David Kennedy Lab

David Kennedy, Ph.D. — Publications

See Dr. Kennedy's NCBI Collection

Kennedy DJ, Chan JM, Kaw D, Ravindaran AM, Ratnam S, Malhotra D, Shapiro JI. Use of Surface Enhanced Laser Desorption/Ionization with Time of Flight (SELDI-TOF) of the Urine in the Assessment of Acute Kidney Injury (AKI). Marshall Journal of Medicine: Vol. 2: Iss. 2, Article 11. DOI: http://dx.doi.org/10.18590/mjm.2016.vol2.iss2.11 Read it here

Drummond CA, Hill MC, Shi H, Fan X, Xie JX, Haller ST, Kennedy DJ, Liu J, Garrett MR, Xie Z, Cooper CJ, Shapiro JI, Tian J. Na/K-ATPase Signaling Regulates Collagen Synthesis Through microRNA-29b-3p in Cardiac Fibroblasts. Physiol Genomics. 2015:physiolgenomics.00116.2015. doi: 10.1152/physiolgenomics.00116.2015

Kennedy DJ, Shrestha K, Sheehey B, Li XS, Guggilam A, et al. Elevated Plasma Marinobufagenin, An Endogenous Cardiotonic Steroid, Is Associated With Right Ventricular Dysfunction and Nitrative Stress in Heart Failure. Circ Heart Fail. 2015 Nov;8(6):1068-76.

Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, et al. Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis. Sci Signal. 2015 Sep 8;8(393):ra91.

Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res. 2015 Jan 30;116(3):448-55.

Brown PM, Kennedy DJ, Morton RE, Febbraio M. CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model. PLoS One. 2015;10(5):e0125126.

Kennedy DJ, Fan Y, Wu Y, Pepoy M, Hazen SL, et al. Plasma ceruloplasmin, a regulator of nitric oxide activity, and incident cardiovascular risk in patients with CKD. Clin J Am Soc Nephrol. 2014 Mar;9(3):462-7

Fedorova LV, Tamirisa A, Kennedy DJ, Haller ST, Budnyy G, et al. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC Nephrol. 2013 Oct 4;14:209.

Shao Z, Shrestha K, Borowski AG, Kennedy DJ, Epelman S, et al. Increasing serum soluble angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure. J Card Fail. 2013 Sep;19(9):605-10.

Kennedy DJ, Tang WH, Fan Y, Wu Y, Mann S, et al. Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease. J Am Heart Assoc. 2013 Apr 4;2(2):e000104

Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, et al. CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. Hypertension. 2013 Jan;61(1):216-24.

Baines RJ, Chana RS, Hall M, Febbraio M, Kennedy D, et al. CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1006-14

Haller ST, Kennedy DJ, Shidyak A, Budny GV, Malhotra D, et al. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Am J Hypertens. 2012 Jun;25(6):690-6.

Liu J, Kennedy DJ, Yan Y, Shapiro JI. Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Int J Nephrol. 2012;2012:381320.

Haller S, Adlakha S, Reed G, Brewster P, Kennedy D, et al. Platelet activation in patients with atherosclerotic renal artery stenosis undergoing stent revascularization. Clin J Am Soc Nephrol. 2011 Sep;6(9):2185-91.

Kolmakova EV, Haller ST, Kennedy DJ, Isachkina AN, Budny GV, et al. Endogenous cardiotonic steroids in chronic renal failure. Nephrol Dial Transplant. 2011 Sep;26(9):2912-9.

Kennedy DJ, Kashyap SR. Pathogenic role of scavenger receptor CD36 in the metabolic syndrome and diabetes. Metab Syndr Relat Disord. 2011 Aug;9(4):239-45.

Nicholls HT, Kowalski G, Kennedy DJ, Risis S, Zaffino LA, et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes. 2011 Apr;60(4):1100-10.

Kennedy DJ, Kuchibhotla S, Westfall KM, Silverstein RL, Morton RE, et al. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res. 2011 Feb 15;89(3):604-13.

Kennedy DJ, Kuchibhotla SD, Guy E, Park YM, Nimako G, et al. Dietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout mice. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1481-7.

Fedorova LV, Raju V, El-Okdi N, Shidyak A, Kennedy DJ, et al. The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol. 2009 Apr;296(4):F922-34.

Cooper CJ, Haller ST, Colyer W, Steffes M, Burket MW, Thomas WJ, Safian R, Reddy B, Brewster P, Ankenbrandt, MA, Virmani R, Dippel E, Rocha-Singh K, Murphy TP, Kennedy DJ, Shapiro JI, D’Agostino RD, Pencina MJ, Khuder S. Embolic protection and platelet inhibition during renal artery stenting. Circulation. 2008 May 27;117(21):2752-60.

Kuchibhotla S, Vanegas D, Kennedy DJ, Guy E, Nimako G, et al. Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II. Cardiovasc Res. 2008 Apr 1;78(1):185-96.

Kennedy DJ, Elkareh J, Shidyak A, Shapiro AP, Smaili S, et al. Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am J Physiol Renal Physiol. 2008 Feb;294(2):F450-4.

Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, et al. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension. 2007 Jan;49(1):215-24.

Kennedy DJ, Malhotra D, Shapiro JI. Molecular insights into uremic cardiomyopathy: cardiotonic steroids and Na/K ATPase signaling. Cell Mol Biol (Noisy-le-grand). 2006 Dec 30;52(8):3-14.

Shapiro JI, Kennedy DJ, Malhotra D, Xie M, Vetteth S. Hypokalemia potentiates ouabain's effect on calcium cycling and cardiac growth. Cell Mol Biol (Noisy-le-grand). 2006 Dec 30;52(8):87-91.

Kennedy DJ, Vetteth S, Xie M, Periyasamy SM, Xie Z, et al. Ouabain decreases sarco(endo)plasmic reticulum calcium ATPase activity in rat hearts by a process involving protein oxidation. Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3003-11.

Kennedy DJ, Burket MW, Khuder SA, Shapiro JI, Topp RV, et al. Quality of life improves after renal artery stenting. Biol Res Nurs. 2006 Oct;8(2):129-37.

Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, et al. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension. 2006 Mar;47(3):488-95.

Periyasamy SM, Liu J, Tanta F, Kabak B, Wakefield B, Malhotra D, Kennedy DJ, Nadoor A, Fedorova O, Gunning W, Xie Z, Bagrov AY, and Shapiro JI. Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. Kidney Int. 2005 May;67(5):1868-77.

Assaly RA, Azizi M, Kennedy DJ, Amauro C, Zaher A, et al. Plasma expansion by polyethylene-glycol-modified albumin. Clin Sci (Lond). 2004 Sep;107(3):263-72.

Kennedy DJ, Colyer WR, Brewster PS, Ankenbrandt M, Burket MW, et al. Renal insufficiency as a predictor of adverse events and mortality after renal artery stent placement. Am J Kidney Dis. 2003 Nov;42(5):926-35.

Reddy BK, Kennedy DJ, Colyer WR, Burket MW, Thomas WJ, et al. Compliance with antihypertensive therapy after renal artery stenting. Biol Res Nurs. 2003 Jul;5(1):37-46.

Priyadarshi S, Valentine B, Han C, Fedorova OV, Bagrov AY, Liu J, Periyasamy SM, Kennedy D, Malhotra, D, Xie, Z, Shapiro JI. Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat. Kidney Int. 2003 May;63(5):1785-90.

Kennedy D, Omran E, Periyasamy SM, Nadoor J, Priyadarshi A, et al. Effect of chronic renal failure on cardiac contractile function, calcium cycling, and gene expression of proteins important for calcium homeostasis in the rat. J Am Soc Nephrol. 2003 Jan;14(1):90-7.

Burket MW, Cooper CJ, Kennedy DJ, Brewster PS, Ansel GM, et al. Renal artery angioplasty and stent placement: predictors of a favorable outcome. Am Heart J. 2000 Jan;139(1 Pt 1):64-71.

Last Updated: 6/27/22