Department of Pharmacology and Experimental Therapeutics

Ming-Cheh Liu, Ph.D.

Photo of Dr. Ming-Cheh Liu
  Professor

  Department of Pharmacology and Experimental Therapeutics
  Frederic and Mary Wolfe Center 294C
  Phone: 419.383.1918
  E-mail: ming.liu@utoledo.edu

 

AREA OF RESEARCH

Our research is focused on the following two areas.

1. Impact of genetic polymorphisms on drug metabolism by Phase II cytosolic sulfotransferases (SULTs)
2. Functional relevance of protein modification by tyrosine sulfation

EDUCATIONAL BACKGROUND

Ph.D. The University of Georgia, 1982
M.S The University of Georgia, 1979
B.S National Taiwan University, 1974

Training

Research Associate, The Rockefeller University, 1983-1986

PUBLICATIONS AND JOURNALS

  1. Kurogi, K., Rasool, M.I., Alherz, F.A., El Daibani, A.A., Bairam, A.F., Abunnaja, M., Yasuda, S., Wilson, L., Hui, Y., Liu, M.C., SULT genetic polymorphisms: physiological, pharmacological and clinical implications, Expert Opin. Drug Metab. Toxicol. (2021) In Press.
  2. Gohal, S.A., Rasool, M.I., Bairam, A.F., Alatwi, E.S., Alherz, F.A., Abunnaja, M.S., El Daibani, A.A., Kurogi, K., Liu. M.C., Effects of Genetic Polymorphisms on the Sulfation of Doxorubicin by Human SULT1C4 Allozymes, J. Biochem. (2021) In Press.
  3. Mei, X., Gohal, S.A., Alatwi, E.S., Hui, Y., Zhou, C., and Liu, M.C., Sulfation of quercitrin, epicatechin and rutin by human cytosolic sulfotransferases (SULTs):  Differential effects of SULT genetic polymorphisms, Planta Medica (2021) 87, 498-506.
  4. Cao, Y., Bairam, A., Jee, A., Liu, M.C., and Uetrecht, J., Investigating the mechanisms of trimethoprim induced skin rash and liver injury, Toxicol. Sci. (2021) 180, 17-25.
  5. El Daibani, A.A., Alherza, F.A., Abunnaja, M.S., Bairam, A.F., Rasool, M.I., Kurogi, K., Liu, M.C., Impact of Human SULT1E1 Polymorphisms on the Sulfation of Estradiol, 4-Hydroxytamoxifen and Diethylstilbestrol by SULT1E1 Allozymes, Eur. J. Drug Metab. Pharmacokinet. (2021) 46, 105-118.
  6. Tsutsumi, S., Tokunaga, Y., Shimizu, S., Kinoshita, H., Ono, M., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.C., and Yasuda S., Effects of indole and indoxyl on the intracellular oxidation level and phagocytic activity of differentiated HL-60 human macrophage cells, J. Toxicol. Sci. (2020) 45, 569-579.
  7. Bairam, A.F., Kermasha, Z.W., Liu, M.C., Kurogi, K., and Yamamoto, K., Functional analysis of novel sulfotransferases in the silkworm Bombyx mori,  Arch. Insect Biochem. Physiol. (2020) 104:e21671.
  8. Tsutsumi, S., Tokunaga, Y., Shimizu, S., Kinoshita, H., Ono, M., Kurogi, K.,, Sakakibara, Y., Suiko, M., Liu, M.C., and Yasuda S., Investigation of the Effects of Indoxyl Sulfate, a Uremic Toxin, on the Intracellular Oxidation Level and Phagocytic Activity using an HL-60-differentiated Human Macrophage Cell Model, Biosci. Biotechnol. Biochem. (2020) 84, 1023-1029.
  9. Alherz, F.A., El Daibani, A.A., Abunnaja, M.S. Bairam, A.F., Rasool1, M.I., Sakakibara, Y., Suiko, M., Kurogi, K., and Liu, M.C., Effect of SULT2B1 Genetic Polymorphisms on the Sulfation of Dehydroepiandrosterone and Pregnenolone by SULT2B1b Allozymes, Mol. Cell. Endocrinol. (2019) 496:110535.
  10. Bairam, A.F., Rasool, M.I., Alherz, F.A., Abunnaja, M.S., El Daibani, A.A., Gohal, S.A., Alatwi, E.S., Kurogi, K., and Liu, M.C., Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes, Pharmacogenet. Genomics (2019) 29, 99-105.
  11. Rasool, M.I., Bairam, A.F., Gohal, S.A., El Daibani, A.A., Alherz, F.A., Abunnaja, M.S., Alatwi, E.S., Kurogi, K., and Liu M.C., Effects of the Human SULT1A1 Polymorphisms on the Sulfation of Acetaminophen, O-Desmethylnaproxen, and Tapentadol, Pharmacol. Rep. (2019) 71, 257-265.
  12. Kurogi, K., Yoshihama, M., Williams, F.E., Kenmochi, N., Sakakibara, Y., Suiko, M., and Liu, M.C., Identification of Zebrafish Steroid Sulfatase and Comparative Analysis of the Enzymatic Properties with Human Steroid Sulfatase, J. Steroid Biochem. Mol. Biol. (2019) 185, 110-117.
  13. El Daibani, A.A., Xi, Y., Luo, L., Mei, X., Zhou, C., Yasuda, S., and Liu, M.C., Sulfation of Hesperetin, Naringenin and Apigenin by the Human Cytosolic Sulfotransferases:  A Comprehensive Analysis, Nat. Prod. Res. (2018) 6, 1-7.
  14. Bairam, A.F., Rasool, M.I., Alherz, F.A., Abunnaja, M.S., El Daibani, A.A., Gohal, S.A., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu M.C., Sulfation of catecholamines and serotonin by SULT1A3 allozymes, Biochem. Pharmacol. (2018) 151, 104-113.
  15. Bairam, A.F., Rasool, M.I., Alherz, F.A., Abunnaja, M.S., El Daibani, A.A., Kurogi, K., and Liu, M.C., Effects of Human SULT1A3/SULT1A4 Genetic Polymorphisms on the Sulfation of Acetaminophen and Opioid Drugs by the Cytosolic Sulfotransferase SULT1A3, Arch. Biochem. Biophys. (2018) 648, 44-52.
  16. Abunnaja, M.S., Alherz, F.A., El Daibani, A.A., Bairam, A.F., Rasool, M.I., Gohal, S.A., Kurogi, K., Suiko, M., Sakakibara, Y., and Liu, M.C., Effects of Genetic Polymorphisms on the Sulfation of Dehydroepiandrosterone and Pregnenolone by Human Cytosolic Sulfotransferase SULT2A1, Biochem. Cell Biol. (2018) 96, 655-662.
  17. Alherz, F.A., El Daibani, A.A., Bairam, A.F., Abunnaja, M.S., Rasool, M.I., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.C., On the Role of Genetic Polymorphisms in the Sulfation of Cholesterol by Human Cytosolic Sulfotransferase SULT2B1b, J. Biochem. (2018) 164, 215-221.
  18. Shimohira, T., Kurogi, K, Liu, M.C., Suiko, M., and Sakakibara, Y., The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the hydroxyl sulfation of bile acids, Biosci. Biotech. Biochem. (2018) 24, 1-7.
  19. Sugahara, S., Fukuhara, K., Tokunaga, Y., Tsutsumi, S., Ueda, Y., Ono, M., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.C., and Yasuda, S., Radical scavenging effects of 1-naphthol, 2-naphthol, and their sulfate-conjugates, J. Toxicol. Sci. (2018) 43, 213-221.
  20. Miller, E., Zalzala, M.H., Abunnaja, M.S., Kurogi, K., Sakakibara, Y., Suiko, M., and Liu M.C., Effects of Human Sulfotransferase 2A1 Genetic Polymorphisms on the Sulfation of Tibolone, Eur J Drug Metab Pharmacokinet. (2018) 43, 415-421.
  21. Kurogi, K., Yoshihama, M., Horton, A., Schiefer, I.T., Krasowski, M.D., Hagey, L.R., Williams, F.E., Sakakibara, Y., Kenmochi, N., Suiko, M., and, Liu, M.C., Identification and characterization of ¡-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the Zebrafish (Danio rerio), J. Steroid Biochem. Mol. Biol. (2017) 174, 120-127.
  22. Hashiguchi, T., Kurogi, K., Shimohira, T., Teramoto, T., Liu, M.C., Suiko, M., Sakakibara, Y., 4-3-Ketosteroids as a new class of substrates for the cytosolic sulfotransferases, Biochim. Biophys. Acta (2017) 1861, 2883-2890.
  23. Tanaka, S., Nishiyori, T., Kojo, H., Otsubo, R., Tsuruta, M., Kurogi, K., Liu, M.C., Suiko, M., Sakakibara, Y., and Kakuta, Y., Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1, Sci. Rep. (2017) 7, 8776.
  24. Kurogi, K., Sakakibara, Y., Suiko, M., and Liu, M.C., Sulfation of vitamin D3-related compounds:  Identification and characterization of the responsible human cytosolic sulfotransferases, FEBS Lett. (2017) 591, 2417-2425.
  25. Kurogi, K., Shimohira, T., Kouriki-Nagatomo, H., Zhang, G, Miller, E.R., Sakakibara, Y., Suiko, M., and Liu, M.C., Human Cytosolic Sulfotransferase SULT1C3:  Genomic Analysis and Functional Characterization of Splice Variant SULT1C3a and SULT1C3d, J. Biochem. (2017) 162, 403-414.
  26. Abunnaja, M.S., Kurogi, K., Mohammed, Y.I., Sakakibara, Y., Suiko, M., Hassoun, E.A., and Liu, M.-C., Identification and Characterization of the Zebrafish Glutathione S-Transferase Pi-1, J. Biochem. Mol. Toxicol. (2017) 10, doi: 10.1002.
  27. Shimohira, T., Kurogi, K., Hashiguchi, T., Liu, M.-C., Suiko, M., and Sakakibara, Y., Regioselective production of sulfated polyphenols using human cytosolic sulfotransferase (SULT)-expressing Escherichia coli cells, Biosci. Bioeng. (2017) 124, 84-90.
  28. Bairam, A.F., Rasool, M.I., Kurogi, K., and Liu, M.-C., On the molecular basis underlying the metabolism of tapentadol through sulfation, Eur. J. Drug Metab. Pharmacokinet. (2017) 42, 793-800.
  29. Rasool, M.I., Bairam, A.F., Kurogi, K., and Liu, M.-C., On the Sulfation of O-desmethyltramadol by Human Cytosolic Sulfotransferases, Pharmacol. Rep. (2017) 69, 953-958.
  30. Alherz, F.A., Almarghalani, D.A., Hussein, N.A., Kurogi, K., and Liu, M.-C., A reappraisal of the 6-O-desmethylnaproxen-sulfating activity of the human cytosolic sulfotransferases, Can. J. Physiol. Pharmacol. (2017) 95, 647-651.
  31. Suiko, M., Kurogi, K., Hashiguchi, T., Sakakibara, Y., and Liu, M.-C., Updated perspectives on the cytosolic sulfotransferases (SULTs) and SUL-mediated sulfation, Biosci. Biotech. Biochem. (2017) 81, 63-72.
Last Updated: 11/3/21