Jian-Ting Zhang, Ph.D.
 |
Jian-Ting Zhang, Ph.D. Professor and Chair Cancer Biology McMaster Endowed Chair of Biochemistry and Cancer Biology jianting.zhang@utoledo.edu Zhang lab website |
EDUCATION:
| 1979 1989 1993 |
B.S. Ph.D. Post Doc |
Biochemistry Molecular and Cell Biology Cancer Biology |
Nanjing University State University of New York, Buffalo University of Toronto |
RESEARCH INTERESTS:
The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental
therapeutics. In cancer biology, we are investigating how eukaryotic translation initiation
factors are involved in regulating gene expression, signal transduction, cell growth
and differentiation. More specifically, we are interested in the role of eIF3 complex
in Wnt/beta-catenin signaling, tumorigenesis and cancer prognosis. In experimental
therapeutics, we are interested in multiple mechanisms of drug resistance including
studies on ABC transporters, 14-3-sigma, survivin and fatty acid synthase. We also
perform drug discovery research targeting these proteins and various other known targets
using chemoinformatics and rational design.
FUNDING:
Ongoing Research Support
R01CA211904, National Cancer Institute
Translational contro in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role: PI
Completed Research Support
100 Voices of Hope
Targeting the immune checkpoint for treatment of metastatic TNBC
2016-2017
Role: P.I.
BC150290, Department of Defense
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: P.I.
R41CA19577, National Cancer Institute/QRKanswer LLC
A novel STAT3 inhibitor targeting its DNA-binding site for drug development
9/1/2016-8/31/2018
Role: Subcontract P.I.
BC150290, Department of Defense
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: P.I.
PUBLICATIONS:
STUDENT OPENINGS: Currently accepting Ph.D., M.D./Ph.D., MD, and M.S. students