Jian-Ting Zhang, Ph.D.
Professor and Chair
Cell and Cancer Biology
McMaster Endowed Chair of Biochemistry and Cell and Cancer Biology
jianting.zhang@utoledo.edu
Zhang lab website
EDUCATION:
| 1983 1989 1993 |
B.S. Ph.D. Post Doc |
Biochemistry Molecular and Cell Biology Cell and Cancer Biology |
Nanjing University State University of New York, Buffalo University of Toronto |
RESEARCH INTERESTS:
The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental
therapeutics. In cancer biology, we are investigating how eukaryotic translation initiation
factors are involved in regulating gene expression, signal transduction, cell growth
and differentiation. More specifically, we are interested in the role of eIF3 complex
in Wnt/beta-catenin signaling, tumorigenesis and cancer prognosis. In experimental
therapeutics, we are interested in multiple mechanisms of drug resistance including
studies on ABC transporters, 14-3-sigma, survivin and fatty acid synthase. We also
perform drug discovery research targeting these proteins and various other known targets
using chemoinformatics and rational design.
FUNDING:
Ongoing Research Support
R01CA211904, National Cancer Institute
Translational contro in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role: PI
Completed Research Support
BC150290, Department of Defense
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: PI
PC131242, Department of Defense
Targeting survivin to overcome acquired taxol resistance in prostate cancer chemotherapy
10/1/2014-9/30/2017
Role: PI
PUBLICATIONS:
STUDENT OPENINGS: Currently accepting Ph.D., M.D./Ph.D., MD, and M.S. students