Department of Cancer Biology

Jian-Ting Zhang, Ph.D.

Professor and Chair
Cancer Biology
McMaster Endowed Chair of Biochemistry and Cancer Biology
jianting.zhang@utoledo.edu
Zhang lab website

EDUCATION
:

1983
1989
1993
B.S.
Ph.D.
Post Doc
Biochemistry
Molecular and Cell Biology
Cancer Biology
Nanjing University
State University of New York, Buffalo
University of Toronto

RESEARCH INTERESTS
The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental therapeutics. In cancer biology, we are investigating how eukaryotic translation initiation factors are involved in regulating gene expression, signal transduction, cell growth and differentiation. More specifically, we are interested in the role of eIF3 complex in Wnt/beta-catenin signaling, tumorigenesis and cancer prognosis. In experimental therapeutics, we are interested in multiple mechanisms of drug resistance including studies on ABC transporters, 14-3-sigma, survivin and fatty acid synthase. We also perform drug discovery research targeting these proteins and various other known targets using chemoinformatics and rational design.

FUNDING:

Ongoing Research
Support
R01CA211904, National Cancer Institute
Translational contro in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role:  PI

Completed Research Support

BC150290, Department of Defense 
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: PI

PC131242, Department of Defense
Targeting survivin to overcome acquired taxol resistance in prostate cancer chemotherapy
10/1/2014-9/30/2017
Role:  PI

PUBLICATIONS:

pm

STUDENT OPENINGS:  Currently accepting Ph.D., M.D./Ph.D., MD, and M.S. students


Last Updated: 9/30/21