Department of Pharmacology and Experimental Therapeutics

Ming-Cheh Liu, Ph.D.

 

Professor
Department of Pharmacology and Experimental Therapeutics

419.383.1918 Phone
419.383.1909 FAX
Frederic and Mary Wolfe Center, 294C
ming.liu@utoledo.edu

Education

B.S. National Taiwan University
M.S. and Ph.D. The University of Georgia
Post Doc The Rockefeller University

Research Interests

  • The cytosolic sulfotransferases (SULTs)
  • Drug metabolism
  • Developmental Pharmacology
  • Oxidative/nitrative Stress
  • Tyrosylprotein sulfotransferases (TPSTs)
  • Protein tyrosine sulfation
  • Zebrafish model

Recent Publications

Kurogi, K., Yoshihama, M., Horton, A., Schiefer, I.T., Krasowski, M.D., Hagey, L.R., Williams, F.E., Sakakibara, Y., Kenmochi, N., Suiko, M., and, Liu, M.-C., “Identification and characterization of 5a-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the Zebrafish (Danio rerio),”J. Steroid Biochem. Mol. Biol. (2017) In Press.

Hashiguchi, T., Kurogi, K., Shimohira, T., Teramoto, T., Liu, M.-C., Suiko, M., Sakakibara, Y., “Δ4-3-Ketosteroids as a new class of substrates for the cytosolic sulfotransferases,” Biochim. Biophys. Acta (2017) In press.

Kurogi, K., Shimohira, T., Kouriki-Nagatomo, H., Zhang, G, Miller, E.R., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Human Cytosolic Sulfotransferase SULT1C3:  Genomic Analysis and Functional Characterization of Splice Variant SULT1C3a and SULT1C3d,” J. Biochem. (2017) In Press.

Bairam, A.F., Rasool, M.I., Kurogi, K., and Liu, M.-C., “On the molecular basis underlying the metabolism of tapentadol through sulfation,” Eur. J. Drug Metab. Pharmacokinet. (2017) In Press.

Abunnaja, M.S., Kurogi, K., Mohammed, Y.I., Sakakibara, Y., Suiko, M., Hassoun, E.A., and Liu, M.-C., “Identification and Characterization of the Zebrafish Glutathione S-Transferase Pi-1,” J. Biochem. Mol. Toxicol. (2017) In Press.

Tanaka, S., Nishiyori, T., Kojo, H., Otsubo, R., Tsuruta, M., Kurogi, K., Liu, M.-C., Suiko, M., Sakakibara, Y., and Kakuta, Y., “Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1,” Sci. Rep. (2017) 7, 8876.

Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of vitamin D3-related compounds:  Identification and characterization of the responsible human cytosolic sulfotransferases,” FEBS Lett. (2017) 591, 2417-2425.

Shimohira, T., Kurogi, K., Hashiguchi, T., Liu, M.-C., Suiko, M., and Sakakibara, Y., “Regioselective production of sulfated polyphenols using human cytosolic sulfotransferase (SULT)-expressing Escherichia coli cells,” J. Biosci. Bioeng. (2017) 124, 84-90.

Rasool, M.I., Bairam, A.F., Kurogi, K., and Liu, M.-C., “On the Sulfation of O-desmethyltramadol by Human Cytosolic Sulfotransferases,” Pharmacol. Rep. (2017) 69, 953-958.

Alherz, F.A., Almarghalani, D.A., Hussein, N.A., Kurogi, K., and Liu, M.-C., “A reappraisal of the 6-O-desmethylnaproxen-sulfating activity of the human cytosolic sulfotransferases,” Can. J. Physiol. Pharmacol. (2017)95, 647-651.

Suiko, M., Kurogi, K., Hashiguchi, T., Sakakibara, Y., and Liu, M.-C., “Updated perspectives on the cytosolic sulfotransferases (SULTs) and SUL-mediated sulfation,” Biosci. Biotech. Biochem. (2017) 81, 63-72.

Yoshimura, T., Kurogi, K., Liu, M.-C., Suiko, M., and Sakakibara, Y., “A proteomic approach for the analysis of S-nitrosylated proteins using a fluorescence labeling technique”, J. Electrophoresis (2016) 60, 5-14.

Yamamoto, Y., Debrah-Pinamang, M., DiModica, N.J., Kurogi, K., Naqvi, A.A., Hui, Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Identification and characterization of the human cytosolic sulfotransferases mediating the sulfation of clioquinol and iodoquinol,” Drug Metab. Lett. (2016) 10, 200-205.

Yamamoto, A., Kurogi, K., Schiefer, I.T., Liu, M.-Y., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Human cytosolic sulfotransferase SULT1A3 mediates the sulfation of dextrorphan,” Biol. Pharm. Bull. (2016) 39, 1432-1436.

Han, Z., Xi, Y., Luo, L., Zhou, C., Kurogi, K., Sakakibara, Y., Suiko, M., andLiu, M.-C., “Sulfate Conjugation of Daphnetin by the Human Cytosolic Sulfotransferases,” J. Ethnopharmacol. (2016) 189, 250-252.

Xi, Y., Seyoum, H., and Liu, M.-C., “Role of SULT-mediated Sulfation in the Biotransformation of 2-Butoxyethanol and Sorbitan Monolaurate:  A Study using Zebrafish SULTs,” Aquat. Toxicol. (2016) 177, 19-21.

Yoshimura, T., Harashima, M., Kurogi, K., Suiko, M., Liu, M.-C., and Sakakibara, Y., “A novel procedure for the assessment of the antioxidant capacity of food components,” Anal. Biochem. (2016) 507, 7-12.

Luo, L., Zhou, C., Hui, Y., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin,” Drug Metab. Pharmacokinet. (2016) 31, 163-166.

Luo, L., Mei, X., Xi, Y., Zhou, C., Hui, Y., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of 6-Gingerol by the Human Cytosolic Sulfotransferases: A Systematic Analysis,” Planta Medica (2016) 82, 238-243.

Zhang, L., Kurogi, K., Liu, M.-Y., Schnapp, A.M., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): A systematic analysis,” J. Appl. Toxicol. (2016) 36, 1090-1094.

Yamamoto, K., and Liu, M.-C., “Identification and characterization of a new type of cytosolic sulfotransferase in the silkworm Bombys mori,” J. Insect Biotechnol. Sericol. (2015) 84, 63-68.

Luo, L., Zhou, C., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs),”Xenobiotica (2015) 17, 1-8.

Jia, C., Luo, L., Kurogi, K., Yu, J., Zhou, C., and Liu, M.-C., “Identification of the Human SULT Enzymes involved in the Metabolism of Rotigotine,” J. Clin. Pharmacol. (2015) 56, 754-760.

Hui, Y., Luo, L., Zhang, L, Kurogi, K., Zhou, C., Sakakibara, Y., Suiko, M., and Liu, M.-C., “Sulfation of Afimoxifene, Endoxifen, Raloxifene, and Fulvestrant by the Human Cytosolic Sulfotransferases (SULTs):  A Systematic Analysis,” J. Pharmacol. Sci. (2015) 128, 144-149.

Yamamoto, A., Liu, M.-Y., Kurogi, K., Sakakibara, Y., Saeki, Y., Suiko, M., and Liu, M.-C., “Sulphation of Acetaminophen by the Human Cytosolic Sulfotransferases: A Systematic Analysis,” J. Biochem. (Tokyo) (2015)158, 497-504.

Hui, Y., and Liu, M.-C., “Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism,”Eur. J. Pharmacol. (2015) 761, 125-129.

Last Updated: 9/11/17