Department of Chemistry and Biochemistry


The University of Toledo

58.       Nandedkar-Kulkarni, N.; Vartak, A.; Sucheck, S. J.; Wall, K.; Quinn, A.; Morran, M.; McInerney, M. Development of a bioconjugate platform for modifying the immune response of autoreactive cytotoxic T lymphocytes involved in type 1 diabetes. Bioconj. Chem. 2019, 30, 2049–2059 DOI: 10.1021/acs.bioconjchem.9b00332

57.       Vartak, A.; Goins, C.; Nogueira de Moura, V. C.; Schreidah, C. M.; Landgraf, A. D.; Lin B.; Du, J.; Jackson, M.;  Ronning D. R.; Sucheck S. J. Biochemical and microbiological evaluation of N-aryl urea derivatives against Mycobacteria and Mycobacterial hydrolases. MedChemComm, 2019,10, 1197–1204, DOI: 10.1039/C9MD00122K

56.       Hossain, M. K.; Vartak, A.; Sucheck, S. J; Wall. K.A.  A liposomal Fc domain conjugated to a cancer vaccine enhances both humoral and cellular immunity. ACS Omega, 2019, 4, 5204–5208. PMCID: PMC6441943, doi: 10.1021/acsomega.9b00029.

55.       Kapil, S.; Petit, C.; Drago, V. N.; Ronning, D. R.; Sucheck, S. J. Synthesis and in vitro characterization of trehalose‐based inhibitors of mycobacterial trehalose 6‐phosphate phosphatases. ChemBiochem 2019, 20, 260–269. PMCID: PMC6467533. doi: 10.1002/cbic.201800551

54.       Vartak, A.; Thanna, S.; Meyer, K.; Dermanelian, M.; Sucheck, S. J. Oligosaccharide synthesis on soluble high-molecular weight pHEMA using a photo-cleavable linker.RSC Adv., 2018, 8, 41612–41619. NIHMSID: 1026069, doi: 10.1039/C8RA08252A

53.       Hossain, M. K.; Vartak, A.; Karmakar, P.; Sucheck, S. J. and K. A. Wall. Augmenting vaccine immunogenicity through the use of natural human anti-rhamnose antibodies. ACS Chem. Biol. In press. doi: 10.1021/acschembio.8b00312.

52.       Vartak, A. and Sucheck, S. J. Advances in synthetic approaches towards glycoantigens. InCarbohydrate-Based Vaccines: From Concept to Clinic; A. Krishna Prasad, Ed.; ACS Symposium Series 1290; American Chemical Society: Washington, DC, 2018; pp175-195; ISBN13: 9780841233379; doi: 10.1021/bk-2018-1290.ch008

51.       Vartak, A.; Hefny, F. M.; Sucheck, J. Synthesis of Oligosaccharide components of the outer core domain of P. aeruginosa lipopolysaccharide using a multifunctional hydroquinone-​derived reducing-​end capping group. Org. Lett. 2017 doi:10.1021/acs.orglett.7b03590

50.       Veleti, S. K.; Petit, C.; Ronning, D. R.; Sucheck, S. J. Zwitterionic pyrrolidene-phosphonates: inhibitors of the glycoside hydrolase-like phosphorylase Streptomyces coelicolor GlgEI-V279S Org. Biomol. Chem., 2017, 15, 3884–3891. doi: 10.1039/C7OB00388A (Hot Article) PMID: 28422240. Author  Correction: Veleti, S. K.; Petit, C.; Lindenberger, J. J.; Ronning, D. R.; Sucheck, S. J.Org. Biomol. Chem., doi: 10.1039/C7OB90121F

49.       Goins, C. M.; Thanna, S, Dajnowicz, S.; Sucheck, S. J.; Parks, J. M.; Ronning, D. R. Exploring covalent allosteric inhibition of Antigen 85C from Mycobacterium tuberculosis by ebselen derivatives. ACS Infect. Dis.20173, 378–387. doi: 10.1021/acsinfecdis.7b00003 PMID: 28285521

48.       Thanna, S.; Goins, C. M.; Knudson, S. E.; Slayden, R. A.; Ronning, D. R ; Sucheck S.  J. Thermal and photoinduced copper-promoted C−Se bond formation: Synthesis of 2-alkyl-1,2-benzisoselenazol-3(2H)ones and evaluation against Mycobacterium tuberculosis J. J. Org. Chem., 2017, 82, 3844–3854. doi: 10.1021/acs.joc.7b00440 PMID: 28273423

47.         Sucheck, S. J. Domino and intramolecular rearrangement reactions as advanced synthetic methods in glycosciences. Eds Z. J. Witczak and R. Bielski. Angew. Chem. Int. Ed. 2016, 55, 11337–11338.Book Review. doi: 10.1002/anie.201606642

46.       Veleti S. K. and Sucheck, S. J. Glycoconjugate-based inhibitors of Mycobacterium tuberculosis GlgE. In Strategies for coupling and decoupling diverse molecular units in the glycosciences; Witczak, Z. J., Bielski, R., Eds.; Wiley: New Jersey, in press

45.       Thanna, S.; Knudson, S. E.; Grezegorzewic, A.; Kapil, S.; Goins,  C. M.; Ronning, D. R.;   Jackson, M.; Slayden, R. A. Sucheck, S. J.  Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis Org. Biomol. Chem., 2016, 14, 6119–6133. doi: 10.1039/C6OB00821F. PMID: 27251120

44.       Vartak, A. and Sucheck, S. J. Recent advances in subunit vaccine carriers. Vaccines (Basel) 2016, 4, pii: E12. doi: 10.3390/vaccines4020012. PMID: 27104575

43.       Thanna, S. and Sucheck S. J. Targeting the trehalose utilization pathways of Mycobacterium tuberculosis. Med. Chem. Commun., 2016, 7, 69–85. doi: 10.1039/C5MD00376H. PMID: 26941930

42.       Karmakar, P.; Lee, K.; Sarkar, S.; Wall, K. A.; Sucheck, S. J. Synthesis of a liposomal MUC1 glycopeptide-based immunotherapeutic and evaluation of the effect of L-rhamnose targeting on cellular immune responses. Bioconjug Chem. 2016, 27, 110–20. PMCID: PMC4837471

41.       Lindenberger, J. J; Veleti, S. K.; Wilson, B.; Sucheck, S. J.; Ronning, D. R. Crystal structures of Mycobacterium tuberculosis GlgE and complexes with noncovalent inhibitors. Sci. Reports. 2015,5, 12830. doi: 10.1038/srep12830. PMID: 26245983

40.       Giatonde, V. and Sucheck, S. J. Anti-tuberculosis drugs based on carbohydrate derivatives. In Carbohydrates Chemistry: State-of-the-art and challenges for drug development; Cipolla, L., Ed.; Imperial College Press: London, Aug 12, 2015. ISBN-10: 1783267194; ISBN-13: 978-1783267194.

39.       Thanna, S.; Lindenberger, J. J.; Vishwanath, G.; Ronning, D. R.; Sucheck, S. J. Synthesis of 2-deoxy-2,2-difluoro-α-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S. Org. Biomol. Chem. 2015, 13, 7542–7550. doi: 10.1039/c5ob00867k. PMID: 26072729

38.       Veleti, S. K.; Lindenberger, J. J.; Thanna, S.; Ronning, D. R.; Sucheck, S. J. Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE. J. Org. Chem. 2014, 79, 9444–9450. PMID:25137149 (Feature Article)

37.       Long, D. E.; KarmakarP.; Wall, K. A.; Sucheck, S. J. Synthesis of α-L-rhamnosyl ceramide and evaluation of its binding with anti-rhamnose antibodies. Bioorg. Med. Chem. 2014, 22, 5279–89. PMCID:PMC4172545

36.       Bouhall S. K and Sucheck, S. J. In situ preactivation strategies for the expeditious synthesis of oligosaccharides: A review.J. Carbohydr. Chem. 2014, 33, 347–367. PMID: 25328276

35.       Gaitonde, V.; Lee, K.; Kirschbaum, K.; Sucheck S. J. Bio-based bisfuran: synthesis, crystal structure, and low molecular weight amorphous polyester. Tetrahedron Lett. 2014, 55, 4141–4145. PMCID:PMC4096679

34.       Veleti, S. K.; Lindenberger, J. J.; Ronning, D. R.; Sucheck S. J. Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE. Bioorg. Med. Chem. 2014, 22, 1404–1411. PMCID:PMC4023634

33.       Sarkar, S.; Sayler, A. C. D.; Wall, K. A.; Sucheck, S. J. Synthesis and immunological evaluation of a MUC1 glycopeptide incorporated into L-rhamnose displaying liposomes. Bioconjugate. Chem. 2013, 24, 363–375. PMCID: PMC3623543

32.       Ibrahim, D. A.; Boucau, J.; Lajiness, D. H.; Veleti, S. K.; Trabbic, K. R.; Adams, S. S.; Ronning, D. R.; Sucheck S. J. Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85C. Bioconjugate Chem. 2012, 23, 2403–2416. PMCID: PMC3548330

31.       Gaitonde, V. and Sucheck S. J. Synthesis of β-Glycosyl amides from N-glycosyl dinitrobenzenesulfonamides J. Carbohydr. Chem. 2012, 31, 433–450. PMCID:PMC3551597

30.       Karmakar, P.; Talan, S. R.; Sucheck, S. J. Mixed-phase synthesis of glycopeptides using a N-peptidyl-2,4-dinitrobenzenesulfonamide-thioacid ligation strategy. Org. Lett. 2011, 13, 5298–5301. PMCID: PMC3188410

29.       Sarkar, S.; Sucheck S. J. Comparing the use of 2-methylenenapthyl, 4-methoxybenzyl, 3,4-dimethoxybenzyl and 2,4,6-trimethoxybenzyl as N–H protecting groups for p-tolyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-β-D-glucosides. Carbohydr. Res. 2011, 346, 393–400.

28.       Sarkar, S.; Lombardo, S. A.; Herner, D. N.; Talan, R. S.; Wall, K. A.; Sucheck S. J. Synthesis of a single molecule L-rhamnose-containing three component vaccine and evaluation of antigenicity in the presence of anti L-rhamnose antibodies. J. Am. Chem. Soc. 2010, 132, 17236–17246.

27.       Umesiri, F. E.; Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Recent advances towards the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med. Res. Rev. 2010, 30, 290–326. doi: 10.1002/med.20190. PMID: 20099253

26.       Talan, R. S.; Sanki, A. K.; Sucheck, S. J. Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids. Carbohydr. Res. 2009, 344, 2048–2050.

25.       Sanki, A. K.; Boucau, J.; Umesiri, F. E.; Ronning, D. R.; Sucheck, S. J. Design, synthesis and biological evaluation of sugar-derived esters, α-ketoesters and α-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85C. Mol. BioSyst. 2009, 5, 945–956. doi: 10.1039/b902284h. PMID: 19668859

24.       Ragupathi, G.; Damani, P.; Srivastava, G.; Srivastava, O.; Sucheck, S. J.; Ichikawa, Y.; Livingston, P. O. Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine. Cancer Immunol. Immunother. 2009, 58, 1397–1405.

23.       Sanki, A. K.; Talan, R. S.; Sucheck, S. J. Synthesis of small glycopeptides by decarboxylative condensation and insight into the reaction mechanism. J. Org. Chem. 2009, 74, 1886–1896.

22.       Sanki, A. K.; Boucau, J.; Ronning, D. R.; Sucheck, S. J. Antigen 85C-mediated acyl-transfer between synthetic acyl donors and fragments of the arabinan. Glycoconjugate J. 2009, 26, 589–596. doi: 10.1007/s10719-008-9211-z. PMID: 19052863

21.       Boucau J.; Sanki, A. K.; Voss, B. J.; Sucheck, S. J.; Ronning D. R. A coupled assay measuring Mycobacterium tuberculosis antigen 85C enzymatic activity. Anal. Biochem. 2009, 385, 120–127. doi: 10.1016/j.ab.2008.10.018. PMID: 18992216

20.       Sanki A. K.; Boucau J.; Srivastava P.; Adams S. S.; Ronning, D. R., Sucheck, S. J Synthesis of methyl 5-S-alkyl-5-thio-arabinofuranosides and evaluation of their antimycobacterial activity. Bioorg. Med. Chem. 2008, 16, 5672–5682. doi: 10.1016/j.bmc.2008.03.062. PMID: 18450455

19.       Demaray, J. A.; Thuener, J. E.; Dawson, M. N.; Sucheck, S. J. Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity. Bioorg. Med. Chem. Lett. 2008, 18, 4868–4871. doi: 10.1016/j.bmcl.2008.07.087. PMID: 18678487


Optimer Pharmaceuticals, Inc.

18.       Liang, C. -H; Romero, A.; Rabuka, D.; Sgarbi, P. W. M.; Marby, K. A.; Duffield, J.; Yao, S.; Cheng, M. L; Ichikawa, Y.; Sears, P.; Hu, C.; Hwang, S.-B.; Shue, Y.-K.; Sucheck, S. J. Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities. Bioorg. Med. Chem. Lett. 2005, 15, 2123–2128. PMID: 15808482

17.       Romero, A.; Liang, C. -H.; Chiu, Y. -H.; Yao, S.; Duffield, J.; Sucheck, S. J.; Marby, K.; Rabuka, D.; Leung, P. Y.; Shue, Y. -K.; Ichikawa, Y.; Hwang, C. -K. An efficient entry to new sugar modified ketolide antibiotics. Tet. Lett. 2005, 46, 1483–1487.

16.       Yao, S.; Sgarbi, P. W. M.; Marby, K. A.; Rabuka, D.; O’Hare, S. M.; Cheng, M. L.; Bairi, M.; Hu, C.; Hwang, S.-B.; Hwang, C.-K.; Ichikawa, Y.; Sears, P.; Sucheck, S. J. Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents. Bioorg. Med. Chem. Lett. 2004, 14,3733–3738. PMID: 15203152

15.       Lee, L. V.; Bower, K. E.; Liang, F. S.; Shi, J.; Wu, D.; Sucheck, S. J.; Vogt, P.K.; Wong, C.-H. Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides. J. Am. Chem. Soc. 2004; 126, 4774–4775.

14.       Agnelli, F.; Sucheck, S. J.; Marby, K. A; Rabuka, D.; S. -L., Yao; Sears, P. S.; Liang, F.-S.; Wong, C. -H. Dimeric aminoglycosides as antibiotics. Angew. Chem. Int. Ed. 2004, 43, 1562–1566. PMID: 15022234

13.       Sucheck, S. J. and Shue, Y.-K. Combinatorial synthesis of aminoglycoside libraries. Curr. Opin. Drug Discovery and Development 2001, 4, 462–470.



12.       Sucheck, S. J.; Wong, C.-H. RNA as a target for small molecules. Curr. Opin. Chem. Biol. 2000, 4, 678–686.

11.       Sucheck, S. J.; Wong, A. L.; Koeller, K. M.; Boehr, D. D.; Draker, K.-A.; Sears, P.; Wright, G. D.; Wong, C.-H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes. J. Am. Chem. Soc. 2000, 122, 5230–5231.

10.       Sucheck, S. J.; Greenberg, W. A.; Tolbert, T., Wong, C.-H. Design of small molecules that recognize RNA: Development of aminoglycosides as potential antitumor agents that target oncogenic RNA sequences. Angew. Chem., Int. Ed. 2000, 39, 1080–1084.



9.         Cagir, A.; Tao, Z.-F.; Sucheck, S. J.; Hecht, S. M. Solid phase synthesis and biochemical evaluation of conformationally constrained analogues of deglycobleomycin A5 Bioorganic Med. Chem. Lett. 2003, 11, 5179–5187.

8.         Sucheck, S. J. Study of naturally occurring nucleic acid interactive agents. 1998, 205 pp.

7.         Chen, J.; Zhang, Y.-H., Wang, L.-K.; Sucheck, S. J.; Snow, A. M.; Hecht, S. M. Inhibitors of DNA polymerase β from Schoepfia Californica. Chem. Commun. 1998, 2769–2770.

6.         Katono, K.; An, H.; Aoyagi, Y. Overhand, M.; Sucheck, S. J.; Stevens, W. C. Jr.; Hess, C. D.; Zhou, X.; Hecht, S. M. Total synthesis of bleomycin group antibiotics. The total synthesis of bleomycin demethyl A2, bleomycin A2 and decarbamoyl bleomycin demethyl A2. J. Am. Chem. Soc. 1998, 120, 11285–11296.

5.         Sucheck, S. J.; Ellena, J. F.; Hecht, S. M. Characterization of Zn(II).deglycobleomycin A2 and interaction with d(CGCATGCG)2. Direct evidence for minor groove binding of the bithiazole moiety. J. Am. Chem. Soc. 1998, 120, 7450–7460.



4.         Skrzypczak-Jankun, E., Sucheck, S., Smith, D.A. 4-Methyl-3,5-dioxopiperazine acetic acid and 4-methyl-3,5-dioxopiperazine-N-methylacetic amide. Cambridge Crystallographic Data Centre, deposition no. CCDC 118966/CCDC 118967, 1999.

3.         Smith, D. A., Sucheck, S.; Cramer, S.; Baker, D. Nitrilotriacetamide: Synthesis in concentrated sulfuric acid and stability in water Synth. Commun. 1995, 25, 4123–4132.

2.         Cramer, S.; Sucheck, S. J.; Skrzypczak-Jankun, E.; Smith, D. A. Facile synthesis of substituted nitrilotriacetamides. Tetrahedron Lett. 1992, 33, 7765–7768.

1.         Sucheck, S. J.; Pinkerton, A. A.; Smith, D. A. Characterization of [Pb(NO3)(ntam)2]NO3 the first metal complex of the neutral tetradentate ligand nitrilotriacetamide (ntam). J. Chem. Soc., Chem. Commun. 1992, 367–368.

Last Updated: 5/27/20