CENTER OF EXCELLENCE IN BIOMARKER RESEARCH & INDIVIDUALIZED MEDICINE (SCHOOL OF BRIM)

brim course spring 2017 schedule

Biomarker Discovery and Individualized Medicine Course
BRIM 6200/8200; Spring 2017

UNIT 1  (Director – Alexei Fedorov, PhD)

Genomics
Delivery: Conventional lecture in classroom will be recorded with Echo 360 and uploaded  on the Web;
Location: HEB Rm 127; every Monday and Thursday
Time 10am -12pm
Exam: Take home exam at the end of the course

Contact Course Director:
Alexei Fedorov, PhD, Department of Medicine, BHS Room 308.
Phone: 419-383-5270
E-mail: Alexei.fedorov@utoledo.edu

1)      January 9, Introduction to 1000 Genomes Project (Alexei Fedorov)
2)      January 12, Human SNPs Part 1  (John Grey)
3)      January 19, Human SNPs Part 2  (John Grey)
4)      January 23, 1000 Genomes Project in details (Alexei Fedorov)
5)      January 26, Complex patterns of SNP arrangements (haplotypes)  (Alexei Fedorov)
6)      January 30, GWAS and Identification of disease-susceptibility genes (George Cicila)
7)      February 2, International Bioinformatics project tranSMART (Natalia Boukharov)
8)      February 6, International Bioinformatics project tranSMART (Natalia Boukharov)
9)      February 9, Human population genetics intricacies (Alexei Fedorov)
10)    February 13, Epigenomics (Ivana de la Serna)
11)    February 16, The Human Microbiome in the Context of Biomarker Research & Individualized Medicine (Robert Blumenthal)
12)    February 20, RNomics Part 1 (Neocles Leontis)
13)    February 23, RNomics Part 2 (Neocles Leontis)
14)    February 27, Genomic recombinations (Alexei Fedorov)
15)    March 2, Take-home exam

March 6 - 10 Spring Break

UNIT 2:  Director – Kathryn Eisenmann, PhD

Individualized Medicine
Delivery: Conventional lecture in classroom will be recorded with Echo 360 and uploaded on Blackboard
Location:  Every Monday and Thursday, room 127 HEB
Time: 10am -12pm
Exam: Take home exam in the mid and at the end of the course

Contact Course Director:
Kathryn Eisenmann, PhD, Dept. of Biochemistry & Cancer Biology, BHS Room 390
Phone: (419)383-4101
E-mail: kathryn.eisenmann@utoledo.edu


Introduction to the course
: Clinical Need - where has it been important

Assigned reading material:

Tenenbaum, JD. 2016. Translational Bioinformatics : Past, Present, and Future. Genomics Proteomics Bioinformatics. Feb;14(1):31-41.

March 13      Lecture 1: DNA damage response biomarkers of cancer (K. Williams, PhD - Dept. Biochemistry   and Cancer Biology, D. Allison, MD – Dept. Surgery);

March 16      Lecture 2: Biomarkers of cancer cell motility (K. Eisenmann, PhD – Dept. Biochemistry and     Cancer Biology);

March 20      Lecture 3: Development of genome-based biomarkers of hypertension (S. Kumarasamy, PhD - Dept. Physiology and Pharmacology);

March 23      Lecture 4:  Biomarkers identification and validation (S. Khuder, PhD – Dept. Medicine); 

March 27      Lecture 5: Discovery of Sjogren’s Syndrome biomarkers using patients saliva (D. Giovannucci – Dept. Neurosciences);

Exam I (March 30 - April 6)

March 30    TAKE HOME EXAM
April 3         TAKE HOME EXAM
April 6         TAKE HOME EXAM DUE

        Lecture 6: Biomarkers for Alzheimer disease (V. Ramsey-Williams, MD, PhD – Dept. Neurology);

        Note: Online lecture only. No in class lecture

April 10         Lecture 7: TBD (M. Kaul Kaw, MD,PhD - Department of Physician Assistant Studies);

April 13         Lecture 8: Individualized immunotherapy (R. Worth, PhD – Dept. Microbiology and Immunology);

April 17         Lecture 9: Targeted transplant, donor-recipient matching (S. Stepkowski, PhD – Dept.  Microbiology and Immunology);

April 20         Lecture 10: Validation - Design and conduct of trials - Patient selection (J. Willey, MD – Dept. Medicine);

April 24         Lecture 11: TBD (M. Kaul Kaw, MD,PhD - Department of Physician Assistant Studies);

Exam II (April 27-May 4)

April 27 TAKE HOME EXAM
May 2   TAKE HOME EXAM
May 4   TAKE HOME EXAM DUE

 

 

 

Last Updated: 3/6/17