Department of Neurology

Faculty - Gretchen E. Tietjen, M.D.

Gretchen E. Tietjen, M.D.Professor 
Director of UTMC Headache Treatment and Research Program                                

SPECIAL INTERESTS

  • Cerebrovascular Diseases in the young
  • Migraine as a stroke risk factor
  • Endothelial Dysfunction in migraine
  • Thrombolytic therapy in stroke    

EDUCATION

M.D.: University of Michigan Medical School, 1980-84.
University of Freiburg, Freiburg, West Germany 1978-1979

Residency:  Department of Internal Medicine, Associated Hospitals Program, University of Rochester, Rochester, New York, 1984-86

Neurology Residency: Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, 1986-89 

Fellowship: Department of Neurology, Center for Stroke Research, Henry Ford Health System, Detroit, Michigan, 1989-1991

PROFESSIONAL APPOINTMENTS

Chair of Neurology Department, MCO/University of Toledo, 2000-present
Professor, Neurology Department MCO/University of Toledo, 2002-present
Associate Professor, Neurology Department, Medical College of Ohio (MCO), 1996-2001
Chief of Neurology, Department of Medicine, Medical College of Ohio, 1997-1999
Senior Staff, Henry Ford Health Sciences Center, Neurology, 1991-1996

CERTIFICATIONS

American Board of Psychiatry and Neurology: Neurology 1990
American Board of Psychiatry and Neurology: Vascular Neurology 2005
United Council for Neurologic subspecialties: Headache Medicine 2006

SOCIETY MEMBERSHIPS

American Academy of Neurology, 1988-present
    Executive Board Member, Section on Headache and Facial Pain, 2000-2005
    Member, Undergraduate Education Subcommittee, 2005-2007
American Neurological Association, 2006-present
    Member, Education Committee, 2008-2010
American Headache Society, 1995-present
    Chair, Clinical Action Team, 2008-2010
    Board Member, 2002-2008
    Chairman, Section on Women's Issues in Headache, 2001-2003
Director, Women's Issues Research Consortium, 2003-2007 
American Heart Association Stroke Council, 1990-present
    Toledo Area Board Member, 2004-present
Ohio Headache Association, 1997-present
    Executive Board Member, 1999-2011
    President, 2007-2009
    Past President, 2009-2011
United Council of Neurologic Subspecialties, 2009-present
    Vice Chair, Certification Council, 2009-2015 
Association of University Professors of Neurology, 1997-present
    Executive Board Member, 2003-2007
    Chair, Medical School Education Committee, 2003-2007
International Headache Society, 1993-present
    Strategic Planning Task Force, 2005-2006
Alliance for Headache Disorders Advocacy, Founding Board Member, 2009-present
Migraine Research Foundation, Medical Advisory Board, 2009-present 
 

AWARDS

University of Toledo College of Medicine and Life Sciences Career Achievement Award, 2018
Visiting Scholar, John R. Graham Headache Center, Brigham and Women's Faulkner Hospital, Harvard, 2017 
The American Headache Society John R. Graham Lecture Award 2017 
Listed in Best Doctors in America 1996 through 2015
Named Clair Martig Endowed Chair in Neurology, University of Toledo, 2014
Recipient of The UTMC Shining Star Award of the year (one of 3 awardees), for exemplifying the iCare standards, 2012
Stroke Gold Plus Performance Award, 2012
Honored as University of Toledo Distinguished Professor, 2012-2017
Harold G. Wolff Lecture Award for Headache Research, 2011
University of Toledo Outstanding Faculty Research Award, 2011
Alpha Omega Alpha Award, 2010
Stroke Innovation Award from the Journal Stroke, 2010
American Headache Society Women's Issues Pink Brain Research Award, 2010
American Headache Society Seymour Solomon Presidential Lecture recipient, 2008
Faculty Club Service Award, Medical College of Ohio, 2004
Dean's Award Excellence in Teaching, Medical College of Ohio, 2001
The Association of University Professors of Neurology Award for outstanding success in encouraging students to elect careers in Neurology, 2001
Hedwig von Ameringen Executive Leadership in Academic Medicine for Women Fellowship, 2000-2001


EDITORIAL

Editorial Board Member, Headache, 2001-present
Assistant Editor, Cephalalgia, 1993-1998
Ad Hoc Reviewer:  Neurology, Headache, Cephalagia, Stroke, Archives of Neurology, Journal of Stroke and Cerebrovascular Diseases, 
European Journal of Neurology, Archives of Internal Medicine, Journal of Clinical Outcomes Management, Journal of Neurological Sciences, British Medical Journal
 

NATIONAL REVIEW PANEL

National Institute of Neurological Disorders and Stroke, United States Department of Health and Human Services Performance and Safety monitoring Board, Division of Stroke and Trauma, Member, 1999-

REPRESENTATIVE PUBLICATIONS

Papers:

Anda R, Tietjen GE, Schulman E, Felitti V, Croft J. Adverse Childhood Experiences and Frequent Headaches in Adults. Headache 2010, in press.

Saper JR, Lake AE, Bain PA, Stillman MJ, Rothrock JF, Mathew NT, Hamel RL, Moriarty M, Tietjen GE. A Practice Guide for Continuous Opioid Therapy for Refractory Daily Headache: Patient Selection, Physician Requirements, and Treatment Monitoring. Headache. 2010 Jul;50(7):1175-1193.

Evans RW, Tepper SJ, Shapiro RE, Sun-Edelstein C, Tietjen GE. The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. Headache. 2010 Jun;50(6):1089-99.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part I). Prevalence and adult revictimization. A multicenter headache clinic survey.  Headache 2010;50:20-31.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part II). Emotional abuse as a risk factor for headache chronification. Headache 2010;50:32-41.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part III). Association with comorbid pain conditions.   Headache 2010;50:42-51.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Allodynia in Migraine: Association with comorbid pain conditions. Headache 2009 Oct;49(9):1333-44.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Heckman BD, Holroyd KA, Himawan L, O'Donnell FJ, Tietjen G, Utley C, Stillman M.  Do psychiatric comorbidities influence headache treatment outcomes? Results of a naturalistic longitudinal treatment study.  Pain. 2009 Nov;146(1-2):56-64.

Tietjen GE. Migraine as a Systemic Vasculopathy. Cephalalgia. 2009 Sep;29(9):987-96.

Tietjen GE, Khubchandani J. Platelet Dysfunction and Stroke in the Female Migraineur. Curr Pain Headache Rep. 2009 Oct;13(5):386-91.

Tietjen GE, Herial NA, Utley C, White L, Yerga-Woolwine S, Joe B. Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in Migraine. Cephalalgia. 2009 Sep;29(9):960-8.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Peterlin BL, Tietjen GE, Brandes JL, Rubin SM, Drexler E, Lidicker JR, Meng S. Posttraumatic stress disorder in migraine. Headache. 2009 Apr;49(4):541-51.

Heckman BD, Holroyd KA, Tietjen G, O'Donnell FJ, Himawan L, Utley C, Watakakosol R, Stillman M. Whites and African-Americans in headache specialty clinics respond equally well to treatment. Cephalalgia. 2009 Feb 2.

Heckman BD, Holroyd KA, O'Donnell FJ, Tietjen G, Utley C. Race Differences in Adherence to Headache Treatment Appointments in Persons with Headache Disorders. Journal of the National Medical Association. 2008 Feb;100(2):247-55.

Peterlin BL, Tietjen GE, Meng S, Lidicker JR, Bigal ME. Post-traumatic stress disorder in Episodic and Chronic Migraine. Headache 2008, 24: 517–522.

Tietjen GE, Migraine and Ischemic Heart Disease and Stroke: Potential mechanisms and treatment implications. Cephalalgia 2007, 27:981-987.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C, Khuder SA. History of childhood maltreatment is associated with comorbid depression in women with migraine. Neurology 2007, 69(10): 959-968.

Tietjen GE, Migraine as a systemic disorder. Neurology 2007, 68:1555-1556.

Tietjen GE, Bushnell C, Hafeez F, Herial NA, Utley C, White L. Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 2007, 47(7):1069-78.

Tietjen GE, Lee Peterlin B, Brandes JL, Hafeez F, Hutchinson S, Martin VT, Dafer RM, Aurora SK, Stein MR, Herial NA, Utley C, White L, Khuder SA. Depression and Anxiety: Effect on the Migraine-Obesity Relationship. Headache 2007, 47(6):866-875.

Tietjen GE, Herial NA, Hardgrove J, Utley C, White L. Migraine Comorbidity Constellations. Headache 2007, 47(6):857-865.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C. High Prevalence of Somatic Symptoms and Depression in Women with Disabling and Chronic Headache. Neurology, 2007, 68:134-140.

Tietjen GE, Conway A, Utley C, Herial NA. Migraine is associated with Menorrhagia and Endometriosis. Headache 2006, 46:422-428.

Tietjen GE, Al-Qasmi MM, Gunda P, Herial NA. Sneddon’s syndrome: another migraine-stroke association? Cephalagia October 2005, doi: 10.1111/j.1468-2982.2005.01032.x

Tietjen GE. The Risk of stroke in patients with Migraine and implications for migraine management. CNS Drugs 2005, 19:683-692.

Tietjen GE, Athanas K, Utley C, Herial N, Khuder S. The Combination of Naratriptan and Prochlorperazine in Migraine Treatment. Headache 2005, 45:751-762. 

Tietjen GE, Gottwald L, Al-Qasmi MM, Gunda P, Khuder S.  Migraine is associated with livedo reticularis: a prospective study.  Headache 2002; 42:263-267. 

Tietjen GE, Al-Qasmi M, Shukair MS.  Livedo reticularis and migraine: a marker for stroke risk?  Headache 2002; 42:352-355.

Tietjen GE, Al-Qasmi MM, Athanas K, Dafer RM, Khuder SA.  Increased von Willebrand factor in migraine.  Neurology 2001;57:334-36.

Tietjen GE. The Relationship of Migraine and Stroke. Neuroepidemiology 2000;19:13-19.

Tietjen GE, Day M, Norris L, Aurora S, Halvorsen A, Schultz LR, Levine SR: Role of anticardiolipin antibodies in young persons with migraine and transient focal neurological events.   A prospective study.  Neurology 1998; 50:1433-1440.

Peer Reviewed:

Karmakar M, Elhai JD, Amialchuk AA, Tietjen GE. Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset. Headache. 2018; 58:243-259.

Slawski DE, Jumaa MA, Salahuddin H, Shawver J, Humayun MJ, Russell T, Seiwert A, Paolini D, Abbas J, Nazzal M, Tietjen GE, Espinosa-Morales A, Korsnack A, Zaidi SF. Emergent carotid endarterectomy versus stenting in acute stroke patients with tandem occlusion. J Vasc Surg. 2018 May 19. pii: S0741-5214(18)30277-5.

Slawski DE, Salahuddin H, Shawver J, Kenmuir CL, Tietjen GE, Korsnack A, Zaidi SF, Jumaa MA. Mechanical Thrombectomy in Elderly Stroke Patients with Mild-to-Moderate Baseline Disability. Interv Neurol. 2018 Apr;7(5):246-255.

Salahuddin H, Espinosa A, Buehler M, Khuder SA, Khan AR, Tietjen G, Zaidi S, Jumaa MA. Mechanical thrombectomy for middle cerebral artery division occlusions: a systematic review and meta-analysis. Interv Neurol. 2017 Oct;6(3-4):242-253

Salahuddin H, Tietjen G, Jumaa M, Zaidi SF. Ischemic stroke due to retrograde thromboembolism during arteriovenous graft thrombectomy. J Vasc Access. 2018 Mar;19(2):201-202.

Tietjen GE, Khubchandani J, Herial N, Palm-Meinders, Koppen Hille, Terwindt G, van Buchem MA, Launer LJ, Ferrari MD, Kruit MC. Migraine and Vascular Disease Biomarkers:  A population-based case-control study. Cephalalgia.  2018 Mar;38(3):511-518.

Tietjen GE, Collins SA. Hypercoagulability and Migraine. Headache. 2017 Feb 9. doi: 10.1111/head.13044.

Tietjen GE, Karmakar M, Amialchuk AA. Emotional Abuse History and Migraine Among Young Adults: A Retrospective Cross-Sectional Analysis of the Add Health Dataset. Headache 2017 Jan;57(1):45-59.

Tietjen GE, Buse DC, Collins SA. Childhood Maltreatment in the Migraine Patient. Curr Treat Options Neurol. 2016 Jul;18(7):31. doi: 10.1007/s11940-016-0415-4. Review.

Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G, Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. Stroke care: initial data from a county-based bypass protocol for patients with acute stroke. J Neurointerv Surg. 2016 Jun 24. pii: neurintsurg-2016-012476. doi: 10.1136/neurintsurg-2016-012476

Tietjen GE. Childhood Maltreatment and Headache Disorders. Curr Pain Headache Rep. 2016 Apr;20(4):26.

Peterlin BL, Mielke MM, Dickens AM, Subroto C, Dash P, Alexander G, Vieira RV, Bandaru VVR, Dorskind JM, Tietjen GE, Haughey NH. Interictal, Circulating Sphingolipids in Women with Episodic Migraine: A Case-Control Study. Neurology 2015;85(14):1214-23.

Chai NC, Gelaye B, Tietjen GE, Dash PD, Gower BA, White LW, Ward TN, Scher AI, Peterlin BL. Ictal adipokines are associated with pain severity and treatment response in episodic migraine. Neurology 2015; 84:1409-18.

Tietjen GE, Buse DC, Fanning KM, Serrano D, Reed ML, Lipton RB. Recall of Maltreatment in Adults with Migraine and Tension-Type Headache: Results of the AMPP Study. Neurology 2015;84:132-40.

Tietjen GE, Khubchandani J. Vacular Biomarkers in Migraine. Cephalalgia 2015;35(2):95-117.

Peterlin BL, Tietjen GE, Gower BA, Ward TN, Tepper SJ, White LW, Dash PD, Hammond ER, Haythornthwaite JA. Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial. Headache. 2013 Mar;53(3):474-90 

Tietjen GE, Khubchandani J, Ghosh S, Bhattacharjee S, Kleinfelder J. Headache symptoms and indoor environmental parameters: results from the EPA BASE study. Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S95-9.

Tietjen GE. Office assessment for abuse and management of the battered patient. Neurol Clin Pract March 2012 2:5-13

Tietjen GE, Khubchandani J, Herial NA, Shah K. Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers. Headache 2012;52:920-929

Nicholas-Bublick S, Irlam JH, Tietjen G. A malignant case of acute promyelocytic leukemia with occlusion of carotid artery by tumor thrombus. J Stroke Cerebrovasc Dis. 2012 May;21(4):325-6

Non Peer Reviewed:

Tietjen GE. Migraine, Stroke, and Heart Disease. American Migraine Foundation Spotlight series. July 14, 2016. https://americanmigrainefoundation.org/migraine-stroke-and-heart-disease

Tietjen GE,  Sacco S. Migraine makes the stroke grow faster. [editorial] Neurology 2015,;85(22):1920-1.

Tietjen GE, Rundek R. Migraine and cryptogenic stroke: The clot thickens.[editorial] Neurology 2015, 85(17):1436-7.

Tietjen GE. Circulating microparticles in migraine with aura: cause or consequence, a link to stroke.[editorial] Cephalalgia. 2015;35(2):85-7

Tietjen GE, Karmakar M. Why emotional abuse in childhood may lead to migraines in adulthood. The Conversation. July 11, 2014. https://theconversation.com/why-emotional-abuse-in-childhood-may-lead-to-migraines-in-adulthood-59226

Tepper SJ, Shapiro RE, Sun-Edelstein C, Evans RW, Tietjen GE. Triptans and Serotonin Syndrome. A response [letter] Headache. 2012 Jul;52(7):1185-1188

Book Chapters:

Tietjen GE. CADASIL. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017. ISBN 9780128093245

Tietjen GE, Faedda N. Child Abuse and Headache in Children and Adolescents. In: Headache and Comorbidities in Childhood and Adolescence. Guidetti V, Arruda M, Ozge A (eds). Springer International Publishing AG, Cham. 2017: In press.

Tietjen GE. CADASIL. In: Encyclopedia of the Neurological Sciences 2nd edition. Aminoff MJ, Daroff RB (Eds). Academic Press. San Diego. 2014

Ramsey-Williams V, Tietjen GE. Antiphospholipid Antibody syndrome, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011:66-67

Ramsey-Williams V, Tietjen GE. Systemic Lupus Erythematosus, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011: 402-403.

Abstracts:

Karmakar M, Amialchuk A, Tietjen G. Association of 30 year Cardiovascular Disease Risk with Migraine Diagnosis and Childhood Abuse in Young Adults - Findings from the Add Health study. Cephalalgia 2017;37 (IS) OC-EP-003:6.  

Karmakar M, Elhai J, Amialchuk A, Tietjen G. Do Personality Traits mediate the relationship between Childhood abuse and Migraine? An Exploration of the Relationships in Young Adults using the Add Health Dataset. Headache 2017;57 (Supplement S3) PS12:186 

Collins SA, Tietjen G. Early life stress increases photophobia in female rats. Headache 2017;57 (Supplement S3) PS74:221

Tietjen G, Karmarkar M, Amialchuk A. 5-HTTLPR Gene Polymorphism predicts migraine in non-hispanic white male adults—results from the Add Health Dataset. Headache 2017;57 (Supplement S3) PF 18:144.

Collins SA, Tietjen GE. Early life stress increases susceptibility to cortical spreading depression and anxiety in rodents. Headache 2016. Late breaking abstract.

Tietjen GE, Karmakar M. CRP and Migraine in Young Adults. Results from the Add Health study. Headache 2016. Late breaking abstract.

Tietjen GE, Karmakar M, Amialchuk A. Emotional Abuse History and Migraine among Young Adults. Results from the Add Health Dataset. Neurology 2016;86 (16 Supplement): S26.003 and I15.010

Tietjen GE, Karmakar M, Elhai JD, Amialchuk A. Exploring the Effect of Childhood Abuse on Migraine, Depression and Anxiety Using Structural Equation Modeling. Neurology 2016;86 (16 Supplement): P2.27

Salahuddin H, Jumaa M, Tietjen G, Zaidi S. Retrograde Thromboembolism to Basilar Artery during Arteriovenous Graft Thrombectomy. Neurology 2016;86 (16 Supplement): P4.353

Salahuddin H, Hussaini S, Sheikh A, Tietjen G. Ischemic Stroke After Plasma Donation. Neurology 2016;86 (16 Supplement): P4.365

Tietjen GE, Khubchandani J. Effect of depression and headache on cardiovascular diseases. Presented at the 56th Annual Scientific Meeting of the American Headache Society. June 27-29, 2014. Los Angeles, CA.

Tietjen GE, Khubchandani J. Depression has an additive effect on headache-associated pain comorbidities. Presented at the 56th Annual Scientific Meeting of the American Headache Society. June 27-29, 2014. Los Angeles, CA.

Tietjen GE, Batizy L, Herial N, White L, Utley C. Depression Diagnosis is associated with heightened risk of other Psychiatric Disorders and of Suicide in Female Migraineurs screened with the M.I.N.I  International Neuropsychiatric Interview. Presented at the 56th Annual Scientific Meeting of the American Headache Society. June 27-29, 2014. Los Angeles, CA.

Chai CN, Gelaye B, Tietjen GE, Dash PD, Gower BA, White LW, Ward TN, Scher AI, Williams MA, Peterlin BL. Ictal Adiponectin Levels are Modulated by Pain Severity and Treatment Response in Episodic Migraineurs. Presented at the 4th European Headache and Migraine Trust International Congress. September, 2014. Copenhagen, Denmark.

Tietjen GE, Thotakura S, Singh J, Utley C, Ramsey-Williams V, Khubchandani J, Khuder S. Headache Prevention with Cranial Electrotherapy Stimulation in Chronic Migraine.  A randomized controlled trial. Headache 2013; late breaking poster, presented at the International Headache Congress, Boston, June 2013.

Tietjen GE, Buse DC, Fanning KM, Serrano D, Reed ML, Lipton RB. The Relationship of Childhood Maltreatment with Migraine and Tension-Type Headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache May 2012, 52 (5): p910 

Tietjen GE, Ghosh S, Bhattacharjee S, Khubchandani J, Kleinfelder J. Association of migraine and headache frequency with indoor environmental parameters in US workers: The EPA BASE study. Headache 2011, 51(S1):26-27

In Press:

Tietjen GE. CADASIL. In: Encyclopedia of the Neurological Sciences 2nd edition. Aminoff MJ, Daroff RB (eds). Academic Press. San Diego. 2012;

Tietjen GE, Khubchandani J, Ghosh S, Bhattacharjee S, Kleinfelder J. Headache symptoms and indoor environmental parameters: results from the EPA BASE study. Ann Indian Acad Neurol 2012;15: 

Last Updated: 9/3/19