Department of Medicinal and Biological Chemistry

William S. Messer, Ph.D.

Photo of Dr. Messer

Professor, Department of Pharmacology

419.383.1958 Phone
419.383.1909 FAX
Frederic and Mary Wolfe Center 274C


B.S. Springfield College Biology
M.S. University of Rochester Neuroscience
Ph.D. University of Rochester Neuroscience

Research Interests

Development of new treatments for neurological disorders; Synthesis of novel M1 agonists for Alzheimer's disease; Synthesis of M4 agonists for schizophrenia; Development of M5 antagonists for the treatment of drug abuse.

Recent Publications

  • Rajeswaran, W.G., Y. Cao, X.-P. Huang, M.E. Wroblewski, T. Colclough, S. Lee, F. Liu, P.I. Nagy, J. Ellis, B.A. Levine, K.H. Nocka and W.S. Messer, Jr. Design, synthesis and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists. J. Med. Chem. 44(26): 4563-4576, 2001.

  • Messer, W.S., Jr., Cholinergic agonists and the treatment of Alzheimer’s disease. Curr. Top. Med. Chem. 2(4): 353-358, 2002.

  • Williams, F.E., D. White and W.S. Messer, Jr. A simple spatial alternation task for assessing memory function in zebrafish. Behav. Proc. 58: 125-132, 2002.

  • Messer, W.S., Jr., The utility of muscarinic agonists in the treatment of Alzheimer’s disease. J. Mol. Neurosci. 19: 187-193, 2002.

  • Wise, D.D., T.V. Barkhimer, P.-A. Brault, J.R. Kirchhoff, W.S. Messer, Jr. and R.A. Hudson. Internal standard method for the measurement of choline and acetylcholine by capillary electrophoresis with electrochemical detection. J. Chromatogr. B Biomed. Sci. Appl. 775(1): 49-56, 2002.

  • Huang, X., H. Xiao, E.B. Rex, R.J. Hobson, W.S. Messer, P.R. Komuniecki and R.W. Komuniecki. Functional characterization of alternatively spliced 5-HT2 receptor isoforms from the pharynx and muscle of the parasitic nematode, Ascaris suum. J. Neurochem. 83: 249-258, 2002.

  • Barkhimer, T., J.R. Kirchhoff, R.A. Hudson and W.S. Messer, Jr. Evaluation of the inhibition of choline uptake in synaptosomes by capillary electrophoresis with electrochemical detection. Electrophoresis 23(21): 3699-704, 2002.

  • Messer, W.S., Jr., K.A. Bachmann, C. Dockery, A.A. El-Assadi, E. Hassoun, N. Haupt, B. Tang and X. Li. Development of CDD-0102 as a selective M1 agonist for the treatment of Alzheimer's disease. Drug Dev. Res. 57(4): 200-213, 2002.

  • Cao, Y., M. Zhang, C. Wu, S. Lee, M.E. Wroblewski, T. Whipple, P.I. Nagy, K. Takács-Novák, A. Balázs, S. Torös and William S. Messer, Jr. Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders. J. Med. Chem. 46: 4273-4286, 2003.

  • Messer, W.S., Jr., Drugs that target muscarinic cholinergic receptors, in Cognitive Enhancing Drugs, edited by J. Buccafusco, Birkhäuser Verlag, pp. 37-48, 2004.

  • Williams, F.E. and W.S. Messer, Jr. Muscarinic acetylcholine receptors in the brain of zebrafish (Danio rerio) measured by radioligand binding techniques. Comp. Biochem. Physiol. 137(4): 349-353, 2004.

  • Messer, W.S., Jr., Bivalent ligands for G protein-coupled receptors, Curr. Pharm. Des., 10: 2015-2020, 2004.

  • Nagy, P.I., F. Tejada and W.S. Messer, Jr. Conformational analysis and derivation of molecular mechanics parameters for esters and thioesters. J. Phys. Chem. (in press).
Last Updated: 6/26/15