Biological Sciences

Faculty Research

Qian Chen

       

Qian Chen

Assistant Professor
Office: WO 4267B
Phone No: 419.530.1594
Email: qian.chen3@utoledo.edu
Lab website: https://chenqianfj.wixsite.com/chenlabtoledo

Ph.D. University of Texas, Austin
M.S. Institute of Genetics, Chinese Academy of Science
B.S. Peking University

Publications

Research

Actin, a ubiquitous eukaryotic protein, plays an essential role in many biological processes of human cells including muscle contraction, immune response, and cell proliferation. We are interested in understanding how actin-assembled cellular structures drive and regulate cell proliferation. We employ yeast genetics, high-resolution fluorescence microscopy, and computational image analysis in our research.


Two main focuses of our lab are:
1. Regulation of actin structures during cell proliferation. Actin structures undergo constant turnover during cell division through their interactions with dozens of actin-binding proteins by unknown mechanisms. We aim to understand this process with quantitative microscopy.
2. Crosstalk between actin structures and signaling pathways during cell proliferation. A few kinase cascades serve as the master regulators of cell division but their interaction with actin is poorly understood. We are studying how such a cascade, the Hippo tumor suppressor pathway, interacts with actin structures.

Current Graduate Students:

Abhishek Poddar

Debatrayee Sinha

Last Updated: 9/27/21