Bina Joe, Ph.D., FAHA
Professor, Program in Physiological Genomics
The Program in Physiological Genomics of the Department of Physiology and Pharmacology is focused on understanding the genetic components of pathophysiological conditions of the cardiovascular, renal and autoimmune systems. The most prominent of all complex traits investigated in the Joe laboratory is blood pressure regulation. Rat models serve as valuable alternatives to human studies for the identification and characterization of genetic factors/genes. The main strategy is to identify the disease causative genetic factor/gene based on its location on the rat genome by linkage analysis and substitution mapping and/or gene expression and protein expression profiling using whole genome systems biology approaches. We have identified at least 16 different genomic regions that harbor quantitative trait loci (QTLs) for hypertension in rats and successfully mapped several of these regions to unparalleled resolutions of a few kilobases. Positional cloning projects have progressed to the identification of multiple novel genes as prominent BP QTLs in rats. Methodical mechanistic studies spanning from molecular to whole-organism physiology/pathophysiology are underway to determine the functional significance of the novel BP QTLs identified. Genetic-engineering technologies such as the application of zinc-finger nuclease-based targeted gene disruption for creation of 'knock-out' and 'knock-in' rat models are also strategies integrated into our research for validation of the positionally cloned causal genetic biomarkers of blood pressure regulation. Finally, the translational significance of our work is exemplified by the validation of the positionally cloned rat genes as being associated or linked with human hypertension.
Watch Dr. Joe speak about: Role of the Gut Microbiome in Hypertension.
Awards and Commendations:
- University of Toledo College of Medicine and Life Sciences Dean’s Award for Research Excellence in Sustained Research, 2015
- University of Toledo Change team leader for Institutions Developing Excellence in Academic Leadership (2011-2012)
- American Society of Hypertension Young Scholar Award, 2010
- Fellow of the American Heart Association, 2010
- Fogarty visiting scientist fellowship award, NIH, Bethesda, USA, 1997
- Nationally competitive Senior Research Scholarship award, Council for Scientific and Industrial Research, India, 1993
- Nationally competitive Junior Research Scholarship award, Council for Scientific and Industrial Research, India, 1989
- National Merit Scholarship award, India, 1988-1990
- Scientist, ASTRA, Bangalore, India, 1996-1997
- Research Assistant Professor, Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, OH, Apr 2001- Mar 2004
- Assistant Professor, Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo College of Medicine, Health Science Campus, April 2004-June 2007
- Associate Professor (Awarded Tenure 2008), Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, July 2007-2010
- Professor, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 2011-present
- Scientific Advisor, Rat Genome Database (http://rgd.mcw.edu/), 2003-present
- Chair, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Health Science Campus, 2015-present
Click here for a complete list of Dr. Joe's publications.