Department of Physiology and Pharmacology

Tao Yang, PhD

 

 

TaoAssistant Professor 

419.383.4139

Tao.Yang2@UToledo.Edu

 

 

 

 

 

 

 

 

education

Ph.D.                                                  University of Florida, Gainesville, FL

Master of Life Sciences                  Jilin University, Changchun, China

Bachelor of Life Sciences              Jilin University, Changchun, China

 

honors and awards

2014   Outstanding International Student Award, University of Florida

2015   New Investigator Award, AHA

2015   Best of Specialty, AHA Scientific Session

2016   Data Sciences International Outstanding Graduate Student, Neural Control & Autonomic Regulation Section, APS

2016   Charles F. Simpson Memorial Scholarship Award, College of Vet Medicine, University of Florida

2018   Experimental Biology Meeting Travel Award, APS

2018   International Hypertension Meeting Travel Award, International Society of Hypertension (ISH)

2018   Mcknight Brain Institute Postdoctoral Fellowship, University of Florida

2019   Trainee Research Recognition Award, Physiological -Omics group, APS

2019   Biocodex Microbiota USA Foundation Research Grant $50,000 (PI)

2019   New Investigator Award, AHA

2019   Best of Specialty, AHA

2020   Star Reviewer for the APS Journal Physiological Genomics

2021   Research Recognition Award, Cardiovascular Section, APS

2021   Stephanie Watts Career Development Award Finalist

 

publications

1)    Yang T, Chakraborty S, Mandal J, Mei X, Joe B. Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation. Comprehensive Physiology. 2021 Apr 1;11(2):1731-1757. doi: 10.1002/cphy.c200009. PubMed PMID: 33792901.

2)    Yang T, Chakraborty S, Saha P, Mell B, Cheng X, Yeo JY, Mei X, Zhou G, Mandal J, Golonka R, Yeoh BS, Putluri V, Piyarathna DWB, Putluri N, McCarthy CG, Wenceslau CF, Sreekumar A, Gewirtz AT, Vijay-Kumar M, Joe B. Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity. Hypertension. 2020 Jul;76(1):e1-e3. doi: 10.1161/HYPERTENSIONAHA.120.15360. Epub 2020 May 19. PubMed PMID: 32426999; NIHMSID:NIHMS1596760.

3)    Yang T, Li H, Oliveira AC, Goel R, Richards EM, Pepine CJ, Raizada MK. Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats. Physiol Genomics. 2020 Mar 1;52(3):121-132. doi: 10.1152/physiolgenomics.00087.2019. Epub 2019 Dec 23. PubMed PMID: 31869283; PubMed Central PMCID: PMC7099409.

4)    Yang T, Magee KL, Colon-Perez LM, Larkin R, Liao YS, Balazic E, Cowart JR, Arocha R, Redler T, Febo M, Vickroy T, Martyniuk CJ, Reznikov LR, Zubcevic J. Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats. Acta Physiol (Oxf). 2019 Jun;226(2):e13256. doi: 10.1111/apha.13256. Epub 2019 Feb 20. PubMed PMID: 30656835; PubMed Central PMCID: PMC7199780. Top Cited Article 2019-2020

5)    Yang T, Aquino V, Lobaton GO, Li H, Colon-Perez L, Goel R, Qi Y, Zubcevic J, Febo M, Richards EM, Pepine CJ, Raizada MK. Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat. J Am Heart Assoc. 2019 Feb 19;8(4):e010721. doi: 10.1161/JAHA.118.010721. PubMed PMID: 30755073; PubMed Central PMCID: PMC6405665.

6)    Yang T, Rodriguez V, Malphurs WL, Schmidt JT, Ahmari N, Sumners C, Martyniuk CJ, Zubcevic J. Butyrate regulates inflammatory cytokine expression without affecting oxidative respiration in primary astrocytes from spontaneously hypertensive rats. Physiol Rep. 2018 Jul;6(14):e13732. doi: 10.14814/phy2.13732. PubMed PMID: 30039527; PubMed Central PMCID: PMC6056753.

7)    Yang T, Richards EM, Pepine CJ, Raizada MK. The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease. Nat Rev Nephrol. 2018 Jul;14(7):442-456. doi: 10.1038/s41581-018-0018-2. Review. PubMed PMID: 29760448; PubMed Central PMCID: PMC6385605.

8)    Yang T, Zubcevic J. Gut-Brain Axis in Regulation of Blood Pressure. Front Physiol. 2017;8:845. doi: 10.3389/fphys.2017.00845. eCollection 2017. Review. PubMed PMID: 29118721; PubMed Central PMCID: PMC5661004.

9)    Yang T, Ahmari N, Schmidt JT, Redler T, Arocha R, Pacholec K, Magee KL, Malphurs W, Owen JL, Krane GA, Li E, Wang GP, Vickroy TW, Raizada MK, Martyniuk CJ, Zubcevic J. Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon. Front Physiol. 2017;8:220. doi: 10.3389/fphys.2017.00220. eCollection 2017. PubMed PMID: 28446880; PubMed Central PMCID: PMC5388758.

10) Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y, Zubcevic J, Sahay B, Pepine CJ, Raizada MK, Mohamadzadeh M. Gut dysbiosis is linked to hypertension. Hypertension. 2015 Jun;65(6):1331-40. doi: 10.1161/HYPERTENSIONAHA.115.05315. Epub 2015 Apr 13. PubMed PMID: 25870193; PubMed Central PMCID: PMC4433416.

11) Yang T, Owen JL, Lightfoot YL, Kladde MP, Mohamadzadeh M. Microbiota impact on the epigenetic regulation of colorectal cancer. Trends Mol Med. 2013 Dec;19(12):714-25. doi: 10.1016/j.molmed.2013.08.005. Epub 2013 Sep 16. Review. PubMed PMID: 24051204; PubMed Central PMCID: PMC3851951. Top 10 Artcile 2014

12) Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S, Qiu Y. Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity. J Biol Chem. 2012 Nov 23;287(48):40279-91. doi: 10.1074/jbc.M112.349704. Epub 2012 Sep 25. PubMed PMID: 23014989; PubMed Central PMCID: PMC3504744.

13)  Xia WJ, Xu ML, Yu XJ, Du MM, Li XH, Yang T, Li L, Li Y, Kang KB, Su Q, Xu JX, Shi XL, Wang XM, Li HB, Kang YM. Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat. Gut Microbes. 2021 Jan-Dec;13(1):1-24. doi: 10.1080/19490976.2020.1854642. PubMed PMID: 33382364.

14) Joe B, McCarthy CG, Edwards JM, Cheng X, Chakraborty S, Yang T, Golonka RM, Mell B, Yeo JY, Bearss NR, Furtado J, Saha P, Yeoh BS, Vijay-Kumar M, Wenceslau CF. Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure. Hypertension. 2020 Dec;76(6):1847-1855. doi: 10.1161/HYPERTENSIONAHA.120.15939. Epub 2020 Oct 19. PubMed PMID: 33070663; PubMed Central PMCID: PMC7666075.

15) Robles-Vera I, de la Visitación N, Sánchez M, Gómez-Guzmán M, Jiménez R, Moleón J, González-Correa C, Romero M, Yang T, Raizada MK, Toral M, Duarte J. Mycophenolate Improves Brain-Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats. Antioxidants (Basel). 2020 Nov 28;9(12). doi: 10.3390/antiox9121199. PubMed PMID: 33260593.

16) Joe B, McCarthy CG, Edwards JM, Cheng X, Chakraborty S, Yang T, Golonka RM, Mell B, Yeo JY, Bearss NR, Furtado J, Saha P, Yeoh BS, Vijay-Kumar M, Wenceslau CF. Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure. Hypertension. 2020 Oct 19;:HYPERTENSIONAHA12015939. doi: 10.1161/HYPERTENSIONAHA.120.15939. [Epub ahead of print] PubMed PMID: 33070663.

17) Robles-Vera I, de la Visitación N, Toral M, Sánchez M, Romero M, Gómez-Guzmán M, Yang T, Izquierdo-García JL, Guerra-Hernández E, Ruiz-Cabello J, Raizada MK, Pérez-Vizcaíno F, Jiménez R, Duarte J. Probiotic Bifidobacterium breve prevents DOCA-salt hypertension.  FASEB J. 2020 Aug 11;. doi: 10.1096/fj.202001532R. [Epub ahead of print] PubMed PMID: 32780919.

18) Sharma RK, Oliveira AC, Yang T, Kim S, Zubcevic J, Aquino V, Lobaton GO, Goel R, Richards EM, Raizada MK. Pulmonary arterial hypertension-associated changes in gut pathology and microbiota. ERJ Open Res. 2020 Jul;6(3). doi: 10.1183/23120541.00253-2019. eCollection 2020 Jul. PubMed PMID: 32743008; PubMed Central PMCID: PMC7383054.

19) Sharma RK, Oliveira AC, Yang T, Karas MM, Li J, Lobaton GO, Aquino VP, Robles-Vera I, de Kloet AD, Krause EG, Bryant AJ, Verma A, Li Q, Richards EM, Raizada MK. Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension. Hypertension. 2020 Jul;76(1):206-216. doi: 10.1161/HYPERTENSIONAHA.120.14931. Epub 2020 May 18. PubMed PMID: 32418496.

20) Chakraborty S, Mandal J, Cheng X, Galla S, Hindupur A, Saha P, Yeoh BS, Mell B, Yeo JY, Vijay-Kumar M, Yang T, Joe B. Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage. Hypertension. 2020 Jul;76(1):59-72. doi: 10.1161/HYPERTENSIONAHA.120.14830. Epub 2020 May 26. PubMed PMID: 32450738; PubMed Central PMCID: PMC7289684.

21) Chakraborty S, Mandal J, Yang T, Cheng X, Yeo JY, McCarthy CG, Wenceslau CF, Koch LG, Hill JW, Vijay-Kumar M, Joe B. Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award. Hypertension. 2020 Jun;75(6):1386-1396. doi: 10.1161/HYPERTENSIONAHA.120.13896. Epub 2020 Apr 27. PubMed PMID: 32336227; PubMed Central PMCID: PMC7225070.

22) Li HB, Yang T, Richards EM, Pepine CJ, Raizada MK. Maternal Treatment With Captopril Persistently Alters Gut-Brain Communication and Attenuates Hypertension of Male Offspring. Hypertension. 2020 May;75(5):1315-1324. doi: 10.1161/HYPERTENSIONAHA.120.14736. Epub 2020 Mar 23. PubMed PMID: 32200676; PubMed Central PMCID: PMC7145738.

23) Robles-Vera I, Toral M, de la Visitación N, Sánchez M, Gómez-Guzmán M, Romero M, Yang T, Izquierdo-Garcia JL, Jiménez R, Ruiz-Cabello J, Guerra-Hernández E, Raizada MK, Pérez-Vizcaíno F, Duarte J. Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids. Mol Nutr Food Res. 2020 Mar;64(6):e1900616. doi: 10.1002/mnfr.201900616. Epub 2020 Feb 6. PubMed PMID: 31953983.

24) Toral M, Robles-Vera I, de la Visitación N, Romero M, Sánchez M, Gómez-Guzmán M, Rodriguez-Nogales A, Yang T, Jiménez R, Algieri F, Gálvez J, Raizada MK, Duarte J. Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats. Acta Physiol (Oxf). 2019 Sep;227(1):e13285. doi: 10.1111/apha.13285. Epub 2019 Jun 2. PubMed PMID: 31004464. Top Cited Article 2019-2020

25) Zubcevic J, Richards EM, Yang T, Kim S, Sumners C, Pepine CJ, Raizada MK. Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension. Circ Res. 2019 Jun 21;125(1):104-116. doi: 10.1161/CIRCRESAHA.119.313965. Epub 2019 Jun 20. Review. PubMed PMID: 31219753; PubMed Central PMCID: PMC6588177.

26) Toral M, Robles-Vera I, de la Visitación N, Romero M, Yang T, Sánchez M, Gómez-Guzmán M, Jiménez R, Raizada MK, Duarte J. Critical Role of the Interaction Gut Microbiota - Sympathetic Nervous System in the Regulation of Blood Pressure. Front Physiol. 2019;10:231. doi: 10.3389/fphys.2019.00231. eCollection 2019. PubMed PMID: 30930793; PubMed Central PMCID: PMC6423906.

27) Sharma RK, Yang T, Oliveira AC, Lobaton GO, Aquino V, Kim S, Richards EM, Pepine CJ, Sumners C, Raizada MK. Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension. Circ Res. 2019 Mar;124(5):727-736. doi: 10.1161/CIRCRESAHA.118.313882. PubMed PMID: 30612527; PubMed Central PMCID: PMC6395495.

28) Bartley A, Yang T, Arocha R, Malphurs WL, Larkin R, Magee KL, Vickroy TW, Zubcevic J. Increased Abundance of Lactobacillales in the Colon of Beta-Adrenergic Receptor Knock Out Mouse Is Associated With Increased Gut Bacterial Production of Short Chain Fatty Acids and Reduced IL17 Expression in Circulating CD4+ Immune Cells. Front Physiol. 2018;9:1593. doi: 10.3389/fphys.2018.01593. eCollection 2018. PubMed PMID: 30483153; PubMed Central PMCID: PMC6242911.

29) Santisteban MM, Qi Y, Zubcevic J, Kim S, Yang T, Shenoy V, Cole-Jeffrey CT, Lobaton GO, Stewart DC, Rubiano A, Simmons CS, Garcia-Pereira F, Johnson RD, Pepine CJ, Raizada MK. Hypertension-Linked Pathophysiological Alterations in the Gut. Circ Res. 2017 Jan 20;120(2):312-323. doi: 10.1161/CIRCRESAHA.116.309006. Epub 2016 Oct 31. PubMed PMID: 27799253; PubMed Central PMCID: PMC5250568.

30) Lightfoot YL, Selle K, Yang T, Goh YJ, Sahay B, Zadeh M, Owen JL, Colliou N, Li E, Johannssen T, Lepenies B, Klaenhammer TR, Mohamadzadeh M. SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis. EMBO J. 2015 Apr 1;34(7):881-95. doi: 10.15252/embj.201490296. Epub 2015 Feb 9. PubMed PMID: 25666591; PubMed Central PMCID: PMC4388597.

31) Owen JL, Yang T, Mohamadzadeh M. New insights into gastrointestinal anthrax infection. Trends Mol Med. 2015 Mar;21(3):154-63. doi: 10.1016/j.molmed.2014.12.003. Epub 2014 Dec 19. Review. PubMed PMID: 25577136; PubMed Central PMCID: PMC4352373.

32) Cheng SX, Lightfoot YL, Yang T, Zadeh M, Tang L, Sahay B, Wang GP, Owen JL, Mohamadzadeh M. Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses. FEBS Lett. 2014 Nov 17;588(22):4158-66. doi: 10.1016/j.febslet.2014.05.007. Epub 2014 May 17. PubMed PMID: 24842610; PubMed Central PMCID: PMC4234694.

33) Sahay B, Owen JL, Zadeh M, Yang T, Lightfoot YL, Abed F, Mohamadzadeh M. Impaired colonic B-cell responses by gastrointestinal Bacillus anthracis infection. J Infect Dis. 2014 Nov 1;210(9):1499-507. doi: 10.1093/infdis/jiu280. Epub 2014 May 14. PubMed PMID: 24829464; PubMed Central PMCID: PMC4271052.

34) Lightfoot YL, Yang T, Sahay B, Zadeh M, Cheng SX, Wang GP, Owen JL, Mohamadzadeh M. Colonic immune suppression, barrier dysfunction, and dysbiosis by gastrointestinal bacillus anthracis Infection. PLoS One. 2014;9(6):e100532. doi: 10.1371/journal.pone.0100532. eCollection 2014. PubMed PMID: 24945934; PubMed Central PMCID: PMC4063899.

35) Sahay B, Owen JL, Yang T, Zadeh M, Lightfoot YL, Ge JW, Mohamadzadeh M. Activation of B cells by a dendritic cell-targeted oral vaccine. Curr Pharm Biotechnol. 2013;14(10):867-77. doi: 10.2174/1389201014666131226120512. Review. PubMed PMID: 24372255; PubMed Central PMCID: PMC4297498.

36) Lightfoot YL, Yang T, Sahay B, Mohamadzadeh M. Targeting aberrant colon cancer-specific DNA methylation with lipoteichoic acid-deficient Lactobacillus acidophilus. Gut Microbes. 2013 Jan-Feb;4(1):84-8. doi: 10.4161/gmic.22822. Epub 2012 Nov 8. Review. PubMed PMID: 23137966; PubMed Central PMCID: PMC3555892.

Last Updated: 6/21/22