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Faculty Research

 

Liu

Song-Tao Liu

Associate Professor 
Office:        WO 4254
Phone No:   419-530-7853
Email:         song-tao.liu@utoledo.edu

B.Sc., Wuhan University                                                                Ph.D. Shanghai Institute of Biochemistry, Chinese Academy of Sciences                                                                                       Postdoc, Fox Chase Cancer Center

Lab Website

Research Overview:     
       Over 90% of solid tumors are aneuploid. The long-term goal of our research is to understand and control aneuploidy and chromosomal instability in cancers. To that end, we have been investigating both subcellular structures (the centromere/kinetochore complex) and regulatory mechanisms (the mitotic checkpoint) involved in chromosome segregation during cell division (mitosis). As recent results suggested that aneuploid cancer cells acquire additional genetic or epigenetic alterations to survive and proliferate, we also aim to identify recurring modifications in aneuploid cancer genomes and test whether they can be used for cancer prognosis and treatment.
        Even though many cancer "signature" genes have been proposed, the biological functions of some “signature” genes remain obscure. We currently focus on characterizing certain chromosomal instability (CIN) signature genes in breast cancers. During the process, we have realized the limitations of regular 2D cell culture therefore are incorporating different 3D cell culture systems and animal models into our research.
        Inquiries to join the lab as undergraduate, graduate or postdoctoral researchers are always welcome. Lab visits can also be arranged for K-12 students, parents and teachers or anyone who is interested in our work. Please see our Lab Website for more information. The lab has been financially supported by the University of Toledo, deArce Memorial Fund, Ohio Cancer Research Associates, Ohio Board of Regents, National Science Foundation (NSF) and National Institutes of Health (NIH).
Current Students
Undergraduate
Zachary Douglas
Simran Marwah
Julia Mendiola
Jana Choberka
Chad Burkholder
Stephen Millner
 
Graduate 
Wenbin Ji
Christopher Arnst
Sreemita Majumdar
Jenna Labelle
Ritu Verma
Postdoctoral
Dr. Ejaz Ahmad
Dr. Michael Moenk
Dr. Yibo Luo
 
Current Laboratory Grants

5/1/2014-4/30/2018 NCI R01CA169500, PI,  TRIP13 AAA-ATPase overexpression in chromosomal instability and breast cancer

5/1/2016-4/30/2018 Administration Supplement to R01CA169500, “Research Supplement to Promote Re-Entry into Biomedical and Behavioral Research Careers” (PA-15-321), funding Dr. Michael Moenk’s career development in the lab

Publications: (*graduate student; **undergraduate student; Bold Type-lab members) 

1. Liu, S.T. and *Zhang, H. (2016) The mitotic checkpoint complex (MCC): looking back and forth after 15 years.  AIMS Molecular Science, 3(4): 597-634. Review for a special issue on Cell Signaling and Signal Transduction. doi: 10.3934/molsci.2016.4.597 [link]

2. *Ji, W., *Arnst, C.A., *Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple mitotic kinases. PLOS ONE. PMID: 27082996. [link] 

3. Eytan, E., *Wang, K., Miniowitz-Shemtov, S., Sitry-Shevah, D., Kaisari, S., Yen, T.J., Liu, S.T. and Hershko, A. (2014) Disassembly of mitotic checkpoint complexes by the joint action of the AAA ATPase TRIP13 and p31comet. Proceedings of National Academy of Sciences USA. PMID: 25092294. [link]

4. *Wang, K., Sturt-Gillespie, B., Hittle, J.C., Macdonald, D., Chan, G.K., Yen, T. J. and Liu, S.T. (2014) Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase is a Novel Mitotic Checkpoint Silencing Protein. Journal of Biological Chemistry. 288(49):35149-58. PMID: 24151075. [link]

5. Liu, S.T. (2014) Kinetochore: Strucuture, Function and Evolution (version 2.0), In: Encyclopedia of Life Sciences (ELS). http://www.els.net/WileyCDA/ [DOI: 10.1002/9780470015902.a0006237.pub2]. Review.

6. Ma, J., Zhang, L., *Tipton, A.R, Wu, J., Messmer-Blust, A., Philbrick, M., Qi, Y., Liu, S.T., Liu, H., Li, J. and Guo, S. (2014) Structural and Functional Analysis of the Related Transcriptional Enhancer Factor-1 (RTEF-1) and Nuclear Factor Kappa B (NF-κB) Interaction. American Journal of Physiology-Heart and Circulatory Physiology. 306(2):H233-42. PMID: 24213609 [link]

7. *Tipton, A.R., *Ji, W., Sturt-Gillespie, B., Bekier, M. E. 2nd, *Wang, K., Taylor, W. R. and Liu, S.T. (2013) Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex.   Journal of Biological Chemistry. 288(49):35149-58. PMID: 24151075. [link]

8. *Tipton, A.R., *Wang, K., **Oladimeji, P., **Sufi, S., Gu, Z. and Liu, S. T. (2012) Identification of novel mitosis regulators through data-mining with human centromere/kinetochore proteins as group queries. BMC Cell Biology. 2012, 13:15. PMID:22712476; PMCID: PMC3419070. [link] (Editor’s Picks)(Highly Accessed) (2012 June Image Highlight) (among MOST VIEWED list)

9. *Tipton, A.R., **Tipton, M., Yen, T. J. and Liu, S.T. (2011) Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle. 10(21): 3740-50. PMID: 22037211. [link]

10. *Tipton, A.R., *Wang, K., **Link, L., Bellizzi, J.J., Huang, H. Yen, T. J. and Liu, S.T. (2011) BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional Mitotic Checkpoint Complex (MCC). Journal of Biological Chemistry. 286(24):21173-9. PMID: 21525009; PMCID: PMC3122179. [link]

11. Bazeley, P.S., Nestor-Kalinoski, A.L., Ways, J., Liu, S.T., Ramdath, R.S., Matsui, S. and Allison, D.C. (2011) A Model for Random Genetic Damage Directing the Selection of Diploid or Aneuploid Tumors. Cell Proliferation, 44(3):212-23.

12. Liu, S.T., Allison, D.C., and Nestor-Kalinoski, A. L. (2010) Chromosomes during Cell Division, In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd. Chichester. DOI: 10.1002/9780470015902.a0005770.pub2. Review.  

13. Liu, S.T. and Yen, T. J. (2008) The kinetochore as target for cancer drug development. In “The Kinetochore: from Molecular Discoveries to Cancer Therapy" (Eds. De Wulf P., and Earnshaw W.C.). Springer Publ. New York. Book Chapter. Review.

Last Updated: 11/1/16