Biological Sciences

Faculty Research

Brian Ashburner

 

Rafael Garcia-Mata

Associate Professor

B.S., Universidad Nacional de Mar del Plata, Argentina, 1995
PhD, University of Alabama at Birmingham, 2002
Postdoc, UNC Chapel Hill

Office: BO 3090
Phone No: 419.530.1996
Email: rafael.garciamata@utoledo.edu 
Lab website: http://garciamatalab.wix.com/garcia-mata-lab

 

 Research Interests

     The research in our lab is centered in understanding the mechanisms of regulation of Rho family of small GTPases. Rho GTPases control many aspects of cell behavior, such as the organization of the cytoskeleton, cell migration, cell–cell and cell–matrix adhesion, cell cycle progression, gene expression and cell polarity. Our lab is particularly interested in the role of Rho GTPases during cell adhesion, migration and cell invasion in both normal and cancer cells. Deregulation in Rho GTPase signaling has been associated with all stages of cancer progression, including proliferation, invasion and metastasis.

      In breast cancer patients, the migration of cancer cells away from the primary tumor and their subsequent metastasis to distant organs is the leading cause of mortality. Cancer cells invade other tissues and enter the bloodstream by forming actin-rich membrane protrusions called invadopodia that degrade the extracellular matrix (ECM). Formation of invadopodia involves a dramatic rearrangement of the actin cytoskeleton, a process that is regulated by the Rho family of GTPases. However, very little is known about the molecular mechanisms controlling Rho GTPases activation, or about the identity of their upstream regulators and downstream effectors during invadopodia formation.

Current Students

Graduate Students

Gabriel Kreider-Letterman

CURRENT Laboratory grants

1R21CA194776-01A1, NIH/NCI (Garcia-Mata, PI) 05/12/2016-03/31/2018, "RhoG Signaling in Invadopodia"

1R15 CA199101-01A1 NIH/NCI (Garcia-Mata, PI) 05/01/2016-03/31/2019, "Regulation of Invadopodia formation by RhoG specific GEFs and GAPs"

1R03CA197227-01A1 NIH/NCI (Garcia-Mata, PI), 07/01/2016-6/30/2018, "A Novel RhoG Protein Interaction Network in Invadopodia"

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Selected Publications

SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Awadia, S., Arnold, T., Goicoechea, S. , Hou, T., Sun YJ., Kreider-Letterman, G. Massimi, P., Banks L., Fuentes E.J., Miller, A.J., Garcia-Mata, R. (In Press, Journal of Cell Biology)

 

 

 

 

Goicoechea S. M., Zinn A. , Awadia S., Snyder K., and Garcia-Mata R. 2017. A RhoG-mediated signaling pathway that modulates invadopodia formation in breast cancer cells, Journal of Cell Science: doi: 10.1242/jcs.195552

Diaphanous-Related Formin mDia2 and CXCL12 Chemokine Signaling Intersect to Drive Tumor Cell Amoeboid Transitions, M. M. Wyse, S.M. Goicoechea, R. Garcia-Mata, A. L. Nestor-Kalinoski, and K. M. Eisenmann, 2017, Biochem Biophys Res Commun. Jan 21. pii: S0006-291X(17)30136-5. doi: 10.1016/j.bbrc.2017.01.087. [Epub ahead of print]

Garcia-Mata R. 2014. Arrested Detachment: A DEPDC1B-mediated de-adhesion mitotic checkpoint. Dev. Cell 31 , 4 , 387-389.

Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, Tenorio GP, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M, Brunet J, Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M, Villanueva A, Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MA. 2014. VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. May 28;16(3):R53.

S.M. Goicoechea , S. Awadia and R. Garcia-Mata. 2014. I'm coming to GEF you. Regulation of RhoGEFs during cell migration. Cell Adhesion & Migration, Apr 2;8(4).

C. Guilluy, L. Osborne, L. Van Landeghem, L. Sharek, R. Superfine, R. Garcia-Mata, and Keith Burridge. 2014. Isolated nuclei adapt to force and reveal a mechanotransduction pathway within the nucleus, Nature Cell Biology Apr;16(4):376-81.

S.M. Goicoechea , R. Garcia-Mata, J. Staub, A. Valdivia, L. Sharek, C.A. McCulloch, R. Hwang, R. Urrutia, J.J. Yeh, H.J, Kim, and C. Otey. 2014. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts, Oncogene (6;33(10):1265-73).

Zhang X, Tao Y, Wang J, Garcia-Mata R, Markovic-Plese S. 2013. Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting MS. Eur J Immunol. 43, 281-289.

Sesma JI, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. 2012. The UDP-sugar-sensing P2Y14 receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol. 303(5):C490-8.

V. Krishna Subbaiah, P. Massimi, S. Shi Boon, M.P. Myers, L. Sharek, R. Garcia-Mata and L. Banks. 2012. The Invasive Capacity of HPV Transformed Cells Requires the hDlg-dependent enhancement of SGEF/RhoG Activity. PLoS Pathogens, 8(2):e1002543.

V.A. Bankaitis, R. Garcia-Mata and C.J. Mousley. 2012. Golgi Membrane Dynamics and Lipid Metabolism. Current Biology, 22, R414-R424.

F. Waheed, P. Speight, Q. Dan, R. Garcia-Mata, K. Szaszi. Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates. 2012 JoVE e3932.

E. Boulter and R. Garcia-Mata. 2012. Role of RhoGDI1 in the regulation of RhoGTPases. I. Methods in Molecular Biology, 827:97-105.

Boulter, E., Estrach, S., Garcia-Mata, R., and Feral, C., 2011. Off the beaten paths: alternative and crosstalk regulation of Rho GTPases. FASEB J. Feb;26(2):469-79.

C. Guilluy, R. Garcia-Mata and K. Burridge. 2011. Rho protein crosstalk: another social network? Trends in Cell Biology 21, 718-726.

C. Guilluy, A.D. Dubash, and R. Garcia-Mata. 2011. Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus. Nature Protocols 6, 2050-2060.

Roney KE, O'Connor BP, Wen H, Holl EK, Guthrie EH, Davis BK, Jones SW, Jha S, Sharek L, Garcia-Mata R, Bear JE, Ting JP. 2011. Plexin-b2 negatively regulates macrophage motility, rac, and cdc42 activation. PLoS One.;6(9): e24795.

R. Garcia-Mata, E. Boulter and K. Burridge. 2011. The Invisible Hand: Regulation of Rho GTPases by RhoGDIs. Nature Reviews in Molecular and Cell Biology.12:493-504 (featured on the cover).

C. Guilluy , V. Swaminathan , R. Garcia-Mata, E. O'Brien III, R. Superfine, and K. Burridge. 2011. The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol 13:722-727.

A.D. Dubash, M. Srougy, C. Guilluy, E. Boulter , K. Burridge and R.Garcia-Mata. 2011. The Small GTPase RhoA Localizes to the Nucleus and is Activated by Net1 and DNA Damage Signals. PLoS one 6, e17380.

E. Boulter and R. Garcia-Mata. 2010. RhoGDI: A rheostat for the Rho switch. Small GTPses, 1, 65-68.

E. Boulter*, R. Garcia-Mata*, C. Guilluy, A.D. Dubash, G. Rossi, P.J. Brennwald and K. Burridge. 2010. Regulation of RhoGTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol. 12:477-483. (*equal contribution)

A.D. Dubash, M. Menold, T. Samson, E. Boulter, R. Garcia-Mata, R. Doughman, K. Burridge. 2009. Focal Adhesions: New angles on an old structure. International Reviews in Cell and Molecular Biology; 277:1-65.

S. Goicoechea, H. Prentice-Dunn, B. Bednarski, R. Garcia-Mata, X. Ding, H.J. Kim, and C.A. Otey. 2009. Palladin Expression Contributes to Invasive Motility in Human Breast Cancer Cells. Oncogene. 28: 587-598.

R. Garcia-Mata, A.D. Dubash, L. Sharek, H.S. Carr, J.A. Frost and K. Burridge. 2007. The nuclear RhoA-exchange factor Net1 interacts with proteins of the Dlg family, affects their localization and influences their tumor suppressor activity Mol. Cell. Biol, 27: 8683-8697.

A.D. Dubash, K. Wennerberg, R. García-Mata, M.M. Menold, W.T. Arthur, K. Burridge. 2007. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J. Cell Sci. 120: 3989-3998. (* This manuscript has been awarded "paper of the year 2007" by J. Cell Sci. editors).

J. Van Buul, M. Allingham, T. Samson, J. Meller, E. Boulter, R. Garcia-Mata and K. Burridge. 2007. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J. Cell Biol. 178: 1279-1293.

R. Garcia-Mata and K. Burridge. 2007. Catching a GEF by its tail. Trends in Cell Biology. 17, 36-43.

S. Goicoechea, D. Arneman, A. Disanza, R. Garcia-Mata, G. Scita and C. A. Otey. 2006. Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. J Cell Sci. 119:3316-3324.

R. Garcia-Mata, K. Wennerberg, W. T. Arthur, N. K. Noren, S. M. Ellerbroek and K. Burridge. 2006. Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol. 406:425-437.

T. Szul, R. Garcia-Mata, E. Brandon, S. Shestopal, C. Alvarez and E. Sztul. 2005. Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1. Traffic. 6:374-385.

R. Garcia-Mata and E. Sztul. 2003. The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor. EMBO Rep. 4:320-325.

R. Garcia-Mata, T. Szul, C. Alvarez and E. Sztul. 2003. ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1. Mol Biol Cell. 14:2250-2261.

E. Brandon, Y. Gao, R. Garcia-Mata, C. Alvarez and E. Sztul. 2003. Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory traffic. Eur J Cell Biol. 82:411-20.

C. Alvarez, R. Garcia-Mata, E. Brandon and E. Sztul. 2003. COPI recruitment is modulated by a Rab1b-dependent mechanism. Mol Biol Cell. 14:2116-127.

H. Ito, K. Kamei, I. Iwamoto, Y. Inaguma, R. Garcia-Mata, E. Sztul and K. Kato. 2002. Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. J Biochem (Tokyo). 131:593-603

R. Garcia-Mata, Y. S. Gao and E. Sztul. 2002. Hassles with taking out the garbage: aggravating aggresomes. Traffic. 3:388-396

C. Alvarez, R. Garcia-Mata, H. P. Hauri and E. Sztul. 2001. The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic. J Biol Chem. 276:2693-2700

A. D. Linstedt, S. A. Jesch, A. Mehta, T. H. Lee, R. Garcia-Mata, D. S. Nelson and E. Sztul. 2000. Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus. J Biol Chem. 275:10196-10201

R. Garcia-Mata, Y. Gao, C. Alvarez and E. S. Sztul. 2000. The membrane transport factor p115 recycles only between homologous compartments in intact heterokaryons. Eur J Cell Biol. 79:229-239

R. Garcia-Mata, Z. Bebok, E. J. Sorscher and E. S. Sztul. 1999. Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J Cell Biol. 146:1239-1254

D. S. Nelson, C. Alvarez, Y. S. Gao, R. Garcia-Mata, E. Fialkowski and E. Sztul. 1998. The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function. J Cell Biol. 143:319-331

R. Garcia-Mata, R. D. Conde and P. M. Sanllorenti. 1998. Contribution of breakdown in the regulation of mouse liver glutathione S-transferase subunits during protein depletion and re-feeding. Biochim Biophys Acta. 1448:46-50

R. Garcia-Mata, J. Capdevielle, J. C. Guillemot, P. Ferrara, R. D. Conde and P. M. Sanllorenti. 1997. Protein depletion and refeeding change the proportion of mouse liver glutathione S-transferase subunits. Biochim Biophys Acta. 1357:272-280

 


SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility

Awadia, S., Arnold, T., Goicoechea, S. , Hou, T., Sun YJ., Kreider-Letterman, G. Massimi, P., Banks L., Fuentes E.J., Miller, A.J., Garcia-Mata, R. (In Press, Journal of Cell Biology)

The small GTPase RhoG regulates microtubule-mediated focal adhesion disassembly

A. Zinn, S. Goicoechea, Maity, D., Awadia, S., Cedeno-Rosario, L., Chen, Y. R. Garcia-Mata. Scientific Reports, volume 9, Article number: 5163 (2019) 

Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio

Alejandra Valdivia, Silvia M. Goicoechea, Sahezeel Awadia, Ashtyn Zinn and Rafael Garcia-Mata, Mol Biol Cell. 2017 May 3. pii: mbc.E16-06-0412. doi: 10.1091/mbc.E16-06-0412. PMID: 28468978 (featured on the cover).

A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells

Silvia M. Goicoechea, Ashtyn Zinn, Sahezeel S. Awadia, Kyle Snyder, Rafael Garcia-Mata, Journal of Cell Science 2017 : doi: 10.1242/jcs.195552

mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions

Visit Dr. Eisenmann's web page for more info on her research

I’m coming to GEF you Regulation of RhoGEFs during cell migration

Silvia M Goicoechea, Sahezeel Awadia, and Rafael Garcia-Mata, Cell Adhesion & Migration 8:4, 1–15; 2014   PDF

Arrested detachment: a DEPDC1B-mediated de-adhesion mitotic checkpoint

Here is a link to the original article this commentary is about

Garcia-Mata, R. Dev Cell. 2014 Nov 24;31(4):387-9.   PDF

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Visit Guilluy's lab for more info on this article

Guilluy C, Osborne LD, Van Landeghem L, Sharek L, Superfine R, Garcia-Mata R, Burridge K.  PDF

Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts

Visit the Otey Lab at UNC for more info about this project

Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis

Visit the Markovic-Plese Lab for more information on this project

Zhang X, Tao Y, Wang J, Garcia-Mata R, Markovic-Plese S. Eur J Immunol. 2013 Jan;43(1):281-9.  PDF

The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils.

Visit the Lazarowski lab for more info on this topic

Sesma JI1, Kreda SM, Steinckwich-Besancon N, Dang H, García-Mata R, Harden TK, Lazarowski ER. Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8. PDF

Golgi Membrane Dynamics and Lipid Metabolism

For more information on this topic vist the Bankaitis lab

Vytas A. Bankaitis, Rafael Garcia-Mata, and Carl J. Mousley. 2012. Current Biology, 22, R414-R424. PDF

Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates.

Video link here

Waheed F, Speight P, Dan Q, Garcia-Mata R, Szaszi K,  J Vis Exp. 2012 Mar 31;(61). pii: 3932.PDF

The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity

For more info on this topic visit the Banks Lab at ICGEB

Krishna Subbaiah V1, Massimi P, Boon SS, Myers MP, Sharek L, Garcia-Mata R, Banks L. PLoS Pathog. 2012 Feb;8(2):e1002543. PDF

Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases

Boulter, E and Garcia-Mata, R. Methods Mol Biol. 2012;827:97-105. PDF

Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus

Guilluy, C., Dubash, A. and Garcia-Mata, R. Nature Protocols,2011 Dec 1;6(12):2050-60. PDF

Off the beaten paths: alternative and crosstalk regulation of Rho GTPases.

Boulter E, Estrach S, Garcia-Mata R, Féral CC., FASEB J. 2012 Feb;26(2):469-79. PDF

Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation

Roney KE, O'Connor BP, Wen H, Holl EK, Guthrie EH, Davis BK, Jones SW, Jha S, Sharek L, Garcia-Mata R, Bear JE, Ting JP. PLoS One. 2011;6(9):e24795. PDF

Rho protein crosstalk: another social network?

Guilluy C, Garcia-Mata R, Burridge K. Trends Cell Biol. 2011 Dec;21(12):718-26. PDF

The ‘invisible hand’: regulation of RHO GTPases by RHOGDIs

This article was featured in the cover of Nature Reviews, Molecular Cell Biology

Rafael Garcia-Mata, Etienne Boulter and Keith Burridge, Nature Reviews Molecular Cell Biology, Vol 12, 493-504, 2011. PDF

RhoGDI: A rheostat for the Rho switch.

Boulter E, Garcia-Mata R. Small GTPases. 2010 Jul;1(1):65-68. PDF

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

Visit the Burridge Lab for more info on this project

Guilluy C, Swaminathan V, Garcia-Mata R, O'Brien ET, Superfine R, Burridge K. Nat Cell Biol. 2011 Jun;13(6):722-7. PDF

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

Etienne Boulter, Rafael Garcia-Mata, Christophe Guilluy, Adi Dubash, Guendalina Rossi, Patrick J. Brennwald1 and Keith Burridge. Nature Cell Biology Vol 12, Number 5, MAY 2010. PDF

The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.

Dubash AD, Guilluy C, Srougi MC, Boulter E, Burridge K, García-Mata R. PLoS One. 2011 Feb 24;6(2):e17380. PDF

Chapter 1. Focal adhesions: new angles on an old structure.

Dubash AD, Menold MM, Samson T, Boulter E, García-Mata R, Doughman R, Burridge K.

Int Rev Cell Mol Biol. 2009;277:1-65. doi: 10.1016/S1937-6448(09)77001-7. Review. PDF

..

Palladin contributes to invasive motility in human breast cancer cells

For more info about Palladin visit the Otey Lab

SM Goicoechea, B Bednarski, R Garcıa-Mata, H Prentice-Dunn, HJ Kim and CA Otey. Oncogene (2008), 1–12. PDF

A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.

See what Dr. Dubash is up to these days!

Dubash AD, Wennerberg K, García-Mata R, Menold MM, Arthur WT, Burridge K.

J Cell Sci. 2007 Nov 15;120(Pt 22):3989-98. PDF

The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.

García-Mata R, Dubash AD, Sharek L, Carr HS, Frost JA, Burridge K.  Mol Cell Biol. 2007 Dec;27(24):8683-97. PDF

RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration

Click here to follow the work of the great Dr. vanBuul

van Buul JD, Allingham MJ, Samson T, Meller J, Boulter E, García-Mata R, Burridge K. J Cell Biol. 2007 Sep 24;178(7):1279-93. PDF

Catching a GEF by its tail

García-Mata R, Burridge K. Trends Cell Biol. 2007 Jan;17(1):36-43. PDF

Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells.

Click to learn more about Otey's work

Goicoechea S, Arneman D, Disanza A, Garcia-Mata R, Scita G, Otey CA.

J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24. PDF

Analysis of activated GAPs and GEFs in cell lysates

García-Mata R, Wennerberg K, Arthur WT, Noren NK, Ellerbroek SM, Burridge K.

Methods Enzymol. 2006;406:425-37. PDF

Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1

Check our Dr. Sztul's lab for more info

Szul T, Garcia-Mata R, Brandon E, Shestopal S, Alvarez C, Sztul E.

Traffic. 2005 May;6(5):374-85. PDF

Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory traffic

Click to see what's going on in Dr. Sztul's lab

Brandon E, Gao Y, Garcia-Mata R, Alvarez C, Sztul E.  Eur J Cell Biol. 2003 Aug;82(8):411-20. PDF

COPI recruitment is modulated by a Rab1b-dependent mechanism

For more information on this topic please visit the Sztul Lab

Alvarez C, Garcia-Mata R, Brandon E, Sztul E., Mol Biol Cell. 2003 May;14:2116-27. PDF

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Write a catchy ADP-ribosylation factor/COPI-dependent events at the endoplasmic reticulum-Golgi interface are regulated by the guanine nucleotide exchange factor GBF1...

More on Dr. Sztul's research

García-Mata R, Szul T, Alvarez C, Sztul E. Mol Biol Cell. 2003 Jun;14(6):2250-61. PDF

The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor

For more info on this topic please visit the Sztul's lab webpage

Rafael García-Mata & Elizabeth Sztul, EMBO reports VOL 4, NO 3, 2003. PDF

Hassles with Taking Out the Garbage: Aggravating Aggresomes

For more information on this topic visit the Sztul lab

Rafael Garcia-Mata, Ya-Sheng Gao and Elizabeth Sztul, 2002, Traffic; 3: 388-396. PDF

Characterization and Dynamics of Aggresome Formation by a Cytosolic GFP-Chimera

12:00 PM

Rafael García-Mata, Zsuzsa Bebök, Eric J. Sorscher, and Elizabeth S. Sztul, 1999, The Journal of Cell Biology, Volume 146, Number 6, Sept. 20, 1239–1254. PDF

Last Updated: 5/27/20