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Department of Pharmacology and Experimental Therapeutics

Shikha Kumari, Ph.D.

Photo of Dr. Shikha Kumari
  Research Assistant Professor

  Department of Pharmacology and Experimental Therapeutics
  Frederic and Mary Wolfe Center 284D
  Phone: 419.383.1930
  E-mail: shikha.kumari@utoledo.edu

 

Area of research

Dr. Kumari's research work primarily employs synthetic medicinal/organic chemistry, chemical biology, and molecular dynamics techniques to rationally design, optimize biologically active small molecules, lead compounds, and preclinical candidates as in vivo probes for therapeutic intervention of targeted human diseases to discover better drugs compared to existing ones.  

EDUCATIONAL BACKGROUND

Postdoctoral Research Associate University of Nebraska Medical Center, Nebraska, US
Postdoctoral Research Associate JMI University, Delhi, India
Ph.D. in Biomedical Sciences University of Delhi, Delhi, India
M.S. in Pharmaceutical Chemistry Banasthali Vidyapeeth University, Rajasthan, India
B.S.  University of Delhi, Delhi, India

Training

Over the years, Dr. Kumari has worked on the development of various novel organic small molecules to identify potent lead compounds and evaluated their in vitro/in vivo efficacy for treatment and/or prevention of multiple central nervous (CNS) diseases such as epilepsy, Alzheimer’s disease, depression, brain stroke and several forms of cancer.

Awards, Honors and Grants

  1. Post-Doctoral Fellowship 2018: Cognitive Science Research Initiative (CSRI), Government of India, Ministry of Science and Technology, Department of Science and Technology (DST), New Delhi, India
  2. DBT Research Associateship 2017: Indian Institute of Science (IISC), Department of Biochemistry, Bangalore, India
  3. DBT Research Associateship 2016: Indian Institute of Science (IISC), Department of Biochemistry, Bangalore, India 

Publications and Journals

  1. Tukaramrao DB, Malla S, Saraiya S, Hanely RA, Ray A, Kumari S, Raman D, Tiwari AK. A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells. Cancers, 2021, 13 (8), 1954.
  2. Mishra CB, Kumari S, Angeli A, Bua, S, Mongre RK, Tiwari M, Supuran CT. Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations. Journal of Medicinal Chemistry, 2021, 64, 6, 3100-3114.
  3. D’Ambrosio K, Fiore AD, Buonanno M, Kumari S, Tiwari M, Supuran CT, Mishra CB, Monti SM and Simone GD. The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development. New Journal of Chemistry, 2021, 45, 147-152.
  4. Kumari S, Carmona AV, Tiwari AK, Trippier PC. Amide bond bioisosteres: Strategies, Synthesis and Successes. Journal of Medicinal Chemistry, 2020, 63, 21, 12290-12358.
  5. Mishra CB, Gusain S, Shalini S, Kumari S, Prakash A, Kumari N, Yadav AK, Kumari J, Kumar K, Tiwari M. Development of novel carbazole derivatives with effective multifunctional action against Alzheimer’s diseases: Design, Synthesis, in silico, in vitro and in vivo investigation. Bioorganic Chemistry, 95, 2020, 103524.
  6. Mishra CB, Shalini S, Gusain S, Prakash A, Kumari J, Kumari S, Yadav AK, Lynn AM, Tiwari M. Development of novel N-(6-methanesulfonyl- benzothiazol-2-yl)-3-(4-substituted-piperazin-1- yl)-propionamides with cholinesterase inhibition, anti-b-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer's disease. RSC Advances. 2020, 10, 17602.
  7. Buthina A, Al-Oudat, Ramapuram H, Malla S, Audat SA, Hussein N, Len, JM, Kumari S, Bedi MF, Ashby CR, Tiwari AK. Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation. Molecules, 2020, 25 (13) 3063.
  8. Mongre RK, Jung S, Mishra CB, Lee BS, Kumari S, Lee MS. Prognostic and Clinicopathological Significance of SERTAD1 in Various Types of Cancer Risk: A Systematic Review and Retrospective Analysis. Cancers(Basel), 2019, 11,3, 337.
  9. Mongre RK, Mishra CB, Prakash A, Jung S, Lee BS, Kumari S, Hong JT, Lee MS. Novel Carbazole-Piperazine Hybrid Small Molecule Induces Apoptosis by Targeting BCL-2 and Inhibits Tumor Progression in Lung Adenocarcinoma in Vitro and Xenograft Mice Model. Cancers, 2019, 11, 1245.
  10. Mishra CB, Kumari S, Angeli A, Bua S, Buonanno M, Monti SM, Tiwari M, Supuran CT. Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal. European Journal of Medicinal Chemistry. 2018, 156, 430-443.
  11. Mishra CB, Kumari S, Siraj F, Yadav R, Kumari Sweta, Tiwari AK, Tiwari M. The Anti-Epileptogenic and Cognition Enhancing Effect of Novel 1-[4-(4-benzo [1, 3] dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3- phenyl-urea (BPPU) in Pentylenetetrazole Induced Chronic Rat Model of Epilepsy. Biomedicine and Pharmacotherapy. 2018, 105, 470-480.
  12. Mishra CB, Kumari S, Angeli A, Bua S, Tiwari M, Supuran CT. Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation. Journal of Medicinal Chemistry. 2018, 61(7), 3151-3165.
  13. Mishra CB, Kumari S, Prakash A, Yadav R, Tiwari AK, Pandey P, Tiwari M. Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase- 2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation. European Journal of Medicinal Chemistry. 2018,151, 520-532. 
  14. Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Tiwari M, Supuran CT. Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis and Pharmacological Assessment. Journal of Medicinal Chemistry. 2017, 60, 6, 2456-2469.
  15. Mishra CB*, Mongre RK*, Kumari S*, Jeong, D.K, Tiwari M. Novel Triazole-Piperazine Hybrid Molecules Induce Apoptosis via Activation of the Mitochondrial Pathway and Exhibit Antitumor Efficacy in Osteosarcoma Xenograft Nude Mice Model. ACS Chemical Biology. 2017, 12, 3, 753-768. (*equal contributing first author).
  16. Mishra CB*, Kumari S*, Manral A*, Saini V*, Prakash A*, Tiwari M. Novel 3, 5 dimethoxyindanone derivatives as multitarget-directed agent for the treatment of Alzheimer’s disease: Design, synthesis, molecular docking, molecular dynamic simulation and pharmacological studies. European Journal of Medicinal Chemistry. 2017, 125, 736-750 (*equal contributing first author).
  17. Kumari S, Mishra CB, Idrees D, Prakash A, Hassan M I, Tiwari M. Design, Synthesis, In-Silico and Biological Evaluation of novel 2-(4-(4- substituted piperazin-1-yl) benzylidene) hydrazine carboxamides. Molecular diversity. 2016, 21, 1, 163-174.
  18. Kumari S, Mishra CB Tiwari M. Polypharamocological drugs for the treatment of epilepsy: The comprehensive review of marketed and new emerging molecules. Current Pharmaceutical Design, 2016, 22, 21, 3212-3225.
  19. Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Prakash A, Tiwari M, Supuran CT. Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3- substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016, 31, 2, 174-179.
  20. Mishra CB*, Manral A*, Kumari S*, Saini V*, Tiwari M. Novel indadinone derivatives as multitarget-directed agent with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease. Bioorganic & Medicinal Chemistry. 2016, 24, 3829-3841. (*equal contributing first author). 
  21. Mishra CB*, Kumari S* Tiwari M. Design and Synthesis of some new 1-Phenyl-3/4-[4- (aryl/heteroaryl/alkyl-piperazine1-yl)-phenyl-ureas as potent anticonvulsant and antidepressant agents. Archives of Pharmacal Research.2016, 39,603–617. (*equal contributing first author).
  22. Mishra CB*, Mongre R.K*, Kumari S*, Jeong, D.K, Tiwari M. Synthesis, in vitro and in vivo anticancer activity of novel 1-(4-imino-1-substituted-1H-pyrazolo [3, 4-d] pyrimidin-5(4H)-yl) urea derivatives. RSC Advances, 2016, 6, 24491-24500, (*equal contributing first author).
  23. Kumari S, Idrees D, Mishra CB, Prakash A, Wahiduzzaman, Ahmad F, Hassan M. I, Tiwari M. Design and synthesis of a novel class of carbonic anhydrase-IXinhibitor1-(3-(phenyl/4-fluorophenyl)-7-imino- 3H- [1,2,3]triazolo[4,5d]pyrimidine. Journal of Molecular Graphics and Modelling, 2016, 64, 101–109.
  24. Kumari S, Mishra CB, Tiwari M. Pharmacological evaluation of novel 1-[4-(4-benzo[1,3] dioxol-5- ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent. Pharmacological Reports, 2016, 68, 250–258.
  25. Mishra CB, Kumari S, Tiwari M. Thiazole: A promising heterocycle for the development of potent CNS active agents. European Journal of Medicinal Chemistry, 2015, 92, 1-34.
  26. Kumari S, Mishra CB Tiwari M. Design, synthesis and pharmacological evaluation of N-[4-(4- (alkyl/ aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1092–1099. 
Last Updated: 6/27/22