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Research Assistant Professor
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Research interests: Dr. Matsushima is studying molecular mechanisms regulating the function of dendritic cells, which play crucial roles in the induction of both innate and adaptive immunity.
Education: Dr. Matsushima earned his Ph.D. in Medical Science in the Division of Human Ecology of Yamanashi Medical University, Yamanashi, Japan.
Publications:
Matsushima, H., Tanaka, H., Mizumoto, N., Takashima, A. Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells. Blood. 2009 Apr 28 [Epub ahead of print]. PMID: 19401559 [PubMed - as supplied by publisher].
Ogawa, Y., N. Mizumoto, H. Tanaka, H. Matsushima, and A. Takashima. Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol. 2006 126:349-353.
Mizumoto, N., J. Gao, H. Matsushima, Y. Ogawa, H. Tanaka, and A. Takashima. Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood. 2005 106:3082-3089.
Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. J Immunol. 2004 173:531-541.
Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells. Eur J Immunol. 2004 34:1910-1919.
Yamada, N., H. Matsushima, Y. Tagaya, S. Shimada, and S. I. Katz. Generation of a large number of connective tissue type mast cells by culture of murine fetal skin cells. J Invest Dermatol. 2003 121:1425-1432.
Matsushima, H., S. Hayashi, and S. Shimada. Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice. J Dermatol Sci. 2003 32:223-230.
Hayashi, S., H. Matsushima, and S. Shimada. Injury to the skin induces p53- and Fas-dependent bystander keratinocyte apoptosis in vivo. Br J Dermatol. 2002 147:614-617.
Fukuhara, S., M. Shimizu, H. Matsushima, H. Mukai, and E. Munekata. Signaling pathways via NK1 receptors and their desensitization in an AR42J cell line. Peptides. 1998 19:1349-1357.