Physiology and Pharmacology : Lijun Liu, M.D., M.S.

• M.D., Clinical Medicine, Capital Medical University, Beijing, China, 1987-1992
• M.S., Pharmacology, Capital Medical University, Beijing, China, 1992-1995
  

• Assistant Professor, Chinese Academy of Preventive Medicine, Beijing, China, 1995-1999
• Postdoctoral Fellow, Department of Pharmacology and Therapeutics, Medical University of Ohio, Toledo, Ohio, 1999-2004
• Assistant Professor, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Toledo, Ohio, 2004-

• Signal transduction of Na/K-ATPase in cardiovascular system and cancer cells

Representative Publications

• Liu, L (1996) Functional foods improve human health. J. of Chinese Functional Food 6:12.
• Liu, L., Han, C., and Chen, J. (1998) Short-term screening of anticarcinogenic ingredients of tea by cell biology assay. J. Hygiene Res. 27:53-56.
• Liu, L. (2000) Trend in chemopreventive agents in colorectal carcinogenesis. (Review) Foreign Med. Sci. (Hygiene section) 27(1):6-10.
• Li, N., Sun, Z., Liu, L., Han, C., and Chen, J. (2002) Chemopreventive effects of tea on human oral precancerous mucosa lesions. J. Hygiene Res. 31:441-443.
• Cui, W., Zhang, X., Liu, L., Wang, W., Sun, Z., Li, N., and Han, C. (2002) Study on the biomarkers in DMBA-induced oral carcinogenesis in hamster. Beijing J. of Stomatology 3:116-118.
• Liu, L., Mohammadi, K., Aynafshar, B., Wang, H., Li, D., Liu, J., Ivanov, A., Xie, Z., and Askari, A. (2003) Role of caveolae in the signal transudcint function of Na+/K+-ATPase.  Am J Physiol Cell Physiol 284:C1150-1160.
• Mohammadi, K., Liu, L., Tian, J., Kometiani, P., Xie, Z., and Askari, A. (2003) The positive inotropic effect of ouabain on the isolated heart is accompanied by the activation of signal pathways that link Na+/K+-ATPase to ERK1/2. J. Cardiovasc. Pharmacol. 41:609-614.
• Liu, L., Mohadmmadi, K., Aynafshar, B., Wang, H., Li, D., Liu, J., Ivanov, A., Xie, Z., and Askari, A. (2003) Role of caveolae in the signal transducing function of Na+/K+-ATPase. Am. J. Physiol. Cell. Physiol. 284:C1550-C1560.
• Abramowitz, J., Dai, C., Hirschi, K.K., Dmitrieva, R.I., Doris, P.A., Liu, L., and Allen, J.C. (2003) Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation 108:3048-3053.
• Liu, L., Abramowitz, A., Askari, A., and Allen, J. (2004) Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype. Am. J. Physiol. Heart Circ. Physiol. 287:H2173-H2182.
• Liu, L., Li, N., Cui, W., Zhang, X., Han, C., and Chen, J.S. (2004) Anti-carcinogenic effects of vitamins and trace elements in tea. Chinese Journal of Public Health 20:1166-1168.
• Kometiani, P.K., Liu, L., and Askari, A. (2005) Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Mol. Pharmacol. 67:929-936.
• Liu, J., Liang, M., Liu, L., Malhotra, D., Xie, Z., Shapiro, J. (2005) Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney International 67(5):1844-1854.
• Tian, J., Cai, T., Yuan, Z., Wang, H., Liu, L., Haas, M., Maksimova, E., Huang, X., and Xie., Z.  (2006)  Binding of Src to Na+/K+-ATPase forms a functional signaling complex.  Molecular Biology of the Cell 17(1):317-326.
• Liu, L. and Askari, A. (2006) The beta-subunit of cardiac Na+/K+-ATPase dictates the concentration of the functional enzyme in caveolae. 291: C569-C578.
• Liu, L., Li, J., Liu, J., Yuan, Z., Pierre, S.V., Qu, W., Zhao, X., and Xie, Z.  (2006) Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes.  Free Radic Biol Med. 41(10):1548-1556.
• Liang, M., Tian, J., Liu, L., Pierre, S., Liu, J., Shapiro, J., and Xie, Z.J.  (2007) Identification of a pool of non-pumping Na/K-ATPase.  J Biol Chem. 282(14):10585-10593.
• Liu, L. and Askari, A. (2006) On the importance and mechanism of amplification of digitalis signal through Na+/K+-ATPase.  Cell Mol Biol (Noisy-le-grand). 52(8):28-30.
• Liu, L., Gable, M.E., Garlid, K.D., and Askari, A. (2007) Interactions of K(+) (ATP) channel blockers with Na (+)/K (+)-ATPase.  Mol Cell Biochem. 306(1-2):231-237.
• Liu, L., Zhao, X., Pierre, S.V., and Askari, A.  (2007)  Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.  Am J Physiol Cell Physiol. 293(5):C1489-497.
• Li, D., Yang, C., Chen, Y., Tian, J., Liu, L., Dai, Q., Wan, X., and Xie, Z.  (2008) Identification of a PKC{varepsilon}-dependent regulation of myocardial contraction by epicatechin-3-gallate.  Am J Physiol. Heart Circ. 294(1):H345-353.
• Cai, T., Wang, H., Chen, Y., Liu, L., Gunning, W.T., Quintas, L.E.M., and Xie, Z.-J. (2008) Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.  Journal of Cell Biology 182 (6):1153-1169, 2008.  Editorial Review by Mitch Leslie, Journal of Cell Biology.
• Tian, J., Li, X., Liang, M., Liu, L., Xie, J.X., Ye, Q., Kometiani, P., Tillekeratne, M., Jin, R., Xie, Z. Changes in Sodium Pump Expression Dictate the Effects of Ouabain on Cell Growth  J Biol Chem. May 29; 284(22):14921-9, 2009. Epub 2009 Mar 27.
• Li, Z., Cai, T., Tian, J., Xie, J.X., Zhao, X., Liu, L., Shapiro, J.I., Xie, Z.  NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells.  J Biol Chem. 2009 Jun 8. [Epub ahead of print]