Jian-Ting Zhang, Ph.D.
Professor and Chair
Senior Associate Dean for Research
Cell and Cancer Biology
McMaster Endowed Chair of Biochemistry and Cell and Cancer Biology
jianting.zhang@utoledo.edu
Zhang lab website
EDUCATION:
| 1983 1989 1993 |
B.S. Ph.D. Post Doc |
Biochemistry Molecular and Cell Biology Cell and Cancer Biology |
Nanjing University State University of New York, Buffalo University of Toronto |
RESEARCH INTERESTS:
The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental
therapeutics. In cancer biology, we are interested in regulation of gene expression
and signal transduction by epigentic mechanisms and by translational control with
a focus on DNA methylation and translation initiation factors. In experimental therapeutics,
we are interested in multiple mechanisms of drug resistance including studies on ABC
transporters, 14-3-sigma, STAT3, survivin and fatty acid synthase. We also perform
drug discovery research targeting these proteins and various other known targets using
chemoinformatics and rational design including repurposing FDA-approved drugs.
FUNDING:
Ongoing Research Support
R01CA288278, National Cancer Institute
Molecular basis and targeting of FASN in expanding PARPi utility for TNBC
02/01/2025-01/31/2030
Role: Contact PI (MPI: Jing-Yuan Liu)
R21CA277252 National Cancer Institute
Targeting FASN to eliminate metastatic breast cancer in the brain
07/01/2023-06/30/2025
Role: P.I.
Completed Research Support
R01CA211904, National Cancer Institute
Translational control in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role: PI
PUBLICATIONS:
STUDENT OPENINGS: Currently accepting Ph.D., M.D./Ph.D., and M.S.M.D. students