Department of Pharmacology and Experimental Therapeutics

Ming-Cheh Liu, Ph.D.

 

Professor
Department of Pharmacology and Experimental Therapeutics

419.383.1918 Phone
419.383.1909 FAX
Frederic and Mary Wolfe Center, 294C
ming.liu@utoledo.edu

Education

B.S. National Taiwan University
M.S. and Ph.D. The University of Georgia
Post Doc The Rockefeller University
Research Interests
  • The cytosolic sulfotransferases (SULTs)
  • Drug metabolism
  • Developmental Pharmacology
  • Oxidative/nitrative Stress
  • Tyrosylprotein sulfotransferases (TPSTs)
  • Protein tyrosine sulfation
  • Zebrafish model

Selected Publications

Kurogi, K., Alazizi, A., Liu, M.-Y., Sakakibara, Y., Suiko, M., Sugahara, T. and Liu, M.-C., “Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs,” Biochem. Pharmacol. (2012) In Press.

Kurogi, K., Davidson, G., Mohammed, Y.I., Williams, F.E., Liu, M.-Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Ethanol Sulfation by the Human Cytosolic Sulfotransferases (SULTs): A Systematic Analysis,” Biol. Pharm. Bull. (2012) In Press.

Kurogi, K., Lee, Y., Chen, M., Shi, B., Yang, T., Liu, M.-Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of Buprenorphine, Pentazocine, and Naloxone by Human Cytosolic Sulfotransferases,” Drug Metab. Lett. (2012) In Press.

Ko, K., Kurogi, K., Davidson, G., Liu, M.-Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of Ractopamine and Salbutamol by the Human Cytosolic Sulfotransferases,” J. Biochem. (2012) 152, 275-283.

Mohammed, Y.I., Kurogi, K., Al Shaban, A., Xu, Z., Liu, M.-Y., Williams, F.E., Sakakibara, Y., Suiko, M., Bhuiyan, S., and Liu, M.-C., “Identification and Characterization of Zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5,” Aquat. Toxicol. (2012) 112-113, 11-18.

Wu, Z., Liu, M.-C., Liang, M., and Fu, J., “Sirt1 Protects Against Thrombomodulin Downregulation and Lung Coagulation Following Particulate Matter Exposure,” Blood (2012) 119, 2422-2429.

Kanda, K., Nishi, K., Kadota, K., Nishimoto, S., Liu, M.-C., and Sugahara, T., “Nobiletin suppresses Adipocyte Differentiation of 3T3-L1 Cells by an Insulin and IBMX Mixture Induction,” Biochim. Biophys. Acta (2012) 1820, 461-468.

Shetty, S., Marudamuthu, A., Abernathy, D., Shetty, R., Shetty, P., Fu, J., Idell, S., Bhandary, Y., Ji, H.L., Liu, M.-C., and Shetty, S., “Regulation of Urokinase Expression at the Posttranscription Level by Lung Epithelial Cells,” Biochemistry (2012) 51, 205-213.

Kurogi, K., Krasowski, M.D., Injeti, E., Liu, M.-Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.-C., “A Comparative Study of the Sulfation of Bile Acids and a Bile Alcohol by the Zebra danio and Human Cytosolic Sulfotransferases (SULTs),” J. Steroid Biochem. Mol. Biol. (2011) 127, 307-314.

Hashiguchi, T., Kurogi, K., Sakakibara, Y., Yamasaki, M., Nishiyama, K., Yasuda, S., Liu, M.-C., and Suiko, M., “Sulfation of Tocopherols and Tocopherol Metabolites by Human Cytosolic Sulfotransferases,” Biosci. Biotech. Biochem. (2011) 75, 1951-1956.

Alazizi, A., Liu, M.-Y., Williams, F.E., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Identification, Characterization, and Ontogenic Study of a Catechol O-methyltransferase from Zebrafish,” Aquat. Toxicol. (2011) 102, 18-23.

Yasuda, S., Yasuda, T., Liu , M.-Y., Shetty, S., Idell, S., Boggaram, V., Suiko, M., Sakakibara, S., Fu, J., and Liu, M.-C., “Sulfation of Chlorotyrosine and Nitrotyrosine by Human Lung Endothelial and Epithelial Cells: Role of the Human SULT1A3,” Toxicol. Appl. Pharmacol. (2011) 251, 104-109.

Xu, Z., Williams, F.E., and Liu, M.-C., “Developmental Toxicity of Dextromethorphan in Zebrafish Embryos/Larvae,” J. Appl. Toxicol. (2011) 31, 157-163.

Kurogi, K., Sakakibara, Y., Yasuda, S., Liu, M.-C., and Suiko, M., “Molecular Cloning of a Novel Canine Sulfotransferase,” In “Animal Cell Technology: Basic & Applied Aspects” (2010) Vol. 16, pp. 221-230, Springer, Dordrecht.

Shirasugi, J., Sakakibara, Y., Yamasaki, M., Nishiyama, K., Matsui, T., Liu, M.-C., and Suiko, M., “Novel screening method of potential skin-whitening compounds using luciferase reporter assay system,” Biosci. Biotech. Biochem. (2010) 74, 2253-2258.

Liu, T.-A., Bhuiyan, S., Liu, M.-Y., Sugahara, T., Sakakibara, Y., Suiko, M., Yasuda, S., Kakuta, Y., Kimura, M., Williams, F.E., and Liu, M.-C., “Zebrafish as a Model for the Study of the Phase II Cytosolic Sulfotransferases,” Current Drug Metabolism (2010) 11, 538-546.

Kurogi, K., Sakakibara, Y., Kamemoto, Y., Takahashi, S., Yasuda, S., Liu, M.-C., and Suiko, M., “Mouse Cytosolic Sulfotransferase SULT2B1b Interacts with Cytoskeletal Proteins via a Proline-Serine-Rich C-Terminus,” FEBS J. (2010) 277, 3804-3811.

Hui, Y., Yasuda, T., Yasuda, S., Liu, M.-Y., Sakakibara, Y., Suiko, M., Wall, K.A., and Liu, M.-C., “Inhibitory Effects of Nitrative Stress on the Sulfation of 17-estradiol and 4-methoxyestradiol by Human MCF 10A Mammary Epithelial Cells,” Biol. Pharm. Bull. (2010) 33, 1633-1637.

Kurogi, K., Dillon, J., Nasser, A., Liu, M.-Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs),” Drug Metab. Lett. (2010) 4, 62-68.

Lu, J., Li, H., Zhang J., Li, M., Liu, M.-Y., An, X., Liu, M.-C., and Chang W., “Crystal Structures of SULT1A2 and SULT1A1*3: Insights into the substrate inhibition and the role of Tyr149 in SULT1A2,” Biochem. Biophys. Res. Commun. (2010) 396, 429-434.

Shirasugi, J., Kamada, M., Matsui, T., Sakakibara, Y., Liu, M.-C., and Suiko, M., “Sulforaphane Inhibits Melanin Synthesis by Regulating Tyrosinase Gene Expression in B16 Mouse Melanoma Cells,” Biosci. Biotech. Biochem. (2010) 74, 579-582.

Shetty, P., Velusamy, T., Bhandary, Y.P., Liu, M.-C., and Shetty, S., “Urokinase Receptor Expression Involves Tyrosine Phosphorylation of Phosphoglycerate Kinase,” Mol. Cell. Biochem. (2010) 335, 235-247.

Yasuda, S., Burgess, M., Yasuda, T., Liu, M.-Y., Bhuiyan, S., Williams, F.E., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “A Novel Hydroxysteroid-sulfating Cytosolic Sulfotransferase, SULT3 ST3, from Zebrafish: Identification, Characterization, and Ontogenic Study,” Drug Metab. Lett. (2009) 3, 217-227.

Teramoto, T., Adachi, R., Sakakibara, Y., Liu, M.-C., Suiko, M., Kimura, M. and Kakuta, Y., “On the similar spatial arrangement of active site residues in PAPS-dependent and phenolic sulfate-utilizing sulfotransferases,” FEBS Lett. (2009) 583, 3091-3094.

Takahashi, S., Sakakibara, Y., Mishiro, E., Kouriki, H., Nobe, R., Kurogi, K., Liu, M.-C., and Suiko, M., “Molecular Cloning, Expression, and Characterization of A Novel Mouse SULT6 Cytosolic Sulfotransferase,” J. Biochem. (2009) 146, 399-405.

Yasuda, S., Yasuda, T., Hui, Y, Liu, M.-Y., Suiko, M., Sakakibara, Y., and Liu, M.-C., “Concerted Action of the Cytosolic Sulfotransferase, SULT1A3, and Catechol-O-Methyltransferase in the Metabolism of Dopamine in SK-N-MC Human Neuroblastoma Cells,” Neurosci. Res. (2009) 64, 273-279.

Liu, T.-A., Yasuda, S., Williams, F.E., Liu, M.-Y., Suiko, M., Sakakibara, Y., Yang, Y.-S., and Liu, M.-C., “A Target-specific Approach for the Identification of Tyrosine-sulfated Hemostatic Proteins,” Anal. Biochem. (2009) 390, 88-90.

Teramoto, T., Sakakibara, Y., Liu, M.-C., Suiko, M., Kimura, M., and Kakuta, Y., “Snapshot of a Michaelis complex in a sulfuryl transfer reaction: Crystal structure of a mouse sulfotransferase, mSULT1D1, complexed with donor substrate and accepter substrate,” Biochem. Biophys. Res. Commun. (2009) 383, 83-87.

Zhang, P., Liu, M.-C., Cheng, L., Liang, M., Ji, H.-L., and Fu, J., “Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice,” J. Innate. Immunity (2009) 1, 358-365.

Teramoto, T., Sakakibara, Y., Liu, M.-C., Suiko, M., Kimura, M. and Kakuta, Y., “Structural basis for the broad range substrate specificity of a novel mouse cytosolic sulfotransferase - mSULT1D1,” Biochem. Biophys. Res. Commun. (2009) 379, 76-80.

Liu, T.-A., Bhuiyan, S., Snow, R., Yasuda, S., Yasuda, T., Yang, Y.-S., Williams, F.E., Liu, M.-Y., Suiko, M., Carter, G., and Liu, M.-C., “Identification and Characterization of Two Novel Cytosolic Sulfotransferases, SULT1 ST7 and SULT1 ST8, from Zebrafish,” Aquat. Toxicol. (2008) 89, 94-102.

Teramoto, T., Sakakibara, Y., Inada, K., Kurogi, K., Liu, M.-C., Suiko,M., Kimura, M., and Kakuta, Y., “Crystal structure of mSULT1D1, a mouse catecholamine sulfotransferase,” FEBS Lett. (2008) 582, 3909-3914.

Yasuda, T., Yasuda, S., Williams, F.E., Liu, M.-Y., Sakakibara, Y., Bhuiyan, S., Snow, R., Carter, G., and Liu, M.-C., “Characterization and Ontogenic Study of Novel Steroid-sulfating SULT3 Sulfotransferases from Zebrafish,” Mol. Cell. Endocrinol. (2008) 294, 29-36.

Takahashi, S., Sakakibara, Y., Mishiro, E., Kouriki, H., Nobe, R., Kurogi, K., Yasuda, S., Liu, M.-C., and Suiko, M., “Molecular Cloning, Expression, and Characterization of Mouse Amine N-Sulfotransferases,” Biochem. Biophys. Res. Commun. (2008) 375, 531-535.

Hui, H., Yasuda, S., Liu, M.-Y., Wu, Y.-Y., and Liu, M.-C., “On the Sulfation and Methylation of Catecholestrogens in Human Mammary Epithelial Cells and Breast Cancer Cells,” Biol. Pharm. Bull. (2008) 31, 769-773.

Velusamy, A., Shetty, P., Bhandary, Y.P., Liu, M.-C., Shetty, S., “Posttranscriptional Regulation of Urokinase Receptor Expression by Heterogeneous Nuclear Ribonuclear Protein C,” Biochemistry (2008) 47, 6508-6517.

Shetty, P., Velusamy, A., Bhandary, Y.P., Shetty, R.S., Liu, M.-C., and Shetty, S., “Urokinase Expression by Tumor Suppressor Protein p53: A Novel Role in mRNA Turnover,” Am. J. Resp. Cell. Mol. Biol. (2008) 39, 364-372.

Liu, T.-A., Liu, M.-C., and Yang, Y.-S., “Immunohistochemical Analysis of A Novel Dehydroepiandrosterone Sulfotransferase-like Protein in Drosophila Neural Circuit,” Biochem. Biophys. Res. Commun. (2008) 367, 14-20.

Yasuda, S., Liu, M.-Y., Suiko, M., Sakakibara, Y., and Liu, M.-C., “Hydroxylated Serotonin and Dopamine as Substrates and Inhibitors for Human Cytosolic SULT1A3,” J. Neurochem. (2007) 103, 2679-2689.

Liu, M.-C., Yasuda, S., and Idell, S., “Sulfation of Nitrotyrosine: Biochemistry and Functional Implications,” IUBMB Life (2007) 59, 622-627.

Yasuda, S., Idell, S., Fu, J., Carter, G., Snow, R., and Liu, M.-C., “Cigarette Smoke Toxicants as Substrates and Inhibitors for Human Cytosolic SULTs,” Toxicol. Appl. Pharmacol. (2007) 221, 13-20.

Yasuda, S., Idell, S., and Liu, M.-C., “Generation and Release of Nitrotyrosine O-Sulfate by HepG2 Human Hepatoma Cells upon SIN-1 Stimulation: Identification of SULT1A3 as the Responsible Enzyme,” Biochem. J. (2007) 401, 497-503.

Last Updated: 6/26/15