The University of Toledo

The Ohio Army National Guard Mental Health Initiative
Department of Defense Congressionally Directed Medical Research Program: W81XHW-07-1-0409
Principle Investigators:  Joseph Calabrese, MD (Case Medical Center), Marijo Tamburrino, MD (UT Medical Center)

Description: This 10-year longitudinal study is a clinical epidemiology and health services project that began enrollment in October 2008. Annual telephone and in-person surveys are conducted to explore risk and resilience factors for combat-related posttrauamatic psychopathology and post-combat adjustment. DNA saliva samples are also collected. 

Feasibility of ACT Against Violence program in Community Health Centers
Investigator: Michelle Knox, PhD

Description: This study examines the feasibility of the ACT program in community health center settings.

Neuroimaging and Genetic Investigation of Resilience and Vulnerability to PTSD in the Ohio National Guard and Army Reserve Cohort
Investigators:Xin Wang, PhD and Marijo Tamburrino, MD

Description:This study is an extension of ongoing collabration among Ann Arbor VA Medical Center, Case West Reserve University, and University of Toledo on Ohio National Gruard Project. We will explore the brain and genetic mechanisms of resilience and vulnerability of PTSD in veterans.

ACT Against Violence Raising Safe Kids Program: Parent and Child Outcomes
Investigator: Michelle Knox, PhD

Description:This multi-site study examines the effects of the ACT RSK program on parenting and child behaviors.

Effects of Depression and Anxiety on Adherence to Cardiac Rehabilitation
Investigators: Angele McGrady, PhD, Daylnn Badenhop, PhD  (UT Cardiac Rehabilitation), Ron McGinnis, MD

Description: This study examines the role of depressive and anxious symptoms on adherence to structured cardiac rehabilitation and the potential of a brief stress management intervention to increase adherence.

Computer Aided Relaxation for Pediatric Anxiety
Investigators: Michelle Knox, PhD, Angele McGrady, PhD

Description: Using an experimental design with randomization to treatment and control groups, this study examines the efficacy of biofeedback-assisted training in relaxation for children and youths with anxiety.

Longitudinal MRI study of PTSD Development within Weeks after Trauma
Supported by Translational Research Stimulation Award (TRSA) of the University of Toledo and ProMedica Health System, and William Bauer fMRI Research Fund.
Investigator:Xin Wang, PhD

Description: this study explores the risk factors for PTSD development in the early post traumatic period in order to design effective approaches to prevent PTSD. The trauma (e.g., motor vehicle accident) survivors are examined using psychological questionnaires and MRI techniques. Patient’s psychological conditions, as well as brain functions and structures, in the days to weeks after trauma are used to predict the PTSD symptoms in the long-term.  

Characteristics of Mental Health Treatment Seeking Children and Youths
Investigators: Michelle Knox, PhD, Kimberly Hunter, PhD

Description: This study examines the characteristics of children and youths who seek outpatient mental health treatment, with a focus on sleep issues, media violence exposure and parental discipline practices.

The Use of Interactive Drama in Medical Education
Investigator: John M. Wryobeck
Description: Interactive drama (ID) involves learners in ways that lectures and standardized patients cannot. ID is experiential in that it involves trained actors who deliver a high degree of reality that is easy to buy into and allows learners to “experience” the situation and concepts being presented. Research has suggested that interactive drama have been effective in developing knowledge, skills and attitudes as well as for creating a “teachable moment.”

Wellness Program for Medical Students
Funded by the David and Lura Lovell Foundation
Investigators: Angele McGrady, PhD, Julie Brennan, PhD (St Luke's Family Medicine) Dan Rapport, MD, Paul Shaefer, MD (UT Family Medicine)

Description: Research focused on the effects of a structured stress management wellness program in first and third year medical students.

The Effects of Training in Child Advocacy and Child Abuse Prevention and Intervention for First Year Medical Students
Investigator: Michelle Knox, PhD

Description: The purpose of this study is to examine the effects of training in child advocacy on students' preparedness to prevent and intervene in cases of suspected child maltreatment.

Recent Faculty Publications 

Knox, M., Burkhart, K., & Khuder, S. (In press). Parental hostility and depression as predictors of young children’s aggression and conduct problems. Journal of Aggression, Maltreatment & Trauma.

Knox, M., Burkhart, K., & Howe, T. (In press). Effects of the ACT Raising Safe Kids parenting program on children’s externalizing problems. Family Relations.

Wryobeck JM, Rubenfire M. Pulmonary Arterial Hypertension: psychosocial implications and treatment. In: M. Riba, L. Wulsin, & M. Rubenfire, (editors). Psychiatry and Heart Disease: the Mind, Brain, and Heart. Wiley-Blackwell, John Wiley & Sons, Ltd., West Sussex, UK; 2012. p. 88-98.

 McGrady, A., Brennan, J., Lynch, & Whearty, K. A wellness program for first year medical students. Applied Psychophysiology and Biofeedback, 2012.

 Sarwar, S., McGinnis, R., "Topiramate-induced Dissociative Disorder" Innovations in Clinical Neuroscience, Vol. 8, No. 8, August 2011. 

Knox, M., Lentini, J., Cummings, T., McGrady, A., Whearty, K., & Sancrant, L. (In press). Game-based biofeedback for pediatric anxiety and depression. Mental Health in Family Medicine.

Elhai JD, Naifeh JA, Forbes D, Ractliffe KC, Tamburrino M. Heterogeneity in Posttraumatic Stress Disorder’s Clinical Presentations Among Medical Patients: Testing Factor Structure Variation Using Factor Mixture Modeling. Journal of Traumatic Stress, 2011;24(4):435-443.

Calabrese JR, Prescott M, Tamburrino MB, Liberzon I, Slembarski R, Goldmann E, Shirley E, Fine T, Goto T, Wilson K, Ganocy S, Chan P, Serrano MB, Sizemore J, Galea S. “PTSD Comorbidity and Suicidal Ideation associated with PTSD within the Ohio Army National Guard.” The Journal of Clinical Psychiatry, 2011;72(8):1072-1078

Goldmann E, Calabrese J, Prescott M, Tamburrino M, Liberzon I, Slembarski R, Shirley E, Fine T, Goto T, Wilson K, Ganocy S, Chan P, Serrano M, Sizemore J, Galea S. “Potentially Modifiable Pre-, Peri-, and Postdeployment Characteristics Associated with Deployment-Related Posttraumatic Stress Disorder Among Ohio Army National Guard Soldiers.” Ann Epidemiol., 2012 Feb;22(2):71-78.

Foran-Tuller William K, Robiner W, Breland-Noble A, Otey-Scott S, Wryobeck J, King C, Sanders K. Early Career Boot Camp: A Novel Mechanism for Enhancing Early Career Development for Psychologists in Academic Healthcare, J Clin Psychol Med S 2012:19:117-125.

Sripada RK, King AP, Garfinkel SN, Wang X, Sripada C, Welsh RC, Liberzon I. Altered Resting-State Amygdala Functional Connectivity in PTSD. J Psychiatry Neurosci. 2012:37(4):241-9

Xie, H., Kane, J., Dennis, M.J., Mooney, Bauer, W.R., Wang, X., & Wall, J.T. (In press) Case series evidence for changed interhemispheric relationships in cortical structure in some amputees. Journal of Clinical Neuroscience. (in press)

 
Feldman L, Williams KS, Knox M. Coates J, Report. "Influencing Controlled Substance Prescribing: Attending and Resident Physician Use of a State Prescription Monitoring Program." Pain Medicine. June 2012.

Tamburrino, MB, Nagel RW, Lynch DJ. Managing Antidepressants in Primary Care: Physicians' Treatment Modifications. Psychological Reports, 2011;108(3):799-804.

Marshall BD, Prescott MR, Liberzon I, Tamburrino MB, Calabrese JR, Galea S. "Coincident Posttraumatic Stress Disorder and Depression Predict Alcohol Abuse during and after Deployment among Army National Guard Soldiers." Drug and Alcohol Dependence, 2012, 124(3):193-199.

Goodwin RD, Prescott M, Tamburrino M, Calabrese JR, Liberzon I, Galea S. Cigarette Smoking and Subsequent Risk of Suicidal Ideation among National Guard Soldiers. Journal of Affective Disorders. (Accepted 5-2-2012)

Williams KS, Franco-Bronson K., "Emotional and Psychiatric Problems in Patients with Cancer." In Handbook of Cancer Chemotherapy 8th ed., RT Skeel, S. Khleif eds., Chapter 32, 678-693, 2011.

Feldman L, Williams KS, Coates J, Knox M. Awareness and Utilization of a Prescription Monitoring Program Among Physicians. Journal of Pain and Palliative Care Pharmacotherapy, Vol. 25, No. 4, Pages 313-317, 2011.

Biehn TL, Contractor A, Elhai JD, Tamburrino M, Fine T, Prescott MR, Shirley E, Chan P, Slembarski R, Liberzon I, Calabrese JR, Galea S. Relations Between the Underlying Dimensions of PTSD and Major Depression using an Epidemiological Survey of Deployed Ohio National Guard Soldiers. Journal of Affective Disorders. (Accepted 6-12-2012)

Elhai JD, Contractor A, Tamburrino M, Fine TH, Prescott MR, Shirley E, Chan PK, Slembarski R, Liberzon I, Galea S, Calabrese JR. The Factor Structure of Major Depression Symptoms: A Test of Four Competing Models Using the Patient Health Questionnaire – 9. Psychiatry Research. (Accepted 5-20-2012)

Knox, M., Lentini, J., Cummings, T., McGrady, A., Whearty, K., & Sancrant, L. Game-based biofeedback for pediatric anxiety and depression. Mental Health in Family Medicine 8: 195-203, 2011.