Department of Cell and Cancer Biology

Student-Faculty Publications


(bold = CCB student, faculty, staff, and alumni) 


Creeden JF, Sevier J, Zhang JT, Lapitsky Y, Brunicardi FC, Jin G, Nemunaitis J, Liu JY, Kalinoski A, Rao D, Liu SH. (2024) Smart exosomes enhance PDAC targeted therapy. J Control Release 368:413-429. doi:10.1016/j.jconrel.2024.02.037

Liu, R., Zhao, Y., Su, S., Kwabil, A., Njoku, P.C., Yu, H., Li, X.  (2024) Unveiling cancer dormancy: Intrinsic mechanisms and extrinsic forces. Cancer Lett. 591:216899.


Ahmad, N., de la Serna, I.L., Marathe, H.G., Fan, X., Dube, P., Zhang, S., Haller, S.T., Kennedy, D.J., Pestov, N.B., and Modyanov, N.N. (2023) Eutherian-specific functions of BetaM acquired through Atp1b4 gene co-option in the regulation of MyoD expression. Life (Basel) 13:414. doi: 10.3390/life13020414

Argueta, C.E., Figy, C., Bouali, S., Guo, A., Yeung, K.C., Fenteany, G. (2023) RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression.  J. Biol. Chem. 299:103023.

Basuroy, T., Dreier, M., Baum, C., Blomquist, T., Trumbly, R., Filipp, F.V., de la Serna, I.L. (2023) Epidgentic and pharmacological control of pigmentatin via Bromodomain Protein 9 (BRD9). Pigment Cell Melanoma Res. 36:19-32. doi: 10.1111/pcmr.13068

Beamer, M.A., Zamora, C., Nestor-Kalinoski, A.L., Fernando, V., Sharma, V., and Furuta, S. (2023) Novel 3D flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity. Sci .Rep. 13:870.

Biswas H, Makinwa Y, Zou Y. (2023) Novel cellular functions of ATR for therapeutic targeting:  Embryogenesis to tumorigenesis. Int J Mol Sci. Jul20;24(14). Doi:10.3390/ijms241411684

Cui, T, Huang, C, Liu J-Y and Zhang J-T (2023) Small molecule inhibitors targeting the "undruggable" survivin: The past, present, and future from a medicinal chemist's perspective.  J Med Chem 66(24): 16515-16545.

Figy, C., Guo, A., Fernando, V.R., Furuta, S., Al-Mulla, F. , Yeung, K. (2023) Changes in expression of tumor suppressor gene RKIP impact how cancers interact with their complex environment. Cancers  (Basel) 15:958.

Ghai, S., Young, A., and Su, K-H. (2023) Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1.  Front. Cardiovasc. Med. 10:1155444, doi: 10.3389/fcvm.2023.1155444

Gurung, D., Danielson, J.A., Tasnim, A., Zhang, J.T., Zou, Y., Liu, J.Y. (2023) Proline isomerization: From the chemistry and biology to therapeutic opportunities. Biology (Basel) 12(7). doi:10.3390/biology12071008.37508437

Heck, H., Tipton, C. Becker, K., Creeden, J., Schroeder, J., Larder, C., Haak, P., Pyles, B., Eisenmann, K. (2023) Impact of COVID-19 on clinical productivity at the University of Toledo Medical Center Specialty Care Clinics. Translation The University of Toledo Journal of Medical Sciences, 11(2). doi:10.46570

Fernando, V., Zheng, X., Sharma, V., Furuta, S. (2023) Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism. Preprint. bioRxiv. 2023;2023.08.22.554238. Published 2023 Aug 22. doi:10.1101/2023.08.22.554238

Letson, J., Furuta, S. (2023) Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast. bioRxiv, 2023 Sep 12:2023.09.07.556714. doi:

Qin, L., Dong, Z., Huang, C., Liu, H., Beebe, J., Subramaniyan, B., Hao, Y., Liu, Y., He, Z., Liu, J-Y., Zhang, J-T. (2023) Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation. Cancer Lett.  567:216266. doi: 10.1016/j.canlet.2023.216266. 

Raman, D., Cimpean, A.M., and De Miglio, M.R. (2023) Editorial: Drug resistance in breast cancer - mechanisms and approaches to overcome chemoresistance. Front Oncol. 12:1080684. doi: 10.3389/fonc.2022.1080684

Zajac, K.K., Malla, S., Babu, R.J., Raman, D., Tiwari, A.K. (2023)  Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer Rep (Hoboken). 2023:e1779. doi:10.1002/cnr2.1779


Alganem, K., Hamoud, A.R., Creeden, J.F. , Henkel, N.D., Imami, A.S., et al. (2022) The active kinome: The modern view of how active protein kinase networks fit in biological research.  Curr. Opin. Pharmacol. 62:117-129. doi: 10.1016/j.coph.2021.11.007

Bach, V.N., Ding, J., Yeung, M., Conrad, T., Odeh, H.N., Cubberly, P., Figy, C., Ding, H-F., Trumbly, R., and Yeung, K.C. (2022) A negative regulatory role for RKIP in breast cancer immune response. Cancers 14:3605.

Balaji, S., Neupane, R., Malla, S., Khupse, R., Amawi, H., Kumari, S., Tukaramrao, D.B., Chattopadhyay, S., Ashby, C.R., Jr., Boddu, S.H.S., Karthikeyan, C., Trivedi, P., Raman, D., and Tiwari, A.K. (2022) IND-2, a Quinoline derivative, inhibits the proliferation of prostate cancer cells by inducing oxidative stress, apoptosis and inhibiting topoisomerase II. Life (Basel) 12(11). Doi:10.3390/life12111879

Beebe, J., Josephraj, S., Wang, C.J., Danielson, J., Cui, Q., Huang, C., Barlow, L., Zhang, R.H., Zhang, T., Nakshatri, H., Dong, Z., Li, X., Liu, JY., and Zhang, JT. (2022) Therapeutic activity of the lansoprazole metabolite 5-hydroxy lansoprazole sulfide in triple-negative breast cancer by inhibiting the enoyl reductase of fatty acid synthase. J. Med. Chem. 65:13681-13691.  doi: 10.1021/acs.jmedchem.2c00642

Becker, K.N., Gifford, C.S., Qaqish, H., Alexander, C., Ren, G., Caras, A., Miller, W.K., Schroeder, J.L. (2022) A population-based study of patients with sleep-wake disorders undergoing elective instrumented spinal surgery. World Neurosurg.

Becker, K.N., Eisenmann, K. M. (2022) New targets in the glioblastoma tumor microtube multiverse: Emerging roles for the TGF-beta/TSP1 signaling axis. Neuro-Oncology,

Becker, K.N., Pettee, K.M., Sugrue, A., Reinard, K.A., Schroeder, J.L., Eisenmann, K.E.  (2022) The cytoskeleton effectors Rho-kinase (ROCK) and mammalian diaphanous-related (mDia) formin have dynamic roles in tumor microtube formation in invasive glioblastoma cells. Cells 11:1159

Biswas, H., Zhao, S., Makinwa, Y., Bassett, J.S., Pike, M., Musich, P.R., Liu, JY,  Zou, Y. (2022) Prolyl isomerization-mediated conformational changes define ATR subcellular compartment-specific functions. Front . Cell Dev. Biol. , 10:826576.  doi: 10.3389/fcell.2022.826576

Butt, E., Howard, C.M., and Raman, D. (2022) LASP1 in cellular signaling and gene expresson: More than just a cytoskeletal regulator. Cells 11:3817. doi: 10.3390/cells11233817

Creeden, J.F., Kipp, Z.A., Xu, M., Flight, R.M., Moseley, H.N.B., et al. (2022) Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents. Hepatol. 76:1376-1388. doi: 10.1002/hep.32467

Elke, B., Howard,C.M., and Raman, D. (2022) LASP1 in cellular signaling and gene expression: More than just a cytoskeletal regulator. Cells 11:3817.

Peery, R., Cui, Q., Kyei-Baffour, K., Josephraj, S., Huang, C., Dong, Z., Dai, M., Zhang, J-T., Liu, J-Y. (2022) A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. Bioorg Med Chem. 65:116761. doi:10.1016/j.bmc.2022.116761

Sharma, V., Letson, J., Furuta, S. (2022) Fibrous stroma: Driver and passenger cancer development.  Sci. Signal. 15. doi: 10.1126/scisignal.abg3449


Becker, K.N., Pettee, K.M., Sugrue, A,. Reinard, K.A., Schroeder, J.L., Eisenmann, K.M. (2021) ROCK and mDia have dynamic roles in glioblastoma tumor microtube invasionCancer Res. 81:2.

Craig, D.J., Crawford, E.L., Massion, P.P., Morrison, T., Willey, J.C. (2021) Low frequency TP53 mutations in airway epithelial cells serve as lung cancer risk biomarker. Cancer Res. 81:1.

Crawford, E.L., Chen T., Craig, D.J., Willey, J.C. (2021) Use of a synthetic spike-in ladder to measure NGS library complexityCancer Res. 81:2.

Creeden, J.F., Imami, A.S., Eby, H.M. Gillman, C., Becker, K.N., Reigle, J., Andari, E., Pan, Z.K., O'Donovan, S.M., McCullumsmith, R.E., and McCullumsmith, C.B. (2021) Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection. Biomed. Pharmacother. 138:111437.

Gardiyawasam, K., Figy, C., Feng, J., Tipton, C., De Castro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, R., Yeung, K.C. (2021) The RhoA dependent anti-metastatic function of RKIP in breast cancer. Nature Sci. Rep. 11:17455.

Kalpana, G., Figy, C., Feng, J., Tipton, C., DeCastro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, Yeung, K.C. (2021) The RhoA dependent anti-metastatic function of RKIP in breast cancer. Nature Sci. Rep. 11:17455.

Li , Z., Hui Wang-Heaton, H., Cartwright, B.M., Makinwa, Y., Hilton, B.A., Musich, P.R., Shkriabai, N., Kvaratskhelia, M.K., Guan, S., Chen, Q., Yu, X., and Zou, Y. (2021) ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling. FASEB J  35(5):e21373.

O'Donovan, S.M., Imami, A., Eby, H., Henkel, N.D., Creeden, J.F., Asah, S., Zhang, X., Wu, X., Alnafisah, R., Taylor, R.T., Reigle, J., Thomran, A., Shamsaei, B., Meller, J., and McCullumsmith, R.E. (2021) Identification of a candidate repurposable drugs to combat COVID-19 using a signature-based approach. Scientific Reports, 11(1): 4495.

Ren, G., Zheng, X., Sharma, V., Letson, J., Nestor-Kalinoski, A.L., Furuta, S. (2021) Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts-An Indicator for Breast CarcinogenesisCancers. 13. 15

Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., and Furuta, S. (2021) S-Nitrosylation in tumor microenvironmentInt. J. Mol. Sci. 22:(9).


Craig, D.J., Creeden, J.F., Einloth, K.R., Gillman, C.E., Stanbery, L., Hamouda, D., Edelman, G., Dworkin, L., and Nemunaitis, J.J.  (2020) Resident memory T cells and their effect on cancerVaccines (Basel)  8(4).

Creeden, J.F., Alganem, K., Imami, A.S., Henkel, N.D., Brunicardi, F.C., Liu, S-H., Shukla, R., Tomar, T., Naji F., and Mccullumsmith, R.E. (2020) Emerging kinase therapeutic targets in pancreatic ductal adenocarcinoma and pancreatic cancer desmoplasia. Int. J. Mol. Sci. 21(22).

Gurung, D., and Blumenthal, R.M. (2020) Distribution of RecBCD and AddAB recombination-associated genes among bacteria in 33 phylaMicrobiology (Reading) 166(11).

Howard, C.M, Estrada, M., Terreo, D., Tiwari, A.K., and Raman, D. (2020) Identification of cardiac glycosides as novel inhibitors of eIF4A1-mediated translation in triple-negative breast cancer cells. Cancers 12(8).

Makinwa, Y., Cartwright, B.M., Musich, P.R., Li, Z., Biswas, H., and Zou, Y. (2020) PP2A regulates phosphorylatin-dependent isomerization of cytoplasmic and mitochondrial-associated ATR by Pin1 in DNA damage responses. Fron. Cell  Dev. Biol. 8:813

Makinwa, Y., Musich, P.R., and Zou, Y. (2020) Phosphorylation-Dependent Pin1 isomerization of ATR: Its role in regulating ATR's anti-apoptotic function at mitochondria, and the implications in cancer. Fron. Cell Dev. Biol. 8:281.

Liu, S-H., Yu, J.H., Creeden, J.F., Sutton, J.M., Markowiak, S., Sanchez, R., Nemunaitis, J., Kalinoski, A., and Zhang, J.T. (2020) Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. Cancer Lett., 491:97107.

Subramaniyan, B., Sridharan, S., Howard, C.M., Basuroy, T., de la Serna, I., Butt, E., and Raman, D. (2020) Role of the CXCR4-LASP1 axis in the stabilization of Snail1 in triple-negative breast cancer. Cancers 12(9).

Tilley, A.M.C., Howard, C.M., Sridharan, S., Subramaniyan, B., Bearss, N.R., Alkhalili, S., and Raman, D. (2020) The CXCR4-dependent LASP1-Ago2 interaction in triple-negative breast cancer. Cancers 12(9).

Trivedi, A., Mehrotra, A., Baum, C.E., Lewis, B., Basuroy, T., Blomquist, T., Trumbly, R., Filipp, F.V., Setaluri, V., and de la Serna, I.L. Epigenetics Chromatin. (2020)  Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation. 10;13(1):14. doi: 10.1186/s13072-020-00333-z.

Zheng, X., Fernando, V., Sharma, V., Walia, Y., Letson, J., Furuta, S. (2020) Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem. Pharmacol. 113887. doi;10.1016/j.bcp.2020.113887.

Makinwa, Y., Cartwright, B.., Musich, P.R., Li, Z., and Zou, Y. (2020) PP2A Regulates phosphorylation-dependent isomerization of cytoplasmic and mitochondrial-associated ATR by Pin1 in DNA damage responses. Front Cell Dev Biol. 8:281.


Last Updated: 5/7/24