Department of Pharmacology : Ezdihar A. Hassoun

Ezdihar A. Hassoun
Professor of Pharmacology
Vice Chair of Pharmacology

419-530-1917 Phone
419-530-1909 FAX
WO 2235
ezdihar.hassoun@utoledo.edu   

Institutions/Degrees

Oxidative stress and oxygen free radicals biochemistry, in vivo and in vitro studies on the toxicities of environmental pollutants.

Selected Publications

• Hassoun EA, Wang, Xin. Ricin-induced toxicity in the macrophage J744A.1 Cells: The role of TNF-alpha and the modulation effects of TNF-alpha polyclonal antibody. J. Biochem. Mol. Toxicol. 14 : 95-101 (2000).
  
  
• Hassoun EA, Li, F, Abushaban, A, Stohs, S. The relative abilities of TCDD and its congeners to induce oxidative stress in the hepatic and brain tissues of rats after subchronic exposure. Toxiology, 145 : 103-113 (2000).
  
  
• Hassoun EA, Li, F, Abushaban A, Stohs, S. Production of Superoxide Anion, Lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners. J. Appl. Toxicl. 21:211-219 (2001).
  
  
• Hassoun EA, Wang H, Abushaban A, Stohs S. Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2, 3, 4, 7, 8 -- pentachlorodibenzofuran and 3, 3, 4, 4, 5 -- pentachlorobiphenyl. J. Toxicol. Environ. Hlth. 65:825-842 (2002).
  
  
• Hassoun E, Al-Ghafri, M, Abushaban, A. The role of antioxidant enzymes in TCDD-induced oxidative stress in various brain regions of rats after subchronic exposure. Free. Rad. Biol. Med., 35: 1028-1036 (2003).
  
  
• Hassoun E, Vidisha Kini. Effects of superoxide dismutase and polyclonal tumor necrosis factor alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages. Comp. Biochem. Pysiol. Part C, 138: 113-120 (2004).
  
  
• Hassoun E, Vodhanel J., Abushaban, A. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J. Biochem. Mol. Toxicol. 18: 196-203 (2004).
  
  
• Alsharif, N., Hassoun E. Protective effects of vitamin A and vitamin E succinate against TCDD-induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice. Basic. Clin. Pharmacol. Toxicol. (In press).
  
  
• Hassoun, E., Kariya, C., Williams, F. Dichloroacetae-induced developmental toxicity and production of reactive oxygen species in zebrafish embryos. J. Biochem. Mol. Toxicol. , 19: 52-57 (2005)
  
  
• Hassoun, E., Vodhanel, J., Holden, B., Abushaban, A. The effects of ellagic acid and vitamin E succinate on antioxidant enzymes activities in different brain regions of rats after subchronic exposure to TCDD. J. Toxicol.Environ. Health . 69:381-393 (2006)
  
  
• Byers, J., Masters, K., Sarver, J., Hassoun, E. Association between the levels of biogenic amines and superoxide anion production in brain regions of rats after subchronic exposure to TCDD. Toxicology : 228: 291-298 (2006).
  
  
• Hassoun, E., and Dey, S. Dichloroacetate- and trichloroacetate-induced phagocytic activation and production of oxidative stress in the hepatic tissues of mice after acute exposure. J. B iochem. Mol. Toxicol. , 22: (In press) 2008.