The University of Toledo

Research Interests and Activities

Interests

• Solubility and Thermodynamic Parameters of Therapeutic Pharmaceutical Agents
• Physico-Chemical Properties of Therapeutic Agents in Relation to Their Mechanism of Action and Their Molecular Orbital Spatial Configurations
• Physico-Chemical Properties of Tablets
• Design and Evaluation of Contemporary Dosage Forms
• Parenteral Dosage Form Stability and Evaluation
• Suspension Theory and Stability
• Stability of Pharmaceuticals and Their Related Excipients in the Solid State
• Transdermal Absorption of Selected Pharmaceutical Agents and the Use of Enhancers to Facilitate Their Absorption
• Mathematical Modeling of Pharmaceutical Systems to Explain Their Deviance from Ideal
• Suspension Stability in the Presence of Pharmaceutical Adjuvants
• The Stability of Simple Drug Moieties in the Solid State
• The Formulation and Stability of New Oral Liquid Pediatric Dosage Forms Used in the Treatment of Acute and Chronic Pediatric/Geriatric Diseases
• The Evaporative Process from a Kinetic and Thermal Viewpoint
• The Formulation of Products for Human Hair and Their Effects
• Stability of Pharmaceutical Agents in the Solid State
• Transdermal Adsorption of Pharmaceutically Important Agents
• Characterization of Volatile Components Used in Aromatherapy, Perfumery, and Flavors
• Characterization of Fully Formulated Commercial Tablets
• Characterization of Polymorphic Materials
• Characterization of Water Present in Solids, Solutions, and Suspensions
• Eutectic and Solid Solution Formation
• Directed undergraduate research projects in the area of: Dosage Form Design and Evaluation for five (5) students since 1973, Solubility and Drug Availability for Commercial "Generic Equivalents" of OTC Products', 1976; Dye Stability for five (5) students, 1986-88; I.V. Admixture Stability for three (3) students, 1988; 1990; 1991; Aminoglycoside Dosing Models for two (2) students, 1989; River Sedimentation 1991, Validation of Stokes' Law 1991.

Activities

• Research advisor in the 'Science Mentor Program' - a joint UT-Toledo Board of Education Summer Science Research Program for 10th and 11th grade high school students who receive college credit and research experience (students supervised): 1985(1); 1986(2); 1987(1); 1988(3)
• Research advisor in the Research Apprenticeship in Science Program - a program to continue the Research Mentor Program sponsored by Toledo Edison (students supervised): 1990 (1); 1991 (1); 1992 (1); 1993 (3); 1994 (1); 1995 (3)
• Thesis advisory committee for M.S. students in pharmaceutics and hospital pharmacy option 1980-85
• Research advisor for M.S. students in The Industrial Pharmacy Option 1985-present
• Research advisor for BSPS students in the Pharmaceutics Option 2005-present

Undergraduate Research

• Honors Thesis
  1. Andrea Schroeder Knapp - Co-Advisor with V. Mauro PharmD. - Thesis research entitled - The In-Syringe Compatibility of Toradol and Other Post-Surgical Injectables, May 1992

Graduate Research

M.Sc. Thesis Advisory Committee for:

1. Mr. John Mroczkowski, MS. 1981 - Thesis entitled: Influence of Some Formulation Factors on the Intramuscular Absorption of Gentamicin.
2. Ms. Alma N Malanyaon, MS Chemistry Dept. - in progress
3. Mrs. Sahaja Rao, MS December 1996, Department of Chemistry, Thesis entitled "Thermal Decomposition Study of Selected Calcium Carboxylates Both in the Presence and also in the Absence of Excipients"
4. Mr. Yuanwen Wu, Chemistry Department, MS in progress
5. Ms. Caroline O'Connell, Chemistry Department, MS June 1998, Department of Chemistry, Thesis entitled "Thermal Decomposition Studies of Selected Fatty Substances and the Substances Used to Preserve Them"
6. Ms. Pauline Phang, Chemistry Department, MS in progress

M.Sc. Thesis Candidates Graduated:

1. Mr. James K. Smith, MS 1987 - project entitled "An Update on Particulate Contamination: Does the Supplier of D5/NS for Injection Make a Difference"
2. Mr. Faroog A. Patel, MS 1988 - project entitled: "An Investigation of Suspensions of China Clay and Kaolin N.F"
3. Mr. VyKuntam Uppala, MS 1990 - Thesis entitled "The Behavior of Concentrate Calcium Carbonate Suspensions"
4. Mr. Kaushik Dani, MS 1990 - Thesis entitled "The Stability of Ascorbic Acid in Tablet Formulations Using Thermal Analytical Techniques"
5. Mr. Rajiu Haribhakt, MS 1990 - Thesis entitled "The Formulation and Stability of Oral Liquid Pediatric Dosage Forms: Acetazolamide"
6. Ms. Shahnaz S. Tata, MS 1990 - Thesis entitled "An Investigation of the Hindered Settling Behavior of Concentrated Magnesium Hydroxide Slurries"
7. Mr. Gireesh V. Gupchup, MS 1990 - Thesis entitled "An Investigation Into the Solid State Behavior of Aspirin in Pharmaceutical Tablet Mixtures Using Thermoanalytical Techniques"
8. Mr. Maddasudin Puddapedi, MS 1991 - Thesis entitled "The Formulation and Stability of Oral Liquid Pediatric Dosage Forms: Procainamide and Hydralazine"
9. Ms. Sujata Swaminathan, MS 1991 - Thesis entitled "The Determination of Stability Constants for the Complexation of Dextrose and Glycine in Intravenous Fluids with Transition Metals"
10. Ms. A. Savitri Murthy, MS 1991 - Thesis entitled "Investigation of Sedimentation Parameters of Concentrated Aluminum Hydroxide Slurries"
11. Mr. Norool-Huda, S.A.F., MS 1992 - Thesis entitled "Investigation and Characterization of Model Carbon Systems in Concentrated Slurries"
12. Mr. Nipun Dawar, MS 1992 - Thesis entitled "Formulation Development and Stability of Alopurinol and Rifampin Suspensions"
13. Ms. Divya Gangwal, MS 1992 - Thesis entitled "Sedimentation Behavior of Concentrated Aluminum Hydroxide Suspensions"
14. Ms. Nandini Konar, MS 1992 - Thesis entitled "Characterization of Cholesterol in Kidney and Gallstone Formation"
15. Ms. Weeriyit Chirarutsami, MS 1992 - Thesis entitled "An Investigation of the Dehydration of Magnesium Hydroxide Paste"
16. Ms. Nuthanun Kusolmanomai, MS 1993- Thesis entitled "The Behavior pf Magnesium Hydroxide Suspensions in the Never Dried State and Flocculated with Polymer Flocculants"
17. Ms. Dipoli Roy, MS 1993 - Thesis entitled "The Determination of Stability Constants for the Complexation of Dextrose and the Amino Acids Arginine and Serine"
18. Mr. Sanjay Rayathatha, MS 1993 - Thesis entitled "Comparison of Isothermal and Non-Isothermal Stability Studies for Hydralazine Pediatric Syrup"
19. Mr. Shyam Vangala, MS 1993 - Thesis entitled "The Formulation and Stability of Oral Liquid Pediatric Dosage Forms: Spironalactone and Metronidazole"
20. Mr. Manish Agrawal, MS 1994 - Thesis entitled "The Stability of Erythrocin Dye"
21. Ms. Dolly Patel, MS 1994 - Thesis entitled "An Investigation Into The Use of Thermal Analysis In Pharmaceutical Applications"
22. Ms. Supattra Ochacharion, MS 1994 - Thesis entitled "The Investigation of Concentrated Suspensions of Aluminum Hydroxide, Magnesium Hydroxide and Calcium Carbonate"
23. Ms. Kavita Nair, MS 1994 - Thesis entitled "An Investigation Into the Thermal Decomposition of Dolomite As Influenced By The Effects of Grinding and The Presence of Excipients Using Thermal Analysis and Associated Techniques"
24. Mr. Pavan Heda, MS 1994 - Thesis entitled "The Stability of Sodium Bicarbonate and Other Formulation Ingredients in Toothpaste"
25. Mr. Abhijit Chakraborty, MS 1994, Thesis entitled "Solubility and Thermodynamic Parameters of Monosubstituted Benzoic Acid s"
26. Mr. Madhusudanrao Kothapalli, MS 1995, Thesis entitled "Development of a Stable Analytical Method for Sodium Citrate" and "Stability of Levothyroxine Pediatric Oral Solution"
27. Mr. Vineet Chaudry, MS 1995, Thesis entitled "The Characterization of Human Hair and the Development of a New Non-Interactive Hair Straightening Formulation"
28. Ms. Ping Tong, MS 1995, Thesis entitled "An Investigation of Concentrated Suspensions of Calcium Phosphate and Calcium Oxalate and Their Relationship to Gall Stone Formation"
29. Mr. Aditya Prendse, MS 1995, Thesis entitled "Hindered Settling Studies Using 'Never-Dried' Suspensions"
30. Mr. Hanumanthrao V. Ramachandruni, MS 1995, Thesis entitled "The Formulation and Stability of Oral Liquid Pediatric Dosage Forms: Captropril and Atenolol"
31. Ms. Supaporn Lerdkanchanaporn, MS 1995, Thesis entitled "Investigation Into the Shelf-Life Stability of Pharmaceutical Products Containing Ascorbic Acid"
32. Mr. Isam Tahboub, MS 1995, Thesis entitled " Investigation of a Carbon Black Model in Aqueous Suspension With Respect to Changes in Reactivity Parameters".
33. Mr. Mohamad Mazin Chwiki, MS 1996, Thesis entitled "An Investigation of the Effect of Microwave Heating on Thermal Stability and Hindered Settling"
34. Mr. Yichun Sun, MS 1996,Thesis entitled "Study of the Evaporation of Benzaldehyde from PEG Base"
35. Ms. Monica Motwani, MS 1996, Thesis entitled "Investigation and Characterization of the Components of a Cosmetic Cream Using Thermogravimetry"
36. Mr. Youssef, Bassam, MS December 1996, thesis entitled "The Application of Thermal Analysis to the Study of the Behavior of Concentrated Aqueous Suspensions or Kaolin and Talc"
37. Ms. Lalitha Arikapudi, MS 1997, thesis entitled "Thermal Characterization and Accelerated Stability Testing of an Extemporaneous Syrup Formulation of Metoprolol Tartrate"
38. Mr. Anirban Basu, MS 1997, thesis entitled "Mathematical Modeling of Hindered Settling Behavior with Respect to Concentrated Magnesium Carbonate Suspensions"
39. Ms. Kranthi Yelamanchely, MS 1997 Thesis entitled: "Treatment Base Compositional Influence on the In Vitro Diffusion of Methyl Salicylate and Effect of the Design of the Diffusion Cell on the Amount of Drug Released."
40. Mr. Bhanu Kalvakota MS 1997, thesis entitled "The Thermal Stability of Aspirin in the Presence of Magnesium Stearate"
41. Ms Li Shen, MS August 1998 thesis entitled "Solid State Stability of Medium Chain Length Fatty Acids with Pharmaceutical Excipients", currently enrolled in the Ph.D. program Chemistry Department University of Toledo
42. Ms. Lihua Zhang, MS December 1998, thesis entitled "Solid State Stability of Medium Chain Length Fatty Acids with Pharmaceutical Excipients", currently employed at Oread, Lawrence, Kansas
43. Ms. Xu Zheng, MS June 1998, thesis entitled "An In Vitro Diffusion Study of Atropine Across Shed Snake Skin Used As A Model Membrane System"
44. Mr. Yu-Hsiu Cheng, MS August 1999, thesis entitled "A Thermal Analysis Study of Methyl Salicylate"
45. Ms. Chunhong Gu, MS December 1999, thesis entitled A Stability Study of Ascorbic Acid Using Thermal Analysis Techniques"
46. Ms. Yu-I Huang, MS December 1999, thesis entitled "A Thermal Analysis Study of Captopril and Its Selected Excipients"
47. Mr. Mahesh N. Samtani, August 2000, thesis entitled: "Thermal Analysis of Ground Dolomite."
48. Mr. Sachin Mittal, August 2000, thesis entitled: "Characterization of Yohimbine HCl Using Analytical Physical, Transdermal and Excipient Compatibility Studies."
49. Ms. Nasreen Khan, August 2000, thesis entitled: "Thermal Decomposition Studies on Selected Magnesium Hydroxy Carbonate Samples."
50. Mr. Rahul Malhotra, August 2000, thesis entitled: "Effects of Compaction and Presence of Excipients on Thermal Decomposition of Magnesium Hydroxide."
51. Mr. Kostuv Chatterjee, August 2000, thesis entitled: "Calculation of Vapor Pressure Curves for Selected Benzoic Acid Derivatives Using Thermogravimetry."
52. Mr. Aditya Tatavarti, August 2000, thesis entitled: "The Application of Thermal Analysis to Study the Behavior of Selected Pharmaceutically Import and Polymers and Polymer Additives."
53. Mr. Nitin Kaila, MS August 2001, thesis entitled "Formulation Development and Stability of an Extemporaneous Suspension prepared from Commercially available Dapsone tablets "
54. Ms. Anasuya Hazra, MS August 2001,thesis entitled ‘Characterization and Kinetics of Essential Oils and Their Key Components Using Thermal Analytical Techniques".
55. Mr. Murali Duvvuri , MS August 2001,thesis entitled "Comparison of Commercially available Saw Palmetto Products against USP’s Nutritional Standards and Other Criteria."
56. Ms. Divya Menon, MS August 2001,thesis entitled "A Thermal Analysis Study of Tableting of Nicotinic acid."
57. Mr. Anuj Kumar, MS August 2001,thesis entitled "An In-Vitro Biological Modelling of Polymethacrylate Microspheres Incorporating Hyoscyamine Hemisulfate."
58. Mr. Parthiv Vora, MS August 2001,theis entitled "Characterization and Thermal Behavior of Vitamins: Nicotinic acid and Nicotinamide using Thermogravimetry.
59. Ms. Simin Hassannejad Tabasi, MS August 2001,thesis entitled," The Stability and Thermal Behavior of Calcium Oxalate in the presence of Cholesterol to Explain the formation of Kidney stones."
60. Ms. Qian Zhu, MS August 2001, thesis entitled "A Hindred Settling Behavior Study for Calcium Hydrogen Phosphate Aqueous Suspensions-Particle Size analysis and Their Associate Liquid Determined Using Thermal analysis."
61. Ms. Farah Khan, MS August 2001,thesis entitled "Thermal Dehydration of Epsom salts and D. Gluconic acid salt."
62. Ms. Akansha Vora, MS December 2001, Thesis entitled: "Thermal Stability of Folic Acid and Associated Excipients."
63. Mr. Ravishankar Vedula - MS, December 2001. Thesis entitled "A Study of the Effect of Particle Size and Other Parameters on the Sedimentation of Concentrated Pumice Suspensions." Currently employed at the Pharmaceutical Industry.
64. Mr. Yuantao Wang - MS, December 2001. Thesis entitled "Suspension Stability of Magnesium Trisilicate in Various Pharmaceutical Dispension Systems." Currently employed in a Biotech firm in NJ.
65. Mr. Shouvik Roy - MS June 2002. Thesis entitled "investigation of the Stability and InVitro Release Profile of Sulfamerazine Polymorphs from Directly Compressed Tablets - A Preformulation Study." Currently enrolled in the PhD program at the University of Colorado.
66. Ms. Renuka Thirumangalathu - MS, August 2002. Thesis entitled" Formulation and Modeling of In-vitro Release Kinetics of Phenylpropenolamine Hydrochloride Microspheres." Currently enrolled in the PhD program at the University of Colorado.
67. Ms. Kavitha Bhasi - MS, August 2002. Thesis entitled "A Study of the Sedimentation of Pumice Using Carbopol Sodium Alginate and Gelatin as Dispensing Agents." Currently enrolled in the PhD program at the State University of New York at Buffalo.
68. Mr. Nagarajan Thyagarajapuram - MS, August 2002. Thesis entitled "Analytical Method Development of Amiodarone Hydrochloride: Formulation and Stability Studies of Extemporaneous Suspensions of Amiodarone Hydrochloride." Currently enrolled in the PhD program at the University of Kansas.
69. Ms. Sarita Kaushik - MS, August 2002. Thesis entitled "Formulation Development and Stability Testing of Extemporaneously Prepared Mexiletine Hydrochloride Solution." Currently seeking employment in the pharmaceutical industry.
70. Ms. Pallabi Mitra - MS, May 2003. Thesis entitled "Analytical method development, formulation development, and stability testing of an extemporaneously prepared propylthiouracil suspension." Currently enrolled in the Ph.D. program at the University of Kansas
71. Mr. Pradyot Nandi - MS, May 2003. Thesis entitled "Thermal Characterization And Kinetics Of Essential Oils And Their Major Constituents Used In Aromatherapy." Currently enrolled in the Ph.D. program at the University of Kansas
72. Mr. Rajesh Vadlapatla - MS, May 2003. Thesis entitled "Solid State Cbhacterization of Anhydrous and Hydrous Forms of Aminophylline and Their In-Vitro Drug Release atternsN." Currently enrolled in the Ph.D. program at the University of Arkansas.
73. Mr. Sumit Majundar - MS May 2003. Thesis entitled "Thermal Characterization of the moisture interaction of the Microcrystalline Cellulose grades in a model Pharmaceutical formulation and their effect on the drug release behavior." Currently enrolled in the PhD program at the University of Kansas
74. Mr. Sandipan Sinha - MS, May 2003. Thesis entitled" Preparation and Evaluation of the Amorphous Form of Sulfapyridine-the Effect of Relative Humidity, Excipients and Temperature" Currently enrolled in the PhD program at the University of Kansas
75. Mr. Lalit M. Oberroi - MS, May 2004. Thesis entitled "Formulation of a fast acting ibuprofen suspension by using nicotinamide as a hydrotropic agent- application of DSC, spectroscopy and microscopy in assessment of the type of interaction." Currently enrolled in the Ph.D. program at the University of Arkansas.
76. Ms. Paroma Chakabarty - MS, May 2004. Thesis entitled "Evaluation of the Crystalline Properties and Dissolution Profiles of Tolbutamide: Effect of Experimental Factors and Solid Dispersions" Currently enrolled in the Ph.D. Program at the University of Minnesota.
77. Ms. Bhaswati DattaChowdhury - MS, May 2004. Thesis entitled "Application of Theoretical Models in the Crystallization Kinetics of Pharmaceuticals from the Amorphous State." Currently enrolled in the Ph.D. program at the University of Kansas.
78. Ms. Marcia A. Williams - MS May 2004. Thesis entitled "A Comparison of the Disintegration Properties of Three Starches and a Super-Disintegrant-A novel Approach", Returned to Jamaica to resume teaching duties in Pharmaceutics at her home University.
79. Ms. Jayeeta Sen - MS, May 2005. Thesis entitled "Synergistic Effects of Ternary Systems on the Release Profiles of Naproxen and Tolbutamide " Currently employed in a pharmaceutical company in India
80. Mr. Amanda Jones - MS, May 2005. Thesis entitled "Pharmaceutical Eutectics: Formation, Evaluation and Relevance in Preformulation Studies Using Thermal Analytical Techniques." Currently enrolled in the Ph.D. program at the Ohio State University
81. Mr. Pinaki Basu - MS, May 2005. Thesis entitled "Crystalliation Kinetics of Amorphous Ketoconazole" Currently enrolled in the Ph.D. program at the University of Colorado
82. Mr. Indranil Rao - MS May 2005. Thesis entitled "A Vaporization Study of Vegetable Oils and Their Constituents: Construction of Vapor Pressure Curves and Kinetics of Degradation by Thermogravimetry" Currently enrolled in the PhD program at the University of Buffalo
83. Ms. Jinal Desai - MS, August 2005. Thesis entitled "Development of Controlled Released Formulations of Dimenhydrinate Using Ethyl Cellulose: Application of the Solid Dispersion and Wet Granulation Technique" Currently employed in a biotech firm in New Jersey
84. Mr. Ping Ma - MS August 2006 Thesis entitled " "

Ph.D. Thesis Advisory Committee for:

1. Mr. Olusola Sunday Ogundiram, Department of Chemical Engineering, Ph.D. 1991, Thesis entitled: Application of Membranes in Chemical Reaction Systems
2. Mr. John D. Skelton Jr., Department of Chemistry, Ph.D., 1993, Thesis entitled: Micellar Behavior and Particle Size Determination of Surfactants and Cholesterol Aggregates
3. Mr. William Jones III, Chemistry Dept. – did not finish
4. Ms. Poonam Aggrawal, Department of Chemistry, Ph.D. March 1997, Thesis entitled "Physicochemical Characteristics of Starch and Modified Starch"
5. Ms. Olga Shulga, Department of Chemistry, MS 2001, Ph.D. 2005
6. Ms. Shamtell F. Wright, Department of Chemistry, MS 2004