College of Pharmacy and Pharmaceutical Sciences

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Wissam Aboualaiwi, M.Sc., Ph.D., FAHA

Dr. Wissam AbouAlaiwiProfessor
Department of Pharmacology and Experimental Therapeutics
University of Toledo College of Pharmacy and Pharmaceutical Sciences

Educational Background

Ph.D. in Biology with outstanding achievement University of Toledo, 2007
M.S. in Biology American University of Beirut, Beirut, Lebanon, 2002
M.S. in Biology (degree equivalent to U.S. M.S. in Biology & Teaching Diploma of Biology & Chemistry at secondary school level) Lebanese University, Beirut, Lebanon, 2000
T.S. in Medical Laboratory Technology Institute of Medical Laboratory Technology, Beirut, Lebanon 1996


illustration of primary ciliaThe AbouAlaiwi Lab studies the role of primary cilia in kidney, cardiovascular and neurodegenerative disease. Polycystic kidney disease (PKD), affecting 1 in 500 individuals, is the most commonly occurring genetic disease arising from dysfunction of primary cilia (ciliopathy) due to mutations in Pkd1/2 genes encoding for polycystin-1 (PC1) and -2 (PC2), respectively. Although PKD is a systemic disease hallmarked by fluid-filled kidney cysts, cardiovascular complications are the leading cause of death among PKD patients. PKD patients are more likely to develop hypertension and congestive heart failure. A primary cilium is a mechanosensory organelle that extends from the apical membrane of a cell to the lumen of blood vessels and kidney tubules. We and others have independently studied abnormality in primary cilia, cell proliferation and polyploidy in the vascular and renal systems in PKD. We propose cilia as a fluid sensory organelle required for sensing fluid shear stress within the cardiovascular and renal systems.


AbouAlaiwi Lab Image 1

Last Updated: 7/15/24