Hong Xie, M.D., Ph.D.

hong

Assistant Professor
Office: 135 Block Health Science Building
419.383.6106
Hong.Xie@utoledo.edu

Education and Training

1992: Medical Bachelor Degree (M.D. equivalent), college of Clinical Medicine, Tianjin Medical University, Tianjin, China
2000: Master of Medical Science, Anesthesiology, Department of Anesthesia, Tianjin Medical University, Tianjin, China
2003: Ph.D, Integration of Traditional Chinese Medicine and Western Medicine (Basic Neuroscience), Department of Integrative Medicine, Shanghai Medical College, Fudan University, Shanghai, China

Postgraduate Medical Education

1992–1998: Residency, Anesthesiology, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China

Postdoctoral Research Fellowship

2004: Postdoctoral Fellow, Neuropharmacology, Department of Pharmacology, University of Michigan, Ann Arbor, MI. Mentor: Dr. Mei-Chuan Ko
2008-2010: Postdoctoral Fellow, Neuroscience, Department of Neuroscience, University of Toledo College of Medicine, Toledo, OH. Mentor: Dr. John Wall

Clinical and Research Employement

1992–1998: Resident Anesthesiologist, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
1992–2003: Clinical Instructor, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
1998–2003: Attending Anesthesiologist, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
2003–2004: Associate Professor, Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China
2008–2014: Research Associate, Department of Neuroscience, University of Toledo College of Medicine, Toledo, OH. Mentor: Dr. John Wall
2014-2015: Research Associate Scientist, Department of Neuroscience, University of Toledo College of Medicine, Toledo, OH. Mentor: Dr. John Wall
2015–2021: Research Assistant Professor, Department of Neuroscience, University of Toledo College of Medicine, Toledo, OH
2021-present: Assistant Professor in Tenure Track, Department of Neuroscience and Psychiatry, University of Toledo College of Medicine, Toledo, OH

Service

Committee, The University of Toledo:

2017-2018: member, Department secretary search committee
2021-present: COMLS council representative

Regional, National and International Professional Societies:

2012-present: member, Society for Neurosciences
2019- present: member, Society of Biological Psychiatry
2021- present: member, Organization for Human Brain Mapping
2024- present: member, State of Ohio Adversity and Resilience (SOAR) Study Presentation and Publication Committee
2024-2027: Guest Editor, Journal of Personalized Medicine Special Issue: Mental Health: Clinical Advances in Personalized Medicine
2026-2028: Editorial Board member, Journal of Personalized Medicine

Scholarship

Major Research Interests

My research interest is focused on stress-, trauma-, and mental disorder- related human brain plasticity by using structural and functional magnetic resonance imaging (MRI), including acute trauma (e.g. car accident), chronic stress (e.g. COVID pandemic), mental disorders (e.g. PTSD), or chronic illness (e.g. amputation). My research is also focused on preexisting high risk factors, like adverse childhood experience, which may contribute to abnormal brain structural and functional changes under trauma exposure. Since my clinical training, my research has been driven by a desire to explore effective interventions to prevent mental and neurological disorders and to improve memory and cognitive functions by developing functional and structural neuroimaging techniques.

Current Research Support

Neuroimaging and Behavioral Investigation of Neurotoxicity of Mercury in Adult Ohioans 4/2026 – 3/2027
Grantor: Case Western Reserve University CTSC Rural Health Themed Pilot Grant
Role: PI

The State of Ohio Adversity and Resilience (SOAR)-Brain Health Study 12/2023 - 6/2027
Grantor: State of Ohio, the University of Ohio (Site PI: Xin Wang)
Role: co-Investigator

Radiology Physics Research 05/2010-present (PI: Xin Wang)
Grantor: University of Toledo
Role: Co-Investigator

Past Research Support

MRI of human cortex after limb loss 2008-2009
Grantor: Translational Research Stimulation Award (TRSA), University of Toledo
PI: John Wall, Department of Neuroscience, University of Toledo
Role: Post-doctoral fellow

Response of neurotrophic factors and cerebral imaging to current exercise recommendations 2011-2013
Grantor: Interdisciplinary Research Initiation Award, University of Toledo
PIs: Barry W. Scheuermann, David L. Weldy
Role: sMRI imaging process and data analyst

Longitudinal MRI study of PTSD development from days to weeks after trauma 04/2013-03/2015
Grantor: NIMH: R21 MH098198-01A1
PI: Xin Wang, Department of Psychiatry, University of Toledo
Role: Co-Investigator

A preliminary neuroimaging study of the development of PTSD following a motor vehicle accident 11/2011-11/2015
Grantor: Translational Research Stimulation Award (TRSA), University of Toledo
PI: Xin Wang, Department of Psychiatry, University of Toledo
Role: Co-Investigator

The impact of managers’ supervisory style on the relation between debt covenants and earnings management: a neuroscience imaging approach 06/2014-12/2016
Grantor: The United Arab of Emirates University
PIs: Hassan Hassab Elnaby, Haitham Elsamaloty, Xin Wang
Role: data Specialist

Study of early brain alterations that predict development of chronic PTSD 09/2016-06/2021
Grantor: NIMH R01MH110483
PI: Xin Wang
Role: Co-Investigator

Administrative Supplements COVID costs. 04/28/2021 –06/30/2022
Grantor: NIH 3R01MH110483-05S1
PI: Xin Wang
Role: Co-Investigator

Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion neurocircuits 2/28/2022 - 2/28/2024
Grantor: NIMH R21 MH126172-01A1
Multi-PI: Hong Xie, Xin Wang

A large sample machine learning network analysis of vertex cortical thickness measures for high resolution definition of PTSD related cortical structure abnormalities. 2/2022-1/2024
Grantor: NIMH R21 MH125277-01A1
PI: Xin Wang
Role: co-Investigator

Publications

Chapters in Book

Liberzon I, Xie H, Wang X. Brain Structural Abnormalities in Posttraumatic Stress Disorder and Relations with Sleeping Problems. Ed. Vermetten E. Sleep and Combat-related Post-Traumatic Stress Disorders. Springer–Verlag. 2018.
Xie H. Transfusion treatment. In: Li. WS, editor. Transfusion Treatment. Beijing, China: Chinese Medical Science Press; P123-131, 1999.

Invited Presentation

Environmental Pollutants Committee Bi-monthly meeting, Toledo-Lucas County Health Department, March 19th, 2025
CTSC Rural Health 4x4, virtual, Case Western Reserve University, January 12th, 2026

Neurosciences and Psychiatry