Department of Pharmacology and Experimental Therapeutics

F. Scott Hall, Ph.D.

Photo of F Scott Hall 

Assistant Professor
Department of Pharmacology and Experimental Therapeutics

Phone: 419.383.1504
Frederic and Mary Wolfe Center 282D
frank.hall@utoledo.edu

Education

1994-1999 Post-doctoral Fellow, National Institute on Alcoholism and Alcohol Abuse
1994 Ph.D. Neurobiology, Cambridge University, Cambridge, U.K.
1987 B.A. Psychology, Harvard College, Cambridge Massachusetts
  Biographical Profile
Research Interests
  • Behavioral genetics of addiction
  • Neurodevelopmental models of psychiatric disorders
  • Genetic models of psychiatric disorders
  • Epigenetic mechanisms in psychiatric disorders
  • Attention deficit hyperactivity disorder
  • Dopamine transporter knockout mice
  • The behavioral and neural consequences of social isolation
  • The role of cell adhesion molecules in addiction
Recent Publications (past five years)
Original Reports
  1. Thomsen M, Hall FS, Uhl GR, Caine SB. (2009) Lack of cocaine self-administration in dopamine but not serotonin transporter knockout mice. Journal of Neuroscience, 29(4):1087-1092.
  2. Kitanaka J, Kitanaka N, Tatsuta T, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Morita Y, Takemura M. (2009) Sigma1 receptor antagonists determine the behavioral pattern of the methamphetamine-induced stereotypy in mice. Psychopharmacology, 203:781-792.
  3. Jones JD, Hall FS, Uhl GR, Rice K, Riley AL. (2009) Differential involvement of dopamine, norepinephrine and serotonin transporters in cocaine-induced taste aversion. Pharmacology Biochemistry and Behavior, 93:75-81.
  4. Kim YS, Shin JH, Hall FS, Linden DJ. (2009) Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. Journal of Neuroscience, 29(26):8530-8538.
  5. Hall FS, Li XF, Randall-Thompson J, Sora I, Murphy DL, Lesch KP, Caron M, Uhl GR. (2009) Cocaine conditioned locomotion in dopamine transporter, norepinephrine transporter and serotonin transporter knockout mice. Neuroscience, 162(4):870-880.
  6. Jones JD, Hall FS, Uhl GR, Riley AL. (2010) The effects of DAT, NET and SERT gene deletion on cocaine-induced taste aversion. Psychopharmacology, 94(4):580-587.
  7. Drgonova J, Liu QR, Zimonjic DB, Hall FS, Uhl GR. (2010) When a knockout is near a relevant QTL: Effect of KEPI (Ppp1r14c) deletion on opiate-related traits in mice of different genetic backgrounds. Neuroscience, 165(3):882-895.
  8. Li BJ, Arime Y, Hall FS, Uhl GR, Sora I. (2010) Impaired spatial working memory and decreased frontal cortex BDNF protein level in dopamine transporter knockout mice. European Journal of Pharmacology, 628(1-3):104-107.
  9. Xu X, Mughal MR, Hall FS, Perona MTG, Pistell PJ, Lathia JD, Chigurupati S, Becker KG, Ladenheim B, Niklason LE, Uhl GR, Cadet JL, Mattson MP. (2010) Dietary restriction ameliorates cocaine-induced impairment of olfactory neurogenesis, and associated molecular and behavioral alterations. Journal of Neurochemistry, 114(1):323-324.
  10. Zhang XW, Bearer EL, Janvelyan D, Boulat B, Hall FS, Uhl GR, Jacobs RE. (2010) Altered Neurocircuitry in the dopamine transporter knockout mouse brain. PLoS ONE, 5(7): e11506. doi:10.1371/journal.pone. 0011506.
  11. Hall FS, Schwarzbaum JM, Perona MTG, Templin JS, Caron MG, Lesch PK, Murphy DL, Uhl GR. (2011) A greater role for the norepinephrine transporter than the serotonin transporter in nociception. Neuroscience, 175:315-327.
  12. Perles-Barbacaru TA, Procissi D, Demyanenko AV, Hall FS, Uhl GR, Jacobs RE. (2011) Quantitative Pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. Neuroimage, 55:622-628.
  13. Ramachandra V, Kang F, Kim C, Nova AS, Bajaj A, Hall FS, Uhl GR, Gonzales RA. (2011) The mu opioid receptor is not involved in ethanol stimulated dopamine release in the ventral striatum of C57BL/6J nice. Alcoholism: Clinical and Experimental Research, 35(5):929-938.
  14. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Tatsuta T, Moriata Y, Tanaka K, Nishiyama N, Takemura M. (2011) Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine. Neurochemical Research, 36:1824-1833.
  15. Komatsu H, Ohara A, Sasaki A, Abe H, Hattori H, Hall FS, Uhl GR, Sora I. (2011) Decreased response to social defeat stress in  opioid receptor knockout mice. Pharmacology Biochemistry and Behavior, 99(4):676-682.
  16. Hall FS, Centeno M, Perona MTG, Adair J, Dobner PR, Uhl GR. (2012) Gene knockout of the neurotensin/neuromedin (NT/N) gene has no effect on the locomotor stimulant or rewarding effects of cocaine. Psychopharmacology, 219:35-45.
  17. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Watabe K, Kubo H, Takahashi H, Tanaka K, Nishiyama N, Tatsuta T, Morita Y, Takemura M. (2012) Single administration of methamphetamine to mice in early light period decreases running wheel activity observed during dark period. Brain Research, 1429:155-163.
  18. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Asano H, Chatani R, Hayata S, Yokoyama H, Tanaka K, Nishiyama N, Takemura M. (2012) Pretreatment with nomifensine or the nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline augments methamphetamine-induced stereotypical behavior in mice. Brain Research, 1439:15-26.
  19. Ramadan E, Basselin M, Chang L, Chen M, Ma K, Hall FS, Uhl GR, Rapoport SI. (2012) Persistent hyperdopaminergia does not alter brain arachidonic acid signaling in awake dopamine transporter (DAT)-deficient mice. International Journal of Neuroscience, 122(7):373-380.
  20. Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Takemura M. (2012) Straub tail reaction in mice treated with 1 receptor antagonist in combination with methamphetamine. Brain Research, 1482:40-46.
  21. Arime Y, Kasahara Y, Hall FS, Uhl GR, Sora I. (2012) Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in animal models of schizophrenia. Neuropsychopharmacology, 37:2522-2530.
  22. Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Watabe K, Kubo H, Takahashi H, Takemura M. (2012) Attenuation of methamphetamine conditioned place preference in mice after a drug-free period and facilitation of this effect by exposure to a running wheel. Journal of Experimental Neuroscience, 6:11-19.
  23. Ishiguro H, Hall F, Horiuchi Y, Sakurai T, Hishimoto A, Grumet M, Uhl G, Onaivi E, Arinami T. (2012) NrCAM regulating neural systems and addiction related behaviors. Addiction Biology, 10.1111/j.1369-1600.2012.00469.x.
  24. Uchiumi O, Kasahara Y, Fukui A, Hall FS, Uhl GR, Sora I. (2013) Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology, 64:348-356.
  25. Gallagher JJ, Zhang X, Hall FS, Uhl GR, Bearer EL, et al. (2013) Altered Reward Circuitry in the Norepinephrine Transporter Knockout Mouse. PLoS ONE 8(3): e57597. doi:10.1371/journal.pone.0057597.
  26. Ohara A, Hata H, Kobayashi H, Numachi Y, Miyoshi I, Hall FS, Uhl GR, Tomita H, Sora I. (2013) Exclusive expression of VMAT2 in noradrenergic neurons increases viability of homozygous VMAT2 knockout mice. Biochemical and Biophysical Research Communications, 432(3):526-532.
  27. Fox MA, Panessiti MG, Hall FS, Uhl GR, Murphy DL. (2013) An evaluation of compulsive, perseverative, and stereotypical behaviors in dopamine transporter (DAT) knockout mice: Possible involvement of the serotonergic system. Psychopharmacology, 227(4):685-695.
  28. Yamashita M, Numachi Y, Yoshida S, Hall FS, Uhl GR, Kobayashi H, Sora I. (2013) Impairment of cliff avoidance reaction in dopamine transporter knockout mice. Psychopharmacology, 227:741-749.
  29. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Fukushima Y, Sawai T, Watabe K, Kubo H, Takahashi H, Tanaka K Nishiyama N, Tatsuta T, Morita Y, Takemura M. (2013) The selective  opioid receptor antagonist -funaltrexamine attenuates methamphetamine-induced stereotypical biting in mice. Brain Research, 1522:88-98.
  30. Hall FS, Itokawa K, Schmitt A, Moessner R, Sora I, Lesch KP, Uhl GR (2014) Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems. Neuropharmacology, 76:146-155.
  31. Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Watabe K, Kubo H, Takahashi H, Tanaka K, Nishiyama N, Takemura M (2014) Agmatine attenuates methamphetamine-induced hyperlocomotion and stereotypical behavior in mice (2014). Behavioural Pharmacology, 25:158-165.
  32. Sakakibara Y, Kasahara Y, Hall FS, Lesch KP, Murphy DL, Uhl GR, Sora I (2014) Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice. Psychopharmacology, In Press.
  33. Sasaki K, Sumiyoshi A, Nonaka H, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Watanabe M, Kawashima R, Sora I (2014) Specific regions display altered gray matter volume in μ-opioid receptor knockout (MOR-KO) mice: MRI voxel - based morphometry. British Journal of Pharmacology, In Press
Book Chapters
  • Sora I, Kasahara Y, Ikeda K, Hall FS, Uhl GR. (2009). Monoamine transporter as a target molecule for psychostimulants. In: Bagetta G, Tiziana Corasantini M, Sakurada T, Sakurada S (eds.) Advances in Neuropharmacology, 85. Academic Press.
  • Hall FS, Sora I, Perona MTG, Uhl GR (2010). The role of the serotonin transporter in drug reward: Gene knockout studies. In: Kalueff A (ed.) Experimental models in serotonin transporter research. Cambridge: Cambridge University Press, pp. 244-269.
  • Moriya Y, Hall FS, Sora I (2013). The role of serotonin in the effects of psychostimulant drugs: Behavioral studies of addiction- and abuse-related phenotypes. In: Hall FS (ed.) Serotonin: Biosynthesis, Regulation and Health Implications. New York: NOVA Science Publishers, pp. 189-210.
  • Hall FS, Perona MTG (2013). The role of serotonin in the neurodevelopmental consequences of early social experience. In: Hall FS (ed.) Serotonin: Biosynthesis, Regulation and Health Implications. New York: NOVA Science Publishers, pp. 168-187.
  • Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Takemura M (2014). Anhedonia in mouse models of methamphetamine-induced drug-seeking behavior. In: Rittsner M. (Ed.) Anhedonia: A Comprehensive Handbook Volume I. New York: Springer, pp. 279-309.
  • Hall FS, Sora I (In Press). Cocaine-related Disorders. In: Crusio WE (Series Ed.) The Encyclopedia of Behavioral Genetics. Crusio WE, Sluyter F, Pietropaolo S (eds.) Vol. 2. Genetic Mouse Models of Neurobehavioral Disorders. Cambridge: Cambridge University Press.

Editorials/Commentaries

  1. Hall FS, Golub SO, Houston-Ludlam AN (2013) Issues in the study of alcohol consumption in genetically modified mice. Journal of Alcoholism and Drug Dependence, 1(7).
  2. Hall FS (2013) What do differences in emotional regulation in individuals addicted to different substances tell us about addiction treatment? International Journal of High Risk Behaviors and Addiction, 2(2):92-93.

Book Editor

  1. Hall FS (Ed.). Serotonin: Biosynthesis, Regulation and Health Implications. New York: NOVA Science Publishers, (2013), 391 pp.

Published Abstracts

  1. Ishiguro H, Horiuchi Y, Hall FS, Hishimoto A, Morikawa M, Sakurai T, Grumet M, Uhl GR. Involvement of an NrCAM related signaling pathway in addiction vulnerability but not analgesia. Japanese Society of Biological Psychiatry Abstr 2009.
  2. Hall FS, Schwarzbaum JM, Perona MTG, Lesch KP, Murphy DL, Caron M, Uhl GR. The relative contribution of norepinephrine and serotonin to nociceptive responses. IBNS Abstr 2009.
  3. Drgonova J, Liu QR, Zimonjic DB, Hall FS, Uhl GR. Effect of KEPI (Ppp1r14c) deletion on morphine reward. SFN Abstr 2009.
  4. Hall FS, Schwarzbaum JM, Perona MTG, Lesch KP, Murphy DL, Caron M, Uhl GR. The relative contributions of norepinephrine and serotonin to antinociceptive responses. SFN Abstr 2009.
  5. Igari M, Chen HW, Hagino Y, Fukushima S, Lesch KP, Murphy DL, Hall FS, Uhl GR, Ikeda K, Sora I. Role of serotonin 1B receptor in methamphetamine-induced behavioral sensitization in mice lacking serotonin transporter. SFN Abstr 2009.
  6. Perona MTG, Hall FS, Dobner PR, Uhl GR. Knockout of the neurotensin/neuromedin N gene has no effect on cocaine-mediated behavior. SFN Abstr 2009.
  7. Ramachandra V, Hall FS, Uhl GR, Gonzales RA. Elucidating the role played by the mu opioid receptor (MOR) in ethanol stimulated dopamine release. SFN Abstr 2009.
  8. Schmitt AG, Hall FS, Perona MTG, Ortega G, Hofmann M, Gagel C, Sora I, Uhl GR, Riederer R, Lesch KP, Gerlach M, Grunblatt E. Stress and methylphenidate treatment, both modulate neuronal activity in an animal model ADHD. Pharmacopsychiatry (2009) 42(5): 240-241.
  9. Arime Y, Hall FS, Uhl GR, Sora I. Prefrontal norepinephrine transporter blockade ameliorates deficits of prepulse inhibition in dopamine transporter knockout mice via cortico-subcortical projections. CINP Abstr 2010.
  10. Komatsu H, Ohara A, Abe H, Hall FS, Uhl GR, Sora I. Decreased psychosocial stress response in mu opioid receptor knockout mice. INRC Abstr 2010.
  11. Arime Y, Li BJ, Hall FS, Uhl GR, Sora I. The effects of nisoxetine on impaired spatial working memory in dopamine transporter knockout mice and MK-801 treated mice. SFN Abstr 2010.
  12. Kasahara Y, Uchiumi O, Arime Y, Hall FS, Uhl GR, Sora I. Recovery of PPI deficits in DAT KO mice by treatment with nicotine. SFN Abstr 2010.
  13. Hall FS, Perona MTG, Adair JE, Dobner PR, Uhl GR. Neurotensin gene knockout prolongs the locomotor stimulant effects of cocaine and enhances its conditioned effects. SFN Abstr 2010.
  14. Drgonova J, Hall FS, Uhl GR. v7-3/SLC6A15 knockout supports roles for neutral amino acid transport in regulating appetite and food preferences. SFN Abstr 2010.
  15. Fox MA, Panessiti MG, Hall FS, Uhl GR, Murphy DL. A re-evaluation and extension of the behavioral and neurochemical phenotype of dopamine transporter (DAT)-deficient mice; a model for neuropsychiatric disorders. SFN Abstr 2010.
  16. Igari M, Shen HW, Hagino Y, Lesch KP, Murphy DL, Hall FS, Uhl GR, Ikeda K, Yaegashi N, Sora I. Serotonin 1B receptor antagonism restores methamphetamine-induced behavioural sensitisation that is disrupted by gene knockout of the serotonin transporter. FENS Abstr 2010.
  17. Igari M, Shen HW, Hagino Y, Lesch KP, Murphy DL, Hall FS, Uhl GR, Ikeda K, Yaegashi N, Sora I. Role of the serotonin 1B receptor in the elimination of methamphetamine-induced behavioural sensitization in serotonin transporter knockout mice. Serotonin Club Meeting, 2010.
  18. Fox MA, Panessiti MG, Hall FS, Uhl GR, Murphy DL. An examination of the serotoninergic system in dopamine transporter (DAT)-deficient mice. ACNP Abstr 2010.
  19. Igari M, Shen HW, Hagino Y, Fukushima S, Y Kasahara, Lesch KP, Murphy DL, Hall FS, Uhl GR, Ikeda K, Yaegashi N, Sora I. Serotonergic regulation of methamphetamine-induced behavioral sensitization. International Symposium on Brain Sciences, Tohoku University, 2011.
  20. Hall FS, Coles SW, Andrews AM, Knutson B. The effects of isolation-rearing and amitriptyline on gene expression in the hippocampus: Can gene expression studies help reveal the underlying mechanisms of gene-environment interactions? IBNS Abstr 2011.
  21. 158. Uchiumi O, Kasahara Y, Fukui A, Hall FS, Uhl GR, Sora I. Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine treatment. SFN Abstr 2011.
  22. Moriya Y, Kasahara Y, Ishihara Y, Hall FS, Hen R, Uhl GR, Sora I. Methamphetamine-induced behavioral sensitization in 5-HT1B-KO mice. SFN Abstr 2011.
  23. Kasahara Y, Shimada M, Sasaki K, Ide S, Komatsu H, Hall FS, Uhl GR, Nagase H, Sora I. Additive effects of -opioid agonist pretreatment and μ-opioid receptor knockout in modulating forced swim test stress. SFN Abstr 2011.
  24. Kubo Y, Kasahara Y, Arime Y, Hall FS, Hall FS, Ikeda K, Uhl GR, Sora I. Age dependent drug responses in DAT KO mice as an animal model of ADHD. SFN Abstr 2011.
  25. Fukui A, Kasahara Y, Arime Y, Hall FS, Uhl GR, Sora I. Selective changes in prefrontal cortex cell morphology in dopamine transporter knockout mice. SFN Abstr 2011.
  26. Perona MTG, Hall FS, Lin Z, Uhl GR. The effects of gene knockout of the vesicular monoamine transporter 2 (VMAT2; SLC18A2) and the dopamine transporter (DAT; SLC3A6) on drinking in the dark (DID). SFN Abstr 2011.
  27. Hall FS, Perona MTG, Tsouvalas CP, Masliah E, Uhl GR. Dopaminergic aging in mice with heterozygous knockout of the vesicular monoamine transporter 2 (VMAT2; SLC18A2) and transgenic overexpression of -synuclein (SYN). SFN Abstr 2011.
  28. Shimada M, Kasahara Y, Kazumasu S, Ide S, Komatsu H, Ikeda K, Hall FS, Uhl GR, Nagase H, Sora I. Additive suppressive effects of -opioid agonist KNT-127 pretreatment and μ-opioid receptor deletion on responses to forced swim stress. ACNP Abstr 2011.
  29. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Tanaka K, Tatsuta T, Morita Y, Nishiyama N, Takemura M. Alterations in hypothalamic histamine levels are associated with expression frequency of methamphetamine-induced stereotypical biting in mice. J Pharm Sci, 115(1):250P.
  30. Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Watabe K, Kubo H, Takahashi H, Tanaka K, Nishiyama N, Takemura M. Effects of running wheel on methamphetamine-induced conditioned place preference in mice. SFN Abstr 2012.
  31. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Takemura M. Nomifensine analogue 1,2,3,4-tetrahydroisoquinoline displays dopaminergic agonist properties in mice. SFN Abstr 2012.
  32. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Tanaka K, Nishiyama N, Takemura M. Hypothalamic histamine levels are negatively correlated with expression frequency of methamphetamine-induced stereotypical biting in mice. Asian Pacific Soc Neurochem 2012.
  33. Fox MA, Moya PR, Sotomayor-Zarate R, Iturriaga-Vasquez P, Hall FS, Chen K, Shih JC, Uhl GR, Reyes-Parada M, Murphy DL. An Examination of Involvement of the Dopamine Transporter (DAT), the Serotonin Transporter (SERT), and Monoamine Oxidase (MAO) A in the Temperature and Locomotor Effects of 4-methylthiomethamphetamine (MTA). ACNP Abstr 2012.
  34. Hall FS, Perona MTG, Tsouvalas CP, Baumann MH, Masliah E, Uhl GR. The effects of heterozygous knockout of the vesicular monoamine transporter (VMAT2) and transgenic overexpression of -synuclein (SYN) on locomotor behavior in mice. ACNP Abstr 2012.
  35. Kitanaka J, Kitanaka N, Hall FS, Uhl GR, Sawai T, Fukushima Y, Tanaka K, Nishiyama N, Takemura M. Opioid receptor antagonists attenuate methamphetamine-induced stereotypical behavior in mice. Jap Neural Network Society Abstr 2013.
  36. Sasaki K, Sumiyoshi A, Nonaka H, Hall FS, Uhl GR, Watanabe M, Kasahara Y, Ikeda K, Kawashima R, Sora I. Increased regional gray matter volume in -opioid receptor knockout mice as determined by MRI voxel-based morphometry. INRC Abstract 2013.
  37. Uhl GR, Drgonova J, Hall FS. Altered dose-response relationships in addiction genetics. ASHG Abstract 2013.
  38. Kitanaka N, Kitanaka J, Hall FS, Uhl GR, Tanaka K,Nishiyama N, Takemura M. Opioid receptor antagonists attenuate methamphetamine-induced stereotypical behavior in mice via  opioid receptors. SFN abstract 2013.
  39. Hall FS, Houston-Ludlam A, Lin Z, Uhl GR. The effects of gene knockout of the vesicular monoamine transporter 2 (VMAT2; SLC18A2) and the dopamine transporter (DAT; SLC3A6) on ethanol consumption and escalation in mice. ACNP Abstract 2013.
  40. Uhl GR, Drgonova J, Hall FS. Genes Harboring Addiction-Related Variants Alter Dose-Response Relationships for Stimulant Reward. ACNP Abstract 2013.
  41. Uhl GR, Drgonova J, Hall FS, Troncoco J, Utani N, Iwakura I. WED/RLS-associated PTPRD variants alter human brain expression/mice with altered expression display WED/RLS features. ANA Abstract 2014.
  42. Kubo Y, Kasahara Y, Arime Y, Hall FS, Ikeda K, Uhl GR, Sora I, Tomita H. Differences in responsiveness between methamphetamine and methylphenidate, may reflect the specific developmental characteristics in juvenile DAT KO mice. SFN Abstr 2014.
  43. Moriya Y, Kasahara Y, Hall FS, Uhl GR, Tomita H, Sora I. Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice. SFN Abstr 2014.
  44. Hall FS, Golub SO, Morrow AM, Drgonova J, Ranscht B, Uhl GR. Cadherin 13 (CDH13) gene knockout affects ethanol consumption. SFN Abstr 2014.
  45. Kasahara Y, Arime Y, Hall FS, Uhl GR, Tomita H. Region-specific dendritic spine loss of pyramidal neurons in dopamine transporter knockout mice. SFN Abstr 2014.
Last Updated: 9/1/17