Dr. Song-Tao Liu's Research
Over 90% of solid tumors are aneuploid. The long term goal of our research is to understand and exploit aneuploidy in cancers. To that end, we have been investigating both subcellular structures (the centromere/kinetochore complex) and regulatory mechanisms (the mitotic checkpoint) involved in chromosome segregation. In addition, as recent results have found that aneuploid cancer cells require genetic or epigenetic alterations to survive and proliferate, we also aim to identify recurring modifications in aneuploid cancer genomes and test whether they can be used for aneuploid cancer prognosis and treatment.
Even though many cancer "signature" genes have been proposed, the biological functions of some of them remain unclear. We currently focus on characterizing certain chromosomal instability (CIN) signature genes in breast cancers. We have realized the limitations of regular 2D cell culture in studying cancer so are incorporating different 3D cell culture systems and animal models into our research.
Dr. Ejaz Ahmad
Dr. Michael Moenk
Dr. Yibo Luo
5/1/2014-4/30/2018 NCI R01CA169500, PI, TRIP13 AAA-ATPase overexpression in chromosomal
instability and breast cancer
5/1/2016-4/30/2018 Administration Supplement to R01CA169500, “Research Supplement to Promote Re-Entry into Biomedical and Behavioral Research Careers” (PA-15-321), funding Dr. Michael Moenk’s career development in the lab
With UT as Affiliation (*graduate student; **undergraduate student)
*Ji, W., *Arnst, C.A., *Tipton, A.R., Bekier, M.E. 2nd, Taylor, W. R., Yen, T.J. and
Liu, S.T. (2016) OTSSP167 abrogates mitotic checkpoint through inhibiting multiple
mitotic kinases. PLOS ONE. PMID: 27082996. [link]
Eytan, E., *Wang, K., Miniowitz-Shemtov, S., Sitry-Shevah, D., Kaisari, S., Yen, T.J., Liu, S.T. and Hershko, A. (2014) Disassembly of mitotic checkpoint complexes by the joint action of the AAA ATPase TRIP13 and p31comet. Proceedings of National Academy of Sciences USA. PMID: 25092294. [link]
*Wang, K., Sturt-Gillespie, B., Hittle, J.C., Macdonald, D., Chan, G.K., Yen, T. J. and Liu, S.T. (2014) Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase is a Novel Mitotic Checkpoint Silencing Protein. Journal of Biological Chemistry. 288(49):35149-58. PMID: 24151075. [link]
Liu, S.T. (2014) Kinetochore Strucuture, Function and Evolution (version 2.0), In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd. Chichester. invited review.
Ma, J. , Zhang, L., *Tipton, A.R, Wu, J., Messmer-Blust, A., Philbrick, M., Qi, Y., Liu, S.T., Liu, H., Li, J. and Guo, S. (2013) Structural and Functional Analysis of the Related Transcriptional Enhancer Factor-1 (RTEF-1) and Nuclear Factor Kappa B (NF-κB) Interaction.American Journal of Physiology-Heart and Circulatory Physiology. 2013 Nov 8. [Epub ahead of print]. PMID: 2421360
*Tipton, A.R., *Ji, W., Sturt-Gillespie, B., Bekier, M. E. 2nd, *Wang, K., Taylor, W. R. and Liu, S.T. (2013) Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex.Journal of Biological Chemistry. 288(49):35149-58. PMID: 24151075
*Tipton, A.R., *Wang, K., **Oladimeji, P., **Sufi, S., Gu, Z. and Liu, S. T. (2012) Identification of novel mitosis regulators through data-mining with human
centromere/kinetochore proteins as group queries. BMC Cell Biology. 2012, 13:15. [link]
*Tipton, A.R., **Tipton, M., Yen, T. J., Liu, S.T. (2011)Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell Cycle. 10(21): 3740-50. PMID: 22037211. [Abstract].
*Tipton, A.R., *Wang, K., **Link, L., Bellizzi, J.J., Huang, H. Yen, T. J. and Liu, S.T. (2011) BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional Mitotic Checkpoint Complex (MCC). Journal of Biological Chemistry. 286(24):21173-9. PMID: 21525009; PMCID: PMC3122179. [Abstract].
Bazeley, P.S., Nestor-Kalinoski, A.L., Ways, J., Liu, S.T., Ramdath, R.S., Matsui, S. and Allison, D.C. (2011) A Model for Random Genetic Damage Directing the Selection of Diploid or Aneuploid Tumors. Cell Proliferation, 44(3):212-23. [Abstract].
Liu, S.T., Allison, D.C., and Nestor-Kalinoski, A. L. (2010) Chromosomes during Cell Division, In: Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd. Chichester. DOI: 10.1002/9780470015902.a0005770.pub2. Review.
Liu, S.T. and Yen, T. J. (2008) The kinetochore as target for cancer drug development. In “The Kinetochore: from Molecular Discoveries to Cancer Therapy" (Eds. De Wulf P., and Earnshaw W.C.). Springer Publ. New York. Review.
Selected Earlier Publications
Liu, S.T., Rattner, J.B., Jablonski, S.A. and Yen, T. J. (2006) Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. Journal of Cell Biology. 175: 41-53.
Chan, G.K., Liu, S.T., and Yen, T. J. (2005) Kinetochore structure and function. Trends in Cell Biology. 15(11):589-98. Review.
Liu, S.T., van Deursen, J. M. and Yen T.J. (2003) The role of mitotic checkpoint in maintaining genomic stability. Current Topics in Developmental Biology (ed. Schatten G. P.). 58: 27-51. Review.
Jablonski, S. A., Liu, S.T., and Yen, T.J. (2003) Targeting the kinetochore for mitosis-specific inhibitors. Cancer Biology and Therapy. 2(3): e21-26. Review.
Liu, S.T., Hittle, J. C., Jablonski, S.A., Campbell, M.S., Yoda, K. and Yen, T.J. (2003) Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nature Cell Biology. 5(4): 341-5.
Liu, S.T., Chan, G.K.T., Hittle, J.C., Fujii G., Lees M. and Yen T.J. (2003) Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.Molecular Biology of the Cell.14(4): 1638-51.