Faculty - Gretchen E. Tietjen, M.D.

Professor and Chair of Neurology
Director of UTMC Headache Treatment and Research Program                               
Director of the UTMC Stroke Program

 


SPECIAL INTERESTS

Cerebrovascular Diseases in the young
Migraine as a stroke risk factor
Endothelial Dysfunction in migraine
Thrombolytic therapy in stroke

Board Certified in Neurology, Vascular Neurologist, Headache Medicine        

Gretchen Tietjen MD

EDUCATION

Undergraduate:
University of Michigan, 1974-1978, B.S.

M.D.:
University of Michigan Medical School, 1980-84.
University of Freiburg, Freiburg, West Germany 1978-1979

Medicine Residency:
Department of Internal Medicine, Associated Hospitals Program, University of Rochester, Rochester, New York, 1984-86

Neurology Residency:
Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, 1986-89 

Fellowship:
Department of Neurology, Center for Stroke Research, Henry Ford Health System, Detroit, Michigan, 1989-1991

PROFESSIONAL APPOINTMENTS

Chair of Neurology Department, MCO/University of Toledo, 2000-present
Professor, Neurology Department MCO/University of Toledo, 2002-present
Associate Professor, Neurology Department, Medical College of Ohio (MCO), 1996-2001
Chief of Neurology, Department of Medicine, Medical College of Ohio, 1997-1999
Senior Staff, Henry Ford Health Sciences Center, Neurology, 1991-1996

CERTIFICATIONS

American Board of Psychiatry and Neurology: Neurology 1990
American Board of Psychiatry and Neurology: Vascular Neurology 2005
United Council for Neurologic subspecialties: Headache Medicine 2006

SOCIETY MEMBERSHIPS

American Academy of Neurology, 1988-present
    Executive Board Member, Section on Headache and Facial Pain, 2000-2005
    Member, Undergraduate Education Subcommittee, 2005-2007
American Neurological Association, 2006-present
    Member, Education Committee, 2008-2010
American Headache Society, 1995-present
    Chair, Clinical Action Team, 2008-2010
    Board Member, 2002-2008
    Chairman, Section on Women's Issues in Headache, 2001-2003
Director, Women's Issues Research Consortium, 2003-2007 
American Heart Association Stroke Council, 1990-present
    Toledo Area Board Member, 2004-present
Ohio Headache Association, 1997-present
    Executive Board Member, 1999-2011
    President, 2007-2009
    Past President, 2009-2011
United Council of Neurologic Subspecialties, 2009-present
    Vice Chair, Certification Council, 2009-2015 
Association of University Professors of Neurology, 1997-present
    Executive Board Member, 2003-2007
    Chair, Medical School Education Committee, 2003-2007
International Headache Society, 1993-present
    Strategic Planning Task Force, 2005-2006
Alliance for Headache Disorders Advocacy, Founding Board Member, 2009-present
Migraine Research Foundation, Medical Advisory Board, 2009-present 
 
AWARDS
 
Listed in Best Doctors in America 1996 through 2014
Named Clair Martig Endowed Chair in Neurology, University of Toledo, 2014
Recipient of The UTMC Shining Star Award of the year (one of 3 awardees), for exemplifying the iCare standards, 2012
Stroke Gold Plus Performance Award, 2012
Honored as University of Toledo Distinguished Professor, 2012-2017
Harold G. Wolff Lecture Award for Headache Research, 2011
University of Toledo Outstanding Faculty Research Award, 2011
Alpha Omega Alpha Award, 2010
Stroke Innovation Award from the Journal Stroke, 2010
American Headache Society Women's Issues Pink Brain Research Award, 2010
American Headache Society Seymour Solomon Presidential Lecture recipient, 2008
Faculty Club Service Award, Medical College of Ohio, 2004
Dean's Award Excellence in Teaching, Medical College of Ohio, 2001
The Association of University Professors of Neurology Award for outstanding success in encouraging students to elect careers in Neurology, 2001
Hedwig von Ameringen Executive Leadership in Academic Medicine for Women Fellowship, 2000-2001

EDITORIAL
 
Editorial Board Member, Headache, 2001-present
Assistant Editor, Cephalalgia, 1993-1998
Ad Hoc Reviewer:  Neurology, Headache, Cephalagia, Stroke, Archives of Neurology, Journal of Stroke and Cerebrovascular Diseases, 
European Journal of Neurology, Archives of Internal Medicine, Journal of Clinical Outcomes Management, Journal of Neurological Sciences, British Medical Journal
 
NATIONAL REVIEW PANEL

National Institute of Neurological Disorders and Stroke, United States Department of Health and Human Services Performance and Safety monitoring Board, Division of Stroke and Trauma, Member, 1999-
 
REPRESENTATIVE PUBLICATIONS

Papers:

Anda R, Tietjen GE, Schulman E, Felitti V, Croft J. Adverse Childhood Experiences and Frequent Headaches in Adults. Headache 2010, in press.

Saper JR, Lake AE, Bain PA, Stillman MJ, Rothrock JF, Mathew NT, Hamel RL, Moriarty M, Tietjen GE. A Practice Guide for Continuous Opioid Therapy for Refractory Daily Headache: Patient Selection, Physician Requirements, and Treatment Monitoring. Headache. 2010 Jul;50(7):1175-1193.

Evans RW, Tepper SJ, Shapiro RE, Sun-Edelstein C, Tietjen GE. The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. Headache. 2010 Jun;50(6):1089-99.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part I). Prevalence and adult revictimization. A multicenter headache clinic survey.  Headache 2010;50:20-31.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part II). Emotional abuse as a risk factor for headache chronification. Headache 2010;50:32-41.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part III). Association with comorbid pain conditions.   Headache 2010;50:42-51.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Allodynia in Migraine: Association with comorbid pain conditions. Headache 2009 Oct;49(9):1333-44.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Heckman BD, Holroyd KA, Himawan L, O'Donnell FJ, Tietjen G, Utley C, Stillman M.  Do psychiatric comorbidities influence headache treatment outcomes? Results of a naturalistic longitudinal treatment study.  Pain. 2009 Nov;146(1-2):56-64.

Tietjen GE. Migraine as a Systemic Vasculopathy. Cephalalgia. 2009 Sep;29(9):987-96.

Tietjen GE, Khubchandani J. Platelet Dysfunction and Stroke in the Female Migraineur. Curr Pain Headache Rep. 2009 Oct;13(5):386-91.

Tietjen GE, Herial NA, Utley C, White L, Yerga-Woolwine S, Joe B. Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in Migraine. Cephalalgia. 2009 Sep;29(9):960-8.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Peterlin BL, Tietjen GE, Brandes JL, Rubin SM, Drexler E, Lidicker JR, Meng S. Posttraumatic stress disorder in migraine. Headache. 2009 Apr;49(4):541-51.

Heckman BD, Holroyd KA, Tietjen G, O'Donnell FJ, Himawan L, Utley C, Watakakosol R, Stillman M. Whites and African-Americans in headache specialty clinics respond equally well to treatment. Cephalalgia. 2009 Feb 2.

Heckman BD, Holroyd KA, O'Donnell FJ, Tietjen G, Utley C. Race Differences in Adherence to Headache Treatment Appointments in Persons with Headache Disorders. Journal of the National Medical Association. 2008 Feb;100(2):247-55.

Peterlin BL, Tietjen GE, Meng S, Lidicker JR, Bigal ME. Post-traumatic stress disorder in Episodic and Chronic Migraine. Headache 2008, 24: 517–522.

Tietjen GE, Migraine and Ischemic Heart Disease and Stroke: Potential mechanisms and treatment implications. Cephalalgia 2007, 27:981-987.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C, Khuder SA. History of childhood maltreatment is associated with comorbid depression in women with migraine. Neurology 2007, 69(10): 959-968.

Tietjen GE, Migraine as a systemic disorder. Neurology 2007, 68:1555-1556.

Tietjen GE, Bushnell C, Hafeez F, Herial NA, Utley C, White L. Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 2007, 47(7):1069-78.

Tietjen GE, Lee Peterlin B, Brandes JL, Hafeez F, Hutchinson S, Martin VT, Dafer RM, Aurora SK, Stein MR, Herial NA, Utley C, White L, Khuder SA. Depression and Anxiety: Effect on the Migraine-Obesity Relationship. Headache 2007, 47(6):866-875.

Tietjen GE, Herial NA, Hardgrove J, Utley C, White L. Migraine Comorbidity Constellations. Headache 2007, 47(6):857-865.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C. High Prevalence of Somatic Symptoms and Depression in Women with Disabling and Chronic Headache. Neurology, 2007, 68:134-140.

Tietjen GE, Conway A, Utley C, Herial NA. Migraine is associated with Menorrhagia and Endometriosis. Headache 2006, 46:422-428.

Tietjen GE, Al-Qasmi MM, Gunda P, Herial NA. Sneddon’s syndrome: another migraine-stroke association? Cephalagia October 2005, doi: 10.1111/j.1468-2982.2005.01032.x

Tietjen GE. The Risk of stroke in patients with Migraine and implications for migraine management. CNS Drugs 2005, 19:683-692.

Tietjen GE, Athanas K, Utley C, Herial N, Khuder S. The Combination of Naratriptan and Prochlorperazine in Migraine Treatment. Headache 2005, 45:751-762. 

Tietjen GE, Gottwald L, Al-Qasmi MM, Gunda P, Khuder S.  Migraine is associated with livedo reticularis: a prospective study.  Headache 2002; 42:263-267. 

Tietjen GE, Al-Qasmi M, Shukair MS.  Livedo reticularis and migraine: a marker for stroke risk?  Headache 2002; 42:352-355.

Tietjen GE, Al-Qasmi MM, Athanas K, Dafer RM, Khuder SA.  Increased von Willebrand factor in migraine.  Neurology 2001;57:334-36.

Tietjen GE. The Relationship of Migraine and Stroke. Neuroepidemiology 2000;19:13-19.

Tietjen GE, Day M, Norris L, Aurora S, Halvorsen A, Schultz LR, Levine SR: Role of anticardiolipin antibodies in young persons with migraine and transient focal neurological events.   A prospective study.  Neurology 1998; 50:1433-1440.

Peer Reviewed:

Peterlin BL, Tietjen GE, Gower BA, Ward TN, Tepper SJ, White LW, Dash PD, Hammond ER, Haythornthwaite JA. Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial. Headache. 2013 Mar;53(3):474-90 

Tietjen GE, Khubchandani J, Ghosh S, Bhattacharjee S, Kleinfelder J. Headache symptoms and indoor environmental parameters: results from the EPA BASE study. Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S95-9.

Tietjen GE. Office assessment for abuse and management of the battered patient. Neurol Clin Pract March 2012 2:5-13

Tietjen GE, Khubchandani J, Herial NA, Shah K. Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers. Headache 2012;52:920-929

Nicholas-Bublick S, Irlam JH, Tietjen G. A malignant case of acute promyelocytic leukemia with occlusion of carotid artery by tumor thrombus. J Stroke Cerebrovasc Dis. 2012 May;21(4):325-6

Non Peer Reviewed:

Tepper SJ, Shapiro RE, Sun-Edelstein C, Evans RW, Tietjen GE. Triptans and Serotonin Syndrome. A response [letter] Headache. 2012 Jul;52(7):1185-1188

Book Chapters:

Ramsey-Williams V, Tietjen GE. Antiphospholipid Antibody syndrome, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011:66-67

Ramsey-Williams V, Tietjen GE. Systemic Lupus Erythematosus, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011: 402-403.

Abstracts:

Tietjen GE, Thotakura S, Singh J, Utley C, Ramsey-Williams V, Khubchandani J, Khuder S. Headache Prevention with Cranial                           Electrotherapy Stimulation in Chronic Migraine.  A randomized controlled trial. Headache 2013; late breaking poster, presented at the International Headache Congress, Boston, June 2013.

Tietjen GE, Buse DC, Fanning KM, Serrano D, Reed ML, Lipton RB. The Relationship of Childhood Maltreatment with Migraine and Tension-Type Headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache May 2012, 52 (5): p910 

Tietjen GE, Ghosh S, Bhattacharjee S, Khubchandani J, Kleinfelder J. Association of migraine and headache frequency with indoor environmental parameters in US workers: The EPA BASE study. Headache 2011, 51(S1):26-27

In Press:

Tietjen GE. CADASIL. In: Encyclopedia of the Neurological Sciences 2nd edition. Aminoff MJ, Daroff RB (eds). Academic Press. San Diego. 2012;

Tietjen GE, Khubchandani J, Ghosh S, Bhattacharjee S, Kleinfelder J. Headache symptoms and indoor environmental parameters: results from the EPA BASE study. Ann Indian Acad Neurol 2012;15: 

Last Updated: 6/26/15