Biological Sciences

Faculty Research

Fan Dong, M.D., Ph.D.
Professor
M.D., Suzhou Medical College, China 1983
Ph.D., Erasmus University, The Netherlands 1995

Office: WO 3257B 
Phone No: 419.530.1577 
Email: fan.dong@utoledo.edu

Research

The long term goal of my research is to understand the molecular mechanisms involved in the regulation of blood cell development in the bone marrow and why disruption of these regulatory mechanisms may lead to blood malignancies, such as leukemia and lymphoma. Specifically, I am interested in two important regulators of blood cell development, i.e., granulocyte colony-stimulating factor (G-CSF) and growth factor independence 1 (Gfi1). G-CSF is a growth factor that plays a major role in the development of neutrophils, a type of white blood cells involved in host defense against bacterial infection. Gfi1 is a transcription factor that is critical for the development of white blood cells including myeloid and lymphoid cells. Aberrant activation of G-CSF signaling or Gfi1 has been implicated in leukemia and lymphoma, which contribute to approximately 8% of all cancer deaths in the United States.  

Current students 

Graduate Student
Yangyang Zhang

CURRENT laboratory grants 

1R15HL112183-01A1, NIH
Dong, Fan (PI)
08/01/12-07/31/16
ELANE and CSF3R mutations in severe congenital neutropenia
The goal of this project is to address the roles of ELANE and CSF3R mutations in severe congenital neutropenia. There is no overlap between this project and the current application.
Role: PI

publications

Last Updated: 3/2/22