Center for Hypertension and Precision Medicine

NEWS

Congratulations to Dr. Sivarajan Kumarasamy and lab! Their manuscript, "COUP-TFII Revisited: Its Role in Metabolic Gene Regulation" was accepted in Steroids journal. Authors are: Usman M Ashraf, Edwin R Sanchez and Sivarajan Kumarasamy.


We are pleased to announce the addition of two adjunct faculty members to the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine. These appointments significantly enhance the footprint of our Center in human hypertension research.

 Dr. Patricia Munroe is a Professor from The William Harvey Research Institute at the Queen Mary University of London (https://www.qmul.ac.uk/whri/people/academic-staff/items/munroepatricia.html) and Dr. Sandosh Padmanabhan is a Professor from the Institute of Cardiovascular and Medical Sciences at University of Glasgow (https://www.gla.ac.uk/researchinstitutes/icams/staff/sandoshpadmanabhan/). They are world leaders in hypertension research and in the field of Precision Medicine and Translational Physiology. Dr. Munroe was named a Thomson Reuters Highly Cited Researcher and has also been listed in the 2015 World’s Most Influential Scientific Minds.  Dr. Padmanabhan has won several awards as well and works in association with Professor Dame Anna Dominiczak’s research group in the University of Glasgow.


We are pleased to announce that Ms. Hannah Saternos, a graduate student of Dr. Wissam Aboualaiwi-who is an NIH-funded member of the Center for Hypertension and Precision Medicine in the College of Pharmacy, has received an American Heart Association (AHA) pre-doctoral grant for two years starting 01/01/2019. Dr. Saternos’ grant scored in the 11.65 percentile and the funding pay line was at 39 percentile. Congratulations on both the mentee and mentor for a job well done!


Congratulations to Dr. Vijay Kumar and his students, Beng and Rachel!  Their manuscript has been accepted for publication in the Journal of Innate Immunity. The title is, “The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity” and the authors are: Dr. Matam Vijay-Kumar (Corresponding Author), Rachel Golonka(Co-author), Beng San Yeoh (Co-author).  Well done!


Congratulations to Saroj (Dr. Bina Joe's lab) and collaborators, for having their manuscript accepted to Cell Reports! The title of the manuscript is, “Salt-responsive Metabolite, b-hydroxybutyrate, Attenuates Hypertension” and the authors are: Chakraborty, S, Galla, S, Cheng X, Yeo, J, Mell, B, Singh V, Yeoh BS, Saha P, Mathew, AV, Vijay-Kumar, M, Joe B.  Well done!


Dr. Bina Joe, Chair of Physiology and Pharmacology was recently featured in the International Society of Hypertension’s Women in Hypertension Spotlight. See more here:  http://ish-world.com/womens-spotlight/i/Dr-Bina-Joe/


The National Heart Lung and Blood Institute awarded Dr. Joe a $2.64 million grant to study the role of gut microbiota in hypertension. Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension. The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension. Other faculty collaborators on this grant are Dr. Matam Vijay-Kumar and Dr. Ritu Chakravarti.

Congratulations!


Congratulations to Sarah Galla from Dr. Bina Joe’s lab! Her work has been featured in a press release from the APS. Congratulations and well done! http://www.the-aps.org/mm/hp/Audiences/Public-Press/2018/49.html

Congratulations to Dr. Saurabh Chattopadhyay and Dr. Terry Hinds! The National Institutes of Health awarded Dr. Saurabh Chattopadhyay (Medical Microbiology & Immunology) and Dr. Terry Hinds (Physiology and Pharmacology) a grant (R21)to study  the function of Interferon Regulatory Factor 3 (IRF3) in alcoholic liver diseases (ALD) titled, “How Non-Transcriptional IRF3 Prevents ALD”. Dr. Chattopadhyay is Principal Investigator and  Dr. Hinds is Co-Investigator.


Congratulations to Dr. Cam McCarthy! He was awarded a post-doc grant from the American Heart Association and funding was effective July 1, 2018. The title of his grant is, “Decreased autophagy leads to proteotoxicity and senescence in hypertension-associated premature vascular aging”.


Congratulations to Dr. Vijay Kumar and Lab! Their manuscript, “Myeloperoxidase Deficiency Attenuates Systemic and Dietary Iron-induced Adverse Effects, has been accepted for publication in The Journal of Nutritional Biochemistry. Authors are: Xia Xiao, Piu Saha, Beng san yeoh, Jennifer Hipp and Matam Vijay-Kumar.


The National Heart Lung and Blood Institute awarded Dr. Bina Joe, Distinguished University Professor and Chair of the Department of Physiology and Pharmacology and Director of the Center for Hypertension and Precision Medicine, a major, $2.64 million, grant to study the role of gut microbiota in hypertension.  Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension.  The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension.  Other faculty collaborators on this grant from the Department of Physiology and Pharmacology are Dr. Matam Vijay-Kumar, Associate Professor & Director of the UT Microbiome Consortium and Dr. Ritu Chakravarti, Assistant Professor.


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


 A special thanks to all the CHPM members and trainees and everyone who participated in the American Heart Walk and activities this year! Whether you made a monetary contribution or walked or ran in the 5K, your contributions and participation are greatly appreciated! (And congrats to Dr. Aboualaiwi, who placed 4th overall in the 5K and 1st in his age group!) Thanks again everyone!


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


Congratulations to Dr. Ritu Chakravarti, joint faculty member of Physiology and Pharmacology and CHPM member, who received funding from the University of Toledo Rocket Fuel Fund for a collaborative project to build a composite sensor that can measure real-time reactive oxygen species in tissues and liquids. This exemplary collaboration is with Dr. Kim, College of Engineering faculty member, who has an interest in developing electrochemical sensors, while Dr. Chakravarti is an expert on reactive oxygen species. The title of the project is “Time Electrochemical Sensor for Detecting Free Radicals” and the funding is for one year.


Congratulations to Dr. Bina Joe and lab! Their manuscript, “Fine mapping of epistatic genetic determinants of blood pressure on rat chromosome 5”, was accepted for publication in the Journal of Hypertension. The authors are: Harshal Waghulde, Resmi Pillai, Xi Cheng, Ying Nie, Blair Mell, Bina Joe


Congratulations Vazquez's lab!! The manuscript: "Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of Trpc3: Obligatory requirement for Trpc3 in a novel macrophage-associated BMP-2 dependent calcification mechanism" by Prabhatchandra Dube, Chikkamenahalli Lakshmikanth, Lutz Birnbaumer and Guillermo Vazquez, has been accepted for publication in Atherosclerosis, a prestigious journal of the European Atherosclerosis Society.


Congratulations to Dr. Ritu Chakravarti, joint faculty of the Department of Phys/Pharm, whose manuscript entitled, “Bioinformatic Analysis Reveals New Determinants of Antigenic 14-3-3 Proteins and A Novel Antifungal Strategy” by Jenna McGowan, Jacqueline Kratch, Saurabh Chattopadhyay, Bina Joe, Heather R. Conti, and Ritu Chakravarti was accepted for publication in PLOS ONE!


Congratulations to Prabhat Dube (Vazquez Lab) who successfully defended his dissertation.  Well done, Prabhat – you did a great job!


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Last Updated: 11/26/18