Center for Hypertension and Precision Medicine

NEWS

Congratulations to Dr. Ritu Chakravarti, whose manuscript was accepted for publication in PNAS!

Title: 14-3-3z-TRAF5 Axis Governs Interleukin-17A Signaling
Authors: Jenna McGowan, Cara Peter, Joshua Kim, Sonam Popli, Brent Veerman, Jessica Saul-McBeth, Heather Conti, Shondra M. Pruett-Miller, Saurabh Chattopadhyay, Ritu Chakravarti#
 
Abstract
Interleukin-17A (IL-17A) is a therapeutic target in many autoimmune diseases. Most non-hematopoietic cells express IL-17A receptors and respond to extracellular IL-17A by inducing pro-inflammatory cytokines. The IL-17A signal transduction triggers two broad, TRAF6- and TRAF5-dependent, intracellular signaling pathways to produce representative cytokines (IL-6) and chemokines (CXCL-1), respectively. Our limited understanding of the crosstalk between these two branches has generated a crucial gap of knowledge leading to therapeutics indiscriminately blocking IL-17A and global inhibition of its target genes. In previous work, we discovered an elevated expression of 14-3-3 proteins in inflammatory aortic disease, a rare human autoimmune disorder with increased levels of IL-17A. Here we report that 14-3-3z is essential for IL-17 signaling by differentially regulating the signal-induced IL-6 and CXCL-1. Using genetically manipulated human and mouse cells, and ex vivo and in vivo rat models, we uncovered a new function of 14-3-3z. As a part of the molecular mechanism, we show that 14-3-3z interacts with several TRAF proteins; in particular, its interaction with TRAF5 and TRAF6 is increased in the presence of IL-17A. Contrary to TRAF6, we found TRAF5 to be an endogenous suppressor of IL-17A-induced IL-6 production, an effect countered by 14-3-3z. Furthermore, we observed that 14-3-3z interaction with TRAF proteins is required for the IL-17A-induced IL-6 levels. Together, our results show that 14-3-3z is an essential component of IL-17A signaling and IL-6 production, an effect that is suppressed by TRAF5. To the best of our knowledge, this is the first report of the 14-3-3z-TRAF5 axis, which differentially regulates IL-17A-induced IL-6 and CXCL-1 production.


 Dr. Lauren Koch was invited to author for News & Views for Nature Reviews Endocrinology entitled "Aerobics — decades of data for future hypothesis-testing research".

https://www.nature.com/articles/s41574-020-00415-8
Sept 7. 2020
 

Also, her manuscript, "Rats Genetically Selected for High Aerobic Exercise Capacity Have Elevated Plasma Bilirubin by Upregulation of Hepatic Biliverdin Reductase-A (BVRA) and Suppression of UGT1A1", has been published in Antioxidants as part of the Special Issue Pharmacological and Clinical Significance of Heme Oxygenase-1:
PDF Version: https://urldefense.com/v3/__https://www.mdpi.com/2076-3921/9/9/889/pdf__;!!LoBwcKfm!yDDM2BCOXovgzIKCf6n6-9sSwBODJPLwAGFpdtV2B7RJ9dPlVECkm1sJhNn4Mvkej6OUAA$

Sept 19, 2020.  


Congratulations to Dr. Camilla Ferreira Wenceslau and the Germ-Free Rat Research Team of the UT Microbiome Consortium! Their manuscript, "Microbiota introduced to germ-free rats restores vascular contractility and blood pressure", was accepted for publication in Hypertension.

Authors: Bina Joe, Cameron G. McCarthy, Jonnelle M. Edwards, Xi Cheng, Saroj Chakraborty, Tao Yang, Rachel M. Golonka, Blair Mell, Ji-Youn Yeo, Nicole Bearss, Janara Furtado, Piu Saha, Beng San Yeoh, Matam Vijay-Kumar, Camilla F. Wenceslau.

Abstract
Commensal gut microbiota are strongly correlated with host hemodynamic homeostasis, but only broadly associated with cardiovascular health. This includes a general correspondence of quantitative and qualitative shifts in intestinal microbial communities found in hypertensive rat models and human patients. However, the mechanisms by which gut microbes contribute to the function of organs important for blood pressure control remain unanswered. To examine the direct effects of microbiota on blood pressure, we conventionalized germ-free (GF) rats with specific pathogen free rats for a short-term period of 10 days, which served as a model system to observe the dynamic responses when reconstituting the holobiome. The absence of microbiota in GF rats resulted with relative hypotension compared to their conventionalized counterparts, suggesting an obligatory role of microbiota in blood pressure homeostasis. Hypotension observed in GF rats was accompanied by a marked reduction in vascular contractility. Both blood pressure and vascular contractility were restored by the introduction of microbiota to GF rats, indicating that microbiota  could be impacting blood pressure through a vascular-dependent mechanism. This is further supported by the decrease in actin polymerization in arteries from GF rats. Improved vascular contractility in conventionalized GF rats, as indicated through stabilized actin filaments, was associated with an increase in cofilin phosphorylation. These data indicate that the vascular system senses the presence (or lack of) microbiota to maintain vascular tone via actin polymerization. Taken together, these results constitute a fundamental discovery of the essential nature of microbiota in blood pressure regulation.


Dr. Camilla Ferreira Wenceslau recently participated in an AJP-Heart Podcast about the potential detrimental effects of prolonged sitting in healthy individuals. Listen to the podcast by clicking the link. https://ajpheart.podbean.com/e/vascular-response-to-prolonged-sitting-in-hypercapnia/


 Congratulations to Dr. Tao Yang! He has been selected as one of the top 3 best performing Star Reviewers for 2019 from the American Physiology Society. The criteria for being chosen for this honor is: timeliness, number of MMS reviewed and consistent willingness to review invites. 


 We are pleased to announce that Dr. Bina Joe was accepted to the editorial board of Genes.  


 The Department was highlighted by a press release from the American Heart Association. Congrats to the Machine Learning Lab on their work being in the spot light! See the list of highlights below:


AHA: https://newsroom.heart.org/news/gut-microbiome-data-may-be-helpful-in-routine-screening-of-cardiovascular-disease

Drug Topics: Study: Gut Microbiome Data May Be Useful in Screening for Heart Disease
Health IT Analytics: Machine Learning Could Improve Cardiovascular Disease Screening
UPI: AI tool screens for heart disease using gut bacteria, study shows
Science Daily: Gut microbiome data may be helpful in routine screening of cardiovascular disease
Home Health Choices: Gut microbiome knowledge could also be useful in routine screening of cardiovascular disease
Medpage Today: Can Machine Learning Make Fecal Testing Part of CVD Screening?


 Congratulations to Dr. Piu Saha! Her abstract has been selected to present at the Crohn's & Colitis Foundation's Research Investigators Symposium 2020. The even will be held virtually on September 30th & October 1st. Her abstract was chosen for an Environmental Triggers presentation. The title is, "Enterobactin, a catecholate-type of siderophore induces pro-inflammatory signature in intestinal epithelial cells."

Authors: Piu Sah, Beng San Yeoh, Xia Xiao, Rachel M Golonka and Matam Vijay-Kumar.


Dr. Saha is a postdoctoral fellow in Dr. Vijay-Kumar's lab.  

 


 2020 NV graduate Avinash Singh has been selected as a Melvin Scholar for the Ohio Academy of Science (OAS) for his scientific presentation at the Academy's Annual Meeting in April 2020. 

Avi completed the AP Capstone Diploma Program at Sylvania Northview. During Avi's senior year, he landed a premier AP research opportunity developed by his teacher, Ms. Kathryn Nelson, and Dr. Bina Joe, Chair of the Department of Physiology and Pharmacology at the University of Toledo, College of Medicine. As part of his AP Research experience, Avi worked for approximately 16 hours per week in Dr. Joe's lab at the Center for Hypertension and Precision Medicine. His investigations resulted in his original research paper titled 'A Novel Ex Vivo Procedure for Monitoring B-Hydroxybutyrate (BOHB) Production Isolated from Whole Livers.' Avi will have the opportunity to present his outstanding scientific contribution at the National meeting of the American Academy for the Advancement of Science meeting (AJAS; February 2021). Avi will also interact with top student scientists and professional researchers, as well as world-renowned scientists and engineers from around the globe. 

We are very proud of Avi, Northview's first Melvin Scholar. We look forward to more exciting things from him as he continues his education at the University of Pennsylvania (an ivy league institution). More information is available at www.ohiosci.org/ajas, and the abstract of his work is on page 20 of the OAS journal https://www.ohiosci.org/s/OJS-AM-Program-Vol-120-No-1.pdf.


 

The Center was highlighted by a press release from the American Heart Association. Congrats to the Machine Learning Lab on their work being in the spot light! See the list of highlights below:

AHA: https://newsroom.heart.org/news/gut-microbiome-data-may-be-helpful-in-routine-screening-of-cardiovascular-disease

Drug Topics: Study: Gut Microbiome Data May Be Useful in Screening for Heart Disease
Health IT Analytics: Machine Learning Could Improve Cardiovascular Disease Screening
UPI: AI tool screens for heart disease using gut bacteria, study shows
Science Daily: Gut microbiome data may be helpful in routine screening of cardiovascular disease
Home Health Choices: Gut microbiome knowledge could also be useful in routine screening of cardiovascular disease
Medpage Today: Can Machine Learning Make Fecal Testing Part of CVD Screening?


Congratulations to Dr. Vijay Kumar! His article, "Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice" has been selected for APSselect, a collection from the APS that showcases some of the best recently published articles in physiological research. Dr. Vijay Kumar received a certificate for this honor. https://journals.physiology.org/journal/apsselect


Congrats to Dr. Camilla Ferriera Wenceslau! She has been elected as a Fellow of the American Heart Association (FAHA).

Dr. Wenceslau has also been invited to join the Journal of Applied Physiology Editorial Board. Members are selected based on scientific enterprise, commitment as reviewers and stature in the field.

Well done!


Congratulations to Dr. Cameron McCarthy! He has been elected as a Fellow of the American Heart Association (FAHA).

Well done!


 

Congratulations, Dr. Piu Saha! Her application application to the National Cancer Institute NOSI (NOT-CA-20-082) entitled, “NCI Emergency Administrative Supplements for Research and Training Continuity of Postdoctoral Fellows during Coronavirus Disease 2019 (COVID-19)” has been approved for funding.


Congrats to Dr. Camilla Ferriera Wenceslau! She has been invited to speak during the (NAVBO) North American Vascular Biology Organization's Vascular Biology 2020 meeting. The meeting will take place virtually October 26-29, 2020.

 Dr. Wenceslau has also been invited as a reviewer for (HM) Hypertension and Microcirculation Study Section Meeting, October 19-20, 2020 via Zoom Video Conference.


 

Congratulations to Sachin Aryal and colleagues! Their manuscript has been accepted for publication in the November 2020 edition of Hypertension.

A machine learning strategy for gut microbiome-based diagnostic screening of cardiovascular disease 
Sachin Aryal, Ahmad Alimadadi, Ishan Manandhar, Bina Joe* and Xi Cheng* 
Bioinformatics & Artificial Intelligence Laboratory, Center for Hypertension and Precision Medicine, Program in Physiological Genomics, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA 

Abstract 
Cardiovascular disease (CVD) is the number one leading cause for human mortality.  Besides genetics and environmental factors, in recent years, gut microbiota has emerged as a new factor influencing CVD. Although cause-effect relationships are not clearly established, the reported associations between alterations in gut microbiota and CVD are prominent. Therefore, we hypothesized that machine learning (ML) could be used for gut microbiome-based diagnostic screening of CVD. To test our hypothesis, fecal 16S rRNA sequencing data of 478 CVD and 473 non-CVD human subjects collected through the American Gut Project were analyzed using 5 supervised ML algorithms including random forest (RF), support vector machine, decision tree, elastic net and neural networks (NN). Thirty-nine differential bacterial taxa were identified between the CVD and non-CVD groups. ML modeling using these taxonomic features achieved a testing AUC (area under the receiver operating characteristic curves; 0.0: perfect anti-discrimination; 0.5: random guessing; 1.0: perfect discrimination) of ~0.58 (RF and NN). Next, the ML models were trained with the top 500 high-variance features of operational taxonomic units (OTUs), instead of bacterial taxa, and an improved testing AUC of ~0.65 (RF) was achieved. Further, by limiting the selection to only the top 25 highly contributing OTU features, the AUC was further significantly enhanced to ~0.70. Overall, our study is the first to identify dysbiosis of gut microbiota in CVD patients as a group and apply this knowledge to develop a gut microbiome-based ML approach for diagnostic screening of CVD.  


 

An abstract from research first authored by Dr. Piotr Czernik and lead by Drs. Vijay-Kumar, Joe and Lecka-Czernik has been selected by the BMA2020 Organizing Committee to be presented as a Plenary Oral presentation at a virtual meeting of the 6th International Meeting on Bone Marrow Adiposity (BMA2020, Marrow Adiposity: Bone, Aging and Beyond). The meeting will be held September 9-10, 2020. 

Abstract Title: Reconstitution of the host holobiont acutely increases bone growth and marrow adiposity of the gnotobiotic rat


Congrats to Saroj Chakravarti, trainee of Dr. Bina Joe, his manuscript has been selected for publication in Hypertension! 

Title: A  single  nucleotide  polymorphism  of Secreted  phosphoprotein  2
 confers  sex-specific effects on blood pressure and bone health

Authors: Saroj Chakraborty, Blair Mell, Ying Nie, Xi Cheng, Sarah Galla, Piotr Czernik2, Beata Lecka-Czernik and Bina Joe

Abstract:
Hypertension is a complex polygenic disease caused by a combination of genetic and environmental factors. Rat models serve as tools to dissect and prioritize genetic factors as candidate genes causing hypertension. One such candidate gene prioritized through systematic linkage and substitution mapping is Secreted Phosphoprotein 2 (Spp2). A non-synonymous G/T single nucleotide polymorphism (SNP) between the Dahl Salt-Sensitive (S) rats and Spontaneously Hypertensive Rats (SHR) at the Spp2 locus was prioritized as a candidate quantitative trait nucleotide (QTN) responsible for the reduction in blood pressure (BP) and bone mineral density (BMD) observed in the S.SHR congenic strain spanning the Spp2 locus. We hypothesized that CRISPR/Cas9 precision-engineering guided replacement of the ‘G’ allele at the Spp2 locus with a ‘T’ allele would lower BP and BMD of the S rat. Radiotelemetry and micro-CT was performed with Spp2 knock-in rats using S rat as control. Systolic BP of the Spp2 knock-in male rats was significantly lower compared to that of the non-founder S rats. However, there was no change in systolic BP of the Spp2 knock-in female rats compared to that of the non-founder S rats. In addition, there was a significant reduction in bone size and bone mass resulting in lower bone volume by total volume (BV/TV) in female Spp2 knock-in rats compared to S. These data provide conclusive evidence for a single nucleotide polymorphism within the Spp2 gene as a quantitative trait nucleotide (QTN) responsible for the sex-dependent inheritance of blood pressure and bone health.   


 

Congratulations to Dr. Matam Vijay-Kumar, Rachel Golonka, and Ahmed Abokor! They had a book chapter published recently.

Textbook: Lipid Signaling and Metabolism (1st Eds)
 
Chapter Title: Gut Microbiota in Host Lipid Metabolism 
 
Citation: Golonka RM, Abokor A, Vijay-Kumar M. 2020. Gut Microbiota Interaction in Host Lipid Metabolism. Ntambi JM (1st Eds), Lipid Signaling and Metabolism. Elsevier Publications. ISBN: 9780128194041

Jonnelle Edwards, trainee of Dr. Camilla F. Wenceslau, was recently featured in UT's Diversity and Inclusion Newletter. Please see link for full spotlight. Read Full Spotlight
A hearty congratulations to Ahmed Abokor, a trainee of Dr. Matam Vijay-Kumar, whose grant application was recommended for funding! He applied for a Diversity Supplement, which is part of the Continuing Umbrella of Research Experiences (CURE) program. Well done!
Congratulations to Dr. Ahmad Alimadadi and colleagues! Their manuscript was accepted to Physiological Genomics.

Title: Machine learning based classification and diagnosis of clinical cardiomyopathies
Authors: Ahmad Alimadadi, Ishan Manandhar, Sachin Aryal, Patricia B. Munroe, Bina Joe, Xi Cheng
Abstract:
Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common types of cardiomyopathies leading to heart failure. Accurate diagnostic classification of different types of cardiomyopathies is critical for precision medicine in clinical practice. In this study, we hypothesized that machine learning (ML) can be used as a novel diagnostic approach to analyze cardiac transcriptomic data for classifying clinical cardiomyopathies.RNA-seq data of human left ventricle tissues were collected from 41 DCM patients, 47 ICM patients and 49 non-failure controls (NF) and tested using five ML algorithms: support vector machine with radial kernel (svmRadial), neural networks with principal component analysis (pcaNNet), decision tree (DT), elastic net (ENet) and random forest (RF).Initial ML classifications achieved ~93% accuracy (svmRadial) for NF vs DCM, ~82% accuracy (RF) for NF vs ICM, and ~80% accuracy (ENet and svmRadial) for DCM vs ICM. Next, 50 highly contributing genes (HCGs) for classifying NF and DCM, 68 HCGs for classifying NF and ICM, and 59 HCGs for classifying DCM and ICM were selected for re-training ML models. Impressively, the re-trained models achieved ~90% accuracy (RF) for NF vs DCM, ~90% accuracy (pcaNNet) for NF vs ICM, and ~85% accuracy (pcaNNet and RF) for DCM vs ICM. Pathway analyses further confirmed the involvement of those selected HCGs in cardiac dysfunctions such as cardiomyopathies, cardiac hypertrophies and fibrosis. Overall, our study demonstrates the promising potential of using artificial intelligence via ML modeling as a novel approach to achieve a greater level of precision in diagnosing different types of cardiomyopathies. 

Ms. Xue Mei, a PhD trainee of Dr. Bina Joe, and Dr. Xi Cheng, a post doc to faculty fellow of Dr. Bina Joe were both selected to receive the HTN New Investigator Travel Award.

Since the meeting is virtual this year, they will both receive complimentary registration, be listed on the conference website and receive award certificates.

Well done, Mei and Dr. Cheng!


Dr. Koch and her collaborator, Dr. Sarah Lessard at Joslin Diabetes Center, Harvard Medical School published a paper July 20, 2020 in Nature Metabolism titled, “Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise.”

 The article was highlighted in nature metabolism news and views: “Sugar not so sweet for training-enhanced fitness”.  https://www.nature.com/articles/s42255-020-0240-7


Soyoung Cheon, who completed her MSBS-MS research work in Dr. Camilla F. Wenceslau's laboratory, was recently invited to present at the High Blood Pressure Research Council of Australia (HBPRCA) Winter School Blitz, being held virtually on July 16th & 17th. The title of her talk is, "Opioids Cause Sex-Specific Vascular Remodeling via Cofilin-ERK Signaling: Female Mice Present Higher Risk of Developing Morphine-Induced Vascular Dysfunction than Male Mice."

Additionally, she had this abstract accepted to the Association of Women Surgeons (AWS) Research Madness. This is a medical student and/or resident research competition where students, residents and fellow members of AWS are able to showcase their work to a large, international audience. It features multiple rounds of abstracts and presentations. Good luck, Soyoung! 


An editorial that Dr. Bina Joe contributed to has been published by the American Journal of Physiology-Lung Cellular and Molecular Physiology.

Title
"An American Physiological Society cross-journal Call for Papers on "Deconstructing organs: Single-cell analyses, decellularized organs, organoids, and organ-on-a-chip models". https://journals.physiology.org/doi/abs/10.1152/ajplung.00311.2020

Authors
Josephine C. Adams, P. Darwin Bell, Sue C. Bodine, Heddwen L. Brooks, Nigel Bunnett, Bina Joe, Kara Hansell Keehan, Thomas R. Kleyman, Andre Marette, Rory E. Morty, Jan-Marino Ramirez, Morten B. Thomsen, Bill J. Yates, Irving H. Zucker. 


Two MSBS students from Dr. Camilla Wenceslau's lab have been selected as oral presenters at the North American Vascular Biology Organization's Summer Camp (VAVBO). The titles of their presentations are listed below.
 
Vaishnavi Aradhyula:
Female rats artificially selected for low and high intrinsic aerobic capacity swap inflammatory cascade in resistance arteries: Mechanisms of cyclooxygenase-derived prostanoids
Aradhyula, Vaishnavi; Bearss, Nicole; McCarthy, Cameron; Edwards, Jonnelle; Joe, Bina; Koch, Lauren; Wenceslau, Camilla
University of Toledo College of Medicine and Life Sciences, Toledo, OH
Vaishnavi will be presenting on July 1st at 2:50PM.
 
Soyoung Cheon:
Opioids cause sex-specific vascular remodeling via Cofilin-ERK signaling: Female mice present higher risk of developing morphine-induced vascular dysfunction than male mice
Cheon, Soyoung; Edwards, Jonnelle; Tomcho, Jeremy; Bearss, Nicole; Joe, Bina; McCarthy, Cameron; Wenceslau, Camilla
University of Toledo College of Medicine and Life Sciences, Toledo, OH
Soyoung presented on June 24th, at 3:30PM.


Our Department has remained highly productive during the lockdown phase as evidenced by the following publications. Some of these publications, especially related to COVID-19 have been downloaded over 8,000 times just within the short period of a few months. This is an impressive performance by our students and faculty, one that speaks to our high level of productivity despite the pandemic.

  1. Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease. Golonka RM, Saha P, Yeoh BS, Chattopadhyay S, Gewirtz AT, Joe B, Vijay-Kumar M. Physiol Genomics. 2020 May 1;52(5):217-221. doi: 10.1152/physiolgenomics.00033.2020. Epub 2020 Apr 10. PMID: 32275178
  2. Artificial intelligence and machine learning to fight COVID-19. Alimadadi A, Aryal S, Manandhar I, Munroe PB, Joe B, Cheng X. Physiol Genomics. 2020 Apr 1;52(4):200-202.doi:10.1152/physiolgenomics.00029.2020. Epub 2020 Mar 27. PMID: 32216577 

  3. Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remodeling in mice. Edwards JM, Roy S, Tomcho JC, Schreckenberger ZJ, Chakraborty S, Bearss NR, Saha P, McCarthy CG, Vijay-Kumar M, Joe B, Wenceslau CF. Vascul Pharmacol. 2020 Feb-Mar;125-126:106633. doi: 10.1016/j.vph.2019.106633. Epub 2019 Dec 13. PMID: 31843471 

  4. Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota. Singh V, Yeoh BS, Abokor AA, Golonka RM, Tian Y, Patterson AD, Joe B, Heikenwalder M, Vijay-Kumar M. Gut Microbes. 2020 Mar 30:1-15. doi: 10.1080/19490976.2020.1743492. Online ahead of print. PMID: 32223398

  5. Genetic predisposition for increased red blood cell distribution width is an early risk factor for cardiovascular and renal comorbidities. Cheng X, Mell B, Alimadadi A, Galla S, McCarthy CG, Chakraborty S, Basrur V, Joe B. Dis Model Mech. 2020 Apr 3:dmm.044081. doi: 10.1242/dmm.044081. Online ahead of print. PMID: 32238420

  6. Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder: 2019 Harriet Dustan Award. Chakraborty S, Mandal J, Yang T, Cheng X, Yeo JY, McCarthy CG, Wenceslau CF, Koch LG, Hill JW, Vijay-Kumar M, Joe B.Hypertension. 2020 Apr 27:HYPERTENSIONAHA12013896. doi: 10.1161/HYPERTENSIONAHA.120.13896. Online ahead of print. PMID: 32336227

  7. Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids. Robles-Vera I, Toral M, de la Visitación N, Sánchez M, Gómez-Guzmán M, Romero M, Yang T, Izquierdo-Garcia JL, Jiménez R, Ruiz-Cabello J, Guerra-Hernández E, Raizada MK, Pérez-Vizcaíno F, Duarte J. Mol Nutr Food Res. 2020 Mar;64(6):e1900616. doi: 10.1002/mnfr.201900616. Epub 2020 Feb 6. PMID: 31953983

  8. The obligatory role of the acetylcholine-induced endothelium-dependent contraction in hypertension: Can arachidonic acid resolve this inflammation? Edwards JM, McCarthy CG, Wenceslau CF. Curr Pharm Des. 2020 Apr 17. doi: 10.2174/1381612826666200417150121. Online ahead of print. PMID: 32303165

  9. Mitophagy in Hypertension-Associated Premature Vascular Aging. Schreckenberger ZJ, Wenceslau CF, Joe B, McCarthy CG. Am J Hypertens. 2020 Apr 6:hpaa058. doi: 10.1093/ajh/hpaa058. Online ahead of print.PMID: 32533696

  10. Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia. Zhang S, Breidenbach JD, Khalaf FK, Dube PR, Mohammed CJ, Lad A, Stepkowski S, Hinds TD, Kumarasamy S, Kleinhenz A, Tian J, Malhotra D, Kennedy DJ, Cooper CJ, Haller ST. J Am Heart Assoc. 2020 Apr 7;9(7):e014072. doi: 10.1161/JAHA.119.014072. Epub 2020 Mar 21. PMID: 32200719

  11. The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication. Subramanian G, Popli S, Chakravarty S, Taylor RT, Chakravarti R, Chattopadhyay S.J Biol Chem. 2020 Apr 9:jbc.RA120.013533. doi: 10.1074/jbc.RA120.013533. Online ahead of print. PMID: 32273341

  12. High Throughput Screening of FDA-Approved Drug Library Reveals the Compounds that Promote IRF3-Mediated Pro-Apoptotic Pathway Inhibit Virus Replication. Glanz A, Chawla K, Fabry S, Subramanian G, Garcia J, Jay B, Ciricillo J, Chakravarti R, Taylor RT, Chattopadhyay S. Viruses. 2020 Apr 14;12(4):E442. doi: 10.3390/v12040442. PMID: 32295140 

  13. Kirkpatrick JF and Turner JWJr  (2020),  Wildlife Contraception and Political Cuisinarts (Chapt. 19),  In ( Allen DM and Howell JW, eds.) Title: Groupthink in Science, (subtitle;  Greed, Pathological Altruism, Ideology, Competition and Culture),  Springer Int’l Publ., New York , 278 pp.  [ ISBN 978-3-030-36822-7 ].

  14. Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity.Yang T, Chakraborty S, Saha P, Mell B, Cheng X, Yeo JY, Mei X, Zhou G, Mandal J, Golonka R, Yeoh BS, Putluri V, Piyarathna DWB, Putluri N, McCarthy CG, Wenceslau CF, Sreekumar A, Gewirtz AT, Vijay-Kumar M, Joe B.Hypertension. 2020 Jul;76(1):e1-e3. doi: 10.1161/HYPERTENSIONAHA.120.15360. Epub 2020 May 19.PMID: 32426999

  15. Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage. Chakraborty S, Mandal J, Cheng X, Galla S, Hindupur A, Saha P, Yeoh BS, Mell B, Yeo JY, Vijay-Kumar M, Yang T, Joe B.Hypertension. 2020 Jul;76(1):59-72. doi: 10.1161/HYPERTENSIONAHA.120.14830. Epub 2020 May 26.PMID: 32450738

  16. Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota. Golonka RM, Xiao X, Abokor AA, Joe B, Vijay-Kumar M.J Nutr Biochem. 2020 Jun;80:108360. doi: 10.1016/j.jnutbio.2020.108360. Epub 2020 Feb 22. PMID: 32163821 Review.


     

The high school students who spent their fall with us obtaining college credit for research presented their work virtually at the State Science Day and won Ohio Academy of Science placements. Shrey Gupta, who worked with Dr. Ritu Chakravarti won an 'Excellent' rating. Daven Serakonda, who worked under Dr. Matam Vijay-Kumar, Avinash Singh who worked closely with Dr. Cameron McCarthy and Evangelina Louis who worked closely with Saroj Chakraborty, all obtained a superior rating. Ms. Louis also won first prize for statistical analysis.  We are proud of these talented students.


Congratulations to Dr. Ritu Chakravarti and Dr. Bina Joe! Their patent, "Materials and Methods for the Prevention of Rheumatoid Arthritis", was published on May 22, 2020.


 

Dr. Usman Ashraf from Dr. Sivarajan Kumarasamy's Lab successfully defended his thesis on May 29, 2020.  Well done, Usman! Usman has accepted a Post-Doc Fellowship at the University of Mississippi Medical Center.  


Congratulations to Dr. Beng San Yeoh, Postdoc  who was selected by the American Physiological Society to submit a full application for the 2020-2021 Postdoctoral Fellowship program.  Good Luck Beng!


Congratulations to Rachel Golonka for her first-authored publication with her colleagues, Dr. Beng San Yeoh, her mentor Dr. Matam Vijay Kumar and their collaborators from the University of Alabama. Their manuscript, "Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer" was accepted for publication in PLoSOne.


Congratulations to Dr. Camilla Wenceslau! She was selected as the winner of the 2020 John Laragh Research Award of the American Journal of Hypertension (AJH).

The editors have judged her work to be exemplary in the field of hypertension. She has been invited to submit a manuscript to the AJH and the award also consists of a plaque and $5,000.  

https://academic.oup.com/ajh/pages/john_laragh_research_award


Congrats to Saroj Chakroborty, mentee of Dr. Bina Joe! His first authored manuscript was accepted for publication in the journal, Hypertension.

Title: Diurnal Timing Dependent Alterations in Gut Microbial Composition Are Synchronously Linked to Salt-Sensitive Hypertension and Renal Damage
Authors:  Saroj Chakraborty, Juthika Mandal, Xi Cheng, Sarah Galla, Anay Hindupur, Piu Saha, Beng San Yeoh, Blair Mell, Ji-Youn Yeo, Matam Vijay-Kumar, Tao Yang, Bina Joe 


Congratulations to Ms. Jonnelle Edwards and Colleagues in the Wenceslau Lab for their review article taking a closer look at a lipid, arachidonic acid, for its effect on vascular tone.
"The Obligatory Role of the Acetylcholine-Induced Endothelium-Dependent Contraction in Hypertension: Can Arachidonic Acid Resolve This Inflammation?"
Authors: Jonnelle M Edwards, Cameron G McCarthy, Camilla F Wenceslau


 

Congratulations to Dr. Tao Yang, et al! Their manuscript was recently accepted for publication in Hypertension!

Gnotobiotic Rats Reveal that Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity

Tao Yang1, Saroj Chakraborty1, Piu Saha1, Blair Mell1, Xi Cheng1, Ji-Youn Yeo1, Xue Mei1, Guannan Zhou1, Juthika Mandal1,  Rachel Golonka1, Beng San Yeoh1, Vasanta Putluri2, Danthasinghe Waduge Badrajee Piyarathna3, Nagireddy Putluri2, Cameron G. McCarthy1, Camilla Wenceslau1, Arun Sreekumar2, Andrew T. Gewirtz4, Matam Vijay-Kumar1, Bina Joe

1Microbiome Consortium, Center for Hypertension and Precision Medicine and the Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

2Dan L. Duncan Cancer Center, Advanced Technology Core, Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX, USA

3Department of Molecular and Cell Biology, Baylor College of Medicine, Houston, TX, USA

4Center for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA

This study clearly showed that gut microbiota represents a critical factor for the regulation of colonic Ace2 expression and associated colonic and systemic factors that likely contribute to the pathology of the gut-lung axis during COVID-19. Therefore, further studies are necessary to examine the gut microbial composition and its role in ACE2 expression in the COVID-19 susceptible and resistant populations, which would importantly inform on better clinical management of COVID-19.



Dr. Matam Vijay-Kumar was among three researchers at the University to receive Medical Research Society funding for COVID-19 research. As noted in the Dean's Update: "Dr. Vijay-Kumar is investigating flagellin — a bacterial component previously shown to eliminate viral infection — as a possible way to harness innate immune responses to fight the novel coronavirus that causes COVID-19. His project is also aimed at identifying biomarkers that can help clinicians diagnose the early and late stage biomarkers." Also, a hearty congratulations to Dr. Vijay-Kumar on his promotion to full Professor in the Department of Physiology and Pharmacology!


Congratulations to Dr. Matam Vijay Kumar and team who published an editorial on COVID-19! The following editorial was accepted for publication to AJP-Physiological Genomics.
Harnessing Innate Immunity to Eliminate SARS-CoV-2 and Ameliorate COVID-19 Disease
Authors: Rachel M. Golonka, Piu Saha, Beng San Yeoh, Saurabh Chattopadhay, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Abstract:
The newest coronavirus disease, COVID-19, has become the cause of a worldwide pandemic. Along with social distancing to minimize the COVID-19 wildfire-like spread, clinicians and research teams around the globe are working toward developing effective vaccines and repurposing anti-viral drugs to fight against COVID-19. Besides these conventional methods, we suggest that immunomodulation of innate immunity could present a novel, non-conventional approach to combat COVID-19.



A publication emanating from Dr. Youjie Zhang's graduate work in Dr. Joe's laboratory has been selected as the cover for the April issue of Physiological Genomics. The art developed by the journal reflects the content of the publication to indicate that the microbiome is vertically co-inherited depending on the selection of the  nuclear and mitochondrial genomes.


Congratulations to Dr. Cameron McCarthy, a Postdoctoral to Faculty Fellow from Dr. Bina Joe's lab! He has secured 5 year K99/R00 funding. This is no small feat. Your hard work and dedication have paid off!

The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers.
 
Project Title: Autophagy regulates β-hydroxybutyrate synthesis to prevent hypertension-associated premature vascular aging Grant Number: 1K99HL151889-01 Project Period: 07/01/2020 – 06/30/2022 (K99); 07/01/2022 - 06/30/2025 (R00)
 
Project Narrative
Hypertension is a condition of premature vascular aging, where the normal decline in vascular function as we age is accelerated and exacerbated. It is well established that upregulation of autophagy can ameliorate this “aged” phenotype; however, underlying mechanisms are yet to be determined. Given that autophagy also serves to mobilize macro- and micronutrients in times of stress, we hypothesize that upregulation of autophagy in the liver, stimulates the production of ketone body, β-hydroxybutyrate, which induces vasodilation, and decreases phenotypes of premature vascular aging associated with hypertension.


Congratulations to Dr. Matam Vijay Kumar and team! Their manuscript was accepted for publication by Physiological Reports.

Title:Distinct Iron Homeostasis in C57BL/6 and Balb/c Mouse Strains
 
Piu Saha#, Xia Xiao#, Yaqi Li, Rachel M. Golonka, Ahmed A. Abokor,  Beng San Yeoh, and Matam Vijay-Kumar
 
# These authors contributed equally
 
Abstract
C57BL/6 (BL6) and Balb/c mice exhibit prototypical Th1- and Th2-dominant immune predispositions, respectively. Iron is a pro-inflammatory metal ion; however, limited information is documented on the differences in iron homeostasis between BL6 and Balb/c strains. The objective of this study was to investigate the extent to which strain-level differences in these mice dictates the regulation of iron homeostasis during physiologic and inflammatory conditions. At basal levels, Balb/c mice displayed significantly higher levels of iron in systemic circulation and tissue compared to BL6 mice. Moreover, Balb/c mice had greater iron absorption as indicated by higher gene expressions of duodenal DcytB, DMT1, Fpn, SFT, and Heph. Similarly, hepatic Tf, TfR1, TfR2, and DMT1 expressions were augmented in Balb/c mice. Interestingly, there was no change in hepatic Hamp expression between the two strains, suggesting that the disparity in their maintenance of iron is independent of hepcidin. Additionally, the basal levels of intracellular labile iron pool in Balb/c intestinal epithelial cells, and bone marrow-derived macrophages and neutrophils, were higher compared to BL6 mice. When mice were challenged with lipopolysaccharide, the acute inflammatory response in BL6 mice was more pronounced than in Balb/c mice, as indicated by the more rapid development of hypoferremia and upregulation of serum IL-6 and TNF-a levels in BL6 mice. In conclusion, this study underscores that iron homeostasis is distinct between BL6 and Balb/c strains under both physiologic and inflammatory conditions.


Congratulations to Dr. Ritu Chakravarti! The Research Council approved her proposal, entitled “14-3-3zeta- A Novel Supressor of Rheumatoid Arthritis” for funding under the deArce-Koch Memorial Endowment Program. The award is in the amount of $20,800.
Well done!


Congratulations to Dr. Vijay Matam Kumar! He was awarded funding for his URFO Biomedical Research Innovation Program application, “Dissecting hypcholesterolemia as a novel risk factor underlying the predisposition toward diet-induced liver cancer”, has been awardedat the amount of $42,000. Well done!


Congratulations to Dr. Ritu Chakravarti on two manuscripts recently accepted from on-going collaborative work with Dr. Saurabh Chattopadhyay! 

Subramanian G, Popli S, Chakravarty S, Taylor RT, Chakravarti R, Chattopadhyay S.
J Biol Chem. 2020 Apr 9. pii: jbc.RA120.013533. doi: 10.1074/jbc.RA120.013533. [Epub ahead of print]
Abstract
Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt-IRF3), RLR (RIG-I-like receptor)-induced IRF3-mediated pathway of apoptosis (RIPA), which triggers apoptotic killing of virus-infected cells. Using knock-in mice expressing a transcriptionally inactive, but RIPA-active, IRF3 mutant, we demonstrated the relative contribution of RIPA to host antiviral defense. Given that RIPA is a cellular antiviral pathway, we hypothesized that small molecules that promote RIPA in virus-infected cells would act as antiviral agents. To test this, we conducted a high throughput screen of a library of FDA-approved drugs to identify novel RIPA activators. Our screen identified doxorubicin as a potent RIPA-activating agent. In support of our hypothesis, doxorubicin inhibited the replication of vesicular stomatitis virus, a model rhabdovirus, and its antiviral activity depended on its ability to activate IRF3 in RIPA. Surprisingly, doxorubicin inhibited the transcriptional activity of IRF3. The antiviral activity of doxorubicin was expanded to flavivirus and herpesvirus that also activate IRF3. Mechanistically, doxorubicin promoted RIPA by activating the extracellular signal-regulated kinase (ERK) signaling pathway. Finally, we validated these results using another RIPA-activating compound, pyrvinium pamoate, which showed a similar antiviral effect without affecting the transcriptional activity of IRF3. Therefore, we demonstrate that the RIPA branch of IRF3 can be targeted therapeutically to prevent virus infection.
 

  • High throughput screening of FDA-approved drug library reveals the compounds that promote IRF3-mediated pro-apoptotic pathway inhibit virus replication.

Glanz A, Chawla K, Fabry S, Subramanian G, Garcia J, Jay B, Ciricillo J, Chakravarti R, Taylor RT, Chattopadhyay S.
Viruses (accepted)
Abstract
The interferon (IFN) system is the first line of defense against virus infection. Recently, using a high-throughput genetic screen of a human IFN-stimulated gene (ISG) shRNA library, we identified a viral restriction factor, Tudor domain containing 7 (TDRD7). TDRD7 inhibits the paramyxo/pneumo viruses (e.g. Sendai virus and respiratory syncytial virus) by interfering with the virus-induced cellular autophagy pathway, which these viruses use for their replication. Here, we report that TDRD7 is a viral restriction factor against herpes simplex virus (HSV-1). Using knockdown, knockout, and ectopic expression systems, we demonstrate the anti-HSV-1 activity of TDRD7 in multiple human and mouse cell types. TDRD7 inhibited the virus-activated AMP-activated protein kinase (AMPK), which was essential for HSV-1 replication. Genetic ablation or chemical inhibition of AMPK activity suppressed HSV-1 replication in multiple human and mouse cells. Mechanistically, HSV-1 replication after viral entry was dependent on AMPK, but not on its function in autophagy. The antiviral activity of TDRD7 was dependent on its ability to inhibit virus-activated AMPK. In summary, our results indicate that the newly identified viral restriction factor TDRD7 inhibits AMPK and thereby blocks HSV-1 replication independently of the autophagy pathway. These findings suggest that AMPK inhibition represents a potential strategy to manage HSV-1 infections.
Kudos to Vaishnavi Aradhyula from Dr. Camilla Wenceslau's lab! She received an honorable mention for her presentation during the Three Minute Thesis Competition.

Congratulations to Dr. Matam Vijay Kumar and team who published an editorial on COVID-19! The following editorial was accepted for publication to AJP-Physiological Genomics.
Harnessing Innate Immunity to Eliminate SARS-CoV-2 and Ameliorate COVID-19 Disease
Authors: Rachel M. Golonka, Piu Saha, Beng San Yeoh, Saurabh Chattopadhay, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Abstract:
The newest coronavirus disease, COVID-19, has become the cause of a worldwide pandemic. Along with social distancing to minimize the COVID-19 wildfire-like spread, clinicians and research teams around the globe are working toward developing effective vaccines and repurposing anti-viral drugs to fight against COVID-19. Besides these conventional methods, we suggest that immunomodulation of innate immunity could present a novel, non-conventional approach to combat COVID-19.


Dr. Bina Joe has been invited to lecture at the Joint Meeting of the European Society of Hypertension (ESH) and the International Society of Hypertension (ISH) that will be held in Glasgow, UK, from 29th May 2020 to 1st June 2020.
 
The lecture will be part of an oral session titled,  "Experimental Hypertension". 


Congratulations to the trainees from our department who have been selected for oral presentations at the 2020 Graduate Research Forum. Below are the topics each will be presenting on. In addition to attending the poster sessions at the forum, I hope that we can all attend our departmental students' oral presentations.

Ahmad Alimadadi (Joe Lab) - "Application of Artificial Intelligence via Machine Learning to Classify Clinical Cardiomyopathies Using RNA-Seq Data"

Saroj Chakraborty (Joe Lab) - "Bile acid metabolites modulate Hypertension"

Jonnelle Edwards (Wenceslau Lab) - "Formyl Peptide Receptor-1 Activation is Crucial for Spontaneous Hypertension in Dahl Salt Sensitive Rats"

Good luck to all!


Our faculty and students are adding to community outreach, which is one of the important activities of the University of Toledo.  On Thursday of last week, several of our department's faculty and students participated as judges for the 2020 Science Fair at Ottawa Hills High School. Mr. Jeremy Nixon, one of the school's science teachers, organized the event.


Congratulations to Dr. Kumar and team! Their manuscript, "Altered Nutrient Status Reprograms Host Inflammation and Metabolic Health via Gut Microbiota" was accepted to Journal of Nutritional Biochemistry. (Impact Factor: 4.518)

The authors are: Rachel M. Golonka, Xia Xiao, Ahmed Abokor, Bina Joe, Matam Vijay-Kumar


Kudos to Juthika Mandal! Juthika, a trainee from Dr. Bina Joe's lab, has been invited for oral presentation not only at EB 2020 but also at the Hypertension 2020 Meeting in Scotland. The title of her abstract is, "Concerted diurnal rhythms of gut microbiota with salt-sensitive hypertension and renal inflammation". 


A hearty congratulations to Saroj Chakraborty! Saroj is a trainee from Dr. Bina Joe's lab and has been selected to participate in the March 2020 Cell Modeling Hackathon.

The hackathon is funded through the National Science Foundation (NSF). Saroj and a team of other selected participants will work as a group to generate a model of any particular cell system of their choice.


Congratulations to the Wenceslau and Joe Labs for two of their trainees, Soyoung Cheon and Juthika Mandal who are invited for oral presentations at the upcoming Experimental Biology Meeting!

Abstract Title: Opioids Cause Vascular Remodeling via Changes in Cofilin-ERK Signaling: Female Mice Present Higher Risk of Developing Morphine-induced Cardiovascular Disease than Male Mice
Presenting Author: Soyoung Cheon (Trainee of Dr. Camilla Wenceslau)
Poster Presentation:
Session Title: Vascular Pharmacology I
Session Day: Tuesday, April 7, 2020
Oral Presentation:
Session Title: Symposium - ASPET Daily Datablitz - Tuesday
Session Day: Tuesday, April 7, 2020
Programming Society: American Society for Pharmacology and Experimental Therapeutics


Abstract Title: Concerted diurnal rhythms of gut microbiota with salt-sensitive hypertension and renal inflammation
Presenting Author: Juthika Mandal (Trainee of Dr. Bina Joe)
Poster Presentation:
Session Title: Diet, Nutrients and the Microbiome in Blood Pressure and Electrolyte Regulation
Session Day: Tuesday, April 7, 2020
Oral Presentation:
Session Title: Featured Topic - Diet, Nutrients and the Microbiome in Blood Pressure and Electrolyte Homeostasis and Allostasis
Session Day: Tuesday, April 7, 2020
Programming Society: The American Physiological Society

Also congratulations to the following high school through postdoctoral trainees who will be representing the department at the annual EB 2020 meeting. Congratulations to all!

Wenceslau Lab:

Abstract 1:
Title: Formyl Peptide Receptor-1 Activation is Crucial for Spontaneous and Salt-Induced Hypertension in Dahl Salt Sensitive Rats: Mitochondria vs. Microbiota

Presenting Author: Jonnelle Edwards
Poster Presentation:
Session Title: CV Section Young Investigators I
Session Day: Sunday, April 5, 2020
Programming Society: The American Physiological Society

Abstract 2:
Title:
 Female Rats Artificially Selected for Low and High Intrinsic Aerobic Capacity Swap Inflammatory Cascade in Resistance Arteries: Mechanisms of Cyclooxygenase-Derived Prostanoids
Presenting Author: Vaishnavi Aradhyula
Poster Presentation:
Session Title: Exercise, Health and Disease
Session Day: Sunday, April 5, 2020
Programming Society: The American Physiological Society

Abstract 3:
Title:
 Commensal microbiota are essential for vascular contractility mediated by actin polymerization
Presenting Author: Janara Furtado
Poster Presentation:
Session Title: Cardiovascular Disease and Metabolic Disorders II
Session Day: Tuesday, April 7, 2020
Programming Society: The American Physiological Society

Joe Lab:

Abstract 1:
Title:
 Gnotobiotic rats reveal an obligatory role of microbiota in blood pressure
Presenting Author: Saroj Chakraborty
Poster Presentation:
Session Title: CV Section Young Investigators II
Session Day: Tuesday, April 7, 2020
Programming Society: The American Physiological Society

Abstract 2:
Title:
 Sex differences in salt-responsive modulation of bile acids by microbiota regulates Hypertension
Presenting Author: Saroj Chakraborty
Poster Presentation:
Session Title: CV Section Young Investigators II
Session Day: Tuesday, April 7, 2020
Programming Society: The American Physiological Society

Abstract 3:
Title:
 &[beta]-Hydroxybutyrate (&[beta]OHB) Activates Gpr109a to Contribute to the Anti-vascular Aging Effect of Autophagy
Presenting Author: Cameron McCarthy
Poster Presentation:
Session Title: Heterocellular Communication in the Heart and Vasculature
Session Day: Tuesday, April 7, 2020
Programming Society: The American Physiological Society

Abstract 4:
Title:
 Reshaping commensal gut microbiota in early life lowers blood pressure potentially via a succinate mediated mechanism
Presenting Author: Saroj Chakraborty
Poster Presentation:
Session Title: Hypertension
Session Day: Tuesday, April 7, 2020
Programming Society: American Society for Pharmacology and Experimental Therapeutics

Abstract 5:
Title:
 A novel ex-vivo procedure for monitoring &[beta]-hydroxybutyrate (&[beta]OHB) production from isolated whole livers
Presenting Author: Avinash Singh
Poster Presentation:
Session Title: Liver Physiology and Pathophysiology
Session Day: Sunday, April 5, 2020
Programming Society: The American Physiological Society


Congratulations to Usman Ashraf, trainee of Dr. Sivarajan Kumarasamy, for his article that was published in the Toledo Blade today! The article is about salt sensitivity and blood pressure and can be viewed here: 

https://www.toledoblade.com/culture/2020/02/03/ut-ressearch-explores-salt-and-blood-pressure


A hearty congratulations to two of Dr. Camilla Wenceslau's trainees!

Jonnelle Edwards and Vaish Aradhyula are both recipients of the 2020 Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award.

This award helps trainees to attend the annual APS Experimental Biology Meeting. This year the meeting is held in April in San Diego.


Congratulations to Dr. Tao Yang! He has been selected to serve on the editorial board of Hypertension. His term will last three years.

Hearty congratulations to both Dr. Beng San Yeoh and MOME Trainee, Rachel Golonka! They will both present at the Society for Mucosal Immunology - Local Chapter Meeting in Ann Arbor, MI. Dr. Yeoh's research entitled 'Persistent IL-1β Signaling Aggravates Murine Enteropathogen, Citrobacter rodentium infection in mice' was accepted for a poster presentation. Rachel's research was accepted for an oral presentation. Her presentation is titled, "Aggravated colitis in Farnesoid X Receptor deficient mice is associated with altered immunological responses and a reshaped gut microbiota". Rachel is a trainee of Dr. Matam Vijay Kumar. SMI brings together researchers from the University of Michigan, Michigan State University, Wayne State University, and the University of Toledo to discuss current topics in immunology at mucosal surfaces.

This symposium is sponsored by the Society for Mucosal Immunology and invites all investigators to share their work, but specifically aims to promote the work of junior investigators.


Dr. Tao Yang has been invited to serve on the Editorial Board of Hypertension, a prestigious international journal of the American Heart Association. 

Dr. Yang is a member of the UT Microbiome Consortium (UT MiCo). He has considerable experience in studying the gut-brain axis in hypertension and was recently recruited from the University of Florida to develop his independent research in this area under Dr. Bina Joe's mentorship.


 Congratulations to Dr. Matam Vijay Kumar and team! Their manuscript entitled, "Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota" was accepted for publication in Gut Microbes.

Authors: Vishal Singh#, Beng San Yeoh#, Ahmed A. Abokor, Rachel M. Golonka, Yuan Tian, Andrew D. Patterson, Bina Joe, Mathias Heikenwalderand Matam Vijay-Kumar
#These authors contributed equally


Dr. Bina Joe has been invited by the Toledo Opera Guild to speak at the International Women's Day celebration to be held at the Pinnacle, Sunday, March 8th from 10 a.m to 3 p.m.  Please see the announcement in the Toledo City Newspaper.
 
There will be educational booths, activities and entertainment throughout the day and her classical dance troupe will be performing at 10:30 a.m. and the speakers begin at 12:15 p.m.

https://toledocitypaper.com/feature/international-womens-day-2020/


Dr. Bina Joe's research was highlighted in the UT Alumni eMagazine. See the link for the whole article. https://alumninews.utoledo.edu/2020/02/17/utoledo-faculty-break-new-ground-in-research-attract-project-funding/


Dr. Matam Vijay-Kumar was invited to speak at the 2020 Microbiome, Viruses, and Cancer Meeting of the American Association for Cancer Research (AACR) in Orlando, FL.

He presented his work during the Microbiota and Gastrointestinal Cancer session and his talk was titled, "Gut microbiota dysbiosis and dietary fermentable fibers in a pickle: a brew for liver cancer".   


An abstract of Usman Ashraf, a trainee of Dr. Sivarajan Kumarasamy, has been selected for a poster presentation during the Midwest Clinical and Translational Research Meeting of CSCTR and MWAFMR at the Holiday Inn Chicago Mart Plaza in Chicago in April. Well done!
 
The title of Usman's abstract is: Transcriptomic  Analysis of Resp18mutant Rat Kidneys Reveals Up-Regulation of Renin-Angiotensin System.


 

Congratulations to Dr. Bina Joe, students and colleagues who recently had a manuscript accepted for publication to JAHA: Journal of the American Heart Association! Title: Exposure to amoxicillin in early life is associated with changes in gut microbiota and reduction in blood pressure: Findings from a study on rat dams and offspring. Authors: Sarah Galla, PhD, Saroj Chakraborty, MS, Xi Cheng, PhD, Ji-Youn Yeo, PhD, Blair Mell, BS, Nathaline Chiu, BS, Camilla F. Wenceslau, PhD, Matam Vijay-Kumar, PhD, Bina Joe, PhD.


 Congratulations to Jonnelle Edwards, mentee of Dr. Camilla Wenceslau, and team! Their manuscript, "Microbiota are critical for vascular physiology: Germ-free status weakens contractility and induces sex-specific vascular remondeling in mice",  was accepted for publication in Vascular Pharmacology!


 Several students and faculty of the Department are engaged in providing research training to honors high school students of Ottawa Hill High School. Dr. Joe was recently featured on WTOL News featuring this UT- Ottawa Hills partnership, which is also supported with funds for a research class at the school by ProMedica. https://www.wtol.com/article/life/family-focus/local-high-school-students-work-with-researchers-on-cancer-dna/512-b98e6325-d366-4467-849d-e5bb766f408e


 Dr. Bina Joe has been selected as the 2020 Distinguished Mayerson-DiLuzio Visting Professor of the Department of Physiology at Tulane University in New Orleans. This award is presented to an outstanding physiologist who is also recognized for their unique relationships with the Tulane Physiology department and faculty.  She will deliver a lecture and accept this award in late March. Congratulations!


Women & Philanthropy at the University of Toledo has funded Dr. Bina Joe and therefore, our Department has newly renovated lab space with state-of-the-art equipment establishing germ-free models to conduct critical experiments in microbiome research.  Faculty, Staff and Students will host  a reception and meet and greet with members of the Women & Philanthropy group, followed by a presentation, demonstration and tour of the new lab on Friday, November 15, 2019 from 4:30-7:30 p.m.  The Lab is the first area of the Germ-Free Facility for Biomedical Research to come on-line. It will increase research opportunities and experimental learning in the College of Medicine. It will also establish increased capabilities centered around microbiome research as it impacts human health and focus attention on the ignored component of our bodies, i.e., microbiota.  


 Congratulations to Dr. Bina Joe! She received the Harriet Dustan Award sponsored by the Council on Hypertension. This award recognizes female investigators who make outstanding contributions in the field of Hypertension. The award was presented to her during the Hypertension Scientific Sessions in September in New Orleans. Read more here: http://news.utoledo.edu/index.php/09_27_2019/utoledo-hypertension-expert-receives-prestigious-american-heart-association-award


Congratulations to Dr. Bina Joe and colleagues! Their manuscript has been accepted for publication to Physiological Genomics. It is also selected to be featured as the cover article for the April 2020 edition!

Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases. Contributing authors: Youjie Zhang, Sivarajan Kumarasamy, Blair Mell, Xi Cheng, Eric Morgan, Steven Britton, Matam Vijay-Kumar, Lauren Koch, and Bina Joe.  Physiological Genomics 


 Dr. Vijay-Kumar was recently invited to present a lecture at the inaugural meeting of the National Cancer Institute (NCI) Center for Cancer Research (CCR) Liver Cancer Program (LCP). 

The NCI-CCR-LCP was launched in 2018 with the mission of developing a multi-disciplinary program focused on the prevention, early detection and improved diagnosis and treatment of liver cancer. 

Dr. Vijay-Kumar was one among many prominent scientists invited from all over the world.  

Congratulations, Dr. Vijay-Kumar!


Congratulations to Dr. Cameron McCarthy! He has been selected to serve as a member of the Editorial Board of Hypertension. This is a big deal considering Hypertension is a top ranking journal in Cardiovascular Sciences. Well done!


Jonnelle Edwards, Ph.D candidate in Dr. Camilla Wenceslau's lab, served the University of Toledo as an exhibitor and undergraduate poster competition judge at the Annual Biomedical Research Conference for Minority Students (ABRCMS) that was held November 13th-16th in Anaheim, California. The conference hosted over 3,000 minoritized students ranging from high school to post-baccalaureate students that are all interested in STEM careers. 


 Several members and trainees also participated in the Council and received awards:

Dr. Bina Joe: recipient of Harriet Dustan award and delivered Harriet Dustan Award Lecture and Poster Moderator of Clinical, Genetic and Epidemiological Mechanisms session
Dr. Matam Vijay-Kumar: Presented data during the Recent Advances: Microbiome session and participated in the Trainee Onsite Poster Competition
Dr.  Lauren Koch: Participated in the Salt and Nutrition poster session and was a Moderator for Vascular Stiffness and Fibrosis session
Dr. Camilla Wenceslau: Participated in the CHAMP Lunch as a mentor and was Poster Moderator for Trainee Onsite Poster Competition
Dr. Sivarajan Kumarasamy: Poster Moderator for Trainee Onsite Poster Competition
Dr. Cameron McCarthy: Recipient of the Council on Hypertension New Investigator Award and presented data in the Vascular Biology and Function session and Poster Moderator for Pharmacology and Non-pharmacological Approaches session
Dr. Tao Yang: Recipient of the Council on Hypertension New Investigator Award and presented data in both the Hypertension in Pregnancy and Offspring session and Regulation of Blood Pressure by the Central Nervous System session
Usman Ashraf:  Presented data in Mechanisms in Chronic Kidney Disease and Fibrosis session and attended the CHAMP Lunch as a mentee
Jonnelle Edwards: Presented data in the Inflammation and Immune Mechanisms session and attended the CHAMP Lunch as a mentee
Shaunak Roy: Recipient of Council on Hypertension Trainee Advocacy Committee New Investigator Award and  presented data in the Vascular Stiffness and Fibrosis session and attended the CHAMP Lunch as a mentee
Jeremy Tomcho: Participated in Trainee Onsite Poster Competition and attended the CHAMP Lunch as a mentee


A book chapter that Dr. Bina Joe wrote with Dr. John Rapp has been accepted for publication  in Comprehensive Physiology.
"Dissecting Epistatic QTL for Blood Pressure in Rats: Congenic Strains Versus Heterogeneous Stocks, a Reality Check" John P. Rapp and Bina Joe*               


Dr. Camilla Wenceslau has been invited to be a member of the Hypertension and Microcirculation Study Section. This study section "reviews applications involving basic and applied aspects of cardiovascular regulation  with focus on the physiology of blood pressure regulation, the pathogenesis of hypertension and the microcirculation and includes  tudies on cell surface receptors and signaling processes of various hormones, paracrines,  and autocrines and their mechanisms of action as related to hypertension, integrated  neural-humoral control of circulation, regional hemodynamics, lymphatic circulation,  and microcirculation".                


Dr. Bina Joe was invited to present a ‘State-of-the-art’ Lecture at the Canadian Hypertension  Congress held in Edmonton, Canada from Sept 25-28. Her talk was titled ‘Pressure from the Bugs Within: Microbiomic and Metabolomic effects on hypertension’. 

The Canadian Hypertension Congress is Canada’s largest national scientific and educational  conference of its kind and is designed to incorporate today’s needs and expectations   of scientists, researchers, and clinicians. This year’s theme was  “A Whole-Patient Approach” and covered the topics in hypertension and adjacent conditions for whole-patient care  listed here:               

  • Cardiovascular Disease (Stroke,      Heart Failure, Atrial Fibrillation)
  • Dementia
  • Diabetes
  • Thresholds & Targets
  • Kidney Disease
  • Obesity

The Congress brings together leading minds from various disciplines and specialties, with more than 500 of Canada’s leading hypertension scientists and researchers, specialists,   physicians, pharmacists, nurses, dietitians, health experts, and public health officials  in attendance.               


Dr. Bina Joe, Distinguished University Professor and Chair of the Department of Physiology and Pharmacology, is featured in The Academic Minute, which is available as a podcast  from NPR,  on the Academic Minute website and shared on Inside Higher Ed, features researchers from colleges and universities in the US and all around the world, bringing updates on what’s new and exciting in the academy and how academic research contributes to solving the world’s problems and to serving the public good. The Academic Minute is also available at:                

·The Academic Minute airs on the WAMC Northeast Public Radio at 7:30 a.m. and 3:56  p.m. weekdays. You should be able to listen live here: https://www.wamc.org/listen-live-wamc

 

·Audio and the written script will be posted on the Academic Minute website: https://academicminute.org/

 

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http://news.utoledo.edu/index.php/09_23_2019/utoledo-researchers-take-over-national-academic-research-program-this-week


Congratulations to Usman Ashraf who was selected to be a speaker at the Ohio Physiological Society Meeting.
He spoke on Saturday, September 21 in the session titled “Kidney Function in Health and Disease,” which was chaired by Dr. Clintoria Williams of Wright State University. 
Well done!


Congratulations to Dr. Xi Cheng! He was awarded as an APS Publications Star Reviewer  - well done!               


Congratulations to Drs. Bina Joe, Camilla Wenceslau and Cameron McCarthy! They have all been invited by the American Journal of Hypertension to become members of their  Editorial Board. The initial terms, starting January 2020 are for three years, with   the possibility of additional three year terms.               


A review paper, "Mechanism and Biomarkers in Aortitis-A Review" by Benjamin Benhuri,  Ammar ELJack, Bashar Kahaleh, and Ritu Chakravarti, was accepted in Journal of Molecular Medicine. Well done, Dr. Chakravarti!               


Congratulations to Dr. Matam Vijay-Kumar and Beng Yeoh! Their manuscript, "inflammation promotes stress erythropoiesis", was featured on the cover of Science Signaling.


Congratulations to our Faculty and Staff who were recognized at the COMLS Recognition Dinner: 
 
New Investigator Research Excellence Award: Dr. Matam Vijay-Kumar
 
Dean’s Award for Staff Career Achievement: Elizabeth Akeman 
 
Nominee for Dean’s Award for Advising Excellence: Dr. Guillermo Vazquez 
 
Nominees for Dean’s Award for Outstanding Staff: Anita Easterly & Celia Egan 


Dr. Vijay Kumar has been selected as the recipient of the University of Toledo College of Medicine and Life Sciences Dean’s Award for New Investigator Research Award for 2019.  Hearty Congratulations!               


Congratulations to Dr. Tao Yang! He has been selected to receive the HTN New Investigator  Award at the AHA Conference on Hypertension in New Orleans to be held in September  for his abstract titled, "Maternal high blood pressure control persistently alters gut-brain communication and attenuates hypertension of offspring".  This award includes  a monetary prize plus complimentary registration to the conference. His abstract has also been selected for podium presentation at the Council for the same abstract as  well as another abstract titled, "Gut dysbiosis impairs serotonergeic gut-brain axis  and increased blood pressure". Well done!               


Congratulations to Dr. Cameron McCarthy from the Joe Lab! His manuscript was accepted for publication in AJP Heart and Circulatory Physiology. Reconstitution of autophagy ameliorates vascular function and arterial stiffening  in spontaneously hypertensive rats. Cameron McCarthy, Camilla Wenceslau, Fabiano Calmasini, Nicole Klee, Michael Brands,   Bina Joe, and R. Clinton Webb               


Congratulations to Blair from the Joe Lab! Her manuscript was accepted in PLOS One. QTL mapping of rat blood pressure loci on RNO1 within a homologous region linked to  human hypertension on HSA15. Blair Mell, Xi Cheng, Bina Joe


Congratulations to Dr. Sivarajan Kumarasamy! He has been invited by the American Heart Association to be part of the AHA Institutional Research Enhancement Award (AIREA) study section. This is to support small-scale research projects related to cardiovascular diseases and stroke at educational institutions that provide baccalaureate or advanced degrees but that have not been major recipients of NIH support.   He also received an invitation from the AHA to sit on the Council on Hypertension Trainee Advocacy Committee (HTN TAC) – which “aims to foster the development of trainees and  early career professionals in the field of hypertension and related fields, including research scientists and clinicians”.            


Congratulations to Dr. Cara Peter from Dr. Ritu Chakravarti’s Lab! She successfully defended her thesis on July 18, 2019. Well done, Cara!               


A warm welcome to Dr. Tao Yang and Dr. Guannan Zhou! They are from the University of Florida. Dr. Tang is a Dean’s Postdoctoral to Faculty Fellow and will be working in Dr. Bina Joe's lab.  Dr. Tang is funded for his research on microbiota through the Biocodex foundation.  Dr. Zhou is a Postdoctoral Fellow and will be working in Dr. Lauren Koch’s  lab.               


Kudos to Dr. Cameron McCarthy! He has been selected to receive the HTN New Investigator Travel Award of the Hypertension 2019 Scientific Sessions! The award will be presented to him during a ceremony in New Orleans.  ABSTRACT: Control 59, Beta-Hydroxybutyrate Synthesis Contributes to the Anti-Vascular Aging Effect of Autophagy Well done!               


Hearty congratulations to Dr. Cheng! His grant titled Genome-wide investigation of circular RNAs in alcohol-related phenotypes using the Hybrid Rat Diversity Panel,  has been funded by the NIDA (National Institute on Drug Abuse) Center of Excellence in Omics, Systems Genetics, and the Addictome.               


Congrats to Shaunak Roy! (Wenceslau Lab) He has been selected to receive the "Hypertension Trainee Advocacy Committee New Investigator Travel Grant" sponsored by the Trainee Advocacy Committee of the AHA's Council on Hypertension! As described on their website,  "Four awardees will be presented a travel grant to help defray travel expenses to  attend the Hypertension Scientific Sessions 2019 and will receive complimentary registration to the conference."               


Congratulations to the Kumarasamy Lab!  A review article with Dr. Kumarasamy as the lead author was accepted for publication in the Endocrinology journal.  Regulated Endocrine-Specific Protein-18, an emerging endocrine protein in physiology:  A literature review . Ealla Atari, Mitchel C. Perry, Pedro A. Jose, and Sivarajan Kumarasamy           


 The APS published a feature about Dr. Bina Joe's work on their website. View the  whole article here:  https://www.the-aps.org/detail/person/bina-joe-phd?SSO=Y


Congratulations to Dr. Cameron McCarthy, Shaunak Roy, Jonnelle Edwards and Usman Ashraf!

 They have all been notified that their abstracts for the AHA 2019 Scientific Sessions Council for Hypertension have been accepted for oral presentation. The meeting takes place in New Orleans, September 5-8. Congratulations to each of you!               


 Congratulations to Dr. Lauren Koch! She had a book chapter published in Rat Genomics – Here are the details:               

Chapter 15 “Rat Models of Exercise for the Study of Complex Disease.” Koch LG, Britton SL. Methods Mol Biol. 2019;2018:309-317. doi: 10.1007/978-1-4939-9581-3_15.               

Dr. Koch mentions “this book provides both a historical perspective on rat research through the years and practical information to support researchers either currently involved in genomic research or planning to begin such a project.”               


 Congratulations to Dr. Ritu Chakravarti and Lab! Their manuscript, “14-3-3zeta - A Novel Immunogen Promotes Inflammatory Cytokine Production” was accepted for publication in Frontiers in Immunology.                

Authors: Jenna McGowan, Cara Peter, Saurabh Chattopadhyay, and Ritu Chakravarti
Abstract: The presence of autoantibodies against 14-3-3z in human autoimmune diseases   indicates its antigenic function. However, neither the cause nor the consequence of  this newly-identified antigenic function of 14-3-3z protein is known. To address this,  we investigated the immunological functions of 14-3-3z by studying ex vivo effects  on human peripheral blood mononuclear cells (PBMC) proliferation, polarization and cytokine production. Exogenous 14-3-3z promoted PBMC proliferation and T cell polarization towards increasing Th1 and Th17 populations. Significant increases in IFN-g and IL-17      levels were observed in the presence of 14-3-3z. A specific increase in Th1 cells and IFN-g production provided strong evidence for MHC class II presentation of 14-3-3z  antigen. Particularly HLA-DRB1*0401 allele strongly promoted 14-3-3z-induced IFN-g  producing cells. In contrast, prednisolone treatment inhibited 14-3-3z-induced both T cell polarization and cytokine production. Overall, we show that MHC presentation and adaptor functions of 14-3-3z participate in promoting IFN-g and IL-17 production,  two of the cytokines commonly associated with autoimmune diseases. To the best of                  our knowledge, this is the first report describing the ex vivo antigenic function of 14-3-3z with human PBMC, thereby providing the basis of its immunological role in human diseases.               


Congratulations to the Dr. Vijay Kumar and Lab! Their manuscript, “Enterobactin, an  Iron Chelating Bacterial Siderophore, Arrests Cancer Cell Proliferation” was accepted  for publication in Journal of Biochemical Pharmacology.

Authors:Piu Saha, Beng San Yeoh, Xia Xiao, Rachel M. Golonka, Sivarajan Kumarasamy  and Matam Vijay-Kumar                     


 Shaun Roy from Dr. Camilla Wenceslau’s lab won first place in the poster competition  at the 46th Annual Pharmacology Colloquium held Friday, June 21, 2019. Congratulations!               


 It is exciting for our Department to be hosting the 46th Annual Colloquium on June 21st. Dr. Clinton Webb will also be with us as the Keynote speaker. Many thanks to Dr. Andrew Beavis for coordinating this event for so many years.               


 Dr. Bina Joe has been selected to receive the Harriet Dustan Award sponsored by the  Council on Hypertension. This award recognizes female investigators who make outstanding   contributions in the field of Hypertension. The award will be presented during the Hypertension Scientific Sessions in September in New Orleans.               


Nineteen High School students, 47 volunteers and 5 days is what it took to successfully complete the first Pre-Med Summer Camp organized by our Department! The camp was led  by Dr. Ritu Chakravarti.  We had raving reviews from both the students and their parents  on the content and organization of this camp. Students came from places as far as  California, Texas, Indiana and also from several schools in the Toledo area. Besides getting exposure to the clinical facets, they appreciated the opportunity to conduct  hands-on experiments in genomic medicine for a whole week! Sincere thanks to the 5   laboratories that participated: Dr. Chakravarti, Dr. Wenceslau, Dr. Kumar, Dr. Kumarasamy  and Dr. Joe. Special thanks to faculty, staff and students of the UT community who also contributed their time for our camp.               


Dr. Bina Joe was recently awarded a grant in the amount of $65,000 from Women & Philanthropy for the Women & Philanthropy Gnotobiotic (Germ-Free) Rat Facility for Biomedical Research.               


 Dr. Vijay Kumar and Lab had a manuscript accepted in Current Pharmacology Reports. This is the second review article where Rachel has been first author. Well done!            

The review is entitled: "Dietary Additives and Supplements Revisited: The Fewer, the  Safer for Liver and Gut Health" Authors: Rachel M. Golonka, Beng San Yeoh, Matam Vijay-Kumar                   


Rachel Golonka from Dr. Kumar’s Lab recently participated in the WISDOM (Women in   STEMM Day of Meetings) event as a chaperone/tour guide. Female sophomore high school  students were invited to explore some different areas in the medical field. During  this event, they toured the Anatomy Museum while learning about plastination; learned  how to make hand sanitizer from scratch (interesting side note: UT is the only university  in the country with an undergraduate program for cosmetology); and also visited the  SIM center, specifically the 'i' space, which provides 3D visualization of human anatomy and other simulations.               


Dr. Ritu Chakravarti recently presented her study, “Characterizing antigenic functions of 14-3-3z-A Novel autoantigen” at the Annual Meeting of American Association of Immunologists in San Diego, CA. She also received an Early Career Faculty Travel grant from AAI. Congrats!


 May 20th Dr. Joe had the pleasure of speaking at the Toledo Rotary Club, Downtown Toledo. The talk was titled ‘Pressure from the Bugs Within’. It was well attended by about 250 Rotarians and others and was well received in the community.

Dr. Terry Hinds’ lab was one of five groups that were highlighted by the UT President for research at UT. They had an interactive exhibit that discussed their new patent on Pegylated-Bilirubin for obesity, diabetes, hyperlipidemia, and cardiovascular disease. There were over 350 donors that attended the reception. Congratulations!


 Congratulations to Drs. Guillermo Vazquez and Matam Vijay Kumar! They have been selected as members of UT Leadership Institute (UTLI).  “Participants were selected to represent a range of colleges, faculty rank, current leadership roles, and overall leadership experiences and will acquire broad perspectives and knowledge of higher education, leadership and careers paths.Discussions will address a range of issues such as the administrative structure of higher education, leadership styles, critical issues facing administrators, funding, diversity and inclusion.


 The Center for Hypertension and Precision Medicine’s annual World Hypertension Day display was a successful day of bringing hypertension awareness to staff and visitors of the Health Science Campus. Many stopped to check their blood pressure and to receive additional information regarding hypertension and high blood pressure. A big thank you to CHPM trainees, Rachel Golonka (Kumar Lab) and Stephanie Clark (Joe Lab) and CHPM secretary, Melody Knotts for making this activity a success!


 Dr. Terry Hinds, Assistant Professor of Department of Physiology and Pharmacology, was the Max Miller Lecture in Diabetes Research Invited Speaker, for the 59th Annual Max Miller Lecture in Diabetes Research. The talk titled, “Bilirubin, from toxic bile substance to metabolic hormone” was given at the Metabolism Club during the 2019 Midwest Clinical & Translational Research Meeting in Chicago, IL.


 Saroj Chakraborty, trainee of Dr. Bina Joe from the Department of Physiology and Pharmacology, was recently featured in the newest edition of The Science Breaker on his work about the relationship between metabolism and hypertension. The article can be viewed here:

https://www.thesciencebreaker.org/breaks/health-physiology/a-novel-mechanism-of-metabolic-regulation-of-blood-pressure


 Dr. Matam Vijay Kumar, Associate Professor of Physiology and Pharmacology and Director of the UT Microbiome Consortium recently traveled to Vienna, Austria as an invited speaker in The European Association for the Study of the Liver (EASL) annual conference, The International Liver Congress. The unique session in which he spoke was on ‘Critical reflection on Landmark papers 2018’. In this session 4 landmark papers were selected by a task force. One of the papers is his Cell paper along with 3 others published in New England Journal of MedicineLancet and Science

The lead author of the publication presents first for 15 minutes and then is challenged by an expert in the field for 15 minutes. Later 10 minutes of questions from the challenger and audience. It was elaborate and very well organized and more than 1,000 audience members were present. 


 May 2-4, 2019 many members and trainees from our Department and the Center for Hypertension and Precision Medicine had the opportunity to attend the 2nd annual Gull Lake Regional Hypertension meeting. It was a valuable experience networking with other researchers in the hypertension field from around the Ohio/Michigan areas. Many of our Department members and trainees presented their research. It was a delight to hear from the organizers from Michigan State University and Faculty members from other Institutions that our student presentations were among the best. This, to me, speaks volumes to the significant improvements in training our students, especially through the TLC. Congratulations to the individual PIs who put their time and effort in conducting cutting-edge research and for being excellent mentors.


 Several members of the Department of Physiology and Pharmacology attended the 2019 Experimental Biology meeting in Orlando, Florida at the beginning of April. While several trainees of the Department delivered poster presentations many of the faculty and trainees received awards in several different categories.

  • Dr. Bina Joe, Distinguished University Professor and Chair, chaired a symposium titled, “Physiological Omics (P-omics) Interest Group” and as recipient of the 2019 Distinguished Lectureship Award, delivered a distinguished lecture during an award ceremony in her honor.
  • Dr. Terry Hinds, Assistant Professor, is the recipient of the American Physiological Society New Investigator Award in Endocrinology and Metabolism.
  • Dr. Cameron McCarthy, Postdoc to Faculty Fellow, placed 3rd in the Cardiovascular Young Investigator competition session.
  • Jonnelle Edwards, trainee of Dr. Camilla Wenceslau, is a recipient of the Martin Frank Diversity Travel Award.
  • Shaunak Roy, MSBS student rotating in Dr. Camilla Wenceslau’s Lab is the recipient of The Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award for Meritorious Research.

Dr. Matam Vijay-Kumar, Associate Professor of Physiology and Pharmacology and Director of the University of Toledo Microbiome Consortium, has been invited to speak at the upcoming AACR Special Conference on The Microbiome and Viruses. The conference will be held from Friday, February 21, 2020 to Monday, February 24, 2020 at the Hyatt Regency Orlando, in Orlando, Florida. The session in which he was invited to speak is titled, “Microbiota and Gastrointestinal Cancers”


Congratulations to  MOME Track MD/PhD candidate Sarah Galla (Joe Lab) for placing 2nd in oral presentation at the 2019 Graduate Research Forum and MOME Track PhD candidate Rachel Golonka (Vijay-Kumar Lab) for placing 3rd poster presentation!


Congratulations to Dr. Vijay Kumar and Beng Yeoh, whose manuscript, “Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-mediated Innate Immune Responses” was accepted in Frontiers in Cellular and Infection Microbiology! Authors are: Beng San Yeoh, Andrew T Gerwitz and Matam Vijay-Kumar. View the article here: https://www.frontiersin.org/articles/10.3389/fcimb.2019.00029/full


Congratulations to Dr. Matam Vijay-Kumar and Lab! Their manuscript, "PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium" was accepted in Mucosal Immunology. Authors: Piu Saha, Beng San Yeoh, Xia Xiao, Rachel M. Golonka, Vishal Singh, Yanming Wang,and Matam Vijay-Kumar


Congratulations to Dr. Bina Joe! She has been nominated and selected by the Physiological Omic Group to be the recipient of the 2019 Distinguished Lectureship Award! The award recognizes a distinguished lecturer in the area of physiological -omics and she will also present the distinguished lecture at the Physiological -Omics Group Symposium at the Experimental Biology 2019 meeting.


Congratulations to Shaunak Roy, MSBS student of Dr. Camilla Wenceslau’s lab!

Shaun was selected by the APS Women in Physiology Committee as one of the recipients of the 2019 Caroline tum Suden/Frances Hellebrandt Professional Opportunity Awards.

As a tum Suden/Hellebrandt Awardee, he will receive a certificate of recognition, early-rate meeting registration reimbursement, and a cash prize upon presentation of his poster at the Experimental Biology (EB) 2019 meeting.


Congratulations to Dr. Matam Vijay-Kumar! He has been invited to speak at the 2019 NCI CCR Liver Cancer Program (LCP) Special Conference on Tumor Metabolism at the National Cancer Institute (NCI), which will be held October 28-29, 2019 at the Masur Auditorium of the NIH Clinical Center, on the NIH Bethesda campus. The conference is organized by the NCI’s Center for Cancer Research (CCR) Liver Cancer Program.


Congratulations to Dr. Terry Hinds! He was selected to receive the 2019 Endocrinology & Metabolism Section New Investigator Award

He will receive his award during the Endocrinology & Metabolism Awards Reception at the Experimental Biology meeting in Orlando in April.


Congratulations to Drs. Kumar and Cheng! They are co-authors in a new publication in Nature Communications titled, " Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway". 


Congratulations to Drs. Wenceslau and McCarthy! Their manuscript, "Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization" was accepted for publication in Pharmacological Research.


Congratulations to Dr. Vijay Kumar’s Lab! Their manuscript, “Deoxyribonuclease I activity, cell-free DNA and risk of liver cancer in a prospective cohort”  was recently accepted for publication by the Journal of National Cancer Institute – Cancer Spectrum (JNCICS). The authors are: Rachel M. Golonka, Beng San Yeoh, Jessica L. Petrick, Stephanie J. Weinstein, Demetrius Albanes, Andrew T. Gewirtz, Katherine A. McGlynn, Matam Vijay-Kumar.


Congratulations to Sarah Galla from the Joe Lab! Her research story , "Researchers study link between bacteria, blood pressure", was published in the Toledo Blade, January 7, 2019.  

https://www.toledoblade.com/medical/2019/01/07/university-of-toledo-bacteria-blood-pressure-medicine-research


Congratulations to Dr. Vishal Singh from the Kumar Lab! He was awarded a Career Development grant from the Crohn’s and Colitis Foundation and funding is effective January 1, 2019. The title of the grant is, “Metabolite-sensing receptors mediated regulation of immune response in inflammatory bowel disease”.  The duration of the award is three years.

 Well done!


Congratulations to Dr. Cameron McCarthy! He was selected by the American Physiological Society-Cardiovascular Section awards committee as a finalist for the 2019 APS-Cardiovascular Section Outstanding Postdoctoral Trainee Award. His application associated with abstract, “BetaHOB Increases Nitric Oxide Synthase Activity in Resistance Arteries from Dahl Salt Sensitive Rats”, was amongst the most highly rated applications submitted to the committee. 

He will orally present his research as part of the Featured Topic Session, “Cardiovascular Section Young Investigator Competition" which will occur on Monday, April 8, 2019. 

Well done!


Congratulations to Dr. Vijay Kumar’s Lab, whose manuscript titled, Microbiota Fermentation-NLRP3 Axis Shapes the Impact of Dietary Fibers on Intestinal Inflammation” was accepted in Gut which is the second ranked leading international journal (impact factor 17) in gastroenterology and hepatology.

List of Authors: Vishal Singh, Beng San Yeoh, Rachel E. Walker, Xia Xiao, Piu Saha, Rachel M. Golonka, Jingwei Cai, Alexis Charles Andre Bretin,Xi Cheng, Qing Liu, Michael D. Flythe,Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew T. Gewirtz, and Matam Vijay-Kumar. 

Well done!


 

CHPM NEWS ARCHIVES

Last Updated: 9/22/20