Rujun Gong Lab

Understanding pathogenesis

Rujun Gong, MD, PhD, FASN

Rujun Gong, MD, PhD, FASNProfessor of Medicine
Vice Chairman for Research, Department of Medicine
Director of Kidney Research, Division of Nephrology
University of Toledo College of Medicine

Office: 419.383.4033
Fax: 419.383.6244
Email: Rujun.Gong@UToledo.edu

The long-term research interests of the Gong Lab focus on understanding the pathogenesis of acute and chronic kidney diseases and developing novel therapies. More specifically, the recent efforts of this research team focus on deciphering the roles of the melanocortinergic signaling pathway and the glycogen synthase kinase 3b (GSK3b) signaling pathway in nephrotic glomerular diseases. Other ongoing research studies of the Gong Lab focus on deciphering the mechanisms responsible for acute and chronic injury, repair and regeneration of solid organs, including the kidney, liver and heart. In addition, this research team is also interested in the pathogenic mechanisms of kidney fibrogenesis and inflammation as well as epistasis in common kidney diseases, immunopathogenesis of autoimmune kidney diseases, like lupus nephritis, and immune tolerance in kidney transplantation.

    

 Lab Members 

RESEARCH HIGHLIGHTED IN NEWS MEDIA

APPROACHES

  • Gene cloning, transfection, expression, knockout, genotyping, microRNA analysis, immunoblotting, immunoprecipitation, immunofluorescence, immunohistochemistry and light/fluorescence/confocal microscopy, Mass spectrometry imaging.
  • In vitroin vivo, ex vivo and in silico experimental models, transgenic gene knockout/over-expression mice.
  • Pre-Clinical models of diverse kidney, liver and heart diseases, glomerular diseases, diabetes, lupus, sepsis, etc.
  • Meta-analysis, receiver operating characteristic curve analysis, Kaplan-Meier analysis
    
          

Full profile Research Interests Publications

Last Updated: 2/12/20