Department of Cancer Biology

Dayanidhi Raman, B.V.Sc., Ph.D.

dr Dayanidhi Raman, B.V.Sc., Ph.D.
Assistant Professor, Dept. Cancer Biology
Co-Director, Biomedical Sciences Cancer Biology track 
dayanidhi.raman@utoledo.edu

RESEARCH INTERESTS

My research is centered on cancer cell biology and mainly focuses on cell signaling, migration, local invasion and metastasis mediated by chemokine receptors CXCR2 and CXCR4 in breast cancer. Metastasis in breast cancer has a very high mortality than the primary breast cancer itself. The chemokine receptors and their adaptor proteins are physiologically involved in innate and adaptive immunity and also in the embryogenesis. Pathologically, chemokine receptors are subverted in the tumor microenvironment facilitating tumor progression and metastasis. Currently, I am specifically working on elucidating the role of CXCR4 in controlling several regulatory aspects of breast cancer cells including 1) stimulation of the epigenetic activity 2) feeding into and augmentation of the translational repression machinery resulting in an altered pro-tumorigenic and pro-metastatic proteome. These processes are mediated through an adaptor protein called LIM and SH3 Protein 1 (LASP-1) by ligand activated CXCR4. I have identified several key epigenetic proteins that bind to nuclear LASP-1 in response to the activation of CXCR4 by CXCL12 in breast cancer cells. Importantly, nuclear localized LASP-1 correlated inversely with longevity of the patients. It is imperative that the link between CXCL12-CXCR4 axis, nuclear LASP-1 and the patient longevity be identified.
 

EDUCATION:

1988 B.V.Sc. (equivalent to D.V.M., Veterinary Medicine, Madras Veterinary College, Madras, India
1995 Ph.D., Biochemistry, Kansas State University, Manhattan, KS

ACADEMIC APPOINTMENTS:

2016-present  Assistant Professor, Dept. Biochemistry & Cancer Biology, University of Toledo College of Medicine
                       & Life Sciences, Toledo, OH
2016-present  Adjunct Assistant Professor, Dept. of Cancer Biology, Vanderbilt University, Nashville, TN
2011-2015      Research Assistant Professor, Dept. of Cancer Biology, Vanderbilt University, Nashville, TN

REPRESENTATIVE PUBLICATIONS:

Vilgelm, A.E., Cobb, P., Malikayil K., Flaherty D., Andrew Johnson, C., Raman, D., Saleh, N., Higgins, B., Vara, B.A., Johnston, J.N., Johnson, D.B., Kelley, M.C., Chen, S.C., Ayers, G.D., and Richmond, A. (2017) MDM2 antagonists counteract drug-induced DNA damage. EBioMedicine  24:43-55. PMID: 29030058 

Duvall-Noelle, N., Karwandyar, A., Richmond, A. and Raman, D. (2016) LASP-1 – A nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene 35:1122-1133. PMCID: 25982273. 

Vilgelm A.E., Johnson, A.C., Prasad, N., Yang, J., Chen, S.C., Ayers, G.D., Pawlikowski, J.S., Raman, D., Sosman, J.A., Kelley, M.C., Ecsedy, J.A., Shyr, Y., Levy, S.E., Richmond, A. (2015) Connecting the dots: Therapy-induced senescence and a tumor suppressive immune microenvironment. J. Natl. Cancer Inst., Dec 30: 108 (6). PMCID: 26719346.

Raman, D., Sai, J., Hawkins, O., and Richmond A. (2014) Adaptor protein 2 (AP2) orchestrates CXCR2-mediated cell migration. Traffic, 15(4):451-69. PMID: 24450359.

Raman D, Sobolik-Delmaire T, Richmond A. (2011) Chemokines in health and disease. Exp. Cell Res. 317(5): 575-89. PMCID: 21223965.

Raman, D., Sai, J. Neel, N.F., Chew, C., Richmond, A. (2010) LIM and SH3 Protein-1 (LASP1) modulates CXCR2-mediated cell migration. PLoS ONE 5 (4): e10050. PMCID: 20419088.

Neel, N. F., Barzik, M., Raman, D., Sobolik-Delmaire, T., Sai, J., Ham, A. J., Mernaugh, R. L., Gertler, F. B., and Richmond, A. (2009) VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J. Cell Sci., 122:1882-94. PMCID: 19435808.

Sai, J., Raman, D., Liu, Y., Wikswo, J. and Richmond, A. 2008. Parallel PI3K-Dependent and Src-Dependent Pathways Lead to CXCL8- Mediated Rac2 Activation and Chemotaxis. J. Biol. Chem. 283(39):26538-47. PMCID: 18662984.

Raman, D., Baugher, P. J., Yee Mon Thu, Richmond, A. (2007). Role of chemokines in tumor growth. Cancer Lett. 256(2):137-65. PMCID: 17629396.

Ao, M., Franco, O. E., Park, D., Raman D., Williams, K., Hayward, S. W. (2007). Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic human epithelium. Cancer Res. 67 (9): 4244-53. PMCID: 17483336.

Ueda, Y., Neel, N. F., Schutyser, E., Raman, D., Richmond, A. (2006). Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells. Cancer Res. 66(11):5665-75. PMCID: 16740704.

 

 

 

 

 

 

 

 




Last Updated: 10/20/17