Department of Cell and Cancer Biology

Jian-Ting Zhang, Ph.D.

Professor and Chair
Cell and Cancer Biology
McMaster Endowed Chair of Biochemistry and Cell and Cancer Biology
jianting.zhang@utoledo.edu
Zhang lab website

EDUCATION
:

1983
1989
1993
B.S.
Ph.D.
Post Doc
Biochemistry
Molecular and Cell Biology
Cell and Cancer Biology
Nanjing University
State University of New York, Buffalo
University of Toronto

RESEARCH INTERESTS

The research in Dr. Zhang's laboratory focuses primarily on cancer biology and experimental therapeutics. In cancer biology, we are interested in regulation of gene expression and signal transduction by epigentic mechanisms and by translational control with a focus on DNA methylation and translation initiation factors. In experimental therapeutics, we are interested in multiple mechanisms of drug resistance including studies on ABC transporters, 14-3-sigma, STAT3, survivin and fatty acid synthase. We also perform drug discovery research targeting these proteins and various other known targets using chemoinformatics and rational design including repurposing FDA-approved drugs.

FUNDING:

Ongoing Research Support

R01CA211904, National Cancer Institute
Translational control in Wnt/ß-catenin signaling and colon tumorigenesis
8/1/2017-7/31/2023
Role:  PI

Completed Research Support

BC150290, Department of Defense 
Targeting FASN for breast cancer treatment by repositioning PPIs
1/1/2016-12/31/2018
Role: PI

PC131242, Department of Defense
Targeting survivin to overcome acquired taxol resistance in prostate cancer chemotherapy
10/1/2014-9/30/2017
Role:  PI

PUBLICATIONS:

pm

STUDENT OPENINGS:  Currently accepting Ph.D., M.D./Ph.D., and M.S.M.D. students


Last Updated: 7/15/24