Z. Kevin Pan, M.D., Ph.D.
Molecular mechanisms of host-pathogen interactions
Office: HEB 200F
-The structural features of the innate immune receptors and the structural changes by which binding of a microbial ligand to the receptor leads to intracellular signaling cascades.
-Negative feedback regulation of inflammatory responses, including septic shock, rheumatoid arthritis, and airway inflammation.
-G protein-coupled chemoattrant receptors function and biology.
Dr. Pan received his M.D. and Ph.D. in 1991 at the Shanghai Second Medical University. After postdoctoral training at The Scripps Research Institute (La Jolla, CA) for immunology, he was appointed to the faculty of the Molecular and Experimental Medicine Department at The Scripps Research Institute in 2000. Dr. Pan joined the Department of Medical Microbiology and Immunology in 2003.
Research group (left to right):
Pan ZK, Fisher C, Li JD, Jiang Y, Huang S, Chen LY. Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD. Int Immunol. 23(6):357-64. 2011
Doerner AM, Chen LY, Ye RD, Yong J, Huang S, Pan ZK. Cell type-specific release of matrix-metallo-proteinase-9 by bacterial chemoattractant in human blood phagocytic leukocytes. Int J Clin Exp Med. 4(1):67-73. 2011
Pan WW, Li JD, Huang S, Papadimos TJ, Pan ZK*, Chen LY. Synergistic activation of NF-kB by bacterial chemoattractant and TNFa is mediated by p38 MAPK-dependent RelA acetylation. J Biol Chem. 285(45):34348-54. 2010. * corresponding author
Mukherjee, S, Chen, L-Y, Papadimos, TJ, Zuraw BL, and Pan, ZK. (2009) LPS driven Th2 cytokine production in monocytes/macrophages is regulated by MyD88 and TRAM. J. Biol. Chem. 23;284(43):29391-8.
Chen, L-Y, Pan, ZK. (2009) Synergistic Activation of Leukocytes by Bacterial Chemoattractants:Potential
Drug Targets. Endocr Metab Immune Disord Drug Targets. Dec 1;9(4):361-370.
L-Y Chen, WW Pan, M. Chen, J-D Li, W Liu, G Chen, S Huang, TJ Papadimos, and ZK Pan. (2009) Synergistic induction of inflammation by bacterial products LPS and fMLP:
An importanat microbial pathogenic mechanism. J. Immunol. 182(4):2518-2524.
Chen L-Y, Doerner A., Lehmann P.F., Huang S., Zhong G., and Pan ZK (2005) A Novel Protein Kinase C Is a Signaling Component Downstream of GTPase RhoA and Mediates Chemoattractant-induced NF-kB Activation in Human Blood Monocytes. J. Biol. Chem. 280:22497-22501.
Joko H., Lim, J.H., Chen, L-F., Xu, H., Trompouki, E., Pan, Z.K., Mosialos, G., Li, J. (2004) NF-kB is essential for induction of CYLD, the negative regulator of NF-kB:
evidence for a novel inducible auto-regulatory feedback pathway. J. Biol. Chem. 279:36171-36174.
Bian, D., Su, S., Mahanivong, C., Cheng, R.K., Han, Q., Pan, Z.K., Sun, P., and Huang, S. (2004) Lysophosphatidic acid stimulates ovarian cancer cell migration via a Ras-MEK kinase 1 pathway. Cancer Res.,64:4209-4217.
Chen, L-Y., Zuraw, B.L., Ye, R.D. and Pan, Z.K.(2004) A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kB activation in human peripheral blood monocytes. J. Biol. Chem. 279:7208-7212.
Su, H., McClarty, G., Dong, F., Hatch, G., Pan, Z., and Zhong, G. (2004) Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J. Biol. Chem. 279:9409-9416.
Pan, Z.K. (2004) Toll-like receptors (TLRs) and TLR-mediated signaling: more questions than answers. Am. J. Physiol. 286:L918-920.
Chen, L-Y., Zuraw, B.L., Zhao, M., Liu, F-T., Huang, S., and Pan, Z.K. (2003) Involvement of protein tyrosine kinase in Toll-like receptor 4 (TLR4)-mediated NF-kB activation in human peripheral blood monocytes. Am. J. Physiol., 284:L607-L613.
Chen, L-Y., Zuraw, B.L., Liu, F-T., Huang S., and Pan, Z.K. (2002) IL-1 Receptor-associated kinase and GTPase RhoA signal molecules are required for bacterial lipopolysaccharide (LPS)-induced cytokine gene transcription. J. Immunol., 169:3934-3939.
Ptasznik, A., Chinta, S., Costa, M.A., Kalota, A., Swider, C.R., Katz, B.A., Demir, G., Pan, Z.K., and Gewirtz, A.M. (2002) Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J. Exp. Med., 196:667-678.
Christiansen, S., Eddleston, J., Woessner, K., Chambers, S., Ye, R.D., Pan, Z.K., and Zuraw, B.L. (2002) Upregulation of functional B1 bradykinin receptors in allergic airway inflammation. J. Immunol., 169:2054-2060.
Chen, J., Bakersville, C., Han, Q., Pan, Z.K., and Huang, S. (2001) av integrin, p38 mitogen-activated protein kinase and urokinase plasminogen activator are functionally linked in invasive breast cancer cells. J. Biol. Chem., 276:47901-47905.
Huang, S., Chen, L-Y., Zuraw, B.L., Ye, R.D., and Pan, Z.K. (2001) Chemoattractant-stimulated NF-kB activation is dependent on the low molecular weight GTPase RhoA. J. Biol. Chem., 276:40977-40981.
Pan, Z.K., Chen, L.Y., Cochrane, C.G., Zuraw, B.L. (2000) fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in Human Peripheral Blood Monocytes: the Role of Phosphatidylinositol 3-kinase. J. Immunol., 164:404-411.
Pan, Z.K., Christiansen, S., Ptasznik, A., Zuraw, B.L. (1999) Requirement of PI 3-kinase activity for bradykinin stimulation of NF-B activation in cultured human epithelial cells. J. Biol. Chem., 274:9918-9922.
Pan, Z.K. (1998) Anaphylatoxin C5a and C3a Induce NF-B activation in Human Peripheral Blood Monocytes. Biochem. Biophys. Acta., 1443:90-98.
Pan, Z.K., Ye, R.D., Christiansen, S.C., Jagels, M.K., Bokoch, G.M., Zuraw, B.L. (1998) Role of the Rho GTPase in bradykinin stimulated NF-B activation and interleukin-1 gene expression in cultured human epithelial cells. J. Immunol., 160:3038-3045.
Pan, Z.K., Zuraw, B., Lung, C. Prossnitz, E.R., Browning, D., Ye, R.D. Bradykinin stimulates NF-kB activation and cytokine gene expression in cultured human fibroblasts. J. Clin. Invest. 98:2042-2049, 1996
Pan, Z., Kravchenko, V.V., Ye, R.D. Platelet-activating factor stimulates transcription of the heparin-binding EGF-like growth factor in monocytes. Correlation with an increased kB binding activity. J. Biol. Chem. 270: 7787-7790, 1995