Center for Hypertension and Precision Medicine

NEWS

Congratulations to Dr. Matam Vijay-Kumar and Lab! Their manuscript, "PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium" was accepted in Mucosal Immunology. Authors: Piu Saha, Beng San Yeoh, Xia Xiao, Rachel M. Golonka, Vishal Singh, Yanming Wang,and Matam Vijay-Kumar


Congratulations to Dr. Bina Joe! She has been nominated and selected by the Physiological Omic Group to be the recipient of the 2019 Distinguished Lectureship Award! The award recognizes a distinguished lecturer in the area of physiological -omics and she will also present the distinguished lecture at the Physiological -Omics Group Symposium at the Experimental Biology 2019 meeting.


Congratulations to Shaunak Roy, MSBS student of Dr. Camilla Wenceslau’s lab!

Shaun was selected by the APS Women in Physiology Committee as one of the recipients of the 2019 Caroline tum Suden/Frances Hellebrandt Professional Opportunity Awards.

As a tum Suden/Hellebrandt Awardee, he will receive a certificate of recognition, early-rate meeting registration reimbursement, and a cash prize upon presentation of his poster at the Experimental Biology (EB) 2019 meeting.


Congratulations to Dr. Matam Vijay-Kumar! He has been invited to speak at the 2019 NCI CCR Liver Cancer Program (LCP) Special Conference on Tumor Metabolism at the National Cancer Institute (NCI), which will be held October 28-29, 2019 at the Masur Auditorium of the NIH Clinical Center, on the NIH Bethesda campus. The conference is organized by the NCI’s Center for Cancer Research (CCR) Liver Cancer Program.


Congratulations to Dr. Terry Hinds! He was selected to receive the 2019 Endocrinology & Metabolism Section New Investigator Award

He will receive his award during the Endocrinology & Metabolism Awards Reception at the Experimental Biology meeting in Orlando in April.


Congratulations to Drs. Kumar and Cheng! They are co-authors in a new publication in Nature Communications titled, " Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway". 


Congratulations to Drs. Wenceslau and McCarthy! Their manuscript, "Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization" was accepted for publication in Pharmacological Research.


Congratulations to Dr. Vijay Kumar’s Lab! Their manuscript, “Deoxyribonuclease I activity, cell-free DNA and risk of liver cancer in a prospective cohort”  was recently accepted for publication by the Journal of National Cancer Institute – Cancer Spectrum (JNCICS). The authors are: Rachel M. Golonka, Beng San Yeoh, Jessica L. Petrick, Stephanie J. Weinstein, Demetrius Albanes, Andrew T. Gewirtz, Katherine A. McGlynn, Matam Vijay-Kumar.


 Congratulations to Sarah Galla from the Joe Lab! Her research story , "Researchers study link between bacteria, blood pressure", was published in the Toledo Blade, January 7, 2019.  

https://www.toledoblade.com/medical/2019/01/07/university-of-toledo-bacteria-blood-pressure-medicine-research


Congratulations to Dr. Vishal Singh from the Kumar Lab! He was awarded a Career Development grant from the Crohn’s and Colitis Foundation and funding is effective January 1, 2019. The title of the grant is, “Metabolite-sensing receptors mediated regulation of immune response in inflammatory bowel disease”.  The duration of the award is three years.

 Well done!

Congratulations to Dr. Cameron McCarthy! He was selected by the American Physiological Society-Cardiovascular Section awards committee as a finalist for the 2019 APS-Cardiovascular Section Outstanding Postdoctoral Trainee Award. His application associated with abstract, “BetaHOB Increases Nitric Oxide Synthase Activity in Resistance Arteries from Dahl Salt Sensitive Rats”, was amongst the most highly rated applications submitted to the committee. 

He will orally present his research as part of the Featured Topic Session, “Cardiovascular Section Young Investigator Competition" which will occur on Monday, April 8, 2019. 

Well done!


Congratulations to Dr. Vijay Kumar’s Lab, whose manuscript titled, Microbiota Fermentation-NLRP3 Axis Shapes the Impact of Dietary Fibers on Intestinal Inflammation” was accepted in Gut which is the second ranked leading international journal (impact factor 17) in gastroenterology and hepatology.

List of Authors: Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin,Xi Cheng, Qing Liu, Michael D. Flythe,Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew T. Gewirtz, and Matam Vijay-Kumar. 

Well done!


Congratulations to Dr. Camilla Wenceslau and Dr. Cameron McCarthy! They were both invited and have accepted to join the AJP-Heart and Circulatory Physiology Editorial Board! Their terms begin January 2019.


CHPM Members, Drs. Steven Haller and David Kennedy from the Department of Medicine recently traveled to Seoul, South Korea, at the 49th Scientific Meeting of the Korean Society of Hypertension in conjunction with the International Society of Hypertension and Hypertension Seoul 2018. The theme was “Understanding Hypertension Pathophysiology from Bench to Bedside”. Drs Haller and Kennedy were invited to give lectures and Dr. Haller spoke on “Pathophysiology of Renal Fibrosis,” while Dr. Kennedy spoke on “Mechanisms of Cardiorenal Syndrome.”


Since its inception in 2012, the Center for Hypertension and Precision Medicine (CHPM), recently recognized by the University of Toledo as a Spotlight Area of Unique Distinction, has promoted interdisciplinary research, education and public awareness in the field of hypertension and associated cardiometabolic diseases. Researchers at CHPM have now made groundbreaking discoveries that link gut microbiota to blood pressure regulation, obesity and liver cancer. 

- Dr. Bina Joe’s lab (Distinguished University Professor and Chair, Department of Physiology and Pharmacology) has pioneered the link between gut microbiota –bacteria residing in the gut- and the genetics of hypertension (https://www.ncbi.nlm.nih.gov/pubmed/25829393). Over the past few years Dr. Joe’s group has been studying the relationship between metabolites produced by the gut microbiota and the function of organ systems that regulate blood pressure. This research has the potential to unravel novel targets, either at the bacterial level or within the host that can be used to treat or even prevent high blood pressure. Dr. Joe was recently awarded a $2.64 million grant from the National Heart, Lung and Blood Institute (http://utnews.utoledo.edu/index.php/09_10_2018/professor-awarded-2-6-million-research-grant-to-further-examine-link-between-gut-bacteria-and-high-blood-pressure).

- Specific pharmacologic treatment of salt-sensitive hypertension remains a challenge. Within this context, Dr. Joe’s lab recently identified a salt-responsive metabolite, beta-hydroxybutyrate, as a key regulator of blood pressure which can attenuate hypertension and protect kidney function despite high salt intake. This work was published in the prestigious journal Cell Reports (https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31503-1).

-  While studying the benefits of the refined soluble fiber inulin, a probiotic, in combating obesity-associated complications, Dr. Matam Vijay-Kumar (Director of the UT Microbiome Consortium and Associate Professor in the Department of Physiology and Pharmacology) and his research team have recently found that after six months on inulin-enriched diet mice develop cholestatic liver cancer. Remarkably, this seems induced by dysregulation of fiber fermentation by the gut microbiota. These seminal findings were published in the prestigious journal Cell (https://www.cell.com/cell/fulltext/S0092-8674(18)31176-0).


 

Congratulations to Dr. Sivarajan Kumarasamy and lab! Their manuscript, "COUP-TFII Revisited: Its Role in Metabolic Gene Regulation" was accepted in Steroids journal. Authors are: Usman M Ashraf, Edwin R Sanchez and Sivarajan Kumarasamy.


We are pleased to announce the addition of two adjunct faculty members to the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine. These appointments significantly enhance the footprint of our Center in human hypertension research.

 Dr. Patricia Munroe is a Professor from The William Harvey Research Institute at the Queen Mary University of London (https://www.qmul.ac.uk/whri/people/academic-staff/items/munroepatricia.html) and Dr. Sandosh Padmanabhan is a Professor from the Institute of Cardiovascular and Medical Sciences at University of Glasgow (https://www.gla.ac.uk/researchinstitutes/icams/staff/sandoshpadmanabhan/). They are world leaders in hypertension research and in the field of Precision Medicine and Translational Physiology. Dr. Munroe was named a Thomson Reuters Highly Cited Researcher and has also been listed in the 2015 World’s Most Influential Scientific Minds.  Dr. Padmanabhan has won several awards as well and works in association with Professor Dame Anna Dominiczak’s research group in the University of Glasgow.


We are pleased to announce that Ms. Hannah Saternos, a graduate student of Dr. Wissam Aboualaiwi-who is an NIH-funded member of the Center for Hypertension and Precision Medicine in the College of Pharmacy, has received an American Heart Association (AHA) pre-doctoral grant for two years starting 01/01/2019. Dr. Saternos’ grant scored in the 11.65 percentile and the funding pay line was at 39 percentile. Congratulations on both the mentee and mentor for a job well done!


Congratulations to Dr. Vijay Kumar and his students, Beng and Rachel!  Their manuscript has been accepted for publication in the Journal of Innate Immunity. The title is, “The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity” and the authors are: Dr. Matam Vijay-Kumar (Corresponding Author), Rachel Golonka(Co-author), Beng San Yeoh (Co-author).  Well done!


Congratulations to Saroj (Dr. Bina Joe's lab) and collaborators, for having their manuscript accepted to Cell Reports! The title of the manuscript is, “Salt-responsive Metabolite, b-hydroxybutyrate, Attenuates Hypertension” and the authors are: Chakraborty, S, Galla, S, Cheng X, Yeo, J, Mell, B, Singh V, Yeoh BS, Saha P, Mathew, AV, Vijay-Kumar, M, Joe B.  Well done!


Dr. Bina Joe, Chair of Physiology and Pharmacology was recently featured in the International Society of Hypertension’s Women in Hypertension Spotlight. See more here:  http://ish-world.com/womens-spotlight/i/Dr-Bina-Joe/


The National Heart Lung and Blood Institute awarded Dr. Joe a $2.64 million grant to study the role of gut microbiota in hypertension. Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension. The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension. Other faculty collaborators on this grant are Dr. Matam Vijay-Kumar and Dr. Ritu Chakravarti.

Congratulations!


Congratulations to Sarah Galla from Dr. Bina Joe’s lab! Her work has been featured in a press release from the APS. Congratulations and well done! http://www.the-aps.org/mm/hp/Audiences/Public-Press/2018/49.html

Congratulations to Dr. Saurabh Chattopadhyay and Dr. Terry Hinds! The National Institutes of Health awarded Dr. Saurabh Chattopadhyay (Medical Microbiology & Immunology) and Dr. Terry Hinds (Physiology and Pharmacology) a grant (R21)to study  the function of Interferon Regulatory Factor 3 (IRF3) in alcoholic liver diseases (ALD) titled, “How Non-Transcriptional IRF3 Prevents ALD”. Dr. Chattopadhyay is Principal Investigator and  Dr. Hinds is Co-Investigator.


Congratulations to Dr. Cam McCarthy! He was awarded a post-doc grant from the American Heart Association and funding was effective July 1, 2018. The title of his grant is, “Decreased autophagy leads to proteotoxicity and senescence in hypertension-associated premature vascular aging”.


Congratulations to Dr. Vijay Kumar and Lab! Their manuscript, “Myeloperoxidase Deficiency Attenuates Systemic and Dietary Iron-induced Adverse Effects, has been accepted for publication in The Journal of Nutritional Biochemistry. Authors are: Xia Xiao, Piu Saha, Beng san yeoh, Jennifer Hipp and Matam Vijay-Kumar.


The National Heart Lung and Blood Institute awarded Dr. Bina Joe, Distinguished University Professor and Chair of the Department of Physiology and Pharmacology and Director of the Center for Hypertension and Precision Medicine, a major, $2.64 million, grant to study the role of gut microbiota in hypertension.  Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension.  The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension.  Other faculty collaborators on this grant from the Department of Physiology and Pharmacology are Dr. Matam Vijay-Kumar, Associate Professor & Director of the UT Microbiome Consortium and Dr. Ritu Chakravarti, Assistant Professor.


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


 A special thanks to all the CHPM members and trainees and everyone who participated in the American Heart Walk and activities this year! Whether you made a monetary contribution or walked or ran in the 5K, your contributions and participation are greatly appreciated! (And congrats to Dr. Aboualaiwi, who placed 4th overall in the 5K and 1st in his age group!) Thanks again everyone!


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


Congratulations to Dr. Ritu Chakravarti, joint faculty member of Physiology and Pharmacology and CHPM member, who received funding from the University of Toledo Rocket Fuel Fund for a collaborative project to build a composite sensor that can measure real-time reactive oxygen species in tissues and liquids. This exemplary collaboration is with Dr. Kim, College of Engineering faculty member, who has an interest in developing electrochemical sensors, while Dr. Chakravarti is an expert on reactive oxygen species. The title of the project is “Time Electrochemical Sensor for Detecting Free Radicals” and the funding is for one year.


Congratulations to Dr. Bina Joe and lab! Their manuscript, “Fine mapping of epistatic genetic determinants of blood pressure on rat chromosome 5”, was accepted for publication in the Journal of Hypertension. The authors are: Harshal Waghulde, Resmi Pillai, Xi Cheng, Ying Nie, Blair Mell, Bina Joe


Congratulations Vazquez's lab!! The manuscript: "Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of Trpc3: Obligatory requirement for Trpc3 in a novel macrophage-associated BMP-2 dependent calcification mechanism" by Prabhatchandra Dube, Chikkamenahalli Lakshmikanth, Lutz Birnbaumer and Guillermo Vazquez, has been accepted for publication in Atherosclerosis, a prestigious journal of the European Atherosclerosis Society.


Congratulations to Dr. Ritu Chakravarti, joint faculty of the Department of Phys/Pharm, whose manuscript entitled, “Bioinformatic Analysis Reveals New Determinants of Antigenic 14-3-3 Proteins and A Novel Antifungal Strategy” by Jenna McGowan, Jacqueline Kratch, Saurabh Chattopadhyay, Bina Joe, Heather R. Conti, and Ritu Chakravarti was accepted for publication in PLOS ONE!


Congratulations to Prabhat Dube (Vazquez Lab) who successfully defended his dissertation.  Well done, Prabhat – you did a great job!


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Last Updated: 1/29/19