Medical Microbiology and Immunology




Additional Information

Contact Us

Health Science Campus
Health Education Building
Medical Microbiology and Immunology
Room 229, MS1021
Office: 419-383-4323
Fax: 419-383-3002

Hironori Matsushima, Ph.D.


 Assistant Professor

Affiliation: Dr. Akira Takashima's Laboratory

Phone: 419-383-4312
Fax:   419-383-3002

Grand Challenges Explorations grant


Research interests:  Dr. Matsushima is studying molecular mechanisms regulating the function of dendritic cells, which play crucial roles in the induction of both innate and adaptive immunity.

Education:  Dr. Matsushima earned his Ph.D. in Medical Science in the Division of Human Ecology of Yamanashi Medical University, Yamanashi, Japan. 


Matsushima, H., and Takashima, A.  Cyclophosphamide, DCs and Tregs: Collaborative relationships?  Blood. 2010;106:3082-3089

Matsushima, H., Takashima, A.  Bidirectional homing of Tregs between the skin and lymph nodes.  J Clin Invest. 2010 Mar;120(3):653-656.  doi: 10.1172/JC142280. Epub 2010 Feb 22.

Matsushima, H., Ogawa, Y., Miyazaki, T., Tanaka, H., Nishibu, A., Takashima, A.  Intravital imaging of IL-1beta production in skin.  J Invest Dermatol. 2010;130:1571-1580.

Mayuzumi, N., Matsushima, H., Takashima, A.  IL-33 promotes DC development in BM culture by triggering GM-CSF production.  Eur J Immunol. 2009 Dec;39(12):3331-3342.

Tanaka, H.*, Matsushima, H., Mizumoto, N., Takashima, A.  Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells.  Cancer Res. 2009;69:6978-6986.  *These authors contributed equally to this work.

Tanaka, H.*, Matsushima, H., Nishibu, A., Clausen, B.E., Takashima, A.  Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation.  Cancer Res. 2009;69:6987-6994.   *These authors contributed equally to this work.

Matsushima, H., Tanaka, H., Mizumoto, N., Takashima, A. Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells. Blood. 2009;114:64-73.

Nagasaka, A., Matsue, H., Matsushima, H., Aoki, R., Nakamura, Y., Kambe, N., Kon, S., Uede, and T., Shimada, S.  Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells.  Eur J Immunol. 2008;38:489-499.

Mizumoto, N., Tanaka, H., Matsushima, H., Vishwanath, M., and Takashima, A.  Colchicine promotes antigen cross-presentation by murine dendritic cells.  J. Invest Dermatol. 2007;127:1543-1546.

Ogawa, Y., N. Mizumoto, H. Tanaka, H. Matsushima, and A. Takashima. Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol. 2006 126:349-353.

Mizumoto, N., J. Gao, H. Matsushima, Y. Ogawa, H. Tanaka, and A. Takashima. Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood. 2005 106:3082-3089.

Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. J Immunol.  2004 173:531-541.

Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells. Eur J Immunol. 2004 34:1910-1919.

Yamada, N., H. Matsushima, Y. Tagaya, S. Shimada, and S. I. Katz. Generation of a large number of connective tissue type mast cells by culture of murine fetal skin cells. J Invest Dermatol. 2003 121:1425-1432.

Matsushima, H., S. Hayashi, and S. Shimada. Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice. J Dermatol Sci. 2003 32:223-230.

Hayashi, S., H. Matsushima, and S. Shimada. Injury to the skin induces p53- and Fas-dependent bystander keratinocyte apoptosis in vivo. Br J Dermatol. 2002 147:614-617.

Fukuhara, S., M. Shimizu, H. Matsushima, H. Mukai, and E. Munekata. Signaling pathways via NK1 receptors and their desensitization in an AR42J cell line. Peptides. 1998 19:1349-1357.




Last Updated: 6/9/16