Department of Medicine: Biostatistics and Epidemiology

Sadik A. Khuder, D.D.S., M.P.H., P.h.D.

Sadik A. Khuder, DDS, MPH, PhDProfessor of Medicine, Statistics, and Public Health
College of Medicine and Life Sciences
The University of Toledo
3120 Glendale Ave
Toledo, Ohio 43614
Phone: (419) 383-4089


  • B.D.S.    General Dentistry, University of Baghdad, 1977
  • M.P.H.   Epidemiology, University of Alabama at Birmingham, 1982
  • Ph.D.      Biostatistics, University of Alabama in Birmingham, 1992


  • 1989-1990      Statistical analyst, Dept. of Biostatistics and Dept. of Medicine, Univ. of Alabama at Birmingham
  • 1990-1992      Biostatistician, Dept. of Medicine, University of Alabama at Birmingham
  • 1992-1993      Biostatistician, Cancer Center & Instructor, Dept. of Preventive Medicine and Community Health, University of Texas Medical Branch
  • 1994-1998      Assistant Professor, Dept. of Medicine, Medical College of Ohio.
  • 1997-1998      Assistant Professor, Dept. of Public Health, Medical College of Ohio
  • 1998-2003      Associate Professor, Dept. of Medicine and Dept. of Public Health, Medical College of Ohio
  • 2004-present   Professor, Dept. of Medicine & School of Population Health, University of Toledo.
  • 2005-present   Senior biostatistician, Jacobson Center for Clinical and Translational Research, University of Toledo Health Science Campus
  • 2014-present  Professor, Department of Mathematics & Statistics, College of Natural Sciences, and Mathematics, University of Toledo.


  • Richard Anderson Research Award / Southern Regional Council on Statistics 1992.
  • International Association for the Study of Lung Cancer / Grant for invited paper in the 9th World Conference on Lung Cancer - Japan, September 2000.
  • Dean’s Award for Advising Excellence 2019.



A. Current Teaching Assignment in the MPH program

PUBH 611 Categorical Data Analysis
Course Coordinator and 100% teaching effort
Fall semester – 2004-present
Number of students    10-15        

PUBH 613 Molecular Epidemiology
Course Coordinator and 100% teaching effort
Fall semester – 2005-present
Number of students    25-45        

PUBH 615 Clinical Epidemiology
Course Coordinator and 100% teaching effort
Spring semester – 2004-2007, 100% DL course (2008-present)
Number of students    30-45       

PUBH 606 Advanced Biostatistics
Course Coordinator and 100% teaching effort
Spring semester – 1998-present
Number of students    45-60        

PUBH 603 Advanced Epidemiology
Course Coordinator and 100% teaching effort
Summer semester – 1998-present
Number of students    45-60        

PUBH 679 Independent Study in Biostatistics
Every semester – 1996-present
Number of students    1-2 per semester

B. Current Teaching Assignment in the Bioinformatics program

BIPG 520  Statistical Methods in Bioinformatics
Course Coordinator and 100% teaching effort
Fall semester – 2003-present
Number of students    10-15        

BIPG 550 Microarray Analysis
Course Coordinator and 100% teaching effort
Summer semester (1 hour credit) – 2009-present
Number of students    5-10       

BIPG Advanced Programming in Bioinformatics
Course Coordinator and 60% teaching effort
Fall semester – 2021
Number of students    2       

BIPG6400 Application of Bioinformatics
Five lectures and labs for 30% teaching effort
Spring semester  – 2003-present
Number of students    10-15    

BRIM6200 Biomarker Discovery, Validation & Implementation
One lecture and lab for 5% teaching effort
Spring semester  – 2009-present
Number of students    10-15    

C. Current Teaching Assignment in the MSBS/PhD program

BSMP 532/732  Statistical Methods I
Course Coordinator and 100% teaching effort
Spring semester – 2001-present
Number of students    20-30     

BMSP6390 Mentored Research
Course Coordinator and 100% teaching effort
Fall / Spring semester – 2018-present
Number of students    1-4         

D. Current Teaching Assignment for Medical Students

Longitudinal Thread - Research  First year medical student
Four lecture for 15% teaching effort
Fall semester  – 2017-present
Number of students    170   

Reproductive System    Second year medical student
One lecture for 5% teaching effort
Fall semester  – 2018-present
Number of students    150   

Cardiovascular System    Second year medical student
One lecture for 5% teaching effort
Fall semester  – 2019-present
Number of students    150   

USMLE Step I  Review of Biostatistics    Second year medical student
Spring semester – 2018

E. Past Teaching Assignment
  • PUBH 600 Public Health Statistics  1996-2004
  • PUBH 601 Public Health Epidemiology 1996-2003
  • MEDI 532 Introductory Biostatistics    1995-2001
  • MEDI 605 Advanced Biostatistics        1995-2000
  • OCCH 602 Research Methods            1996-1997


  • Tammy Arthur, “Prevalence of infectious diseases and associated symptoms in wastewater treatment employees”,December 1997
  • Zachary Krabill, “The incidence of work-related injuries and illnesses in Ohio hospitals : a comparative study of the workers' compensation claims from 1993 to 1996”,  December 1997
  • Dan Helman, “Worker exposure to airborne chromium and its association with reported clinical symptomology”, December 1997
  • Linda King, “Reported occupational exposure to HIV : incidence and application of recent recommendations for post-exposure chemoprophylaxis (immune deficiency)”, June 1998
  • Michele Franketi, “Assessment of complete blood count variations associated with low-level benzene exposure”, June 1998
  • Steven Kinn, “The effectiveness of safety and health education/training within the plumbing and pipefitting industry of northwestern Ohio”, June 2000
  • Robert Koedam, “A comparison of the injuries and illnesses experienced by employees in the metal fabrication and nursing home industry in Philadelphia”, December 2001
  • Meenakshi Kaw, “Meta-analysis of agricultural risk factors for non-Hodgkin's lymphoma 1”,  December 2001
  • Mahdi Jahangir-Blourchian, “Meta-analysis of agricultural risk factors for non-Hodgkin's lymphoma 2”,  December 2001
  • Arif Peshmam, “Environmental risk factors for autoimmune diseases “,  December 2003


  • Eric Haynes, “Identifying common genes from rheumatoid arthrisis, systemic lupus, multiple sclerosis and Sjögren's Syndrome by pooling existing microarray data”, June 2013
  • Nicole Carr, “Data pooling to identify differentially expressed genes in lung cancer of nonsmokers”,  June 2016.
  • Oluwatobi Lasisi, “Potential genetic biomarkers for Sjogren’s syndrome”,  December 2019. 
  • Prabhjot Kaur, “Combining transcriptomic data for COPD”,  December 2019.
  • Ammar Eljack, “Potential genetic biomarkers for cardiomyopathy”, June 2020.
  • Joyeeta Dutta, “Identifying a biomarker for Systemic Sclerosis using existing genomic data”, June 2021.
  • Bhuwan Rai, “Data Pooling to Investigate the Abundance of Gut Microbiome Composition in Autoimmune Disease”, June 2021.
  • Alexander McCartney, “'Using Existing Omics Data to Identify Multiple Sclerosis Biomarkers',  June 2021.


  • Dan Cipriani. Application of the Rasch Measurement Model to examine the utility of medical diagnostic tests. Applied Measurement and Statistics (Christine  Fox, Chair), 2005
  • Suoto Akpanudo. Clinical Psychologists and Smoking Cessation: Treatment Practices and Perceptions. Health Education (James Price, Chair), June 2006
  • D’Anna Mullins, Transcriptional regulation of antioxidant and DNA repair transcript abundance in human bronchial epithelial cells Biomedical Sciences (James Willey , Chair), June 2007
  • Marlyne Wood. Parental/guardian predictors of well controlled and poorly controlled asthmatic African American youths.Health Education (James Price, Chair),  June 2007
  • Joyce Balls. African American primary care physicians’ perceptions and practices regarding smoking cessation therapy.Health Education (James Price, Chair), June 2009
  • Michael Valigosky. Infection control perceptions and practices of spiritual care providers: An application of the protection motivation theory. Health Education (Debra Boardley, Chair), June 2009
  • Sam Shepard. The characterization and utilization of middle-range sequence patterns within the human genome. Bioinformatics (Alexei Fedorov, Chair),  June 2010
  • Ashwin Prakash. Evolution and function of compositional patterns in mammalian genomes. Bioinformatics (Alexei Fedorov, Chair),  June 2011
  • Jennifer Wohlwend. An examination of emergency contraception use by undergraduate college students in the Midwest using the integrated behavioral model.  Health Education (Tavis Glassman, Chair), June 2012
  • April Ames. Application of Geographic Information Systems to investigate the association of health symptoms near biosolid applied fields.  Geography (Kevin Czajkowski, chair)   June 2014
  • Shuhao Qiu. Computational simulation and analysis of uutations: nucleotide fixation, allelic age and rare genetic variations in population.  Bioinformatics (Alexei Fedorov, Chair), June 2015
  • Ying Nie. Positional Mapping for Blood Pressure Loci on Rat Chromosome 9. Cardiovascular and Metabolic Diseases (Bina Joe, Chair), June 2015
  • Xiaolu Zhang. Cis-acting genetic variants that alter ERCC5 regulation as a prototype to characterize cisregulation of key protective genes in normal bronchial epithelial cells.  (James C. Willey, Chair), June 2017
  • Rajib Dutta. 1000 human genomes carry widespread signatures of GC biased gene conversion.  Bioinformatics (Alexei Fedorov, Chair), June 2017.
  • Dulat Bekbolsynov. Medical Microbiology and Immunology. A new concept of immunogenicity to calculate the risk Stratification for kidney transplantation. Medical Microbiology & Immunology (Stanislaw Stepkowski, Chair),  June 2017.
  • Daniel Craig. Low Frequency Airway Epithelial Cell Mutation Pattern Associated with Lung Cancer Risk. Cancer Biology (James Willey, Chair), June 2019.
  • Ahmed Al-Khudhair.  Anti PD-1/PD-L1 Immunotherapy, New Era in the Fight Against Cancer, Genomic and Transcriptomic Exploration. Molecular Medicine (Juan Jaume, Chair), December 2019.
  • Zakaria Alyousif. Passive Leg Movement and NO-Mediated Vascular Function: The Impact of Obstructive Sleep Apnea (OSA). Exercise and Rehabilitation Sciences (Barry Scheuermann, Chair), June 2020.
  • Priti Singh.  Using Rauch model. Applied Measurement and Statistics (Noela Haughton, Chair),  June 2020.
  • Katsumi Takeno.  Within- and Between-Day Reliability of Corticomotor Excitability Assessment Techniques in the Upper Extremity: A Reliability Study. Exercise and Rehabilitation Sciences (Grant Norte, Chair), June 2020.
  • Nilgun Sezginis. Factors Associated with Breast Cancer Screening Behaviors among the United States Born Versus Foreign Born Middle Eastern Women: A Mixed Methods Approach. Health Education (Shipra Singh, Chair), December 2020.
  • Lijun Liu, Measurement (Noela Haughton, Chair), June 2021.
  • Monica William. Analyzing the impact of Social Network Strength of Ties on Diabetes Self-Care Management in Older Adults. Health Education (Victoria Steiner, Chair), June 2021.
  • Rajesh Nagisetty, Geography and planning (Bhuiyam Alam, Chair), expected June 2022.
  • Khaled Alganem. Network-based multi-omics integration of chip-based kinase activity arrays with transcriptional and proteomic cellular signatures. Neuroscience (Robert McCullumsmith, Chair), expected June 2022.
  • Abdul-rizaq Hamoud. Examining differential cancer rates in severe mental illness. Neuroscience (Robert McCullumsmith, Chair), expected June 2023.


  • Page Miller. Measurements of organic vapor emissions from petroleum wastewater treatment vents. (Michael Bisesi, Chair), June 1997
  • Ralph Caringi. Measurement of airborne volatile organic vapors collected at an oil refinery wastewater treatment operation. (Michael Bisesi, Chair), June 1997
  • David Breitigam. Particle size distribution analysis on various processes in a beryllia ceramics plant. (Farhang Akbar, Chair), June 1997
  • Denny Bitovski. Occupational and non-occupational exposure to extremely low frequency magnetic fields of school employees in a Canadian school district. (Farhang Akbar, Chair), June 1997
  • James Swanson. Evaluation of airborne carbon monoxide gas levels in residential settings and comparison to reported levels in ambient and occupational settings. (Michael Bisesi, Chair), June 1997
  • Gina Rejent. An evaluation of work related incident trends for a hazardous waste cleanup company. (Farhang Akbar, Chair), June 1997
  • Barbara Kessler Cotton. Analysis of Arsenic-in Flyash Exposure Derived from Archived Database in Coal Burning Facilities. (Farhang Akbar, Chair), June 1997
  • Monty Stollar. Comparison of air sampling results for total, inhalable, and respirable particulates at a pulp and paper mill. (Michael Bisesi, Chair), June 1997
  • Kent Huang. Postural stability and balance of individuals using respirators   (Farhang Akbar, Chair), June 1997
  • Paul Kriwinsky. Stress levels in MRI and CT technicians.  (Farhang Akbar, Chair), June 1997
  • Maureen Sullivan. Comparison of colorimetric and atomic absorption spectrometric analyses for detection of lead in paint. (Michael Bisesi, Chair), June 1997  
  • Frank Petrik. Occupational exposure evaluation of explosive aerosols and vapors and bioaerosols during soil excavation and screening and composting of nitroaromatic and nitroamine contaminated soils.  (Michael Bisesi, Chair), June 1997
  • Owen Wagner. Relationship between OSHA safety and health program assessment (Form 33) and the number of violations. (Farhang Akbar, Chair), June  1998
  • Gerald Schutt. Exposure of Tube Mill Operators to Extremely Low Frequency Magnetic Fields and Radiofrequency Electromagnetic Fields  (Farhang Akbar, Chair), June 1998
  • David Cronk. Airborne levels of respirable and non-respirable gram-negative bacteria and total bacteria associated with specific phases of municipal wastewater treatment. (Michael Bisesi, Chair), June 1998               
  • Edgar Pulido. Feasibility of respirators and goggles use to control formaldehyde exposure in gross anatomy laboratories.  (Farhang Akbar, Chair), June 1998
  • Michael Lampl. A perception survey to determine the effectiveness of an ergonomics injury management (EIM) process. (Sandra Woolley, Chair), June 1999
  • Michael Groh. The industrial hygienists guide to performing effective limited indoor air quality investigations with biological implications. (Michael Bisesi, Chair), June  1999
  • Barbara Wenzinger. An analysis of the level of lead fume and lead dust present in the lead fabrication area in medical radiation therapy departments.  (Michael Bisesi, Chair), June 1999
  • Yin Tan. Ventilation efficiency in a selected group of restaurants.  (Farhang Akbar, Chair), June    2000
  • Cynthia Twining. Bioaerosol levels of gram-negative bacteria at specific locations within phases of municipal waste water treatment.  (Michael Bisesi, Chair), June 2000
  • Karen McGhee. Comprehensive sampling of total aerobic and anaerobic bacteria at a waste water treatment. (Michael Bisesi, Chair), June 2000
  • Brigitte Frank. Bioaerosol levels of fungi at specific locations within phases of municipal waste water treatment. (Michael Bisesi, Chair), June 2000
  • Duan Deboo. Data Analysis Related to Some Indicators of Tobacco Smoke in Restaurants with Designated Smoking and Non-smoking Sections. (Farhang Akbar, Chair), June 2000
  • Randall Brillhart. Silica dust exposure during concrete grinding in the construction industry.    (Farhang Akbar, Chair), June  2000
  • Rick Scott. StreamKeeper : a two-year investigation of potential biological pollution in the Swan Creek watershed of Northwest Ohio.  (Michael Bisesi, Chair), June 2000
  • Michael Gregory. Trends and causes of occupational fatalities in the United States from 1992 through 1999 : a review   (Farhang Akbar, Chair), June  2001
  • Sam Windom. Controlling environmental tobacco smoke by designating smoking rooms in nursing homes.  (Farhang Akbar, Chair), June 2002
  • Pet Bollenbacher. Surface sampling for fungi in the metalworking fluid environment. (Brian Harrington , Chair), June 2002
  • Sonia Rosenberger. Biosafety education and training for human, animal, and plant pathogens.  (Michael Bisesi, Chair), June 2004
  • Ken Smigielski. Design and set up of a system for testing HEPA filter efficiency.  (Farhang Akbar, Chair), June 2007
  • Bess Weaver. Solar ultraviolet radiation exposure in outdoor work environment at Bowling Green, Ohio.  (Farhang Akbar, Chair), June 2008 
  • Eugene Smith. Skid loader noise exposure assessment in a confinement dairy barn. (Sheryl Milz, Chair), June 2010


  • Steven Haller. Marinobufagenin induced uremic cardiomyopathy: the role of passive immunization, rapamycin, and CD40 signaling in the generation of renal fibrosis.  (Christopher Cooper, Chair), June 2005
  • Andrew McSweeny. Identification of candidate genes within blood pressure QTL containing regions using gene expression data.  (George Cicila, Chair), June 2008
  • Malebari, Afnan Sami S. Improving a Method for High-Resolution HLA-Typing In Transplantation. (Stanislaw Stepkowski, Chair), June 2017.


  • Jason Bechtel. Characterization of genomic midrange inhomogeneity. (Alexei Fedorov, Chair),    June 2008
  • Theodor Rais. Conserved signals of non coding RNA across a set of 73 genes associated with autistic spectrum disorders.  (Alexei Fedorov, Chair), June 2009
  • Andrew McSweeny. Genome evolution model (GEM). (Alexei Fedorov, Chair), June 2010
  • Maryam Nabiyouni. Mega-scale bioinformatics investigation of codon bias in vertebrates. (Alexei Fedorov, Chair), June 2011
  • Arnab Saha Mandal. Computational analysis of the evolution of non-coding genomic sequences. (Alexei Fedorov, Chair), June 2014.
  • Ahmad Alkhudhair. Inter-and-Intra-Populated Genetic Variations in Humans (Alexei Fedorov, Chair).  December 2014.
  • Diego A. Morales. A Bioinformatical Approach to COPD (James Willey, Chair), December 2016.
  • Joseph S. Mainsah. Determnation of Early Human Intercontinental Migration from Genomic IBD Segments Flow Analysis  (Alexei Fedorov, Chair), December 2016.
  • Yuriy R. Yatskiv. Haplotype Analysis of an Archaic Denisovan Genome. (Alexei Fedorov, Chair), December 2016.
  • Sharmistha Chakrabortty. SNPs and Indels Analysis in Human Genome using Computer Simulation and Sequencing Data. (Alexei Fedorov, Chair), June 2017
  • Subhanwita Ghosh . (Alexei Fedorov, Chair), June 2017
  • Patrick J Brennan. An Investigation of Personal Ancestry Using Haplotypes. (Alexei Fedorov, Chair), June 2017.
  • Cole J. White. (Heather Conti, Chair), June 2018.
  • Melisa Curtis. The effects of developmental pesticide exposure in mouse brain using integrative multi-omics" . (James Burkett, Chair), December 2020.
  • John Dillon (Heather Conti, Chair), December 2020.


  • Tessa  Hasting. Examining the impact of hybrid pharmacy practice model on medication adherence in patients with metabolic syndrome. Pharmacy  (Robert Bechtol, Chair), June 2015.
  • Duy Vu Le. Inflammatory bowel disease : cost-driving factors and the impact of different levels of cost sharing on health resource utilization  (Varun Vaidya, Chair), May 2016.
  • Janvi Sah. Factors and Outcomes Associated with 90-Days’ Supply of Prescription Medications  (Varun Vaidya, Chair), May 2017.
  • May F Alskaabi. Cost-Effectiveness of oral agents in Relapsing-Remitting Multiple Sclerosis Compared to Interferon-Based Therapy in Saudi Arabia. (Varun Vaidya, Chair), May 2017.
  • Monika Salkar. Gender Disparity in Childhood Immunizations in India. (Varun Vaidya, Chair), May 2017.
  • Angela Simon. Factors that Influence the Intent of Pharmacists in the Provision of Medication Therapy Management Services. (Sharrel Pinto, Chair), May 2018.

Articles Published in Peer-reviewed Journals

Khuder SA, Mutgi AB.  Meta  analysis  of  multiple  myeloma  and  farming. Am J Ind Med  1997 Nov;32(5):510-6. PMID: 9327075 

Khuder SA, Arthur T, Bisesi MS, Schaub EA. Prevalence of infectious diseases and associated symptoms in wastewater treatment workers. Am J Ind Med  1998  Jun;33(6):571-577. PMID:9582949

Khuder SA, Schaub E, Keller-Byrne J. Meta-analyses of Non-Hodgkin's lymphoma and  farming. Scand J Work Environ Health 1998  Aug; 24:255-61. PMID:9754856

Khuder SA, Mutgi AB, Schaub E.  Meta-analyses of brain cancer and farming. Am J Ind Med  1998 Sep;34:252-60. PMID:9698994

Khuder SA, Dayal HH, Mutgi AB, Willey JC, Dayal G. Effect of cigarette smoking on major histological types of lung cancer. Lung Cancer  1998 Oct; 22:15-21. PMID:9869103 

Khuder SA, Schaub EA, Bisesi MS, Krabill ZT. Injuries and illness among hospital workers in Ohio: a study of workers’ compensation claims from 1993 to 1996. J Occup Environ Med  1999 Jan; 41:53-59. PMID:9924721

Khuder SA. Etiological clues to lip cancer from epidemiologic studies on farmers. Scand J Work Environ Health  1999  Apr; 25:125-130. PMID:10360467

Khuder SA, Youngdale MC, Bisesi MS, Schaub EA. Assessment of complete blood count variations among workers exposed to low levels of benzene. J Occup Environ Med  1999  Sep; 41:821-826. PMID:10491799 

Khuder SA, Dayal HH, Mutgi AB. Age at smoking onset and its effect on smoking cessation. Addict Behav  1999  Sep-Oct; 24:673-677. PMID:10574304

Khuder SA, Mutgi AB, Schaub E, Tano BD. Meta-analyses of Hodgkin's disease among farmers. Scand J Work Environ Health  1999  Oct; 25:436-441. PMID:10569464

Khuder SA, Simon VJ Jr. Is there an association between passive smoking and breast cancer? Eur J Epidemiol  2000;16:1117-21.  PMID:11484800

Khuder SA.  Effect of cigarette smoking on major histological types of lung cancer: a meta-analysis. Lung Cancer 2001  Feb-Mar; 31:139-148. PMID:11165392

Khuder SA, Mutgi AB. Breast cancer and NSAID use: a meta-analysis. Br J Cancer 2001 May 4; 84 (9):1188-1192. PMID:11336469

Khuder SA, Mutgi AB, Nugent S. Smoking and breast cancer: a meta-analysis. Rev Environ Health. 2001 Jul-Sep; 16(4):253-261.  PMID:12041881

Khuder SA, Mutgi AB. Effect of smoking cessation on major histological types of lung cancer. Chest  2001  Nov;120:1577-83. PMID:11713137

Khuder SA, Herial NA, Mutgi AB, Federman DJ. Nonsteroidal antiinflammatory drug use and lung cancer: a metaanalysis. Chest.  2005  Mar; 127:748-54.  PMID:15764753

Khuder SA, Milz S, Jordan T, Price J, Silvestri K, Butler P. The impact of a smoking ban on hospital admissions for coronary heart disease. Prev Med. 2007 Jul;45(1):3-8. PMID:17482249

Khuder S, Milz S, Bisesi M, Vincent R, McNulty W, Czajkowski K. Health Survey of Residents Living Near Biosolids Permitted Farm Fields.  Arch Environ Occup Health. 2007 Jan-Feb; 62(1): 5-11. PMID:18171641

Khuder SA, Price JH, Jordan T, Khuder SS, Silvestri K. Cigarette smoking among adolescents in Northwest Ohio: correlates of prevalence and age at onset. Int J Environ Res Public Health. 2008 Dec;5(4):278-89.  PMID:19190357

Khuder SA, Foos M, Herial NA, Mutgi AB, Khuder BS, Jung R. Urban/rural differences in hospital admissions with multiple sclerosis in selected counties in Ohio 1999-2004. The Open Epidemiology Journal.  2009, 2, 51-54.

Khuder SA, Al-Hashimi I, Mutgi AB, Altorok N.  Identification of potential genomic biomarkers for Sjögren's syndrome using data pooling of gene expression microarrays. Rheumatol Int 2015  May; 35(5):829-36.  PMID: 25327574.

Khuder SA, Akpunonu B. Characteristics and Impact of Covid-19 Pandemic: A Word of Caution for Dental Practices. The Open Dentistry Journal, Volume 14, 2020.

Complete List of Published Work in MyBibliography:

Last Updated: 6/28/22