Jyl S. Matson, Ph.D.
Associate Professor
Vibrio cholerae stress response mechanisms and pathogenesis
Office: HEB 243
Telephone: 419.383.3971
Fax: 419.383.3002
jyl.matson@utoledo.edu
Research Interests
Cholera, an epidemic disease characterized by voluminous watery diarrhea, is produced when the Gram negative curved bacillus Vibrio cholerae colonizes the upper small intestine of its human host. V. cholerae are found throughout the world in coastal areas and are transmitted to humans through consumption of contaminated food or water. Despite its long history as a research target, cholera continues to afflict approximately 5 million people each year and remains an important public health problem in many areas of the globe.
One aspect of Dr. Matson’s research is using next generation sequencing (RNAseq) to uncover new knowledge about how bacteria respond to various stressors. Our lab is particularly interested in using RNAseq to determine the function of previously uncharacterized V. cholerae proteins. We performed RNAseq analysis on V. cholerae grown in the presence and absence of sublethal concentrations of antimicrobial peptides and identified a new mechanism to defend against their negative effects. Our ongoing work aims to better understand how the SipA and OmpA proteins work together to relieve cellular stress.
Graphic: Saul-McBeth, J, Matson, JS. A periplasmic antimicrobial peptide-binding protein is required for stress survival in Vibrio cholerae. Frontiers in Microbiology. 2019; 10:161.
Dr. Matson received her Ph.D. in Microbiology and Immunology from the University of North Dakota under the mentorship of Dr. Matthew Nilles. She then completed her postdoctoral training at the University of Michigan in the laboratory of Dr. Victor DiRita. Dr. Matson joined the Department of Medical Microbiology and Immunology in June of 2013.
Media
- Toledo Blade: UT students set their sights on cholera prevention
- Toledo Blade: UT researchers take new approach in cholera prevention
- UToledo News: Cholera Researcher Makes Surprising Discovery Close to Home
- Holland - Springfield Journal: Springfield High School students dive into hands-on medical discovery at UT Medical Campus
Publications
Thornburg JA, Nguy P, Mortland KM, Mortland KM, Sloup RE, Naylor BK, Topp RV, Matson JS, Bigioni TP. In Vitro and In Vivo Testing of Microbe Growth on Antimicrobial Nursing Scrubs. Clinical Nursing Research. 2024 Mar 17:10547738241238250.
Akolkar, JK, Matson, JS. Stress responses in pathogenic Vibrios and their role in host and environmental survival. Advances in Experimental Medicine and Biology. 2023; 1404:213-232.
Daboul, J, Weghorst, L, DeAngelis, C, Plecha, SC, Saul-McBeth, J, Matson, JS. Characterization of Vibrio cholerae isolates from freshwater sources in northwest Ohio. PLOS ONE. 2020. Sep 3;15(9):e0238438.
Pennetzdorfer, N, Lembke, M, Pressler, K, Matson, JS, Reidl, J, Schild, S. Targeted proteolysis in Vibrio cholerae allowing rapid adaptation. Frontiers in Cellular and Infection Microbiology. 2019; 9:214.
DeAngelis, CM, Nag, D, Withey, JH, Matson, JS. Characterization of the Vibrio cholerae phage shock protein response. Journal of Bacteriology. 2019; 201(14).
Saul-McBeth, J, Matson, JS. A periplasmic antimicrobial peptide-binding protein is required for stress survival in Vibrio cholerae. Frontiers in Microbiology. 2019; 10:161.
Matson, JS. Genome sequence of Vibrio cholerae strain D1, isolated from the Maumee River in Toledo, Ohio. Microbiology Resource Announcements. 2018; 7 (16).
DeAngelis, CM, Saul-McBeth, J, Matson, JS. Vibrio responses to extracytoplasmic stress. Environmental Microbiology Reports. 2018; 10 (5):511-521.
Matson, JS. Infant mouse model of Vibrio cholerae infection and colonization. Methods in Molecular Biology. 2018; 1839:147-152.
Matson, JS. Preparation of Vibrio cholerae samples for RNA-seq analysis. Methods in Molecular Biology. 2018; 1839:29-38.
Matson, JS. Random transposon mutagenesis of Vibrio cholerae. Methods in Molecular Biology. 2018; 1839:39-44.
Matson, JS. Rapid arbitrary PCR insertion libraries, a new tool for defining bacterial promoter regions. Journal of Bacteriology. 2018; March 12.
Gupta, TT, Matson, JS, Ayan, H. Antimicrobial Effectiveness of Regular Dielectric Barrier Discharge (DBD) and Jet DBD Plasma on the Viability of Pseudomonas aeruginosa. IEEE Transactions on Plasma Science. 2017;PP(99). doi:10.1109/TPS.2017.2748982.