The University of Toledo

Isaac T. Schiefer

Isaac T. Schiefer
Research Assistant Professor
Department of Medicinal and Biological Chemistry
Office: HEB-284C
Lab: HEB-275C
Phone: 419.383.1935
isaac.schiefer@utoledo.edu

 

Institutions/Degrees:

Bach. Sci. Pharm. Sci.    Medicinal Chemistry, 2007        The University of Toledo

Ph.D.                             Medicinal Chemistry, 2012        University of Illinois at Chicago

Post-doctoral Fellow     Chemical Biology, 2012-2013    Northwestern University

Research Interests:

My lab carries out research in two areas at the interface of medicinal chemistry and chemical biology:

1)      small molecule hit-to-lead optimization- using synthetic, bioanalytical, and bioorganic chemistry

2)      target identification using techniques in chemical and cellular biology

We are interested in creating and developing novel therapies for neurodegeneration, with an emphasis on Alzheimer’s disease (AD). Our primary long-term objective is to translate SAFE and EFFECTIVE novel small molecule therapies into the clinic to improve patient outcomes and human health. Our current work involves the development of attenuated nitric oxide (NO) mimetics as novel therapeutic candidates for stroke and AD.


Representative Recent Publications (starting from most recent):

Schiefer, I. T.; Tapadar, S.; Litosh, V.; Siklos, M.; Scism, R.; Wijewickrama, G. T.; Chandrasena, E. P.; Sinha, V.; Tavassoli, E.; Brunsteiner, M.; Fa’, M.; Arancio, O.; Petukhov, P.; Thatcher, G. R. J. Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors. Journal of Medicinal Chemistry, 2013, 56, 6054–68.

Schiefer, I. T.; VandeVrede, L.; Fa', M.; Arancio, O.; Thatcher, G.R.J. Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents. Journal of Medicinal Chemistry, 2012, 55, 3076-3087.

Schiefer, I. T.; Abdul-Hay, S.; Wang, H.; Vanni, M.; Qin, Z.; Thatcher, G. R. J. Inhibition of Amyloidogenesis by Nonsteroidal Anti-inflammatory Drugs and Their Hybrid Nitrates. Journal of Medicinal Chemistry, 2011, 54, 2293-2306.

Abdul-Hay, S.; Schiefer, I. T.; Chandrasena, R. E. P.; Li, M.; Abdelhamid, R.; Wang, Y.-T.; Tavassoli, E.; Michalsen, B.; Asghodom, R. T.; Luo, J.; Thatcher, G. R. J. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. ACS Medicinal Chemistry Letters, 2011, 2, 656-661.


Abdelhamid, R.; Luo, J.; VandeVrede, L.; Kundu, I.; Michalsen, B.; Litosh, V. A.; Schiefer, I. T.; Gherezghiher, T.; Yao, P.; Qin, Z.; Thatcher, G. R. J. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism. ACS Chemical Neuroscience, 2011, 2, 256-268.

Anand, S.; Schiefer, I. T.; Thatcher, G.R. J. Nitric Oxide Donor and Mimetic Molecules in Cancer Chemotherapy and Chemoprevention. Forum on Immunological Diseases and Therpies, 2010, 1, 251-279.

Sinha, V.; Wijewickrama, G. T.; Chandrasena, R. E. P.; Xu, H.; Edirisinghe, P. D.; Schiefer, I. T.; Thatcher, G. R. J. Proteomic and Mass Spectroscopic Quantitation of Protein S-Nitrosation Differentiates NO-Donors. ACS Chemical Biology, 2010, 5, 667-680.