College of Health and Human Services

Physical Therapy Program- Abraham Lee, P.T., Ph.D.

Abraham Lee, P.T., Ph.D. received his Ph.D. degree in Exercise Science (emphasis on Exercise Physiology) from Arizona State University followed by post-doctoral training under the supervision of John O. Holloszy, M.D., an internally known muscle physiologist at Washington University School of Medicine, St. Louis, MO. Dr. Lee obtained an M.S. degree in Physical Therapy from Texas Woman's University, an M.S. degree in Exercise Physiology & Cardiac Rehabilitation from Northeastern Illinois University, and an M.S. degree in Physical Education from Yonsei University, South Korea. He did his undergraduate work (B.S.) in Physical Education at Kyungpook National University in South Korea.

The area of Dr. Lee’s research interest is metabolic adaptation in skeletal muscle and other vital organs in the body in response to exercise training with focus on carbohydrate and fat metabolism. The Lee’s laboratory has recently observed that training improves insulin action in rats with heterogenetic backgrounds, and that this response is a heritable phenotype. Furthermore, the Lee’s team in collaboration with Dr. Cicila observed that an adaptation with swim training in key hepatic gluconeogenic enzyme activities in inbred rats (DA & COP) depends on a genetic background. In addition, in collaboration with the Dr. Najjar, the Lee’s team has observed an alteration in muscle glucose transport activity in transgenic mice with the inactivation or overexpression of hepatic CEACAM1. Recently, Dr. Lee’s research team in collaboration with Dr. McLoughlin, Dept. of Kinesiology, has investigated the effect of the overexpression of FOXO1 in skeletal muscle of mice on carbohydrate metabolism. The results of some of these works have been published in high impact scientific journals, i.e., Nature Genetics, Endocrinology, and American Journal of Physiology, and presented at several national meetings. The work has thus far been supported by an institutional start-up fund.

Dr. Lee teaches Clinical Pathophysiology, Applied Exercise Physiology, and Cardiovascularpulmonary PT in Doctor of Physical Therapy program, Dept. of Rehabilitation Sciences. Dr. Lee is active in professional societies as a member of the American Physical Therapy Association, American College of Sports Medicine, and the American Physiological Society.

Publications

Abram Katz and Abraham D. Lee, (1988) Glucose 1,6-bisphosphate in human skeletal muscle after isometric contraction. Am. J. Physiol. 255: C145-C148

Abraham D. Lee and Abram Katz, (1989) Transient increase in glucose 1,6-bisphosphate in human skeletal muscle during isometric contraction. Biochem. J. 258: 915-918

Yasuo Kida, Abram Katz, Abraham D. Lee and David M. Mott, (1989) Contraction-mediated inactivation of glycogen synthase is accompanied by inactivation of glycogen synthase phosphatase in human skeletal muscle. Biochem. J. 259: 901-904

Abraham D. Lee, Eric A. Gulve, May Chen, and John O. Holloszy, (1995) Effects of Ca2+ ionophore ionomycin on insulin-stimulated and basal glucose transport in muscle. Am. J. Physiol. 268: R997-R1002.

Abraham D. Lee, Polly A. Hansen and John O. Holloszy, (1995) Wortmannin inhibits insulin-stimulated glucose transport but not contraction-stimulated glucose transport in skeletal muscles. FEBS letters 361: 51-54.

Abraham D. Lee, Polly A. Hansen, Jane Schluter, Eric Gulve, Jiaping Gao and John O. Holloszy, (1997) The effect of epinephrine on insulin-stimulated glucose uptake and GLUT-4 phosphorylation. Am. J. Physiol. 273: C1082-C1087.

M.N. Poy, Y. Yang, M.A. Fernstrom, A.D. Lee, Y. Kido and S.M. Najjar, “CEACAM1 regulates insulin clearance in liver” Nature Genetics 30:270-276, 2002, 34 Supplement: S80

Tong Dai, Qusai Al-Share, Yan Yang, Mats A. Fersstrom, Abraham D. Lee, Lawrence Sweetman, Antonio Amato, Marzia Pasquale, Gary D. Lopaschuk, Sandra K. Erikson, and Sonia M. Najjar, (2004) “Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice” J. Biol. Chem. 279:45155-45161

Koch LG, Green CL, Lee AD, Hornyak JE, Cicila GT, Britton SL., “Test of the principle of initial value in rat genetic models of exercise capacity” Am. J. Physiol 288:R466-R472, 2005

Thomas A. Bowman,* Sadeesh K. Ramakrishnan,* Meenakshi Kaw, Sang Jun Lee, Payal R. Patel, Varun K. Golla, Raymond E. Bourey, Per Magnus Haram, Lauren G. Koch, Steven L. Britton, Ulrik Wisløff, Abraham D. Lee, and Sonia M. Najjar, “Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity” Endocrinology 151: 5157–5164, 2010

Garrett Heinrich, Sumona Ghosh,*,Anthony M. Deangelis, Jill M. Schroeder Gloeckler, Payal R. Patel, Tamara R. Castaneda, Shane Jeffers, Abraham D. Lee, Dae Young Jung, zhiyou Zhang, Darren M. Opland, Martin G. Myers Jr., Jason K. Kim, and Sonia M. Najjar, “Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2 Controls, “Energy Balance and Peripheral Insulin Action in Mice” Gastroenterology 139:644–652, 2010