Department of Neurology

Faculty - Gretchen E. Tietjen, M.D.

 

Distinguished University Professor Emeritus
Inaugural Chair of Neurology 1/2000-7/2019
Director, UT Headache Treatment & Research Program 1996-2020
Director, UT Stroke Program 1997-201

SPECIAL INTERESTS

Migraine as a stroke risk factor
Endothelial Dysfunction in migraine
Early life stress and migraine
Cerebrovascular Diseases in the young

EDUCATION

M.D.: University of Michigan Medical School, 1980-84.
Medicine Residency: Department of Internal Medicine, Associated Hospitals Program, University of Rochester, Rochester, New York, 1984-86
Neurology Residency: Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, 1986-89
Vascular Neurology Fellowship: Department of Neurology, Center for Stroke Research, Henry Ford Health System, Detroit, Michigan, 1989-1991

PROFESSIONAL APPOINTMENTS

Chair of Neurology Department, University of Toledo, 4/1999 – 7/2019
Chief of Neurology, Department of Medicine, Medical College of Ohio, 1997-1999
Professor, Neurology Department, University of Toledo, 2002-present
Associate Professor, Neurology Department, Medical College of Ohio, 1996-2002
Senior Staff, Henry Ford Health Sciences Center, Neurology, 1991-1996

Certifications

American Board of Psychiatry and Neurology: Neurology 1990
American Board of Psychiatry and Neurology: Vascular Neurology 2005
United Council for Neurologic subspecialties: Headache Medicine 2006, 2016

SOCIETY MEMBERSHIPS

AWARDS

American Heart Association Toledo Northwest Ohio Division Legacy Award, 2020
American Headache Society Women’s Health Research Lecture Award, 2019
University of Toledo College of Medicine and Life Sciences Career Achievement Award, 2018
Visiting Scholar, John R. Graham Headache Center, Brigham and Women's Faulkner Hospital, Harvard, 2017
American Headache Society John R. Graham Lecture Award 2017
Listed in Best Doctors in America 1996 through 2019
Clair Martig Endowed Chair in Neurology, University of Toledo, 2014-2019
American Heart Association Toledo Northwest Ohio Division Heart of Gold Award, 2020
Recipient of The UTMC Shining Star Award of the year (one of 3 awardees), for exemplifying the iCare standards, 2012
Honored as University of Toledo Distinguished Professor, since 2012
American Headache Society Harold G. Wolff Lecture Award for Headache Research, 2011
University of Toledo Outstanding Faculty Research Award, 2011
Alpha Omega Alpha Induction, 2010
Stroke Innovation Award from the American Heart Association Journal Stroke, 2010
American Headache Society Women's Issues Research Award, 2010
American Headache Society Seymour Solomon Presidential Lecture recipient, 2008
Faculty Club Service Award, Medical College of Ohio, 2004
Dean's Award Excellence in Teaching, Medical College of Ohio, 2001
The Association of University Professors of Neurology Award for outstanding success in encouraging students to elect careers in Neurology, 2001
Hedwig von Ameringen Executive Leadership in Academic Medicine for Women Fellowship, 2000-2001

EDITORIAL

NATIONAL REVIEW PANEL

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Selected PUBLICATIONS

Papers
Jumaa MA, Castonguay AC, Salahuddin H, Shawver J, Saju L, Burgess R, Kung V, Slawski DE, Tietjen G, Lindstrom D, Parquette B, Korsnack A, Cole K, Afreen E, Bafna K, Zaidi SF. Long-term implementation of a prehospital severity scale for EMS triage of acute stroke: a real-world experience. J Neurointerv Surg. 2019 Jul 2. pii: neurintsurg-2019-014997.

Minen MT, Weissman J, Tietjen GE. The Relationship Between Migraine or Severe Headache and Chronic Health Conditions: A Cross-Sectional Study from the National Health Interview Survey 2013-2015. Pain Med. 2019 May 25. pii: pnz113.

Slawski DE, Salahuddin H, Saju L, Shawver J, Korsnack A, Tietjen G, Papadimos TJ, Castonguay AC, Kung V, Burgess R, Zaidi SF, Jumaa MA. Monitored Anesthesia Care by Sedation-Trained Providers in Acute Stroke Thrombectomy. Front Neurol. 2019 Mar 28;10:296.

Salahuddin H, Sheikh AA, Hussaini S, Verghese C, Tietjen GE. Ischemic Stroke After Plasmapheresis. Am J Med Sci. 2018 Oct;356(4):399-403. Review.

Karmakar M, Elhai JD, Amialchuk AA, Tietjen GE. Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset. Headache. 2018; 58:243-259.

Slawski DE, Jumaa MA, Salahuddin H, Shawver J, Humayun MJ, Russell T, Seiwert A, Paolini D, Abbas J, Nazzal M, Tietjen GE, Espinosa-Morales A, Korsnack A, Zaidi SF. Emergent carotid endarterectomy versus stenting in acute stroke patients with tandem occlusion. J Vasc Surg. 2018 Oct;68(4):1047-1053.

Slawski DE, Salahuddin H, Shawver J, Kenmuir CL, Tietjen GE, Korsnack A, Zaidi SF, Jumaa MA. Mechanical Thrombectomy in Elderly Stroke Patients with Mild-to-Moderate Baseline Disability. Interv Neurol. 2018 Apr;7(5):246-255.

Salahuddin H, Tietjen G, Jumaa M, Zaidi SF. Ischemic stroke due to retrograde thromboembolism during arteriovenous graft thrombectomy. J Vasc Access. 2018 Mar;19(2):201-202.

Tietjen GE, Khubchandani J, Herial N, Palm-Meinders, Koppen Hille, Terwindt G, van Buchem MA, Launer LJ, Ferrari MD, Kruit MC. Migraine and Vascular Disease Biomarkers: A population-based case-control study. Cephalalgia. 2018 Mar;38(3):511-518. Tietjen GE, Collins SA. Hypercoagulability and Migraine. Headache. 2018 Jan;58(1):173-183.

Salahuddin H, Espinosa A, Buehler M, Khuder SA, Khan AR, Tietjen G, Zaidi S, Jumaa MA. Mechanical thrombectomy for middle cerebral artery division occlusions: a systematic review and meta-analysis. Interv Neurol. 2017 Oct;6(3-4):242-253.

Tietjen GE, Karmakar M, Amialchuk AA. Emotional Abuse History and Migraine Among Young Adults: A Retrospective Cross-Sectional Analysis of the Add Health Dataset. Headache 2017 Jan;57(1):45-59.

Tietjen GE, Buse DC, Collins SA. Childhood Maltreatment in the Migraine Patient. Curr Treat Options Neurol. 2016 Jul;18(7):31. doi: 10.1007/s11940-016-0415-4. Review.

Zaidi SF, Shawver J, Espinosa Morales A, Salahuddin H, Tietjen G, Lindstrom D, Parquette B, Adams A, Korsnack A, Jumaa MA. Stroke care: initial data from a county-based bypass protocol for patients with acute stroke. J Neurointerv Surg. 2016 Jun 24. pii: neurintsurg-2016-012476. doi: 10.1136/neurintsurg-2016-012476

Tietjen GE. Childhood Maltreatment and Headache Disorders. Curr Pain Headache Rep. 2016 Apr;20(4):26.

Peterlin BL, Mielke MM, Dickens AM, Subroto C, Dash P, Alexander G, Vieira RV, Bandaru VVR, Dorskind JM, Tietjen GE, Haughey NH. Interictal, Circulating Sphingolipids in Women with Episodic Migraine: A Case-Control Study. Neurology 2015;85(14):1214-23.

Chai NC, Gelaye B, Tietjen GE, Dash PD, Gower BA, White LW, Ward TN, Scher AI, Peterlin BL. Ictal adipokines are associated with pain severity and treatment response in episodic migraine. Neurology 2015; 84:1409-18.

Tietjen GE, Buse DC, Fanning KM, Serrano D, Reed ML, Lipton RB. Recall of Maltreatment in Adults with Migraine and Tension-Type Headache: Results of the AMPP Study. Neurology 2015;84:132-40.

Tietjen GE, Khubchandani J. Vacular Biomarkers in Migraine. Cephalalgia 2015;35(2):95-117.

Peterlin BL, Tietjen GE, Gower BA, Ward TN, Tepper SJ, White LW, Dash PD, Hammond ER, Haythornthwaite JA. Ictal adiponectin levels in episodic migraineurs: a randomized pilot trial. Headache. 2013 Mar;53(3):474-90

Tietjen GE, Khubchandani J, Ghosh S, Bhattacharjee S, Kleinfelder J. Headache symptoms and indoor environmental parameters: results from the EPA BASE study. Ann Indian Acad Neurol. 2012 Aug;15(Suppl 1):S95-9.

Tietjen GE, Khubchandani J, Herial NA, Shah K. Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers. Headache 2012 ;52:920-929.

Nicholas-Bublick S, Irlam JH, Tietjen G. A malignant case of acute promyelocytic leukemia with occlusion of carotid artery by tumor thrombus. J Stroke Cerebrovasc Dis. 2012 May;21(4):325-6.

Tietjen GE. Office assessment for abuse and management of the battered patient. Neurol Clin Pract March 2012 2:5-13.

Tietjen GE, Peterlin BL. Childhood abuse and migraine: epidemiology, sex differences, and potential mechanisms. Headache 2011, 51(6):869-79.

Peterlin BL, Nijjar SS, Tietjen GE. Post Traumatic Stress Disorder and migraine: epidemiology, sex differences and potential mechanisms. Headache 2011, 51(6):860-8.

Ali II, Herial NA, Orris M, Horrigan T, Tietjen GE. Migraine prophylaxis with topiramate and bone health in women. Headache. 2011 Apr;51(4):613-6.

Tietjen GE. Is there a link between abuse in childhood and pain disorders? Expert Rev Neurother. 2010 Nov;10(11):1625-7.

Anda R, Tietjen GE, Schulman E, Felitti V, Croft J. Adverse Childhood Experiences and Frequent Headaches in Adults. Headache 2010 Oct;50(9):1473-81.

Saper JR, Lake AE, Bain PA, Stillman MJ, Rothrock JF, Mathew NT, Hamel RL, Moriarty M, Tietjen GE. A Practice Guide for Continuous Opioid Therapy for Refractory Daily Headache: Patient Selection, Physician Requirements, and Treatment Monitoring. Headache. 2010 Jul;50(7):1175-1193.

Evans RW, Tepper SJ, Shapiro RE, Sun-Edelstein C, Tietjen GE. The FDA alert on serotonin syndrome with use of triptans combined with selective serotonin reuptake inhibitors or selective serotonin-norepinephrine reuptake inhibitors: American Headache Society position paper. Headache. 2010 Jun;50(6):1089-99.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part I). Prevalence and adult revictimization. A multicenter headache clinic survey. Headache 2010;50:20-31.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part II). Emotional abuse as a risk factor for headache chronification. Headache 2010;50:32-41.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Childhood maltreatment and migraine (Part III). Association with comorbid pain conditions. Headache 2010;50:42-51.

Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA. Allodynia in Migraine: Association with comorbid pain conditions. Headache 2009 Oct;49(9):1333-44.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Heckman BD, Holroyd KA, Himawan L, O'Donnell FJ, Tietjen G, Utley C, Stillman M. Do psychiatric comorbidities influence headache treatment outcomes? Results of a naturalistic longitudinal treatment study. Pain. 2009;146:56-64.

Tietjen GE. Migraine as a Systemic Vasculopathy. Cephalalgia. 2009 Sep;29(9):987-96.

Tietjen GE, Khubchandani J. Platelet Dysfunction and Stroke in the Female Migraineur. Curr Pain Headache Rep. 2009 Oct;13(5):386-91.

Tietjen GE, Herial NA, Utley C, White L, Yerga-Woolwine S, Joe B. Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in Migraine. Cephalalgia. 2009 Sep;29(9):960-8.

Tietjen GE, Herial NA, White LM, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009, Sep;40(9):2977-82.

Peterlin BL, Tietjen GE, Brandes JL, Rubin SM, Drexler E, Lidicker JR, Meng S. Posttraumatic stress disorder in migraine. Headache. 2009 Apr;49(4):541-51.

Heckman BD, Holroyd KA, Tietjen G, O'Donnell FJ, Himawan L, Utley C, Watakakosol R, Stillman M. Whites and African-Americans in headache specialty clinics respond equally well to treatment. Cephalalgia. 2009 Feb 2.

Mathew NT, Landy S, Stark S, Tietjen GE, Derosier FJ, White J, Lener SE, Bukenya D. Fixed-Dose Sumatriptan and Naproxen in Poor Responders to Triptans With a Short Half-Life. Headache 2009 Jul;49(7):971-82.

Heckman BD, Holroyd KA, O'Donnell FJ, Tietjen G, Utley C. Race Differences in Adherence to Headache Treatment Appointments in Persons with Headache Disorders. Journal of the National Medical Association. 2008 Feb;100(2):247-55.

Peterlin BL, Tietjen GE, Meng S, Lidicker JR, Bigal ME. Post-traumatic stress disorder in Episodic and Chronic Migraine. Headache 2008, 24: 517–522.

Tietjen GE, Migraine and Ischemic Heart Disease and Stroke: Potential mechanisms and treatment implications. Cephalalgia 2007, 27:981-987.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C, Khuder SA. History of childhood maltreatment is associated with comorbid depression in women with migraine. Neurology 2007, 69(10): 959-968.

Tietjen GE, Migraine as a systemic disorder. Neurology 2007, 68:1555-1556.

Tietjen GE, Bushnell C, Hafeez F, Herial NA, Utley C, White L. Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache 2007, 47(7):1069-78.

Tietjen GE, Lee Peterlin B, Brandes JL, Hafeez F, Hutchinson S, Martin VT, Dafer RM, Aurora SK, Stein MR, Herial NA, Utley C, White L, Khuder SA. Depression and Anxiety: Effect on the Migraine-Obesity Relationship. Headache 2007, 47(6):866-875.

Tietjen GE, Herial NA, Hardgrove J, Utley C, White L. Migraine Comorbidity Constellations. Headache 2007, 47(6):857-865.

Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C. High Prevalence of Somatic Symptoms and Depression in Women with Disabling and Chronic Headache. Neurology, 2007, 68:134-140.

Tietjen GE, Al-Qasmi MM, Athanas K, Utley C, Herial NA. Altered hemostasis in migraineurs studied with a dynamic flow system. Thromb Res. 2007;119(2):217-22.

Murugappan A, Coplin WM, Al-Sadat AN, McAllen KJ, Schwamm LH, Wechsler LR, Kidwell CS, Saver JL, Starkman S, Gobin YP, Duckwiler G, Krueger M, Rordorf G, Broderick JP, Tietjen GE, Levine SR.Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology 2006, Mar 14;66(5):768-70.

Tietjen GE, Conway A, Utley C, Herial NA. Migraine is associated with Menorrhagia and Endometriosis. Headache 2006, 46:422-428.

Tietjen GE, Al-Qasmi MM, Gunda P, Herial NA. Sneddon’s syndrome: another migraine-stroke association? Cephalagia October 2005, doi: 10.1111/j.1468-2982.2005.01032.x

Tietjen GE. The Risk of stroke in patients with Migraine and implications for migraine management. CNS Drugs 2005, 19:683-692.

Tietjen GE, Athanas K, Utley C, Herial N, Khuder S. The Combination of Naratriptan and Prochlorperazine in Migraine Treatment. Headache 2005, 45:751-762.

Bruno A, McConnell JP, Cohen SN, Tietjen GE, Wallis RA, Gorelick PB, Bang NU. Plasma Thrombosis Markers Following Cerebral Infarction in American Americans. Thrombosis Research 2005, Vol. 115/1-2:73-77.

Bruno A, McConnell JP, Mansbach HH, Cohen, SN, Tietjen GE, Wallis RA, Gorelik PB, Bang NU. Serial Urinary 11-dehydrothromboxane B2 Measurements in African Americans with Ischemic Stroke: Correlation with Aspirin Dose and Vascular Events. Stroke 2004, Mar. 35(3):727-30.

McGrady A, Vasudeva S, Claggett AL, Tietjen GE. Biofeedback Assisted Relaxation in Migraine Headache: Relationship to Cerebral Blood Flow Velocity in the Middle Cerebral Artery. Headache, 2003, 43(3): 245-250.

Tietjen GE, Gottwald L, Al-Qasmi MM, Gunda P, Khuder S. Migraine is associated with livedo reticularis: a prospective study. Headache 2002; 42:263-267.

Tietjen GE, Al-Qasmi M, Shukair MS. Livedo reticularis and migraine: a marker for stroke risk? Headache 2002; 42:352-355.

Bruno A, McConnell JP, Mansbach, HH III, Cohen SN, Tietjen GE, Bang NU. Aspirin dose and thromboxane metabolism in African American Stroke patients. Stroke 2002; 33:57-30.

Tietjen GE, Al-Qasmi MM, Athanas K, Dafer RM, Khuder SA. Increased von Willebrand factor in migraine. Neurology 2001;57:334-36.

Aurora SK, Tietjen GE. Vertebrobasilar artery ectasia: a reversible cause of dementia. Journal of Stroke and Cerebrovascular Disease 2000;9:196-198.

Tietjen GE. The Relationship of Migraine and Stroke. Neuroepidemiology 2000;19:13-19.

Loder E, Tietjen GE, Marcus DA: Evaluation and Management Issues in Migraine; Journal of Clinical Outcomes Management, 1999; 6:58-76.

Jacobson MW, Rapport LJ, Keenan PA, Coleman RD, Tietjen GE: Neuropsychological deficits associated with antiphospholipid antibodies. J Clin Exp Neuropsychol, 1999; 21:254-64.

McGrady AV, Andrasik F, Davies T, Striefel S, Wickramasekera I, Baskin SM, Penzien DB, Tietjen GE: Psychophysiologic Therapy for Chronic Headache in Primary Care. Primary Care Companion J Clin Psychiatry, August 1999; 4:96-102.

Zorowitz R, Tietjen GE: Medical Complications of Acute Stroke. In: Advanced Acute Stroke Care Curriculum, M Gorman, SR Levine (eds). Journal of Stroke and Cerebrovascular Disease 1999; 8:192-196.

Verro P, Levine SR, Tietjen GE: Cerebrovascular Ischemic Events with High Positive Anticardiolipin Antibodies; Stroke, 1998; 29:2245-2253.

Tietjen GE, Day M, Norris L, Aurora S, Halvorsen A, Schultz LR, Levine SR: Role of anticardiolipin antibodies in young persons with migraine and transient focal neurological events. A prospective study. Neurology 1998; 50:1433-1440.

Jacobson MA, Abraham E, Tietjen GE: A review of neurologic sequelae and cognitive deficits associated with antiphospholipid antibodies. Journal of Stroke and Cerebrovascular Diseases 1996;6:61-66.

Matthew NT, Tietjen GE, Lucker C: Serotonin Syndrome complicating migraine pharmacotherapy. Cephalalgia 1996;16:323-7.

Tietjen GE: Transient focal neurologic events in young adults: TIA, migraine and their relationship to stroke. The Neurologist 1995;1:248-258.

Fagan SC, Kertland HR, Tietjen GE: Safety of Aspirin in combination with heparin or warfarin in acute stroke patients. Ann Pharmacother 1994; 28:441-443.

Tietjen GE, Futrell N, Schultz LR: Embolic Infarcts of Carotid Origin differ in size and site with contralateral carotid patency. Journal of Neurological Sciences 1993;118:217-222.

Tietjen GE, Levine SR, Masha E, Brown E, Welch KMA: Factors that predict antiphospholipid immunoreactivity in young people with transient focal neurologic events. Archives of Neurology. 1993;50:833-836.

Tietjen GE, Mitsias P: Cerebral Venous Thrombosis. Heart Disease and Stroke 1993; 2:19-25.

Tietjen GE: Migraine and Antiphospholipid Antibodies. Cephalalgia 1992; 12:69-74.

Tietjen GE, Futrell N, Garcia JH, Millikan C: Platelet emboli in rat brain cross when the contralateral carotid is occluded. Stroke 1991; 22:1053-1058.

Ramadan NM, Tietjen GE, Levine SR, Welch KMA: Scintillating scotomata associated with internal carotid artery dissection: Report of three cases. Neurology 1991; 41:1084-1087.

Fagan SC, Ewing JR, Levine SR, Tietjen GE, Ramadan NM, Welch KMA: Assessing the effects of antihypertensive medication on cerebral blood flow: Demonstration in internal carotid artery occlusion. DICP 1991; 25:1299-1301. 

Tietjen GE, Drury I: Familial Creutzfeldt-Jakob Disease without periodic EEG activity. Ann Neurol 1990; 28:585-588.

Oldham SB, Lipson LG, Tietjen GE: Presence of calmodulin parathyroid adenomas. Minerals and Electrolyte Metabolism 1982; 7(5):273-80.

Lipson LG, Bush MJ, Tietjen GE, Yoon A: Role of the adenylate cyclase system in altered insulin release from Islets of Langerhans of aging rats. Acta Endocrinologica (Cophen) 1981; 96(2):222-226.

Lipson LG, Bobryci VA, Bush MJ, Tietjen GE: Insulin release in aging: studies on adenylate cyclase, phosphodiesterase, and protein kinase in isolated islets of Langerhans of the rat. Endocrinology 1981; 108(2):620-624.

Multicenter Trial Publications

Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, Kernan WN; IRIS Trial Investigators. Smoking cessation and outcome after ischemic stroke or TIA. Neurology. 2017;89(16):1723-1729.

Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, Brass LM, Schwartz GG, Adams HP Jr, Berger L, Carolei A, Clark W, Coull B, Ford GA, Kleindorfer D, O'Leary JR, Parsons MW, Ringleb P, Sen S, Spence JD, Tanne D, Wang D, Winder TR; IRIS Trial Investigators. Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. N Engl J Med. 2016;374(14):1321-31.

Farkouh ME, Domanski M, Sleeper LA, Siami FS, Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky A, Boineau R, Weinberger J, Ramanathan K, Sousa JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, Muratov V, Bansilal S, King S 3rd, Bertrand M, Fuster V; FREEDOM Trial Investigators. Strategies for multivessel revascularization in patients with diabetes N Engl J Med. 2012;367(25):2375-84.

Morrow DA, Braunwald E, Bonaca MP, Ameriso SF, Dalby AJ, Fish MP, Fox KA, Lipka LJ, Liu X, Nicolau JC, Ophuis AJ, Paolasso E, Scirica BM, Spinar J, Theroux P, Wiviott SD, Strony J, Murphy SA; TRA 2P–TIMI 50 Steering Committee and Investigators. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med. 2012;366(15):1404-13.

Furlan AJ, Reisman M, Massaro J, Mauri L, Adams H, Albers GW, Felberg R, Herrmann H, Kar S, Landzberg M, Raizner A, Wechsler L; CLOSURE I Investigators. Closure or medical therapy for cryptogenic stroke with patent foramen ovale. N Engl J Med. 2012;366(11):991-9.

Bushnell CD, Olson DM, Zhao X, Pan W, Zimmer LO, Goldstein LB, Alberts MJ, Fagan SC, Fonarow GC, Johnston SC, Kidwell C, Labresh KA, Ovbiagele B, Schwamm L, Peterson ED; AVAIL Investigators. Secondary preventive medication persistence and adherence 1 year after stroke. Neurology. 2011;77(12):1182-90.

Kernan WN, Viscoli CM, Demarco D, Mendes B, Shrauger K, Schindler JL, McVeety JC, Sicklick A, Moalli D, Greco P, Bravata DM, Eisen S, Resor L, Sena K, Story D, Brass LM, Furie KL, Gutmann L, Hinnau E, Gorman M, Lovejoy AM, Inzucchi SE, Young LH, Horwitz RI; IRIS Trial Investigators. Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs). Neurology. 2009;72(15):1345-51.

Chaturvedi S, Zivin J, Breazna A, Amarenco P, Callahan A, Goldstein LB, Hennerici M, Sillesen H, Rudolph A, Welch MA; SPARCL Investigators. Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack. Neurology. 2009;72(8):688-94.

Diener HC, Sacco RL, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008 Oct;7(10):875-84. Erratum in: Lancet Neurol. 2008 Nov;7(11):985.

Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008;359(12):1225-37.

Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359(12):1238-51.

Goldstein LB, Amarenco P, Lamonte M, Gilbert S, Messig M, Callahan A, Hennerici M, Sillesen H, Welch KM; SPARCL Investigators. Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Stroke. 2008;39(9):2444-8.

Sherman DG, Atkinson RP, Chippendale T, Levin KA, NgK, et al.: Intravenous ancrod for treatment of acute ischemic stroke: the STAT study: a randomized controlled trial. Stroke Treatment with Ancrod Trial. JAMA. 2000; 283:2395-403.

Albers GW, Bates VE, Clark WM, Bell R, Verro P, Hamilton SA: Intravenous Tissue-Type Plasminogen Activator for Treatment of Acute Stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) Study. JAMA 2000; 283(9) 1145-1150.

Lewandowski CA, Frankel M, Tomsick TA, Broderick J, Frey J, Clark W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T: Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: emergency management of stroke (EMS) bridging trial. Stroke 1999; 30(12):2598-605.

Gorelick PB, Leurgans S, Richardson D, Harris Y, Billingsley M, and the AAASPS Investigators: African-American Antiplatelet Stroke Prevention Study (AAASPS): Clinical Trial Design. J Stroke Cerebrovasc Dis. 1998; 72:426-434.

Executive Committee for the Asymptomatic Carotid Atherosclerosis Study (collaborating investigator). Endarterectomy for asymptomatic carotid artery stenosis. JAMA 1995; 273:1421-1428.

Editorials, Letters, and other

Tietjen GE. Migraine, Stroke, and Heart Disease. American Migraine Foundation Spotlight series. July 14, 2016. https://americanmigrainefoundation.org/migraine-stroke-and-heart-disease

Tietjen GE, Sacco S. Migraine makes the stroke grow faster. [editorial] Neurology 2015,;85(22):1920-1.

Tietjen GE, Rundek R. Migraine and cryptogenic stroke: The clot thickens.[editorial] Neurology 2015, 85(17):1436-7.

Tietjen GE. Circulating microparticles in migraine with aura: cause or consequence, a link to stroke.[editorial] Cephalalgia. 2015;35(2):85-7

Tietjen GE, Karmakar M. Why emotional abuse in childhood may lead to migraines in adulthood. The Conversation. July 11, 2014. https://theconversation.com/why-emotional-abuse-in-childhood-may-lead-to-migraines-in-adulthood-59226

Tepper SJ, Shapiro RE, Sun-Edelstein C, Evans RW, Tietjen GE. Triptans and Serotonin Syndrome. A response [letter] Headache. 2012 Jul;52(7):1185-1188

Book Chapters

Tietjen GE. CADASIL. In Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017. ISBN 9780128093245

Tietjen GE, Faedda N. Child Abuse and Headache in Children and Adolescents. In: Headache and Comorbidities in Childhood and Adolescence. Guidetti V, Arruda M, Ozge A (eds). Springer International Publishing AG, Cham. 2017: In press.

Tietjen GE. CADASIL. In: Encyclopedia of the Neurological Sciences 2nd edition. Aminoff MJ, Daroff RB (Eds). Academic Press. San Diego. 2014

Ramsey-Williams V, Tietjen GE. Antiphospholipid Antibody syndrome, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (Eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011:66-67.

Ramsey-Williams V, Tietjen GE. Systemic Lupus Erythematosus, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (Eds). Lippincott Williams & Wilkins. Philadelphia PA. 2011: 402-403.

Tietjen GE. Auditing Headache Care. In: Headache Care, Research, and Education Worldwide. Frontiers in Headache Research, Volume 17. Olesen J, Ramadan NR, (Eds). Oxford University Press. Oxford UK. 2010: 99-106.

Tietjen GE. Cerebral Venous Thrombosis. In: The Headaches, third edition. Olesen J, Ramadan NR, Welch KMA (Eds). Lippincott Williams & Wilkins. Philadelphia PA. 2006: 919-924.

Dafer R, Tietjen GE. Antiphospholipid Antibody syndrome, Neurologic Complications. In: The 5-Minute Neurology Consult. Lynn DJ, Newton HB, Rae-Grant AD (Eds). Lippincott Williams & Wilkins. Philadelphia PA. 2004:66-67.

Tietjen GE, Brey RM. Oral Contraception, Estrogen Replacement Therapy, Migraine and Stroke. In: Migraine and Women. Loder EW, Marcus D (Eds). B.C. Decker, Inc. Hamilton, ON, 2004: 134-143

Tietjen GE. CADASIL. In: Encyclopedia of the Neurological Sciences. Aminoff MJ, Daroff RB (Eds). Academic Press. San Diego. 2003; Vol. 1;495-496.

Tietjen GE. Transient monocular blindness. In: Encyclopedia of the Neurological Sciences. Aminoff MJ, Daroff RB (Eds). Academic Press. San Diego. 2003; Vol. 4;551-552.

Tietjen GE. Oral contraceptives and postmenopausal estrogen replacement therapy. In: The Prevention of Stroke. Gorelick PB, Alter M (Eds). Parthenon Publishing. Lancaster UK. 2002;7:83-91.

Tietjen GE. Mechanisms and treatment of migrainous infarction. In: Seminars in Headache Management. Ramadan NM (Eds). Decker Periodicals Publishing. 1997;2:11-14.

Dafer R, Tietjen GE, Asherson RA: Drug Treatment of stroke in patients with antiphospholipid antibodies. In: CNS Drugs, 1997, 8(3):219-226. Adis International Limited

Tietjen GE: Transient Focal Neurologic Events. In: Primer on Cerebrovascular Diseases, Welch KMA, Caplan L, Reis D, Siesjo B, Weir B (eds). Academic Press 1997;358-361.

Levine SR, Tietjen GE, Dafer R, Feldmann E: Hematological abnormalities and stroke. In: Cerebrovascular Disease. Pathophysiology, Diagnosis, and Treatment, Bogousslavsky J, Ginsberg M, Hennerici M, Van Gijn, Caplan L, and Adams H (Eds). Blackwell Science, Inc.

Tietjen GE, Grover S, Day M, Norris L, Schultz L, Levine SR: Differences in ictal headache of migraine with aura and TIA in persons under 60 years. In: New Advances in Headache Research:4. F. Clifford Rose (ed). Smith-Gordon, Nishimura, 1994;51-55.

Tietjen GE, Levine SR: Sneddon's Syndrome. In: Neurobase.1995 Tietjen GE, Levine SR: Sneddon's Syndrome and Divry-Van Bogaert Disease. In: Stroke Syndromes, J. Bogousslavsky & L. Caplan (Eds). Cambridge University Press, New York 1995; 422-429.

Tietjen GE, Levine SR, Welch KMA: Migraine and Antiphospholipid Antibodies. In: Current Neurology, Stanley H. Appel (Ed), Vol XII. Mosby Year Book, Chicago, IL 1992;201-213.