Rujun Gong Lab

Rujun Gong, MD, PhD — Publications

Peer-reviewed articles | Chapters in books | Patents 

 Peer-reviewed articles published in scientific journals


SELECTED Research Articles


1. Shaffner J, Chen B, Malhotra DK, Dworkin LD, Rujun Gong*.
Therapeutic Targeting of SGLT2: A New Era in the Treatment of Diabetes and Diabetic Kidney Disease.

Frontiers in Endocrinology 12:749010.2021.


1. Sairah Sharif, Bohan Chen, Pamela Brewster, Tian Chen, Lance Dworkin, Rujun Gong*.
Rationale and Design of Assessing the Effectiveness of Short-Term Low-Dose Lithium Therapy in Averting Cardiac Surgery-Associated Acute Kidney Injury: A Randomized, Double Blinded, Placebo Controlled Pilot Trial.
Frontiers in Medicine  8:639402. 2021.

1. Chen B, Wang P, Liang X, Jiang C, Ge Y, Lance D. Dworkin and Rujun Gong*.
Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease.
Cell Death and Disease  12:432. 2021

1. Chang M, Chen B, Shaffner J, Dworkin LD, Rujun Gong*.
Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities.
Frontiers in Physiology  12:651236.2021

1. Jiahui Zhang, Fnu Anshul, Deepak K Malhotra, Juan Jaume, Lance D Dworkin, Rujun Gong*.
Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes.
Antioxidants (Basel). 10(1):E138. doi: 10.3390/antiox10010138. 2021.

2. Snehal Shrivastava, Bohan Chen, Lance D Dworkin, Deepak K Malhotra, Rujun Gong*.
Relapse of Nephrotic Syndrome after Adrenocorticotropic Hormone-Induced Remission: Implications of Adrenocorticotropic Hormone Antibodies.
American Journal of Nephrology 51(5):390-394, 2020.

3. Qiao Y, Wang P, Chang M, Chen B, Ge Y, Malhotra DK, Dworkin LD, Rujun Gong*.
Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling. (Cover Story)
Clinical Science (London). 134(7):695-710, 2020.

5. Xu Y, Guan X, Zhou R, Rujun Gong*

Melanocortin 5 receptor signaling pathway in health and disease.
Cellular and Molecular Life Sciences 2020 Apr 4. doi: 10.1007/s00018-020-03511-0.
 6. Rujun Gong, Wang P, Dworkin L.

What we need to know about the effect of lithium on the kidney.
American Journal of Physiology Renal Physiology  2016 Dec 1;311(6):F1168-F1171.

7. Rujun Gong*.
Leveraging melanocortin pathways to treat glomerular diseases. [Invited Review]
Advances in Chronic Kidney Disease  21(2):134-151, 2014.

8. Andrew S. Brem, David J. Morris, Xiangpo Li, Yan Ge, Sunil Shaw, Rujun Gong*.
Adrenalectomy amplifies aldosterone induced injury in cardiovascular tissue: An effect attenuated by adrenally derived steroids.
Steroids  78(3):347-55, 2013.

9. Rujun Gong*.
The renaissance of corticotropin therapy in proteinuric nephropathies.
Nature Reviews Nephrology   8(2):122-8, 2012.

10. Si J, Ge Y, Zhuang S, Wang LJ, Chen S, Rujun Gong*
Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and -independent mechanisms. 
Kidney International   2013 Apr;83(4):635-46. 

11. Andrew Brem, David Morris, Rujun Gong*.
Aldosterone induced fibrosis in the kidney: Questions and controversies.
American Journal of Kidney Disease   58(3):471-479, 2011.

12. Andrew S. Brem, David J. Morris, Yan Ge, Lance Dworkin, Evelyn Tolbert, Rujun Gong*.
Direct fibrogenic effects of aldosterone on normotensive kidney: An effect modified by 11b-HSD activity.
American Journal of Physiology Renal Physiology   298(5): F1178-F1187, 2010.

13. Jin Si, Yan Ge, Shougang Zhuang, Rujun Gong*.
Inhibiting nonmuscle myosin II impedes inflammatory infiltration and ameliorates progressive renal disease.
Laboratory Investigation   90(3): 448-458, 2010.
     Featured article with commentary:
        Putting the brakes on inflammatory cell motility. Laboratory Investigation 90(3): 346-347, 2010.

14. Rujun Gong*.
Multi-target anti-inflammatory action of hepatocyte growth factor. [Review]
Current Opinion in Investigational Drugs   9(11):1163-1170, 2008.



 Chapters in books

  1. Rujun Gong, Lance D. Dworkin, Barry M. Brenner and David Maddox. The Renal Circulations and Glomerular Ultrafiltration. In: Brenner and Rector's, The Kidney, 8th Edition, Volume 1: 91-129. W.B. Saunders Company, Philadelphia, 2007.


  1. Lance D. Dworkin, Rujun Gong. Compositions and Method for Detecting and Treating Renal Injury and Inflammation. U.S. Patent Application No. 11/731,250, March 2007.
  2. Steve Cartt, Rujun Gong. ACTH Prophylactic Treatment of Renal Disorders. U.S. Patent Application 13/281,175 08/05/2015.


Last Updated: 7/15/24