The University of Toledo

The Ohio Army National Guard Mental Health Initiative
Department of Defense Congressionally Directed Medical Research Program: W81XHW-07-1-0409
Principle Investigators:  Joseph Calabrese, MD (Case Medical Center), Marijo Tamburrino, MD (UT Medical Center)

Description: This 10-year longitudinal study, that began enrollment in October 2008, is a clinical epidemiology and health services project to explore risk and resilience factors for combat-related posttraumatic psychopathology and post-combat adjustment. DNA saliva samples are also collected. 

Early Intervention to Reduce Alcohol Misuse and Abuse in the Ohio Army National Guard
Congressionally Directed Medical Research Program: 13277015
Principle Investigator: Fred Blow, PhD (University of Michigan), Co-Investigator: John M. Wryobeck, PhD (UT Medical Center)

Description: This is a 5 year study which begins in 2014 and will develop and test a Web- and text- based alcohol brief intervention and compare it to an enhanced usual care condition for National Guard members in the state of Ohio who meet criteria for unhealthy drinking.

Neuroimaging and Genetic Investigation of Resilience and Vulnerability to PTSD in the Ohio National Guard and Army Reserve Cohort
Supported by Translational Research Stimulation Award of the University of Toledo & Promedica Health System 
Investigators: Marijo Tamburrino, MD, Xin Wang, PhD and Ahmed Janjua, MD (ProMedica)

Description:This study is an extension of ongoing collabration among Ann Arbor VA Medical Center, Case West Reserve University, and University of Toledo on Ohio National Gruard Project. We will explore the brain and genetic mechanisms of resilience and vulnerability of PTSD in veterans.

ACT Against Violence Raising Safe Kids Program: Parent and Child Outcomes
Investigator: Michelle Knox, PhD

Description:This multi-site study examines the effects of the ACT RSK program on child maltreatment and related parenting and child outcomes. The study also addresses characteristics of parents and parenting that relate to harsh discipline and abuse.

Effects of Depression and Anxiety on Adherence to Cardiac Rehabilitation
Investigators: Angele McGrady, PhD, Daylnn Badenhop, PhD  (UT Cardiac Rehabilitation), Ron McGinnis, MD

Description: This study examines the role of depressive and anxious symptoms on adherence to structured cardiac rehabilitation and the potential of a brief stress management intervention to increase adherence.

Longitudinal MRI study of PTSD Development within Weeks after Trauma
Supported by National Institute of Mental Health and William Bauer fMRI Research Fund.
Investigator:Xin Wang, PhD

Description: this study explores the risk factors for PTSD development in the early post traumatic period in order to design effective approaches to prevent PTSD. The trauma (e.g., motor vehicle accident) survivors are examined using psychological questionnaires and MRI techniques. Patient’s psychological conditions, as well as brain functions and structures, in the days to weeks after trauma are used to predict the PTSD symptoms in the long-term.  

Characteristics of Mental Health Treatment Seeking Children and Youths
Investigators: Michelle Knox, PhD, Kimberly Hunter, PhD

Description: This study examines the characteristics of children and youths who seek outpatient mental health treatment, with a focus on sleep issues, media violence exposure and parental discipline practices.

The Effects of Training in Child Advocacy and Child Abuse Prevention and Intervention for First Year Medical Students
Investigator: Michelle Knox, PhD

Description: The purpose of this study is to examine the effects of training in child advocacy on students' preparedness to prevent and intervene in cases of suspected child maltreatment.

Recent Faculty Publications 

 2012-2013

Prescott MR, Tamburrino M, Calabrese J, Liberzon I, Slembarski R, Shirley E, Fine T, Goto T, Wilson K, Ganocy S, Chan P, Derus A, Serrano MB, Sizemore J, Kauffman J, Galea S. Validation of lay-administered mental health assessments in a large Army National Guard cohort. International Journal of Methods in Psychiatric Research. (accepted 12-7-12)

Fine TH, Ateka CA, Tamburrino MB, Elhai JD, Prescott MR, Cohen GH, Shirley E, Chan PK, Goto T, Slembarskid R, Liberzon I, Galea S,. Calabrese JR. Validation of the telephone-administered PHQ-9 against the in-person administered SCID-I major depression module. Journal of Affective Disorders; September 2013; 150 (3): 1001-1007

Burkhart, K., Knox, M. & Brockmyer, J. Pilot Evaluation of the ACT Raising Safe Kids Program on children's bullying behavior.   Journal of Child and Family Studies, 2012.

Knox, M., Pelletier, H., & Vieth, V. Effects of medical student training in child advocacy and child abuse prevention and intervention. Psychological Trauma: Theory, Research, Practice, and Policy, on-line, 2013.

 McGrady, A., Brennan, J., Lynch, & Whearty, K. A. (2012). Wellness program for first year medical students. Applied Psychophysiology and Biofeedback, 37(4): 253-60.

Knox, M., Burkhart, K. & Cromley, A. Supporting positive parenting in community health centers: The ACT Raising Safe Kids Program. Journal of Community Psychology. 41:395 – 407, 2013.

 Panchajanya, P., McGinnis, R., McGrady, A., Whearty, K., & Rapport, D. A comparison of treatment outcomes of bipolar disorder patients at an academic medical center treated by psychiatric residents and attending physicians", submitted to Academic Psychiatry (MS ID APPI-AP-11-12-0220), 2012. 

 Rais, T. Valproate induced hyperammonemic encephalopathy: a case report, Innovations in Clinical Neuroscience (volume 10, numbers 5-6, May-June 2013).

 Brennan, J. McGrady, A., Whearty, K., Lynch D., Rapport D., Schaefer, P. (2012). Emotional status of third year medical students and their responses to a brief intervention. Annals of Behavioral Science and Medical Education, 18(2): 10-14.

 Marshall BD, Prescott MR, Liberzon I, Tamburrino MB, Calabrese JR, Galea S. "Coincident Posttraumatic Stress Disorder and Depression Predict Alcohol Abuse during and after Deployment among Army National Guard Soldiers." Drug and Alcohol Dependence, 2012, 124(3):193-199.

 Biehn TL, Contractor A, Elhai JD, Tamburrino M, Fine T, Prescott MR, Shirley E, Chan P, Slembarski R, Liberzon I, Calabrese JR, Galea S. Relations Between the Underlying Dimensions of PTSD and Major Depression using an Epidemiological Survey of Deployed Ohio National Guard Soldiers. Journal of Affective Disorders, Jan. 10, 2013; 144(1-2):106-111.

 Goodwin RD, Prescott M, Tamburrino M, Calabrese JR, Liberzon I, Galea S. Cigarette Smoking and Subsequent Risk of Suicidal Ideation among National Guard Soldiers. Journal of Affective Disorders, Feb. 15, 2013; 145(1):111-114.

 Elhai JD, Contractor A, Tamburrino M, Fine TH, Prescott MR, Shirley E, Chan PK, Slembarski R, Liberzon I, Galea S, Calabrese JR. The Factor Structure of Major Depression Symptoms: A Test of Four Competing Models Using the Patient Health Questionnaire – 9. Psychiatry Research, Oct. 30, 2012; 199(3):169-173.

 Marshall BDL, Prescott MR, Liberzon I, Tamburrino MB, Calabrese JR, Galea S. Posttraumatic Stress Disorder, Depression, and HIV Risk Behavior among Army National Guard Soldiers. Journal of Traumatic Stress, 2013; 26(1):64-70.

 Goodwin RD, Prescott M, Tamburrino M, Calabrese JR, Liberzon I, Galea S. Smoking is a Predictor of Depression Onset among National Guard Soldiers. Psychiatry Research, 2013 April 30; 206(2-3):321-3. Epub 2013 Jan 3. PMID:23291043.

 Eilbeck NK, Tamburrino MB. Sleepless and Paranoid: Cases that Test Your Skills, Current Psychiatry, April 2013; 12(4):39-43.

 Smith MK, Tamburrino MB, Nagel RW, Lynch DJ. Comorbidity of Anxiety in Depressed Primary Care Patients. Psychiatry On-Line, May 25, 2013. http://www.priory.com/psychiatry/depression_comorbid_anxiety.htm

 Lubomirsky B, Wang X, Hong X, Smirnoff JB, Biehn T, Contractor AA, Elhai JD, Sutu C, Brickman KR, Liberzon I, McLean SA, Tamburrino MB, Preliminary study on the relationship between visitation in the emergency department and post-traumatic mental health. Social Work in Mental Health (accepted August 24, 2013).

 Wryobeck JM, Haines ME, Wynkoop TE, Swanson MA. Depressive Disorders. In C.A. Noggle & R.S. Dean, (editors). The Neuropsychology of Psychopathology. New York: Springer Publishing Company; 2013. p. 201-220.

 Sripada RK, King AP, Garfinkel SN, Wang X, Sripada C, Welsh RC, Liberzon I. Altered resting-state amygdala functional connectivity in PTSD. Journal of Psychiatry Neuroscience 37(4):241-9; 2012

 Sripada RK, King AP, Welsh RC, Garfinkel SN, Wang X, Sripada CS, Liberzon I. Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks. Psychosomatic Medicine 74(9):904-11; 2012.

 Xie, H, Kane, J, Dennis, MJ, Mooney R, Bauer WR, Wang X, Wall JT. Case series evidence for changed interhemispheric relationships in cortical structure in some amputees. Journal of Clinical Neuroscience. 20(4):523-6; 2013

 
McGrady, A., Moss, D. Pathways to Illness, Pathways to Health (March 2013). Springer Publishing, New York, New York.

Knox, M., Burkhart, K., & Khuder, S. (In press). Parental hostility and depression as predictors of young children’s aggression and conduct problems. Journal of Aggression, Maltreatment & Trauma.

Knox, M., Burkhart, K., & Howe, T. (In press). Effects of the ACT Raising Safe Kids parenting program on children’s externalizing problems. Family Relations.

Wryobeck JM, Rubenfire M. Pulmonary Arterial Hypertension: psychosocial implications and treatment. In: M. Riba, L. Wulsin, & M. Rubenfire, (editors). Psychiatry and Heart Disease: the Mind, Brain, and Heart. Wiley-Blackwell, John Wiley & Sons, Ltd., West Sussex, UK; 2012. p. 88-98.

 McGrady, A., Brennan, J., Lynch, & Whearty, K. A wellness program for first year medical students. Applied Psychophysiology and Biofeedback, 2012.

 Sarwar, S., McGinnis, R., "Topiramate-induced Dissociative Disorder" Innovations in Clinical Neuroscience, Vol. 8, No. 8, August 2011. 

Knox, M., Lentini, J., Cummings, T., McGrady, A., Whearty, K., & Sancrant, L. (In press). Game-based biofeedback for pediatric anxiety and depression. Mental Health in Family Medicine.

Elhai JD, Naifeh JA, Forbes D, Ractliffe KC, Tamburrino M. Heterogeneity in Posttraumatic Stress Disorder’s Clinical Presentations Among Medical Patients: Testing Factor Structure Variation Using Factor Mixture Modeling. Journal of Traumatic Stress, 2011;24(4):435-443.

Calabrese JR, Prescott M, Tamburrino MB, Liberzon I, Slembarski R, Goldmann E, Shirley E, Fine T, Goto T, Wilson K, Ganocy S, Chan P, Serrano MB, Sizemore J, Galea S. “PTSD Comorbidity and Suicidal Ideation associated with PTSD within the Ohio Army National Guard.” The Journal of Clinical Psychiatry, 2011;72(8):1072-1078

Goldmann E, Calabrese J, Prescott M, Tamburrino M, Liberzon I, Slembarski R, Shirley E, Fine T, Goto T, Wilson K, Ganocy S, Chan P, Serrano M, Sizemore J, Galea S. “Potentially Modifiable Pre-, Peri-, and Postdeployment Characteristics Associated with Deployment-Related Posttraumatic Stress Disorder Among Ohio Army National Guard Soldiers.” Ann Epidemiol., 2012 Feb;22(2):71-78.

Foran-Tuller William K, Robiner W, Breland-Noble A, Otey-Scott S, Wryobeck J, King C, Sanders K. Early Career Boot Camp: A Novel Mechanism for Enhancing Early Career Development for Psychologists in Academic Healthcare, J Clin Psychol Med S 2012:19:117-125.

Sripada RK, King AP, Garfinkel SN, Wang X, Sripada C, Welsh RC, Liberzon I. Altered Resting-State Amygdala Functional Connectivity in PTSD. J Psychiatry Neurosci. 2012:37(4):241-9

Xie, H., Kane, J., Dennis, M.J., Mooney, Bauer, W.R., Wang, X., & Wall, J.T. (In press) Case series evidence for changed interhemispheric relationships in cortical structure in some amputees. Journal of Clinical Neuroscience. (in press)

 
Feldman L, Williams KS, Knox M. Coates J, Report. "Influencing Controlled Substance Prescribing: Attending and Resident Physician Use of a State Prescription Monitoring Program." Pain Medicine. June 2012.

Tamburrino, MB, Nagel RW, Lynch DJ. Managing Antidepressants in Primary Care: Physicians' Treatment Modifications. Psychological Reports, 2011;108(3):799-804.

Marshall BD, Prescott MR, Liberzon I, Tamburrino MB, Calabrese JR, Galea S. "Coincident Posttraumatic Stress Disorder and Depression Predict Alcohol Abuse during and after Deployment among Army National Guard Soldiers." Drug and Alcohol Dependence, 2012, 124(3):193-199.

Goodwin RD, Prescott M, Tamburrino M, Calabrese JR, Liberzon I, Galea S. Cigarette Smoking and Subsequent Risk of Suicidal Ideation among National Guard Soldiers. Journal of Affective Disorders. (Accepted 5-2-2012)

Williams KS, Franco-Bronson K., "Emotional and Psychiatric Problems in Patients with Cancer." In Handbook of Cancer Chemotherapy 8th ed., RT Skeel, S. Khleif eds., Chapter 32, 678-693, 2011.

Feldman L, Williams KS, Coates J, Knox M. Awareness and Utilization of a Prescription Monitoring Program Among Physicians. Journal of Pain and Palliative Care Pharmacotherapy, Vol. 25, No. 4, Pages 313-317, 2011.

Biehn TL, Contractor A, Elhai JD, Tamburrino M, Fine T, Prescott MR, Shirley E, Chan P, Slembarski R, Liberzon I, Calabrese JR, Galea S. Relations Between the Underlying Dimensions of PTSD and Major Depression using an Epidemiological Survey of Deployed Ohio National Guard Soldiers. Journal of Affective Disorders. (Accepted 6-12-2012)

Elhai JD, Contractor A, Tamburrino M, Fine TH, Prescott MR, Shirley E, Chan PK, Slembarski R, Liberzon I, Galea S, Calabrese JR. The Factor Structure of Major Depression Symptoms: A Test of Four Competing Models Using the Patient Health Questionnaire – 9. Psychiatry Research. (Accepted 5-20-2012)

Knox, M., Lentini, J., Cummings, T., McGrady, A., Whearty, K., & Sancrant, L. Game-based biofeedback for pediatric anxiety and depression. Mental Health in Family Medicine 8: 195-203, 2011.