Student-Faculty Publications
PUBLICATIONS
(bold = CCB student, faculty, staff, and alumni)
2025
Becker, K.N., Hagood, M.C., Stuckert, M., Heck, H., Pettee, K., Schroeder, J., Eisenmann, K.M. (2025)Targeting glioblastoma invasion and therapy resistance: Emerging trends and molecular pathways. Tumor Discov. 4:8578. doi: 10.36922/td.8578
Ghai, S., Shrestha, R., Su, K-H. (2025) HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms. Front Cell Dev Biol. 12:1500880. doi: 10.3389/fcell.2024.1500880
Luo, Y., Biswas, H., Makinwa, Y., Liu, SH., Dong, Z., Liu, JY., Zhang, JT., Zou, Y. (2025) A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC. Cancer Lett. 627:217790. doi: 10.1016/j.canlet.2025.217790.
Schwarz, G., Ren, X., Xie, W., Guo, H., Jiang, Y. and Zhang, J. (2025) Engineered exosomes: a promising drug delivery platform with therapeutic potential. Front. Mol. Biosci. 12:1583992. doi.org/10.3389/fmolb.2025.1583992
Sharma, V., Fernando, V., Zheng, X., Choi, E-S., Sweef, O., Thomas, V., Szpendyk, J., Furuta, S. (2025) Immunogenic shift of arginine metabolism triggers systemic metabolic and immulological reprogramming to suppress HER2+ breast cancer. Cancer Metab. 13:15. https://doi.org/10.1186/s40170-025-00384-4
2024
Barlow, L., Josephraj, S., Gu, B., Dong, Z., Zhang, JT. (2024) FASN negatively regulates the expression of p65 by diminishing its stability through phosphorylation at Thr254 and isomerization by Pin1. J Lipid Res. 65:100529. doi:10.1016/j.jlr.2024.100529
Creeden, J.F., Sevier, J., Zhang, J.T., Lapitsky, Y., Brunicardi, F.C., Jin, G., Nemunaitis, J., Liu, JY., Kalinoski, A., Rao, D., Liu, SH. (2024) Smart exosomes enhance PDAC targeted therapy. J Control Release 368:413-429. doi:10.1016/j.jconrel.2024.02.037
Dreier, M.R., Walia, J., de la Serna, I.L. (2024) Targeting SWI/SNF Complexes in Cancer: An Overview of Pharmacological Strategies and Consequences. Epigenomes. 2024 8:7. doi:10.3390/epigenomes8010007
Fernando, V., Zheng, X., Sharma, V., Sweef, O., Choi, E-S., and Furuta, S. (2024) Reprogramming of Breast Tumor-Associated Macrophages with Modulation of Arginine Metabolism. Life Sci Alliance 7:e202302339. doi: 10.26508/lsa.202302339.
Han, D., Labaf, M., Zhao, Y., Owiredu, J., Zhang, S., Patel, K., Venkataramani, K., Steinfeld, J.S., Han, W., Li, M., Liu, M., Wang. Z., Besschetnova, A., Patalano, S., Mulhearn, M.J., Macoska, J.A., Yuan, X., Balk, S.P., Nelson, P.S., Plymate, S.R., Gao, S., Siegfried, K.R., Liu, R., Stangis, M.M., Foxa, G., Czernik, P.J., Williams, B.O., Zarringhalam, K., Li, X., Cai, C. (2024) Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs. J Clin Invest. 30:e168649. doi:10.1172/JCI168649
Letson, J., Ren, G., Zheng, X., Sweef, O., Corcino, Y.L., Furuta, S. Reduced S-nitrosylation of TGFβ1 elevates its binding affinity toward the receptor and promotes fibrogenic signaling in the breast. J Biol Chem. 2024 Dec;300(12):108011. doi:10.1016/j.jbc.2024.108011
Liu, R., Zhao, Y., Su, S., Kwabil, A., Njoku, P.C., Yu, H., Li, X. (2024) Unveiling cancer dormancy: Intrinsic mechanisms and extrinsic forces. Cancer Lett. 591:216899. https://doi.org/10.1016/j.canlet.2024.216899
Makinwa, Y., Luo, Y., Musich, P.R., Zou, Y. (2024) Canonical and noncanonical functions of the BH3 domain protein bid in apoptosis,
oncogenesis, cancer therapeutics, and aging. Cancers 16:2199. doi:10.3390/cancers16122199
2023
Ahmad, N., de la Serna, I.L., Marathe, H.G., Fan, X., Dube, P., Zhang, S., Haller, S.T., Kennedy, D.J., Pestov, N.B., and Modyanov, N.N. (2023) Eutherian-specific functions of BetaM acquired through Atp1b4 gene co-option in the regulation of MyoD expression. Life (Basel) 13:414. doi: 10.3390/life13020414
Argueta, C.E., Figy, C., Bouali, S., Guo, A., Yeung, K.C., Fenteany, G. (2023) RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression. J. Biol. Chem. 299:103023. https://doi.org/10.1016/j.jbc.2023.103023
Basuroy, T., Dreier, M., Baum, C., Blomquist, T., Trumbly, R., Filipp, F.V., de la Serna, I.L. (2023) Epidgentic and pharmacological control of pigmentatin via Bromodomain Protein 9 (BRD9). Pigment Cell Melanoma Res. 36:19-32. doi: 10.1111/pcmr.13068
Beamer, M.A., Zamora, C., Nestor-Kalinoski, A.L., Fernando, V., Sharma, V., and Furuta, S. (2023) Novel 3D flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity. Sci .Rep. 13:870. https://doi.org/10.1038/s41598-023-28233-8
Biswas H, Makinwa Y, Zou Y. (2023) Novel cellular functions of ATR for therapeutic targeting: Embryogenesis to tumorigenesis. Int J Mol Sci. Jul20;24(14). Doi:10.3390/ijms241411684
Cui, T, Huang, C, Liu J-Y and Zhang J-T (2023) Small molecule inhibitors targeting the "undruggable" survivin: The past, present, and future from a medicinal chemist's perspective. J Med Chem 66(24): 16515-16545. https://doi.org/10.1021/acs.jmedchem.3c01130
Figy, C., Guo, A., Fernando, V.R., Furuta, S., Al-Mulla, F. , Yeung, K. (2023) Changes in expression of tumor suppressor gene RKIP impact how cancers interact with their complex environment. Cancers (Basel) 15:958. https://doi.org/10.3390/cancers15030958
Ghai, S., Young, A., and Su, K-H. (2023) Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1. Front. Cardiovasc. Med. 10:1155444, doi: 10.3389/fcvm.2023.1155444
Gurung, D., Danielson, J.A., Tasnim, A., Zhang, J.T., Zou, Y., Liu, J.Y. (2023) Proline isomerization: From the chemistry and biology to therapeutic opportunities. Biology (Basel) 12(7). doi:10.3390/biology12071008.37508437
Heck, H., Tipton, C. Becker, K., Creeden, J., Schroeder, J., Larder, C., Haak, P., Pyles, B., Eisenmann, K. (2023) Impact of COVID-19 on clinical productivity at the University of Toledo Medical Center Specialty Care Clinics. Translation The University of Toledo Journal of Medical Sciences, 11(2). doi:10.46570
Fernando, V., Zheng, X., Sharma, V., Furuta, S. (2023) Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism. Preprint. bioRxiv. 2023;2023.08.22.554238. Published 2023 Aug 22. doi:10.1101/2023.08.22.554238
Letson, J., Furuta, S. (2023) Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast. bioRxiv, 2023 Sep 12:2023.09.07.556714. doi: https://doi.org/10.1101/2023.09.07.556714
Qin, L., Dong, Z., Huang, C., Liu, H., Beebe, J., Subramaniyan, B., Hao, Y., Liu, Y., He, Z., Liu, J-Y., Zhang, J-T. (2023) Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation. Cancer Lett. 567:216266. doi: 10.1016/j.canlet.2023.216266.
Raman, D., Cimpean, A.M., and De Miglio, M.R. (2023) Editorial: Drug resistance in breast cancer - mechanisms and approaches to overcome chemoresistance. Front Oncol. 12:1080684. doi: 10.3389/fonc.2022.1080684
Zajac, K.K., Malla, S., Babu, R.J., Raman, D., Tiwari, A.K. (2023) Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer Rep (Hoboken). 2023:e1779. doi:10.1002/cnr2.1779
2022
Alganem, K., Hamoud, A.R., Creeden, J.F. , Henkel, N.D., Imami, A.S., et al. (2022) The active kinome: The modern view of how active protein kinase networks fit in biological research. Curr. Opin. Pharmacol. 62:117-129. doi: 10.1016/j.coph.2021.11.007
Bach, V.N., Ding, J., Yeung, M., Conrad, T., Odeh, H.N., Cubberly, P., Figy, C., Ding, H-F., Trumbly, R., and Yeung, K.C. (2022) A negative regulatory role for RKIP in breast cancer immune response. Cancers 14:3605. https://doi.org/10.3390/cancers14153605
Balaji, S., Neupane, R., Malla, S., Khupse, R., Amawi, H., Kumari, S., Tukaramrao, D.B., Chattopadhyay, S., Ashby, C.R., Jr., Boddu, S.H.S., Karthikeyan, C., Trivedi, P., Raman, D., and Tiwari, A.K. (2022) IND-2, a Quinoline derivative, inhibits the proliferation of prostate cancer cells by inducing oxidative stress, apoptosis and inhibiting topoisomerase II. Life (Basel) 12(11). Doi:10.3390/life12111879
Beebe, J., Josephraj, S., Wang, C.J., Danielson, J., Cui, Q., Huang, C., Barlow, L., Zhang, R.H., Zhang, T., Nakshatri, H., Dong, Z., Li, X., Liu, JY., and Zhang, JT. (2022) Therapeutic activity of the lansoprazole metabolite 5-hydroxy lansoprazole sulfide in triple-negative breast cancer by inhibiting the enoyl reductase of fatty acid synthase. J. Med. Chem., 65:13681-13691. doi: 10.1021/acs.jmedchem.2c00642
Becker, K.N., Gifford, C.S., Qaqish, H., Alexander, C., Ren, G., Caras, A., Miller, W.K., Schroeder, J.L. (2022) A population-based study of patients with sleep-wake disorders undergoing elective instrumented spinal surgery. World Neurosurg., https://doi.org/10.1016/j.wneu.2022.01.008
Becker, K.N., Eisenmann, K. M. (2022) New targets in the glioblastoma tumor microtube multiverse: Emerging roles for the TGF-beta/TSP1 signaling axis. Neuro-Oncology, https://doi.org/10.1093/neuonc/noac00
Becker, K.N., Pettee, K.M., Sugrue, A., Reinard, K.A., Schroeder, J.L., Eisenmann, K.E. (2022) The cytoskeleton effectors Rho-kinase (ROCK) and mammalian diaphanous-related (mDia) formin have dynamic roles in tumor microtube formation in invasive glioblastoma cells. Cells 11:1159 https://doi.org/10.3390/cells11091559
Biswas, H., Zhao, S., Makinwa, Y., Bassett, J.S., Pike, M., Musich, P.R., Liu, JY, Zou, Y. (2022) Prolyl isomerization-mediated conformational changes define ATR subcellular compartment-specific functions. Front . Cell Dev. Biol. , 10:826576. doi: 10.3389/fcell.2022.826576
Butt, E., Howard, C.M., and Raman, D. (2022) LASP1 in cellular signaling and gene expresson: More than just a cytoskeletal regulator. Cells 11:3817. doi: 10.3390/cells11233817
Creeden, J.F., Kipp, Z.A., Xu, M., Flight, R.M., Moseley, H.N.B., et al. (2022) Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents. Hepatol. 76:1376-1388. doi: 10.1002/hep.32467
Elke, B., Howard,C.M., and Raman, D. (2022) LASP1 in cellular signaling and gene expression: More than just a cytoskeletal regulator. Cells 11:3817. https://doi.org/10.3390/cells11233817
Peery, R., Cui, Q., Kyei-Baffour, K., Josephraj, S., Huang, C., Dong, Z., Dai, M., Zhang, J-T., Liu, J-Y. (2022) A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. Bioorg Med Chem. 65:116761. doi:10.1016/j.bmc.2022.116761
Sharma, V., Letson, J., Furuta, S. (2022) Fibrous stroma: Driver and passenger cancer development. Sci. Signal. 15. doi: 10.1126/scisignal.abg3449
2021
Becker, K.N., Pettee, K.M., Sugrue, A,. Reinard, K.A., Schroeder, J.L., Eisenmann, K.M. (2021) ROCK and mDia have dynamic roles in glioblastoma tumor microtube invasion. Cancer Res. 81:2.
Craig, D.J., Crawford, E.L., Massion, P.P., Morrison, T., Willey, J.C. (2021) Low frequency TP53 mutations in airway epithelial cells serve as lung cancer risk biomarker. Cancer Res. 81:1.
Crawford, E.L., Chen T., Craig, D.J., Willey, J.C. (2021) Use of a synthetic spike-in ladder to measure NGS library complexity. Cancer Res. 81:2.
Creeden, J.F., Imami, A.S., Eby, H.M. Gillman, C., Becker, K.N., Reigle, J., Andari, E., Pan, Z.K., O'Donovan, S.M., McCullumsmith, R.E., and McCullumsmith, C.B. (2021) Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection. Biomed. Pharmacother. 138:111437.
Gardiyawasam, K., Figy, C., Feng, J., Tipton, C., De Castro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, R., Yeung, K.C. (2021) The RhoA dependent anti-metastatic function of RKIP in breast cancer. Nature Sci. Rep. 11:17455. https://doi.org/10.1038/s41598-021-96709-6
Kalpana, G., Figy, C., Feng, J., Tipton, C., DeCastro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, Yeung, K.C. (2021) The RhoA dependent anti-metastatic function of RKIP in breast cancer. Nature Sci. Rep. 11:17455.
Li , Z., Hui Wang-Heaton, H., Cartwright, B.M., Makinwa, Y., Hilton, B.A., Musich, P.R., Shkriabai, N., Kvaratskhelia, M.K., Guan, S., Chen,
Q., Yu, X., and Zou, Y. (2021) ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation
of PARP1 without DNA damage signaling. FASEB J 35(5):e21373.
O'Donovan, S.M., Imami, A., Eby, H., Henkel, N.D., Creeden, J.F., Asah, S., Zhang, X., Wu, X., Alnafisah, R., Taylor, R.T., Reigle, J., Thomran, A.,
Shamsaei, B., Meller, J., and McCullumsmith, R.E. (2021) Identification of a candidate repurposable drugs to combat COVID-19 using a signature-based
approach. Scientific Reports, 11(1): 4495.
Ren, G., Zheng, X., Sharma, V., Letson, J., Nestor-Kalinoski, A.L., Furuta, S. (2021) Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts-An Indicator for Breast Carcinogenesis. Cancers. 13. 15
Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., and Furuta, S. (2021) S-Nitrosylation in tumor microenvironment. Int. J. Mol. Sci. 22:(9).
2020
Craig, D.J., Creeden, J.F., Einloth, K.R., Gillman, C.E., Stanbery, L., Hamouda, D., Edelman, G., Dworkin, L., and Nemunaitis, J.J. (2020) Resident memory T cells and their effect on cancer. Vaccines (Basel) 8(4).
Creeden, J.F., Alganem, K., Imami, A.S., Henkel, N.D., Brunicardi, F.C., Liu, S-H., Shukla, R., Tomar, T., Naji F., and Mccullumsmith, R.E. (2020) Emerging kinase therapeutic targets in pancreatic ductal adenocarcinoma and pancreatic cancer desmoplasia. Int. J. Mol. Sci. 21(22).
Gurung, D., and Blumenthal, R.M. (2020) Distribution of RecBCD and AddAB recombination-associated genes among bacteria in 33 phyla. Microbiology (Reading) 166(11).
Howard, C.M, Estrada, M., Terreo, D., Tiwari, A.K., and Raman, D. (2020) Identification of cardiac glycosides as novel inhibitors of eIF4A1-mediated translation in triple-negative breast cancer cells. Cancers 12(8).
Makinwa, Y., Cartwright, B.M., Musich, P.R., Li, Z., Biswas, H., and Zou, Y. (2020) PP2A regulates phosphorylatin-dependent isomerization of cytoplasmic and mitochondrial-associated ATR by Pin1 in DNA damage responses. Fron. Cell Dev. Biol. 8:813
Makinwa, Y., Musich, P.R., and Zou, Y. (2020) Phosphorylation-Dependent Pin1 isomerization of ATR: Its role in regulating ATR's anti-apoptotic function at mitochondria, and the implications in cancer. Fron. Cell Dev. Biol. 8:281.
Liu, S-H., Yu, J.H., Creeden, J.F., Sutton, J.M., Markowiak, S., Sanchez, R., Nemunaitis, J., Kalinoski, A., and Zhang, J.T. (2020) Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma. Cancer Lett., 491:97107.
Subramaniyan, B., Sridharan, S., Howard, C.M., Basuroy, T., de la Serna, I., Butt, E., and Raman, D. (2020) Role of the CXCR4-LASP1 axis in the stabilization of Snail1 in triple-negative breast cancer. Cancers 12(9).
Tilley, A.M.C., Howard, C.M., Sridharan, S., Subramaniyan, B., Bearss, N.R., Alkhalili, S., and Raman, D. (2020) The CXCR4-dependent LASP1-Ago2 interaction in triple-negative breast cancer. Cancers 12(9).
Trivedi, A., Mehrotra, A., Baum, C.E., Lewis, B., Basuroy, T., Blomquist, T., Trumbly, R., Filipp, F.V., Setaluri, V., and de la Serna, I.L. Epigenetics Chromatin. (2020) Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation. 10;13(1):14. doi: 10.1186/s13072-020-00333-z.
Zheng, X., Fernando, V., Sharma, V., Walia, Y., Letson, J., Furuta, S. (2020) Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem. Pharmacol. 113887. doi;10.1016/j.bcp.2020.113887.
Makinwa, Y., Cartwright, B.., Musich, P.R., Li, Z., and Zou, Y. (2020) PP2A Regulates phosphorylation-dependent isomerization of cytoplasmic and mitochondrial-associated ATR by Pin1 in DNA damage responses. Front Cell Dev Biol. 8:281.