Islam Osman, B.Pharm., M.s., Ph.d.
Assistant Professor
Phone: 419.383.5307
Email: Islam.Osman@Utoledo.edu
Vascular Biology LaboratoryComplete List of Publications
Education and training
1999-2004 B. Pharm. Pharmacy, Cairo University (CU), Egypt.
2007-2010 M.S. Pharmacology and Toxicology, German University in Cairo (GUC), Egypt.
2014 Foreign Pharmacy Graduate Equivalency Committee (FPGEC) certification program
offered by the
National Association of Boards of Pharmacy.
2012-2016 Ph.D. Clinical and Experimental Therapeutics, University of Georgia (UGA),
USA.
professional Experience
2004-2007 Retail Pharmacist, Community Pharmacy, Cairo, Egypt.
2006-2010 Teaching Assistant, Department of Pharmacology and Toxicology, School of
Pharmacy
and Biotechnology, GUC, Egypt.
2010-2011 Assistant Lecturer, Department of Pharmacology and Toxicology, School of
Pharmacy
and Biotechnology, GUC, Egypt.
2012-2016 Predoctoral fellow, Program in Clinical and Experimental Therapeutics,
University of Georgia, Augusta, GA. Advisor: Lakshman Segar, Ph.D.
2016-2020 Postdoctoral fellow, Department of Pharmacology and Toxicology, Augusta
University,
Augusta GA. Advisor: Jiliang Zhou, Ph.D.
08/2020-03/2021 Senior Postdoctoral fellow, Department of Pharmacology and Toxicology,
Augusta
University, Augusta GA. Advisor: Jiliang Zhou, Ph.D.
Honors and Awards
2007-2010 Graduate Scholarship for completion of M.S. Degree in Pharmacology and Toxicology,
School of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Summer 2008 Graduate Research Training Scholarship in the University Hospital of Wurzburg,
Germany, sponsored by the German Academic Exchange Service.
2012-2016 Graduate Scholarship, University of Georgia.
2014 Travel Award, Southern Translational Education and Research Conference.
2015 University of Georgia Research Excellence Award: 1st place Best Predoctoral Poster
Presentation.
2015 Travel Award, Southern Translational Education and Research Conference.
2015 Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology Scientific Sessions.
2016 Travel Award, Arteriosclerosis, Thrombosis, and Vascular Biology Scientific Sessions.
2017 Augusta University Research Excellence Award: 1st place Best Postdoctoral Poster
Presentation, Augusta University.
2018 Travel Award for Research excellence, 2nd International MADS Box Conference.
2019 Augusta University Research Excellence Award: 1st place Best postdoctoral Oral
presentation, Augusta University.
2019 Invited Talk, University of Georgia.
2019 Oral presentation, Vascular Discovery: From Genes to Medicine Scientific Sessions.
2019 Oral presentation, CAAC-ATVB Metabolic Vascular Disease Symposium.
2019 2nd place Young Investigator Award, CAAC-ATVB Metabolic Vascular Disease
Symposium.
2018-2020 Postdoctoral Fellowship award, The American Heart Association (AHA, 18POST34030400).
Title: The role of TEA Domain Transcription Factor 1 in Vascular Smooth Muscle Cell
proliferation and Neointima Formation.
2020-2025 NIH Pathway to Independence Award K99/R00, The National Heart, Lung, and
Blood Institute (NIH/NHLBI, 1K99HL153896-01). Title: YAP1, neointima formation, and
blood pressure regulation.
Select Publications
Dong K, Shen J, He X, Hu G, Wang L, Osman I, Bunting KM, Dixon-Melvin R, Zheng Z, Xin H, Xiang M,
Vazdarjanova A, Fulton DJR, Zhou J. CARMN Is an Evolutionarily Conserved Smooth Muscle
Cell-
Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin. Circulation. 2021 Dec
7;144(23):1856-1875. doi: 10.1161/CIRCULATIONAHA.121.055949. Epub 2021 Oct 25. PubMed
PMID:
34694145; PubMed Central PMCID: PMC8726016.
Osman I, Dong K, Kang X, Yu L, Xu F, Ahmed ASI, He X, Shen J, Hu G, Zhang W, Zhou J. YAP1/TEAD1
upregulate platelet-derived growth factor receptor beta to promote vascular smooth
muscle cell
proliferation and neointima formation. J Mol Cell Cardiol. 2021 Jul;156:20-32. doi:10.1016/j.yjmcc.2021.03.005.
Epub 2021 Mar 19. PubMed PMID: 33753119; PubMed Central PMCID:PMC8217227.
He X, Dong K, Shen J, Hu G, Liu J, Kang X, Wang L, Atawia RT, Osman I, Caldwell RW, Xiang M, Zhang
W, Zheng Z, Li L, Fulton DJR, Deng K, Xin H, Zhou J. Deficiency of the novel high
mobility group protein
HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. Proc Natl Acad Sci U
S A. 2021 Feb 16;118(7). doi: 10.1073/pnas.2021862118. PubMed PMID: 33563757.
Liu J, Wen T, Dong K, He X, Zhou H, Shen J, Fu Z, Hu G, Ma W, Li J, Wang W, Wang L,
Akerberg BN,
Xu J, Osman I, Zheng Z, Wang W, Du Q, Pu WT, Xiang M, Chen W, Su H, Zhang W, Zhou J. TEAD1
protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear
DNA-encoded
mitochondrial genes. Cell Death Differ. 2021 Jan 19; doi: 10.1038/s41418-020-00732-5. [Epub ahead
of print] PubMed PMID: 33469230; NIHMSID:NIHMS1658520.
Osman I, Wang L, Hu G, Zheng Z, Zhou J. GFAP (Glial Fibrillary Acidic Protein)-Positive Progenitor
Cells
Contribute to the Development of Vascular Smooth Muscle Cells and Endothelial Cells. Arterioscler Thromb Vasc Biol.
2020 May;40(5): 1231-1238. doi: 10.1161/ATVBAHA. 120.314078. Epub 2020 Mar 12. PubMed
PMID: 32160776;
PubMed Central PMCID: PMC7180117. Selected as “Cover article” for ATVB, May 2020 Issue.
Wen T, Liu J, He X, Dong K, Hu G, Yu L, Yin Q, Osman I, Peng J, Zheng Z, Xin H, Fulton D, Du Q, Zhang W, Zhou J.
Transcription factor TEAD1 is essential for vascular development by promoting vascular
smooth muscle differentiation.
Cell Death Differ. 2019 Dec;26(12):2790-2806. doi:
10.1038/s41418-019-0335-4. Epub 2019 Apr 25. PubMed PMID: 31024075; PubMed Central
PMCID:PMC7224394.
Osman I, He X, Liu J, Dong K, Wen T, Zhang F, Yu L, Hu G, Xin H, Zhang W, Zhou J. TEAD1 (TEA
Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating
SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake. Circ Res. 2019 Apr
26;124(9):1309-1322. doi: 10.1161/CIRCRESAHA.118.314187. PubMed PMID: 30801233; PubMed
Central PMCID: PMC6493685.
-Selected as “Editor’s pick”.
-Highlighted by an “Editorial” in Circulation Research in the same issue (PMID: 31021728).
-Highlighted in Circulation Research “In This Issue” Anthology in which the editors
highlight
particularly important articles. (https://www.ahajournals.org/doi/10.1161/RES.0000000000000272).
-As the first author of this high-impact publication in Circulation Research, I was
invited to write a short
autobiography that was published in Circulation Research
(https://www.ahajournals.org/doi/10.1161/RES.0000000000000271)
Ahmed ASI, Dong K, Liu J, Wen T, Yu L, Xu F, Kang X, Osman I, Hu G, Bunting KM, Crethers D, Gao
H, Zhang W, Liu Y, Wen K, Agarwal G, Hirose T, Nakagawa S, Vazdarjanova A, Zhou J.
Long noncoding
RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching
of vascular
smooth muscle cells. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8660-E8667. doi:
10.1073/pnas.1803725115. Epub 2018 Aug 23. PubMed PMID: 30139920; PubMed Central PMCID:
PMC6140535.
Osman I, Fairaq A, Segar L. Pioglitazone Attenuates Injury-Induced Neointima Formation in
Mouse
Femoral Artery Partially through the Activation of AMP-Activated Protein Kinase. Pharmacology.
2017;100(1-2):64-73. doi: 10.1159/000471769. Epub 2017 May 9. PubMed PMID: 28482342;
PubMed
Central PMCID: PMC5884074.
Fairaq A, Shawky NM, Osman I, Pichavaram P, Segar L. AdipoRon, an adiponectin receptor agonist,
attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent
of
AMPK: Implications toward suppression of neointimal hyperplasia. Pharmacol Res. 2017 May;119:289-
302. doi: 10.1016/j.phrs.2017.02.016. Epub 2017 Feb 22. PubMed PMID: 28237515; PubMed
Central
PMCID: PMC5392421.
Osman I, Poulose N, Ganapathy V, Segar L. High fructose-mediated attenuation of insulin receptor
signaling does not affect PDGF-induced proliferative signaling in vascular smooth
muscle cells. Eur J
Pharmacol. 2016 Nov 15;791:703-710. doi: 10.1016/j.ejphar.2016.10.007. Epub 2016 Oct 8. PubMed
PMID: 27729247; PubMed Central PMCID: PMC5107134.
Osman I, Segar L. Pioglitazone, a PPARγ agonist, attenuates PDGF-induced vascular smooth
muscle
cell proliferation through AMPK-dependent and AMPK-independent inhibition of mTOR/p70S6K
and ERK
signaling. Biochem Pharmacol. 2016 Feb 1;101:54-70. doi: 10.1016/j.bcp.2015.11.026. Epub 2015 Nov
28. PubMed PMID: 26643070; PubMed Central PMCID: PMC4753090.
Pyla R, Osman I, Pichavaram P, Hansen P, Segar L. Metformin exaggerates phenylephrine-induced
AMPK phosphorylation independent of CaMKKβ and attenuates contractile response in
endotheliumdenuded
rat aorta. Biochem Pharmacol. 2014 Nov 15;92(2):266-79. doi: 10.1016/j.bcp.2014.08.024.
Epub 2014 Aug 29. PubMed PMID: 25179145; PubMed Central PMCID: PMC4252840.