Laboratory of Cardiovascular Mechanobiology and Therapeutics
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OUR RESEARCH
Mechanical Signaling in Tumor Angiogenesis, Growth and Metastasis
Selected Publications:
Guarino, B., Katari, V., Adapala, R.K.., Bhavnani, N., Dougherty, J.A.,Khan, M.Paruchuri, S., and Thodeti, C.K. (2021) Tumor-derived extracellular vesicles induce abnormal angiogenesis via TRPV4 downregulation and subsequent activation of YAP and VEGFR2. Front Bioengg Biotechnol. 9:790489. doi: 10.3389/fbioe.2021.790489.
Kanugula. A.K., Adapala, R.K., Jamaiyar, A., Lenkey, N., R, Guarino, B., Liedtke, W., Yin, L., Paruchuri, S. and Thodeti, C.K. (2021) Endothelial TRPV4 channel deletion promotes tumor growth and metastasisAngiogenesis doi: 10.1007/s10456-021-09775-9.)
Cappelli, H.C., Kanugula, A.K., Adapala, R.K., Amin, V., Sharma, P., Paruchuri, S., and Thodeti, C.K. (2019)Mechanosensitive TRPV4 channels regulate tumor vascular integrity and metastasis through stabilization of VE-cadherin junctions. Cancer Lett 442:15-20.
Adapala, R., Thoppil, R., Ghosh, K., Cappelli, H., Dudley, A.C., Paruchuri, S., Keshamouni, V., Klagsbrun, M., Meszaros, J.G., Chilian, W.M., Ingber, D. and Thodeti, C.K. (2016) Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. Oncogene. 35(3):314-22.
Duah, E., Teegala, L.R., Kondeti, V., Adapala, R., Keshamouni, V., Kanaoka, Y., Austen,
K.F., Thodeti, C.K. and Paruchuri, S (2019) Cysteinyl leukotriene 2 receptor promotes endothelial permeability,
tumor angiogenesis and metastasis. Proc Natl Acad Sci, USA116(1):199-204.
TRPV4 Mechanotransduction in Fibrosis and Myocardial Adaptation to Ischemia
Selected publications:
Adapala, R., Katari, V., Teegala, L.R., Thodeti, S., Paruchur, S. and Thodeti, C.K. (2021) TRPV4 Mechanotransduction in Fibrosis. Cells 10(11):3053. doi: 10.3390/cells10113053.
Adapala, R., Kanugula.A, Paruchuri, S., Chilian, W.M.and Thodeti, C.K. (2020) TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation Basic Res Cardiol 115(2):14. doi: 10.1007/s00395-020-0775-5.
Thodeti, C.K*. (2015) A bouquet for a broken heart: can flowers repair a damaged heart? Circ. Res.116(11):1729-31. doi: .1161/CIRCRESAHA.115.306590.
Rahaman SO, Grove LM, Paruchuri S, Southern BD, Abraham S, Niese KA, Scheraga RG, Ghosh S, Thodeti CK, Zhang DX, Moran MM, Schilling WP, Tschumperlin DJ, Olman MA. (2014). TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. J Clin Invest.124(12):5225-38.
Adapala, R., Thoppil, R., Luther, D.J., Sailaja, P., Meszaros, J.G., Chilian, W.M., and Thodeti, C.K. (2012)TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J. Mol.Cell.Cardiol. 54:45-52.
TRPV4 in Retinopathy and other Ocular Diseases
Selected publications:
Cappelli, H., Guarino, B., Kanugula, A.K., Adapala, R.K., Perera, V., Smith, M., Paruchuri, S and Thodeti, C.K. (2020) Transient receptor potential vanilloid 4 channel deletion regulates pathological but not physiological retinal angiogenesis. J Cell Physiol Oct 20. doi: 10.1002/jcp.30116.
Guarino, B., Paruchuri, S and Thodeti, C.K. (2020) Role of Transient receptor potential vanilloid 4 channels in ocular function. Exp. Eye Res. 201:108257.
Heart Failure: Mechanical Control of Coronary Angiogenesis
Selected publications/abstracts:
Katari, V., Bhavnani, N., Paruchuri, S. and Thodeti, C.K. TRPV4 regulates matrix stiffness-dependent activation of YAP/VEGFR2 signaling via Rho/ Rho kinase/ LATS1/2 pathway. ASIOA 9th National Annual Meeting, Jan 16-17, 2021.
Ravi Adapala, Anantha K Kanugula, Vahagn A Ohanyan, Sailaja M Paruchuri, William M Chilian and Charles K Thodeti. Endothelial TRPV4 Deletion Protects Myocardium Against Pressure Overload Induced Hypertrophy via Preserved Angiogenesis and Reduced Cardiac Fibrosis. Circulation Volume 140, Issue Suppl_119 November 2019
Ravi K Adapala, Anantha K Kanugula, Vahagn Ohanyan, Nina Lenkey, Sailaja Paruchuri, William M Chilian and Charles K Thodeti (2019) Trpv4 Deletion in Endothelium Protects Heart Against Pressure Overload Induced Hypertrophy. Circulation Research. 2019;125: A814.
Paruchuri, S. and Thodeti, C.K. (2018) Form follows function: Polymorphisms in mAKAP alter cardiac cAMP/PKA signalling. Am J Physiol Heart Circ Physiol 315(3):H626-H628. doi: 10.1152/ajpheart.00248.2018. Epub 2018 May 4.
Kanugula, A.K. and Thodeti, C.K. (2018) AMP-activated kinase “Keaps” ischemia/reperfusion-induced necroptosis under control. International Journal of Cardiology 259:168-169.
Thodeti, C.K. (2017) Changing the Channels: Nature’s remote Controlling in Health and Disease. Circ Res 120(4):599-601.
Thodeti, C.K*. (2015) A bouquet for a broken heart: can flowers repair a damaged heart? Circ. Res. 116(11):1729-31. doi: .1161/CIRCRESAHA.115.306590
Adapala, R.K., Talasila, P.K., Bratz, I.N., Zhang, D.X., Suzuki, M., Meszaros., J.G. and Thodeti, C.K.(2011) PKCa mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells Am.J. Physiol. Heart Circ. Physiol 301(3):H757-65.
Thodeti, C.K., Matthews, B., Ravi, A., Mamotto, A., Ghosh, K., and Bracha, A., Ingber, D.E. (2009) TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin to integrin signaling. Circ. Res. 104:1123-1130.