)
Kumarasamy, S*., Gopalakrishnan, K*., Kim, DH., Abraham, NG., Johnson, WD., Joe, B, and Gupta, AK. (2011). Dysglycemia induces abnormal circadian blood pressure variability. Cardiovasc Diabetol, 2011, 10(1), 104. (* Equal Contribution).
Kumarasamy, S., Gopalakrishnan, K., Toland, EJ., Yerga-Woolwine, S., Farms, P., Morgan, EE., and Joe, B. (2011). Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models. Hypertens Res, 2011, 34(12), 1263-70.
Gopalakrishnan, K., Morgan, E E., Yerga-Woolwine, S., Farms, P., Kumarasamy, S., Kalinoski, A., Liu, X., Wu, J., Liu, L., and Joe B. Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short QT-interval and hypertension. Hypertension, 2011, 57:764-771.
Gopalakrishnan K, Saikumar J, Peters CG, Kumarasamy S, Farms P, Yerga-Woolwine S, Toland EJ, Schnackel W, Giovannucci DR, Joe B. Defining a rat blood pressure quantitative trait locus to a <81.8kb congenic segment: comprehensive sequencing and renal transcriptome analysis. Physiol Genomics, 2010, 42A, 153–161.
Kumarasamy, S*., Gopalakrishnan, K*., Shafton, A., Nixon, J., Thangavel, J., Farms, P., and Joe, B. Mitochondrial polymorphisms in rat genetic models of hypertension. Mamm Genome, 2010, 21(5-6), 299–306. (* Equal Contribution).
Tamilselvan J, Jayaraman G, Sivarajan K, Panneerselvam C. Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: Role of carnitine and lipoic acid. Free Radic Biol Med. 2007 Dec 15;43(12):1656-69.
Tamilselvan J, Sivarajan K, Anusuyadevi M, Panneerselvam C. Cytochrome c Oxidase Rather than Cytochrome c is a Major Determinant of Mitochondrial Respiratory Capacity in Skeletal Muscle of Aged Rats: Role of Carnitine and Lipoic Acid. Rejuvenation Res. 2007 Sep;10(3):311-26.
Savitha S, Sivarajan K, Haripriya D, Kokilavani V, Panneerselvam C. Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging. Clin Nutr. 2005 Oct;24(5):794-800.
Kumaran S, Panneerselvam KS, Shila S, Sivarajan K, Panneerselvam C. Age associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: Role of carnitine and lipoic acid. Mol Cell Biochem. 2005 Dec;280(1-2):83-9.