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Research interests: Dr. Matsushima is studying molecular mechanisms regulating the function of dendritic
cells, which play crucial
roles in the induction of both innate and adaptive immunity.
Education: Dr. Matsushima earned his Ph.D. in Medical Science in the Division of Human Ecology
of Yamanashi Medical
University, Yamanashi, Japan.
Matsushima, H., and Takashima, A. Cyclophosphamide, DCs and Tregs: Collaborative relationships? Blood. 2010;106:3082-3089
Matsushima, H., Takashima, A. Bidirectional homing of Tregs between the skin and lymph nodes. J Clin Invest. 2010 Mar;120(3):653-656. doi: 10.1172/JC142280. Epub 2010 Feb 22.
Matsushima, H., Ogawa, Y., Miyazaki, T., Tanaka, H., Nishibu, A., Takashima, A. Intravital imaging of IL-1beta production in skin. J Invest Dermatol. 2010;130:1571-1580.
Mayuzumi, N., Matsushima, H., Takashima, A. IL-33 promotes DC development in BM culture by triggering GM-CSF production. Eur J Immunol. 2009 Dec;39(12):3331-3342.
Tanaka, H.*, Matsushima, H., Mizumoto, N., Takashima, A. Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells. Cancer Res. 2009;69:6978-6986. *These authors contributed equally to this work.
Tanaka, H.*, Matsushima, H., Nishibu, A., Clausen, B.E., Takashima, A. Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation. Cancer Res. 2009;69:6987-6994. *These authors contributed equally to this work.
Matsushima, H., Tanaka, H., Mizumoto, N., Takashima, A. Identification of crassin acetate as a new immunosuppressant triggering heme oxygenase-1 expression in dendritic cells. Blood. 2009;114:64-73.
Nagasaka, A., Matsue, H., Matsushima, H., Aoki, R., Nakamura, Y., Kambe, N., Kon, S., Uede, and T., Shimada, S. Osteopontin is produced by mast cells and affects IgE-mediated degranulation and migration of mast cells. Eur J Immunol. 2008;38:489-499.
Mizumoto, N., Tanaka, H., Matsushima, H., Vishwanath, M., and Takashima, A. Colchicine promotes antigen cross-presentation by murine dendritic cells. J. Invest Dermatol. 2007;127:1543-1546.
Ogawa, Y., N. Mizumoto, H. Tanaka, H. Matsushima, and A. Takashima. Identification of novel pharmacological activities of an antifungal agent, nystatin, to promote dendritic cell maturation. J Invest Dermatol. 2006 126:349-353.
Mizumoto, N., J. Gao, H. Matsushima, Y. Ogawa, H. Tanaka, and A. Takashima. Discovery of novel immunostimulants by dendritic-cell-based functional screening. Blood. 2005 106:3082-3089.
Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. TLR3-, TLR7-, and TLR9-mediated production of proinflammatory cytokines and chemokines from murine connective tissue type skin-derived mast cells but not from bone marrow-derived mast cells. J Immunol. 2004 173:531-541.
Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells. Eur J Immunol. 2004 34:1910-1919.
Yamada, N., H. Matsushima, Y. Tagaya, S. Shimada, and S. I. Katz. Generation of a large number of connective tissue type mast cells by culture of murine fetal skin cells. J Invest Dermatol. 2003 121:1425-1432.
Matsushima, H., S. Hayashi, and S. Shimada. Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice. J Dermatol Sci. 2003 32:223-230.
Hayashi, S., H. Matsushima, and S. Shimada. Injury to the skin induces p53- and Fas-dependent bystander keratinocyte apoptosis in vivo. Br J Dermatol. 2002 147:614-617.
Fukuhara, S., M. Shimizu, H. Matsushima, H. Mukai, and E. Munekata. Signaling pathways via NK1 receptors and their desensitization in an AR42J cell line. Peptides. 1998 19:1349-1357.