Jian-Ting Zhang, Ph.D.
Professor and Chair
Cell and Cancer Biology
McMaster Endowed Chair of Biochemistry and Cell and Cancer Biology
jianting.zhang@utoledo.edu
Zhang lab website
EDUCATION:
| 1983 1989 1993 |
B.S. Ph.D. Post Doc |
Biochemistry Molecular and Cell Biology Cell and Cancer Biology |
Nanjing University State University of New York, Buffalo University of Toronto |
RESEARCH INTERESTS:
The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental therapeutics. In cancer biology, we are interested in regulation of gene expression and signal transduction by epigentic mechanisms and by translational control with a focus on DNA methylation and translation initiation factors. In experimental therapeutics, we are interested in multiple mechanisms of drug resistance including studies on ABC transporters, 14-3-sigma, STAT3, survivin and fatty acid synthase. We also perform drug discovery research targeting these proteins and various other known targets using chemoinformatics and rational design including repurposing FDA-approved drugs.
FUNDING:
Ongoing Research Support
R01CA211904, National Cancer Institute
Translational control in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role: PI
Completed Research Support
BC150290, Department of Defense
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: PI
PC131242, Department of Defense
Targeting survivin to overcome acquired taxol resistance in prostate cancer chemotherapy
10/1/2014-9/30/2017
Role: PI
PUBLICATIONS:
STUDENT OPENINGS: Currently accepting Ph.D., M.D./Ph.D., and M.S.M.D. students