HIGHLIGHTED RESEARCH
Grants
Dr. Jennifer Hill's R01 HD081792 grant “Defective melanocortin signaling underlying T2D-associated erectile
dysfunction” received funding from National Institutes of Health (04/01/2015-03/31/2020) Department
of Physiology and Pharmacology, University of Toledo. Role: Principal Investigator.
Dr. Jennifer Hill's grant “Investigating the Role of the MC4R Oxytocin Signaling in Regulating Female Sexual Behavior” received funding from University of Toledo Biomedical Research Innovation Grant (07/2016-07/2017) Department of Physiology and Pharmacology, University of Toledo Role: Principal Investigator.
Dr. Jennifer Hill's grant “Intergenerational obesity resulting from lactational impairment ” was funded by National Institutes of Health (P30DK092926:5556) & Michigan Diabetes Research and Training Center Pilot & Feasibility Study Grants Program (01/2016-12/2016) Department of Physiology and Pharmacology, University of Toledo. Role: Principal Investigator.
Dr. Jennifer Hill's grant F31-HD-75608-02 “Simultaneous insulin and leptin signaling in POMC neurons promotes fertility” was funded by National Institutes of Health (01/01/2013 – 02/28/2016) PI: Latrice Faulkner, Graduate Student in Department of Physiology and Pharmacology, University of Toledo. Role: Sponsor
Dr. Jennifer Hill's grant “Inflammatory processes driving insulin resistance in polycystic ovary syndrome” received funding by National Institutes of Health (P30DK092926:5556) & Michigan Diabetes Research and Training Center Pilot & Feasibility Study Grants Program (01/2014-6/2015) Department of Physiology and Pharmacology, University of Toledo Role: Principal Investigator
Dr. Jennifer Hill's grant NIH R21 grant entitled “Inflammatory triggers of polycystic ovarian syndrome” received funding by the National Institute of Child Health and Development (NICHD) (April 2012-March 2014). The aim of this project is to determine whether inflammation precedes ovarian dysfunction in a potential mouse model of PCOS.
Dr. Sonia Najjar's NIH R01 grant entitled “CEACAM1 and insulin action” was renewed for the third time by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (August 2010-April 2015). The major goal of this project is to characterize the causative role for CEACAM1-dependent insulin clearance pathways in diet-induced insulin resistance and obesity.
Dr. Sonia Najjar's new NIH R01 grant entitled "CEACAM 1: A Link between Metabolic and Cardiovascular
Diseases" received funding by the National Heart Lung and Blood Institute (NHLBI)
(January 2012-December 2016). The major goal of this project is to identify a role for CEACAM1 in linking
insulin resistance to the pathogenesis of atherosclerosis.
Dr. Guillermo Vazquez's newNIH R01 grant entitled "Role of TRPC3 channels in molecular and cellular aspects of
atherogenesis" has received funding by the National Heart Lung and Blood Institute
(NHLBI) (December 2011-November 2015). Dr. Vazquez’s group has recently pioneered
the demonstration that in coronary artery endothelium, TRPC3 is an obligatory component
of the signaling regulating expression of cell adhesion molecules, monocyte recruitment
to the subintima and macrophage survival and apoptosis, all critical events in early
and advanced stages of atherosclerotic lesion development. The proposal further investigates
the role of TRPC3 in the pathogenesis of atherosclerosis.
Highlighted Publications
Dr. Sonia Najjar's paper Development of Non-alcoholic Steatohepatitis in Insulin Resistant L-SACC1 Mice received an Editorial Review by: Rexford S. Ahima: Gastroenterology, 135:1860-1862
Dr. Sonia Najjar's paper Increased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic
antigen-related cell adhesion molecule 2 has been selected to be featured 'Up front' by Diabetologia to merit special attention
for 2012. The paper is highlighted on the Editor website.
Highlighted Abstracts
Dr. Marcia F. McInerney's abstract entitled "The Interplay between Macrophages and Adipocytes in Inflammation
Associated with Diet-induced Obesity and Diabetes." has been selected for Poster Presentation
at the 12th International Immunology of Diabetes Society Conference, in Victoria, British Columbia
Canada on June 15th-19th, 2012.
Dr. Jennifer Hill
Roles of Insulin Receptors and IGF-1 Receptors in Leptin-Responsive Neurons in Regulation of Body Weight, Growth, Pubertal Development and Fertility. Mengjie Wang & Jennifer Wootton Hill. Poster, Endocrine Society annual meeting. Orlando Florida, April 2017 Outstanding Abstract Award.
Prenatal androgen exposure increases risk of hypertension and gut microbiota dysbiosis in female wistar rats. Jennifer W. Hill & Shermel Sherman. Oral Presentation. Androgen Excess & PCOS Society Update Meeting (Endocrine Society Satellite Meeting), Orlando Florida, March 31st 2017.
Insulin action in non-neuronal cells and the regulation of puberty and reproduction. Iyad Manaserh. Oral Presentation, 8th Annual Midwest Graduate Research Symposium, March 25th 2017.
Prenatal androgen exposure increases risk of hypertension and gut microbiota dysbiosis in female wistar rats. Shermel Sherman. Oral Presentation. 1st Northern Ohio Alliances for Graduate Education and the Professoriate (NOA-AGEP) Research Symposium & 8th Annual Midwest Graduate Research Symposium, March 25th 2017.
IGF-1 Receptors in Leptin Responsive Neurons Control Body Weight, Growth and Pubertal Development. Wang M., Manaserh I., and Hill JW. Oral Presentation, Endocrine Society annual meeting April 2016 * Outstanding Abstract Award.
Reduced Melanocortin Production Causes Sexual Dysfunction in Male Mice with Pomc Neuronal Insulin and Leptin Insensitivity. Faulkner LD, Dowling AR, Stuart R, Nillni EA, and Hill JW. Poster, Endocrine Society annual meeting March 2015 Presidential Poster Competition winner.
Reproductive Effects of Disrupted Melanocortin Signaling Accompanying the Metabolic Syndrome. Hill JW ORAL PRESENTATION 2nd International Conference on Endocrinology October 2014.
Leptin and Insulin Signaling in POMC Neurons Mediates Metabolic and Reproductive Homeostasis in male Rodents. Authors: Faulkner LD, Dowling AR, Stuart RC, Nillni EA, Hill JW. Poster, Endocrine Society annual meeting June 2013
Leptin and Insulin Signaling in POMC Neurons Mediates Metabolic and Reproductive Homeostasis
in male Rodents. Authors: Faulkner LD, Dowling AR, Stuart RC, Nillni EA, Hill JW.
Poster, Keystone Conference on Neuronal Control of Appetite, Metabolism and Weight,
March 2013
Effects of Genetic Background on Insulin Resistance and Fertility in a Polycystic
Ovarian Syndrome Mouse Model. Abigail Rebecca Dowling, Laura Beth Nedorezov, Joseph
Scott Marino, XiaoLiang Qiu, Jennifer Wooten Hill. Symposium: The developmental origins
of disease, University of Michigan October 2012
Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and Metabolic
Homeostasis in Male Rodents. Authors: Latrice D Faulkner, Abigail R Dowling, Jennifer
W Hill. Poster, Endocrine Society 2012 annual meeting
Insulin and Leptin Action on Kiss1 Neurons and the Regulation of Puberty and Reproduction.
Authors: Xiaoliang Qiu, Abigail Dowling, Joseph Marino, Latrice Faulkner, Laura Nedorezov,
Jennifer Hill. Poster, Endocrine Society 2012 annual meeting
Effects of Genetic Background on Insulin Resistance and Fertility in a Polycystic
Ovarian Syndrome Mouse Model. Abigail Rebecca Dowling, Laura Beth Nedorezov, Joseph
Scott Marino, XiaoLiang Qiu, Jennifer Wooten Hill. Poster, Endocrine Society 2012
annual meeting
Insulin Action in Kiss1 Neurons and the Regulation of Puberty and Reproduction, 39th Annual Pharmacology Research Colloquium, University of Michigan 2011 Oral Presentation
Leptin Receptors in POMC Neurons Regulate Cholesterol Metabolism. Authors: JS Marino,
AR Dowling, X Qiu, L Nedorezov, LFC Mueller, JW Hill POSTER : Experimental Biology
annual meeting, April 2012
Insulin Action in Kiss1 Neurons and the Regulation of Puberty and Reproduction Authors:
X Qiu, AR Dowling, JS Marino, LB Nedorezov, JW Hill POSTER, Endocrine Society annual
meeting June 2011
Apolipoprotein A-1 Mimetic Treatment of Ovarian Dysfunction in Two Mouse Models of
Polycystic Ovary Syndrome Authors: LB Nedorezov, AR Dowling, JS Marino, X Qiu, JW
Hill POSTER Endocrine Society annual meeting June 2011
Evidence of an Inflammatory State in a Mouse Model of Polycystic Ovary Syndrome Authors:
JS Marino, AR Dowling, X Qiu, L Nedorezov, LFC Mueller, JW Hill POSTER Endocrine Society
annual meeting June 2011,
Apolipoprotein A-1 Mimetic Treatment of Ovarian Dysfunction in Two Mouse Models of
Polycystic Ovary Syndrome Authors: LB Nedorezov, AR Dowling, JS Marino, X Qiu, JW
Hill POSTER National Conference on Undergraduate Research March 2011
Evidence of an Inflammatory State in a Mouse Model of Polycystic Ovary Syndrome Authors:
JS Marino, AR Dowling, X Qiu, L Nedorezov, LFC Mueller, JW Hill POSTER Experimental
Biology annual meeting, April 2011
Evidence of an Inflammatory State in a Mouse Model of Polycystic Ovary Syndrome Authors:
LB Nedorezov, AR Dowling, JS Marino, X Qiu, JW Hill POSTER Michigan Metabolomics
and Obesity Center 2011 Symposium Jan 2011
ApoA-1 Mimetic Treatment of Ovarian Dysfunction In ob Mice. Poster, Society for the
Study of Reproduction, Milwaukee August 2010
Sexual Dimorphism in the Diabetic Phenotype of CEACAM2 Knockout Mice Authors: J Marino;
L Fedorova; J Hill, Poster. Keystone Symposium on Diabetes April, 2010
Reproductive Complications of Obesity and Insulin Resistance: Mechanisms of Ovarian
Dysfunction. Poster, UT College of Medicine Research Day, March 2010
The reproductive effect of simulaneous deletion of insulin and leptin receptors in
POMC neurons. Poster, Society for Neuroscience Meeting, Chicago 2009
Simultaneous Deletion of Insulin and Leptin Signaling In POMC neurons. Poster, Society
for Neuroscience Meeting, Washington DC 2008
Disruption of PI3K signaling in POMC neurons. Poster, Keystone Symposium, Keystone
CO, January 2007
Simultaneous deletion of insulin and leptin receptors in POMC neurons. Poster, Keystone
Symposium, Keystone CO, January 2006
Highlighted Presentations
Dr. Beata Lecka-Czernik
Dr. Beata Lecka-Czernik was invited to present her work to the ADA Order of the Amaranth’s National Assembly
on June 24, 2012 in Ontario, Canada.
16th International Congress of Endocrinology & 96th Annual Meeting of The Endocrine Society, Chicago, IL: Marrow, Fat and the Skeleton, 2014
Organizer and Speaker, ASBMR Topical Meeting “Bone and Diabetes”, Houston, TX: Fat Metabolic Status and Bone, 2014
Invited Speaker and session Chair, First European Meeting on Bone Marrow Adiposity, Lille, France: Bone marrow adipocytes: phenotype and function, 2015
Invited Speaker for “Diabetes Metabolism – From Basic to Clinical Science” Danish Diabetes Academy Postdoctoral Winter School, Malaga, Spain 14-17 March 2016
Media
Dr. Beata Lecka-Czernik is recognized for her research in UT Discovers April 2013. Dr. Lecka-Czernik mentioned in the article that she owes much of her research discoveries
to her association with other researchers in CeDER whose aim is to track diabetes
from different directions and perspectives.
Dr. Jennifer Hill was featured in the UT news on April 7, 2010 for her study on how the brain controls
weight gain and regulates blood glucose levels. Dr. Hill's study appears in the April
7th issue of Cell Metabolism.