Center for Hypertension and Precision Medicine

CHPM NEWS ARCHIVES


Congratulations to Dr. Camilla Wenceslau and Dr. Cameron McCarthy! They were both invited and have accepted to join the AJP-Heart and Circulatory Physiology Editorial Board! Their terms begin January 2019.


CHPM Members, Drs. Steven Haller and David Kennedy from the Department of Medicine recently traveled to Seoul, South Korea, at the 49th Scientific Meeting of the Korean Society of Hypertension in conjunction with the International Society of Hypertension and Hypertension Seoul 2018. The theme was “Understanding Hypertension Pathophysiology from Bench to Bedside”. Drs Haller and Kennedy were invited to give lectures and Dr. Haller spoke on “Pathophysiology of Renal Fibrosis,” while Dr. Kennedy spoke on “Mechanisms of Cardiorenal Syndrome.”


Since its inception in 2012, the Center for Hypertension and Precision Medicine (CHPM), recently recognized by the University of Toledo as a Spotlight Area of Unique Distinction, has promoted interdisciplinary research, education and public awareness in the field of hypertension and associated cardiometabolic diseases. Researchers at CHPM have now made groundbreaking discoveries that link gut microbiota to blood pressure regulation, obesity and liver cancer. 

- Dr. Bina Joe’s lab (Distinguished University Professor and Chair, Department of Physiology and Pharmacology) has pioneered the link between gut microbiota –bacteria residing in the gut- and the genetics of hypertension (https://www.ncbi.nlm.nih.gov/pubmed/25829393). Over the past few years Dr. Joe’s group has been studying the relationship between metabolites produced by the gut microbiota and the function of organ systems that regulate blood pressure. This research has the potential to unravel novel targets, either at the bacterial level or within the host that can be used to treat or even prevent high blood pressure. Dr. Joe was recently awarded a $2.64 million grant from the National Heart, Lung and Blood Institute (http://utnews.utoledo.edu/index.php/09_10_2018/professor-awarded-2-6-million-research-grant-to-further-examine-link-between-gut-bacteria-and-high-blood-pressure).

- Specific pharmacologic treatment of salt-sensitive hypertension remains a challenge. Within this context, Dr. Joe’s lab recently identified a salt-responsive metabolite, beta-hydroxybutyrate, as a key regulator of blood pressure which can attenuate hypertension and protect kidney function despite high salt intake. This work was published in the prestigious journal Cell Reports (https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31503-1).

-  While studying the benefits of the refined soluble fiber inulin, a probiotic, in combating obesity-associated complications, Dr. Matam Vijay-Kumar (Director of the UT Microbiome Consortium and Associate Professor in the Department of Physiology and Pharmacology) and his research team have recently found that after six months on inulin-enriched diet mice develop cholestatic liver cancer. Remarkably, this seems induced by dysregulation of fiber fermentation by the gut microbiota. These seminal findings were published in the prestigious journal Cell (https://www.cell.com/cell/fulltext/S0092-8674(18)31176-0).


 

Congratulations to Dr. Sivarajan Kumarasamy and lab! Their manuscript, "COUP-TFII Revisited: Its Role in Metabolic Gene Regulation" was accepted in Steroids journal. Authors are: Usman M Ashraf, Edwin R Sanchez and Sivarajan Kumarasamy.


We are pleased to announce the addition of two adjunct faculty members to the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine. These appointments significantly enhance the footprint of our Center in human hypertension research.

 Dr. Patricia Munroe is a Professor from The William Harvey Research Institute at the Queen Mary University of London (https://www.qmul.ac.uk/whri/people/academic-staff/items/munroepatricia.html) and Dr. Sandosh Padmanabhan is a Professor from the Institute of Cardiovascular and Medical Sciences at University of Glasgow (https://www.gla.ac.uk/researchinstitutes/icams/staff/sandoshpadmanabhan/). They are world leaders in hypertension research and in the field of Precision Medicine and Translational Physiology. Dr. Munroe was named a Thomson Reuters Highly Cited Researcher and has also been listed in the 2015 World’s Most Influential Scientific Minds.  Dr. Padmanabhan has won several awards as well and works in association with Professor Dame Anna Dominiczak’s research group in the University of Glasgow.


We are pleased to announce that Ms. Hannah Saternos, a graduate student of Dr. Wissam Aboualaiwi-who is an NIH-funded member of the Center for Hypertension and Precision Medicine in the College of Pharmacy, has received an American Heart Association (AHA) pre-doctoral grant for two years starting 01/01/2019. Dr. Saternos’ grant scored in the 11.65 percentile and the funding pay line was at 39 percentile. Congratulations on both the mentee and mentor for a job well done!


Congratulations to Dr. Vijay Kumar and his students, Beng and Rachel!  Their manuscript has been accepted for publication in the Journal of Innate Immunity. The title is, “The Iron Tug-of-War between Bacterial Siderophores and Innate Immunity” and the authors are: Dr. Matam Vijay-Kumar (Corresponding Author), Rachel Golonka(Co-author), Beng San Yeoh (Co-author).  Well done!


Congratulations to Saroj (Dr. Bina Joe's lab) and collaborators, for having their manuscript accepted to Cell Reports! The title of the manuscript is, “Salt-responsive Metabolite, b-hydroxybutyrate, Attenuates Hypertension” and the authors are: Chakraborty, S, Galla, S, Cheng X, Yeo, J, Mell, B, Singh V, Yeoh BS, Saha P, Mathew, AV, Vijay-Kumar, M, Joe B.  Well done!


Dr. Bina Joe, Chair of Physiology and Pharmacology was recently featured in the International Society of Hypertension’s Women in Hypertension Spotlight. See more here:  http://ish-world.com/womens-spotlight/i/Dr-Bina-Joe/


The National Heart Lung and Blood Institute awarded Dr. Joe a $2.64 million grant to study the role of gut microbiota in hypertension. Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension. The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension. Other faculty collaborators on this grant are Dr. Matam Vijay-Kumar and Dr. Ritu Chakravarti.

Congratulations!


Congratulations to Sarah Galla from Dr. Bina Joe’s lab! Her work has been featured in a press release from the APS. Congratulations and well done! http://www.the-aps.org/mm/hp/Audiences/Public-Press/2018/49.html

Congratulations to Dr. Saurabh Chattopadhyay and Dr. Terry Hinds! The National Institutes of Health awarded Dr. Saurabh Chattopadhyay (Medical Microbiology & Immunology) and Dr. Terry Hinds (Physiology and Pharmacology) a grant (R21)to study  the function of Interferon Regulatory Factor 3 (IRF3) in alcoholic liver diseases (ALD) titled, “How Non-Transcriptional IRF3 Prevents ALD”. Dr. Chattopadhyay is Principal Investigator and  Dr. Hinds is Co-Investigator.


Congratulations to Dr. Cam McCarthy! He was awarded a post-doc grant from the American Heart Association and funding was effective July 1, 2018. The title of his grant is, “Decreased autophagy leads to proteotoxicity and senescence in hypertension-associated premature vascular aging”.


Congratulations to Dr. Vijay Kumar and Lab! Their manuscript, “Myeloperoxidase Deficiency Attenuates Systemic and Dietary Iron-induced Adverse Effects, has been accepted for publication in The Journal of Nutritional Biochemistry. Authors are: Xia Xiao, Piu Saha, Beng san yeoh, Jennifer Hipp and Matam Vijay-Kumar.


The National Heart Lung and Blood Institute awarded Dr. Bina Joe, Distinguished University Professor and Chair of the Department of Physiology and Pharmacology and Director of the Center for Hypertension and Precision Medicine, a major, $2.64 million, grant to study the role of gut microbiota in hypertension.  Dr. Joe pioneered the discovery of the link between gut microbiota and inherited hypertension.  The new grant titled ‘Genetic, Epigenetic and Dietary Salt effects on Microbiota and Hypertension’ aims to follow up on this pioneering discovery to study the various mechanisms by which gut microbiota contribute to the inheritance and progression of salt-sensitive forms of inherited hypertension.  Other faculty collaborators on this grant from the Department of Physiology and Pharmacology are Dr. Matam Vijay-Kumar, Associate Professor & Director of the UT Microbiome Consortium and Dr. Ritu Chakravarti, Assistant Professor.


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


 A special thanks to all the CHPM members and trainees and everyone who participated in the American Heart Walk and activities this year! Whether you made a monetary contribution or walked or ran in the 5K, your contributions and participation are greatly appreciated! (And congrats to Dr. Aboualaiwi, who placed 4th overall in the 5K and 1st in his age group!) Thanks again everyone!


Dr. Bina Joe, from the Department of Physiology and Pharmacology and the Center for Hypertension and Precision Medicine, delivered the Keynote Address titled ‘Manipulating Microbiota for the treatment of Hypertension: Hype?” at the 2018 Michigan Hypertension Meeting, held May 3-4, 2018 in Gull Lake, MI. Also invited for oral presentations were faculty and fellows from the Center for Hypertension and Precision Medicine, Dr. Lauren Koch, Dr. Xi Cheng, Mr. Saroj Chakraborty and Ms. Sarah Galla.


Congratulations to Dr. Ritu Chakravarti, joint faculty member of Physiology and Pharmacology and CHPM member, who received funding from the University of Toledo Rocket Fuel Fund for a collaborative project to build a composite sensor that can measure real-time reactive oxygen species in tissues and liquids. This exemplary collaboration is with Dr. Kim, College of Engineering faculty member, who has an interest in developing electrochemical sensors, while Dr. Chakravarti is an expert on reactive oxygen species. The title of the project is “Time Electrochemical Sensor for Detecting Free Radicals” and the funding is for one year.


Congratulations to Dr. Bina Joe and lab! Their manuscript, “Fine mapping of epistatic genetic determinants of blood pressure on rat chromosome 5”, was accepted for publication in the Journal of Hypertension. The authors are: Harshal Waghulde, Resmi Pillai, Xi Cheng, Ying Nie, Blair Mell, Bina Joe


Congratulations Vazquez's lab!! The manuscript: "Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of Trpc3: Obligatory requirement for Trpc3 in a novel macrophage-associated BMP-2 dependent calcification mechanism" by Prabhatchandra Dube, Chikkamenahalli Lakshmikanth, Lutz Birnbaumer and Guillermo Vazquez, has been accepted for publication in Atherosclerosis, a prestigious journal of the European Atherosclerosis Society.


Congratulations to Dr. Ritu Chakravarti, joint faculty of the Department of Phys/Pharm, whose manuscript entitled, “Bioinformatic Analysis Reveals New Determinants of Antigenic 14-3-3 Proteins and A Novel Antifungal Strategy” by Jenna McGowan, Jacqueline Kratch, Saurabh Chattopadhyay, Bina Joe, Heather R. Conti, and Ritu Chakravarti was accepted for publication in PLOS ONE!


Congratulations to Prabhat Dube (Vazquez Lab) who successfully defended his dissertation.  Well done, Prabhat – you did a great job!


Congratulations to Dr. Wissam AbouAlaiwi and his students on the acceptance of their manuscript entitled ” "Distribution and Function of the Muscarinic Receptor Subtypes in the Cardiovascular System" (PG-00062-2017R2) in Physiological Genomics. Please note that this manuscript has been majorly handled by the students both graduate and undergrads. The student authors with their names in the order as they appear in the manuscript are below.


“Hannah C. Saternos, Daniyah A. Almarghalani, Hayley M. Gibson, Mahmood A. Meqdad, Raymond B. Antypas, Ajay Lingireddy and Wissam A. AbouAlaiwi”.

Congratulations to Dr. Wissam Aboualaiwi, CHPM member, who was elected as FAHA (Fellow of the American Heart Association) during the AHA Council on Hypertension held in San Francisco, September 14-17th.


Congratulations to Prabhat Dube (Vazquez Lab), he is the winner of the UTRA Scholarship award! His scientific and community accomplishments confirmed that he was the top choice by a large margin. Congratulations again, on this prestigious award and thank you for all of your hard work and professional career as a doctoral student in the University of Toledo (College of Medicine and Life Sciences) Biomedical Science Program within the Molecular Medicine Track. Well done!!


Congratulations to the Joe Lab! Their manuscript has been accepted for publication in PLOS Genetics.
"Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA" Xi Cheng, Harshal Waghulde, Blair Mell, Eric E. Morgan, Shondra M. Pruett-Miller, Bina Joe

Well done!


Congratulations to Dr. Xi Cheng and Dr. Bina Joe! Their manuscript, "Circular RNAs in Rat Models of Cardiovascular and Renal Diseases" was accepted for publication in Physiological Genomics. Congratulations to Dr. Haller, whose manuscript, “Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease" Jeffrey X. Xie, BS, Helen Alderson, MD, James Ritchie, MD Philip A. Kalra, MD, Yanmei Xie, MA, Kaili Ren, Ph.D, Hanh Nguyen, MA, Tian Chen, Ph.D, Pamela Brewster, MA, Rajesh Gupta, MD, Lance D. Dworkin, MD, Deepak Malhotra, MD, Ph.D., Christopher J. Cooper, MD, Jiang Tian, Ph.D., Steven T. Haller, Ph.D. was accepted for publication in Scientific Reports.

 He also received a grant from The University of Toledo Medical Research Society. Well done!


Congratulations Prabhat (Vazquez lab)! The paper entitled: "EVIDENCE FOR CONSTITUTIVE BONE MORPHOGENETIC PROTEIN-2 SECRETION BY M1 MACROPHAGES: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages" Prabhatachandra Dube, Lutz Birnbaumer, Guillermo Vazquez has been accepted for publication in Biochemical and Biophysical Research Communications.


Congratulations to CHPM trainee, Jeffery Xie, for successfully defending his thesis! His advisors were Dr. Jiang Tian and Dr. Steve Haller.


 Congratulations to CHPM Trainee, Xie Cheng, for successfully defending his thesis! His advisor was Dr. Bina Joe.


Dr. Zahoor Shah received an AHA grant for two years starting from July 1, 2017 titled: “Cofilin and Inflammation in hemorrhagic brain injury”. Congratulations!


Congratulations to CHPM trainee, Prince Ampem, for successfully defending his thesis! His advisor was Dr. Guillermo Vazquez.


Dr. David Kennedy, whose R01 grant proposal "Counter regulatory mechanisms of cardiotonic steroids in cardiorenal syndrome" has been funded by the National Heart, Lung and Blood Institute! Congratulations Dr. Kennedy!!


Congratulations to Fawaz Alasmari (student in Dr. Sari’s lab) and Drs. Sari and Drummond for this new publication! The manuscript entitled “Effects of chronic inhalation of electronic cigarettes containing nicotine on glial glutamate transporters and α-7 nicotinic acetylcholine receptor in female CD-1 mice” has been published in Progress in Neuropsycopharmacology and Biological Psychiatry and set the ground for two grant submissions from Dr. Sari’s group.

Dr. Sari acknowledges the important role of the Center for Hypertension and Precision Medicine in facilitating integration of research talent and effort and promoting collaborative research, of which this project constitutes a superb example!

Congratulations Dr. Sari and Dr. Drummond for your success and best of luck with your grants!


Congratulations to CHPM trainee, Sumeet Solanki! Sumeet successfully defended his thesis April 3, 2017. His Advisor was Dr. Guillermo Vazquez.


Congratulations to Dr. Ritu Chakravarti for receiving a 2017 Trainee Travel Award to present her work at the upcoming Central Society for Clinical and Translational Research and Midwestern Section American Federation for Medical Research combined Annual Meeting, which will be held at The Mid-America Club in Chicago, IL, April 20-21 2017.

Our Center conducts funded research by the NHLBI/ National Institutes of Health and the American Heart Association. We support the Go Red day. https://www.goredforwomen.org/fight-heart-disease-women-go-red-women-official-site/about-go-red/

Why is the red dress the symbol of women and heart disease?

In 2003, the National Heart, Lung and Blood Institute (NHLBI), the AHA and other organizations committed to women’s health joined together to raise awareness of women and heart disease. The NHLBI introduced the red dress as a national symbol for women and heart disease awareness and the AHA adopted this symbol to create synergy among all organizations committed to fighting this cause.

By working together to advance this important cause, the AHA, NHLBI and other women’s health groups will have a greater impact than any one group could have alone.

Wear Red


Congratulations to CHPM trainee, Harshal Waghulde! Harshal successfully defended his thesis on August 1, 2016. His advisor was Dr. Bina Joe. 


Congratulations Dr. Bina Joe! In 2014 the National Heart, Lung, and Blood Institute convened a Working Group (WG) to discuss new emerging aspects of the impact of salt on human health and disease, with emphasis on hypertension.  The WG brought together experts from a variety of scientific backgrounds. Dr. Bina Joe was among those experts and as part of this WG, she co-authored the recently released WG's review report published in Hypertension. Please, find the link to the full article below, and join us in congratulating Dr. Joe for such a high distinction!

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence. Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG.

http://hyper.ahajournals.org/content/68/2/281.full


Please enjoy a new video highlighting the 'Hot topics in Hypertension' session of the American Heart Association Council on Hypertension Annual meeting held in Orlando, FL.

https://www.youtube.com/watch?v=R5GMmXcHQ8o&list=PLzCpCvMeTCs42B2_xHhm_2LBJNQW5Wp3j&index=6

Our Chair and Director, Dr. Bina Joe, was an invited speaker at this session and she is interviewed about the topic of 'Microbiota and Hypertension'.

The associated executive summary of the Working group  of the NHLBI on 'Microbiota and Hypertension' is available at http://www.nhlbi.nih.gov/research/reports/role-microbiota-blood-pressure-regulation-executive-summary


Congratulations to Dr. Brahma Raju Mopidevi for being awarded a New Investigator Research Recognition Award from the APS journal Physiological Genomics -the Physiological Genomics Group!! Dr. Mopidevi is an Assistant Professor in the Department of Physiology and Pharmacology and member of the Center for Hypertension and Precision Medicine. The Award will be presented at the Experimental Biology 2016 Physiologic Genomic Group Luncheon and Awards Ceremony which will be held on Monday, April 4, 2016 from 12:30-1:30 PM at The Old Spaghetti Factory.


Congratulations Dr. David Kennedy, Assistant Professor in the Division of Cardiovascular Medicine and member of CHPM, for receiving the Central Society for Clinical and Translational Research Early Career Development Award! The Central Society for Clinical and Translational Research (CSCTR) is one of the oldest and largest academic medical societies in the Midwest. It was created by distinguished academic physicians in the Midwest to advance medical science and disseminate this science to the members by publishing research for national and international distribution and by sponsoring scientific meetings. The CSCTR provides annual Early Career Development Awards to support the research of outstanding new investigators who are conducting translational research within a clinical department or hold an appointment in a clinical department. Additional information can be found at www.CSCR.com


On Thursday January 14th, at a Faculty Recognition Ceremony held at the Radisson at UTMC Mahogany Room, Dr. Bina Joe, Professor and Chair of the Department of Physiology and Pharmacology and Director of the Center for Hypertension and Precision Medicine, received the 2015 College of Medicine and Life Sciences Dean’s Award for Research Excellence in Sustained Research. Congratulations Dr. Joe!


Congratulations Prabhat Dube, graduate student in the Molecular Medicine track and trainee of the CHPM (Dr. Vazquez's lab), for having his research published in the Toledo Blade. Below is the link to Prabhat’s article: 

 http://www.toledoblade.com/Medical/2016/01/04/Understanding-the-slow-journey-of-struggling-arteries.html


Congratulations Dr. Wissam Aboualaiwi, Assistant Professor in the Department of Pharmacology at UT College of Pharmacy and active member of CHPM, who has received the American Association of Colleges of Pharmacy (AACP) New Investigator Award grant.


Dr. Patrick Mulrow, who was chairman of the Department of Medicine and a leading researcher in hypertension at the former Medical College of Ohio, now University of Toledo College of Medicine and Life Sciences, died Thursday December 3, 2015, at Jupiter Medical Center, Florida. 

Read more at http://www.toledoblade.com/Deaths/2015/12/06/Dr-Patrick-Mulrow-1926-2015-MCO-chairman-a-noted-researcher-of-hypertension.html 


Congratulations to Prince Ampem, graduate student in the Molecular Medicine track and trainee of the CHPM (Dr. Vazquez's lab), for having his research published in the Toledo Blade. Below is the link to Prince’s article: http://www.toledoblade.com/Medical/2015/09/07/UT-discovering-new-ways-to-combat-clogged-arterie.html


Congratulations to Sumeet Solanki, graduate student in the Molecular Medicine track and trainee of the CHPM (Dr. Vazquez's lab), for having his research published in the Toledo Blade. Below is the link to Sumeet's article: http://www.toledoblade.com/news/2015/05/04/Heart-Attacks-The-view-from-inside-your-arteries.html


Congratulations to Sumeet Solanki in Dr. Vazquez's lab for being awarded a pre-doctoral fellowship from the American Heart Association.


Congratulations to Ying Nie who successfully defended her Ph.D. thesis on May 1, 2015, "Positional Mapping for Blood Pressure Loci on Rat Chromosome 9" Advisor: Dr. Bina Joe


Congratulations to Resmi Pillai who successfully defended her Ph.D. thesis on April 30, 2015, "High Resolution Substitution Mapping for Genetic Elements Controlling Blood Pressure Located on Rat Chromosomes 5 and 10" Advisor: Dr. Bina Joe.


Congratulations to Dr. Bina Joe, she received the Outstanding Research Award at the Outstanding Faculty & Advisor Awards Ceremony on April 27, 2015.


Congratulations to Dr. Terry Hinds, along with colleagues at University of Mississippi Medical Center and Montclair State University, published "Biliverdin Reductase Isozymes in Metabolism" in the High-impact Journal Trends in Endocrinology and Metabolism.  Note that Dr. Hinds was able to involve two Medical Students in preparing this review, and they are among the authors.  This is a great way to get medical students [including MSBS students] and other students productively involved.


Congratulations to Dr. Guillermo Vazquez's laboratory, who's work entitled "Increased Size and Cellularity of Advanced Atherosclerotic Lesions in Mice with Endothelial Overexpression of the Human TRPC3 Channel" (authors:  Smedlund K, Birnbaumer L, Vazquez G) has been accepted for publication in The Proceedings of the National Academy of Sciences USA.


Congratulations to Dr. Chris Drummond, a postdoctoral fellow in Dr. Jiang Tian's lab, for having his abstract "MicroRNA 29b and Cardiotonic Steroid-Induced Cardiac Fibrosis in Adult Cardiac Fibroblasts",selected for oral presentation at the American Physiological Society (APS) organized session, "Trainee Highlights in Physiological Genomics" at the Experimental Biology 2015 Meeting.


Congratulations to Xi Cheng, a graduate student in Dr. Bina Joe's lab, for having his abstract "A CRISPR/Cas9 System Based Targeted Disruption of a Novel Rat Long Non-coding RNA in a Rat Genetic Model of Hypertension," accepted for oral presentation at the American Physiological Society (APS) organized session, "Trainee Highlights in Physiological Genomics" at the Experimental Biology 2015 Meeting.


Congratulations to Harshal Waghulde, a graduate student in Dr. Bina Joe's lab, for having his abstract "Development of Novel Gper-1 Knock-out Rat Model Using a Modified CRISPR/Cas9 Technology," accepted for oral presentation at the American Physiological Society (APS) organized session, "Physiological Effects of Sex Chromosome Complementation and Chromosome Y Genetic Variants" at the Experimental Biology 2015 Meeting.


Congratulations to Dr. Bina Joe, New Publication in Nature Communications "Cross-talk between two transcription factors regulates blood pressure"  See article in the March 2015 JCCTR Newsletter


Congratulations to Dr. Bina Joe for being named the Shining Star Award winner for Outstanding Research by the Office of the Provost at the University of Toledo.   View Video


Congratulations to Dr. Bina Joe for the appointment as Editor-in-Chief of an American Physiological Society journal. Dr. Joe will assume office as the Editor of Physiological Genomics from July 1, 2015.


Congratulations! to Robert Lee who successfully defended his Ph.D. thesis on November 13, 2014, "Alpha 7 Nicotinic Acetylcholine Receptor:  Novel Role in Macrophage Survival and Murine Atherosclerosis" Advisor: Dr. Guillermo Vazquez


Congratulations! to Anita Rana, Ph.D., she has been selected to receive a Basic Cardiovascular Sciences (BCVS) Abstract Travel Grant to attend the AHA Scientific Sessions 2014 in Chicago, IL, November 15-19, 2014.  This award recognizes meritorious work by young investigators, encourages participation in the AHA Scientific Sessions and provides a small stipend to help defer the council's international presenters' travel expenses to present research at the AHA Scientific Sessions.


Congratulations! to Brahma Raju Mopidevi, Ph.D., on being selected for the Kidney Council New Investigator Travel Award for the abstract he submitted, "A Genetic Variant of Human Aldosterone Synthase Gene Causes Salt-Dependent High Blood Pressure in Transgenic Mice".  The High Blood Pressure Research (HBPR) 2014 Scientific Session will be held at the Hilton San Francisco, September 9-12, 2014.  Dr. Mopidevi's abstract is among the top 10 percent of the accepted abstracts.  He will present a poster presentation at the Scientific Sessions 2014, Chicago, IL, November 15-19, 2014.


Congratulations! to Bina Joe, Ph.D. who has been named the 2014 Lewis K. Dahl Memorial Lecturer by The American Heart Association's Council on High Blood Pressure Research (soon to be Hypertension).  The Lewis K. Dahl Memorial Lecture was established in 1988 by the Council for High Blood Pressure Research in honor of Dr. Dahl's pioneering work on the relations between salt, the kidney, and hypertension, and his establishment of a major genetically based experimental model of hypertension, the Dahl salt-sensitive rat.  Dr. Joe will attend the conference in San Francisco, CA, September 9-12, 2014.

Video - 2014 Lewis K Dahl Memorial Lecture Bina Joe, PhD, FAHA


Congratulations! to Dr. Sivarajan Kumarasamy, Assistant Professor, and newly appointed faculty member in the Department of Physiology and Pharmacology.


Congratulations! to Bina Joe, Ph.D. who has been selected as the recipient of the American Physiological Society (APS) Physiological Genomics Distinguished Service Award.  This award is given to recognize those who have made outstanding contribution to the development of the APS Physiological Genomics group.


 Congratulations to Terry Hinds, Ph.D. who has been named to the Editorial Board of the Journal of Diabetes Research.


Congratulations to Resmi Pillai graduate student in Dr. Bina Joe's Laboratory who has won the Young Investigator Award from the American Physiological Society (APS), which is awarded to the first author of the best paper published in an APS journal-Physiological Genomics in 2013.  Title of publication:  "Isolation and high-throughput sequencing of two-closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains", Resmi Pillai, Harshal Waghulde, Ying Nie, Kathirvel Gopalakrishnan, Sivarajan Kumarasamy, Phyllis Farms, Michael R. Garrett, Santosh S. Atanur, Klio Maratou, Timothy J. Aitman, Bina Joe.  Physiological Genomics - Published 11 June 2013 Vol. no. DOI: 10.1152/physiolgenomics.00077.2013  


Congratulations to Moustafa Sayed who successfully defended his Ph.D. thesis on March 28, 2014, "Effects of Na/K-ATPase Pump and its Ligands on the Differentiation of Bone-marrow Stem Cells" Advisor:  Dr. Jiang Tian


Congratulations to Varunkumar Pandey who successfully defended his Ph.D. thesis on August 28, 2013, "The effect of glucocorticoids on regulation of the human angiotensinogen gene and blood pressure." Advisor: Dr. Ashok Kumar.


Congratulations to Dr. Meenakshi Kaw, Assistant Professor, and newly appointed faculty member in the Department of Physiology and Pharmacology.


Welcome! to Dr. Ahmad Mushtaq, Assistant Professor, Department of Pharmacology & Therapeutics, Khyber Medical College in Peshawar, Pakistan.  Dr. Mushtaq is sponsored by a Khyber Medical College Visiting Scholar program, a long standing exchange program between the College of Medicine and Khyber Medical College that is sponsored by Dr. S. Amjad Hussain.  Dr. Mushtaq will be working with Dr. Guillermo Vazquez for the next 3 months.


 Welcome! to Danielle Rice...SURF (Summer Undergraduate Research Fellowship) in the laboratory of Dr. Guillermo Vazquez.  Danielle will receive training in techniques used to study mechanisms of endoplasmic reticulum stress-induced apoptosis in coronary endothelium. 


 Congratulations! Ph.D. graduates spring 2013


Congratulations!  New Investigator Research Award presented to Dr. Guillermo Vazquez, April 2012. Dr. Guillermo Vazquez, Ph.D., Associate Professor, was presented with the New Investigator Award at the Faculty Recognition Reception on April 17, 2012.  Dr. Nader Abraham, Department Chairman, presented the award to Dr. Vazquez.

Last Updated: 8/5/19