David Kennedy Lab

Understanding pathogenesis

David Kennedy, Ph.D.

David J. Kennedy, Ph.D.Associate Professor of Medicine
Co-Director, Women & Philanthropy Genetic Analysis Center

Office: 419.383.6822
Laboratory: 419.383.6823
Fax: 419.383.3344
Email: David.Kennedy@UToledo.edu

Our lab studies how interrelated organ systems such as heart, kidney and liver regulate cellular damage (particularly inflammation and fibrosis) and repair during the course of chronic ailments such as heart failure, hypertension, diabetes, obesity and chronic kidney disease.  We are particularly interested in developing new preventative and therapeutic strategies to help people suffering from these diseases through establishing novel biomarkers and molecular diagnostics to assist risk stratification as well as identifying new drugs and drug targets and enhancing endogenous counter-regulatory mechanisms. Given our community’s ties to and dependence on the Great Lakes as a source of clean water for drinking, recreation, fishing and agriculture, our laboratory also places a special emphasis on discovering new diagnostic, preventative and therapeutic strategies targeting cellular damage caused by environmental stressors that impair our land-water-food nexus.


B.S., Biology, John Carroll University, 1995
M.S., Biological Sciences, Medical College of Ohio, 2001
Ph.D., Biomedical Sciences, Medical University of Ohio, 2006

Postgraduate Training

  • University of Toledo Health Science Center, Department of Medicine, Toledo, Ohio (Director: Professor Joseph I. Shapiro, Mercy Health Partners Endowed Chair of Medicine), 2006-2007
  • David and Lindsay Morgenthaler Endowed Fellowship, Lerner Research Institute Cleveland Clinic Foundation, Department of Cell Biology, Cleveland, Ohio (Director: Professor Roy L. Silverstein, Vice Chair (Translational Research), Jan Bleeksma Endowed Chair in Vascular Biology Cleveland Clinic Lerner College of Medicine of Case Western Reserve University), 2007-2011

Academic Appointments

  • Research Associate, Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 2011-2013
  • Secondary Appointment to Department of Nephrology and Hypertension, Glickman Urological & Kidney Institute, Cleveland Clinic, 2011-2015
  • Project Scientist, Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 2014-2015
  • Assistant Professor of Medicine, Division of Cardiovascular Medicine, Department of Medicine, University of Toledo College of Medicine and Life Sciences, 2015-2020
  • Associate Professor (with Tenure) of Medicine, Division of Cardiovascular Medicine, Department of Medicine, University of Toledo College of Medicine and Life Sciences, 2020-Present

Awards and Commendations

  • Liberato J.A. DiDio Award for Excellence in Graduate Research, 2001, 2003, 2004
  • American Heart Association, Predoctoral Fellowship, 2003-2005
  • Dr. Roberto Franco-Saenz Memorial Scholarship in Internal Medicine, 2004
  • Cleveland Clinic Foundation/Lerner Research Institute, David and Lindsay Morgenthaler Endowed Fellowship, 2007-2010
  • American Association for the Advancement of Science/Science Program for Excellence in Science, 2007
  • American Heart Association, Postdoctoral Fellowship, 2008-2010
  • American Society for Biochemistry and Molecular Biology Travel Award, 2009
  • Manuscript of the Quarter, Department of Cell Biology, Lerner Research Institute, 2009
  • The William E. Lower Award for Basic Science Research, 2010
  • The Chairman’s Award for Art & Science, 2010
  • The Department of Cell Biology Elsa Albrecht Fellow Award, 2010
  • Fifth International Conference on Paraoxonases Young Scientist Travel Award, 2012
  • American Society of Nephrology Advances in Research Travel Award, 2013
  • Central Society for Clinical and Translational Research Early Career Development Award, 2016
  • University of Toledo Leadership Institute, 2018-2019
  • University of Toledo President’s Award for Excellence in Grantsmanship, 2019

Research Interests Publications


Dr. Kennedy discloses funding from EMD Millipore related to US Patent US8524507B2 and attests that

a) these funds are not sole clinical or educational resources or a source to learners

b) this relationship/affiliation will not bias or otherwise influence Dr. Kennedy's involvement in any CME activity

c) practice recommendations given relevant to the companies with whom I have relationships/affiliations will be supported by best available evidence or, absent evidence, will be consistent with generally accepted medical and scientific practice and

d) that all reasonable clinical alternatives will be discussed when making practice recommendations.

Last Updated: 7/7/22