Department of Medicinal and Biological Chemistry

Erin Prestwich, Ph.D.

 Photo of Dr. Prestwich

Assistant Professor of Medicinal Chemistry

419.530.1944 (Office) 
419.530.1947 (Lab)
Wolfe Hall 2209
erin.prestwich@utoledo.edu

Education

  • BA, Chemistry, 1999, Wellesley College
  • Ph.D., Chemistry, 2006, Boston College 

Research Interests

Research in the Prestwich laboratory employs analytical and chemical tools to probe the pathophysiology of disease and find new targets for pharmaceuticals. We focus on the discovery of mechanisms for biomolecular damage and on developing methods to characterize and quantify molecules involved in pathophysiology. We are interested in discovering novel nucleic acid modifications and determining the mechanisms and consequences of these modifications. We are focused on discovering novel targets for new antimicrobials to combat problems inherent in the increased pace of antibiotic resistance. This involves using bioanalytical tools, especially mass spectrometry, along with microbiology, synthetic organic chemistry, and chemical biology to discover and study novel mechanisms present in pathogenic bacteria that are lacking in humans. 

Publications

  1. “Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.” Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL. J Immunol.2018 May 1;200(9):3244-3258.
  2. “Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomons aeruginosa.” Jaroensuk J, Atichartpongkul S, Chionh YH, Wong YH, Liew CW, McBee ME, Thongdee N, Prestwich EG, DeMott MS, Mongkolsuk S, Dedon PC, Lescar J, Fuangthong M., Nucleic Acids Research, 2016, Dec 15;44(22):10834-10848.
  3. “A multidimensional platform for the purification of non-coding RNA species.” Chionh Y.H., Ho C.H., Pruksakorn D, Intrakanti R, Ng C.S., Hia F, McBee M.E., Su D, Pang Y.L.J., Gu C, Dong H, Prestwich E.G., Shi P.Y., Preiser P, Alonso S, Dedon P.C., Nucleic Acids Research, 2013, Sep;41(17):e168.
  4. “DNA methylation regulates gene expression and enhances survival of hypoxia in Mycobacterium tuberculosis.” Shell, S.S., Prestwich, E.G., Baek, S.H., Shah, R.R., Sassetti, C.M., Dedon, P.C., Fortune, S.M., PLOS Pathogens, 2013, Jul;9(7):e1003419.
  5. “Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.” Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR, Proc. Nat. Acad. Sci., 2013, Jun 25; 110(26):E2332-41.
  6. “Increased levels of inosine in a mouse model in inflammation.” Prestwich, E.G., Mangerich, A., Pang, B., McFaline, J.F., Lonkar, P., Sullivan, M.R., Trudel, L.J., Taghizadeh, K., Dedon, P.C., Chem. Res. Tox., 2013, 26, 538-546.
  7. “Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, Rose Bengal-photosensitized singlet oxygen, and gamma irradiation.” Cui, L., Ye, W., Prestwich, E. G., Wishnok,J. S., Koli Taghizadeh, K., Dedon,P. C., Tannenbaum, S. R., Chem. Res. Tox., 2013, 26 (2), 195-202.
  8. “Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.” Mangerich, A.,  Knutson, C.G., Parry, N.M., Muthupalani, S., Ye, W., Prestwich, E., Cui, L., McFaline, J.L., Mobley, M., Ge, Z., Taghizadeh, K., Wishnok, J.S., Wogan, G.N., Fox, J.G., Tannenbaum, S.R., Dedon, P.C., PNAS, 2012, 109(27), E1820-9. 
  9. “Tunable DNA cleavage by intercalating peptidoconjuages.”  Mahon, K.P. Jr., Roy, M.D., Carreon, J.R., Prestwich, E. G., Rouge, J. L., Shin, S., Kelley, S.O., ChemBioChem, 2006, 7, 766-773.
  10. “Oxidative strand scission induced by peptides.” Prestwich, E. G., Roy, M. D., Rego, J. R., Kelley, S. O., Chemistry and Biology, 2005, 12, 695-701.
  11. “Phototoxicity of peptidoconjugates modulated by a single amino acid.”  Wittenhagen, L. M., Carreon, J. R., Prestwich, E. G., Kelley, S. O., Angew. Chem. Int. Ed., 2005, 44, 2542-2546.
  12. “Photosensitized DNA cleavage promoted by amino acids.”  Mahon, K. P., Jr., Ortiz-Meoz, R. F., Prestwich, E. G., Kelley, S. O., Chem. Comm., 2003, 1956-1957. (*featured in Chemical and Engineering News, 7/21/03.)
  13. “Discrimination of pheromone enantiomers by two pheromone binding proteins from the gypsy moth Lymantria dispar.”  Plettner, E., Lazar, J., Prestwich, E. G., Prestwich, G. D., Biochemistry, 2000, 39, 8953-8962.
Last Updated: 8/8/18